LLPS-Hos-a648
RAB5A

▼ OVERVIEW

Status: Reviewed
Protein Name: Ras-related protein Rab-5A
Gene Name: RAB5A, RAB5
Ensembl Gene: ENSG00000144566.10
Ensembl Protein: ENSP00000403533.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 4Q9U (A, B, C) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASRGATRPN  GPNTGNKICQ  FKLVLLGESA  VGKSSLVLRF  VKGQFHEFQE  STIGAAFLTQ  60
61    TVCLDDTTVK  FEIWDTAGQE  RYHSLAPMYY  RGAQAAIVVY  DITNEESFAR  AKNWVKELQR  120
121   QASPNIVIAL  SGNKADLANK  RAVDFQEAQS  YADDNSLLFM  ETSAKTSMNV  NEIFMAIAKK  180
181   LPKNEPQNPG  ANSARGRGVD  LTEPTQPTRN  QCCSN  215
Nucleotide CDS Sequence (FASTA)
1     ATGGCTAGTC  GAGGCGCAAC  AAGACCCAAC  GGGCCAAATA  CGGGAAATAA  AATATGCCAG  60
61    TTCAAACTAG  TACTTCTGGG  AGAGTCCGCT  GTTGGCAAAT  CAAGCCTAGT  GCTTCGTTTT  120
121   GTGAAAGGCC  AATTTCATGA  ATTTCAAGAG  AGTACCATTG  GGGCTGCTTT  TCTAACCCAA  180
181   ACTGTATGTC  TTGATGACAC  TACAGTAAAG  TTTGAAATAT  GGGATACAGC  TGGTCAAGAA  240
241   CGATACCATA  GCCTAGCACC  AATGTACTAC  AGAGGAGCAC  AAGCAGCCAT  AGTTGTATAT  300
301   GATATCACAA  ATGAGGAGTC  CTTTGCAAGA  GCAAAAAATT  GGGTTAAAGA  ACTTCAGAGG  360
361   CAAGCAAGTC  CTAACATTGT  AATAGCTTTA  TCGGGAAACA  AGGCCGACCT  AGCAAATAAA  420
421   AGAGCAGTAG  ATTTCCAGGA  AGCACAGTCC  TATGCAGATG  ACAATAGTTT  ATTATTCATG  480
481   GAGACATCCG  CTAAAACATC  AATGAATGTA  AATGAAATAT  TCATGGCAAT  AGCTAAAAAA  540
541   TTGCCAAAGA  ATGAACCACA  AAATCCAGGA  GCAAATTCTG  CCAGAGGAAG  AGGAGTAGAC  600
601   CTTACCGAAC  CCACACAACC  AACCAGGAAT  CAGTGTTGTA  GTAACTAA  648

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Endocytosis
Endosome
GTP-binding
Lipoprotein
Membrane
Nucleotide-binding
Phagocytosis
Prenylation
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin cytoskeleton
Cellular Component
Anchored component of synaptic vesicle membrane
Cellular Component
Axon
Cellular Component
Axon terminus
Cellular Component
Clathrin-coated vesicle membrane
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic side of early endosome membrane
Cellular Component
Cytosol
Cellular Component
Dendrite
Cellular Component
Early endosome
Cellular Component
Early endosome membrane
Cellular Component
Early phagosome
Cellular Component
Endocytic vesicle
Cellular Component
Endosome
Cellular Component
Endosome membrane
Cellular Component
Extracellular exosome
Cellular Component
Melanosome
Cellular Component
Membrane raft
Cellular Component
Neuronal cell body
Cellular Component
Phagocytic vesicle
Cellular Component
Phagocytic vesicle membrane
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic early endosome
Cellular Component
Ruffle
Cellular Component
Somatodendritic compartment
Cellular Component
Synaptic vesicle
Cellular Component
Terminal bouton
Molecular Function
GDP binding
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Amyloid-beta clearance by transcytosis
Biological Process
Blood coagulation
Biological Process
Early endosome to late endosome transport
Biological Process
Endocytosis
Biological Process
Intracellular protein transport
Biological Process
Membrane organization
Biological Process
Phagocytosis
Biological Process
Phosphatidylinositol biosynthetic process
Biological Process
Positive regulation of exocytosis
Biological Process
Post-translational protein modification
Biological Process
Rab protein signal transduction
Biological Process
Receptor internalization involved in canonical Wnt signaling pathway
Biological Process
Regulation of autophagosome assembly
Biological Process
Regulation of endocytosis
Biological Process
Regulation of endosome size
Biological Process
Regulation of filopodium assembly
Biological Process
Regulation of long-term neuronal synaptic plasticity
Biological Process
Regulation of synaptic vesicle exocytosis
Biological Process
Synaptic vesicle recycling
Biological Process
Viral RNA genome replication

