LLPS-Sus-4797
CFD
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Complement factor D; Adipsin; C3 convertase activator; Properdin factor D |
| Gene Name: | CFD, DF |
| Ensembl Gene: | ENSSSCG00000013418.4 |
| Ensembl Protein: | ENSSSCP00000014267.2 |
| Organism: | Sus scrofa |
| Taxa ID: | 9823 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSSSCT00000014662.4 | ENSSSCP00000014267.2 |
| UniProt | P51779, CFAD_PIG | |
| GeneBank | Z49058, U29948 | CAA88844.1, AAA73627.1 |
| RefSeq | XM_013994801.1 | XP_013850255.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADRSGHLAA LILLGAAVCV AQPRGRILGG QEAKSHERPY MASVQVNGKH VCGGFLVSEQ 60 61 WVLSAAHCLE DVAEGKLQVL LGAHSLSQPE PSKRLYDVLR AVPHPDSQPD TIDHDLLLLK 120 121 LSEKAELGPA VQPLAWQRED HEVPAGTLCD VAGWGVVSHT GRRPDRLQHL LLPVLDRTTC 180 181 NLRTYHDGTI TERMMCAESN RRDSCKGDSG GPLVCGGVAE GVVTSGSRVC GNRKKPGIYT 240 241 RLASYVAWID GVMADSAAA 259 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGACC GCTCCGGGCA CCTGGCAGCC CTGATCCTCC TCGGAGCAGC TGTATGTGTG 60 61 GCACAGCCCC GTGGCCGGAT CCTGGGTGGC CAGGAGGCCA AGTCCCACGA GAGACCCTAC 120 121 ATGGCATCGG TGCAGGTGAA CGGCAAGCAC GTGTGCGGAG GCTTCCTGGT GTCTGAGCAG 180 181 TGGGTGCTGA GTGCAGCACA CTGCCTGGAG GACGTGGCCG AGGGGAAGCT GCAGGTTCTC 240 241 CTGGGTGCGC ACTCCCTGTC ACAGCCCGAG CCCTCGAAGC GCCTGTACGA CGTGCTCCGC 300 301 GCCGTGCCCC ACCCAGACAG CCAGCCTGAC ACCATCGACC ATGATCTCCT CCTGCTGAAG 360 361 CTCTCCGAGA AGGCCGAGCT GGGCCCTGCC GTGCAGCCCC TTGCCTGGCA ACGAGAGGAC 420 421 CACGAGGTTC CGGCAGGCAC GCTCTGCGAC GTGGCCGGCT GGGGAGTGGT CAGTCACACT 480 481 GGCCGCCGGC CCGACCGTCT GCAGCACCTG CTCCTACCGG TGCTGGACCG CACCACCTGC 540 541 AACCTGCGCA CATACCACGA TGGCACCATC ACCGAGCGCA TGATGTGCGC GGAGAGCAAC 600 601 CGTCGGGACA GCTGCAAGGG CGACTCCGGA GGCCCGCTGG TGTGCGGGGG TGTGGCCGAG 660 661 GGAGTGGTTA CCTCAGGCTC CCGAGTCTGC GGCAACCGCA AGAAACCCGG CATCTACACG 720 721 CGCTTGGCGA GCTACGTGGC CTGGATCGAC GGAGTGATGG CTGACAGCGC AGCCGCCTAA 780 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular space | |
Molecular Function | Serine-type endopeptidase activity | |
Biological Process | Complement activation, alternative pathway | |
Biological Process | Response to bacterium |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fec-3130 | Felis catus | 91.07 | 5e-24 | 103 |
| LLPS-Caf-2328 | Canis familiaris | 88.43 | 1e-146 | 418 |
| LLPS-Bot-1799 | Bos taurus | 86.87 | 3e-150 | 427 |
| LLPS-Ova-2347 | Ovis aries | 86.49 | 2e-149 | 425 |
| LLPS-Aim-2688 | Ailuropoda melanoleuca | 85.85 | 7e-106 | 312 |
| LLPS-Cea-1991 | Cercocebus atys | 85.59 | 7e-140 | 400 |
| LLPS-Paa-1475 | Papio anubis | 85.47 | 3e-137 | 395 |
| LLPS-Man-2117 | Macaca nemestrina | 85.17 