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a640Pan troglodytes99.542e-158446
LLPS-Pap-a633Pan paniscus99.542e-158446
LLPS-Cas-a552Carlito syrichta99.531e-159449
LLPS-Nol-a627Nomascus leucogenys99.531e-159449
LLPS-Mal-a628Mandrillus leucophaeus99.076e-159447
LLPS-Fec-a639Felis catus99.076e-159447
LLPS-Urm-a587Ursus maritimus99.076e-159447
LLPS-Aim-a615Ailuropoda melanoleuca99.076e-159447
LLPS-Tut-a346Tursiops truncatus99.076e-159447
LLPS-Caj-a633Callithrix jacchus99.076e-159447
LLPS-Mup-a621Mustela putorius furo99.076e-159447
LLPS-Aon-a643Aotus nancymaae99.076e-159447
LLPS-Dio-a616Dipodomys ordii99.076e-159447
LLPS-Chs-a626Chlorocebus sabaeus99.076e-159447
LLPS-Maf-a640Macaca fascicularis99.076e-159447
LLPS-Eqc-a638Equus caballus99.076e-159447
LLPS-Man-a643Macaca nemestrina99.076e-159447
LLPS-Paa-a639Papio anubis99.076e-159447
LLPS-Rhb-a634Rhinopithecus bieti99.076e-159447
LLPS-Ict-a631Ictidomys tridecemlineatus98.62e-158446
LLPS-Orc-a602Oryctolagus cuniculus98.63e-158446
LLPS-Loa-a620Loxodonta africana98.62e-158446
LLPS-Bot-a644Bos taurus98.62e-158446
LLPS-Mum-a642Mus musculus98.142e-157444
LLPS-Ova-a628Ovis aries98.144e-157443
LLPS-Cap-a635Cavia porcellus98.141e-155439
LLPS-Fud-a615Fukomys damarensis98.147e-158445
LLPS-Sus-a642Sus scrofa97.672e-156441
LLPS-Meg-a520Meleagris gallopavo96.282e-154436
LLPS-Gaga-a577Gallus gallus95.818e-154434
LLPS-Anc-a591Anolis carolinensis95.357e-153432
LLPS-Scf-a537Scleropages formosus93.528e-148419
LLPS-Xet-a555Xenopus tropicalis92.594e-147417
LLPS-Gaa-a541Gasterosteus aculeatus91.584e-123357
LLPS-Xim-a563Xiphophorus maculatus86.064e-127367
LLPS-Asm-a550Astyanax mexicanus85.718e-126363
LLPS-Orn-a553Oreochromis niloticus85.578e-123356
LLPS-Ran-a634Rattus norvegicus85.142e-107316
LLPS-Mea-a606Mesocricetus auratus84.542e-120350
LLPS-Pof-a557Poecilia formosa84.041e-126366
LLPS-Ten-a527Tetraodon nigroviridis83.944e-128369
LLPS-Icp-a557Ictalurus punctatus83.897e-124358
LLPS-Scm-a537Scophthalmus maximus83.872e-126365
LLPS-Tar-a528Takifugu rubripes83.493e-125362
LLPS-Dar-a559Danio rerio82.953e-121352
LLPS-Mam-a630Macaca mulatta82.554e-121352
LLPS-Orl-a545Oryzias latipes82.114e-122354
LLPS-Otg-a635Otolemur garnettii81.992e-96287
LLPS-Cea-a644Cercocebus atys77.212e-114333
LLPS-Gog-a635Gorilla gorilla75.868e-97289
LLPS-Lac-a561Latimeria chalumnae75.813e-115337
LLPS-Leo-a556Lepisosteus oculatus74.881e-115338
LLPS-Zem-a058Zea mays69.322e-81250
LLPS-Brr-a061Brassica rapa68.182e-79245
LLPS-Myl-a594Myotis lucifugus66.982e-97290
LLPS-Viv-a056Vitis vinifera66.672e-76236
LLPS-Hov-a051Hordeum vulgare66.267e-72228
LLPS-Prp-a049Prunus persica63.416e-71223
LLPS-Gor-a063Gossypium raimondii62.562e-82253
LLPS-Lep-a048Leersia perrieri62.071e-71225
LLPS-Brd-a056Brachypodium distachyon62.071e-70224
LLPS-Sem-a060Selaginella moellendorffii61.996e-71223
LLPS-Orb-a053Oryza barthii61.495e-71225
LLPS-Orp-a051Oryza punctata61.494e-71225
LLPS-Orr-a055Oryza rufipogon61.46e-71223
LLPS-Orni-a055Oryza nivara61.46e-71223
LLPS-Orm-a043Oryza meridionalis61.46e-71223
LLPS-Orgl-a055Oryza glumaepatula61.46e-71223
LLPS-Tra-a079Triticum aestivum61.272e-79245
LLPS-Nia-a054Nicotiana attenuata61.275e-84257
LLPS-Sob-a063Sorghum bicolor61.146e-72226
LLPS-Brn-a074Brassica napus60.986e-82251
LLPS-Org-a052Oryza glaberrima60.956e-70221
LLPS-Orbr-a059Oryza brachyantha60.822e-70222
LLPS-Sei-a054Setaria italica60.571e-70223
LLPS-Phv-a058Phaseolus vulgaris60.575e-70221
LLPS-Ors-a060Oryza sativa60.455e-71225
LLPS-Bro-a067Brassica oleracea60.23e-81251
LLPS-Glm-a067Glycine max60.01e-72228
LLPS-Dac-a045Daucus carota59.641e-65208
LLPS-Mua-a061Musa acuminata59.524e-79244
LLPS-Php-a067Physcomitrella patens59.431e-67216
LLPS-Amt-a047Amborella trichopoda59.417e-80246
LLPS-Coc-a051Corchorus capsularis59.122e-70222
LLPS-Art-a048Arabidopsis thaliana58.381e-67215
LLPS-Arl-a056Arabidopsis lyrata58.382e-67214
LLPS-Sol-a054Solanum lycopersicum58.29e-69218
LLPS-Thc-a052Theobroma cacao57.432e-74234
LLPS-Pot-a057Populus trichocarpa56.782e-72227
LLPS-Abg-a054Absidia glauca56.627e-66211
LLPS-Mae-a059Manihot esculenta56.253e-74232
LLPS-Via-a050Vigna angularis54.952e-69219
LLPS-Met-a059Medicago truncatula54.732e-71225
LLPS-Ori-a060Oryza indica53.651e-68218
LLPS-Aso-a028Aspergillus oryzae53.055e-64208
LLPS-Asf-a026Aspergillus flavus53.055e-64208
LLPS-Asg-a012Ashbya gossypii50.983e-64206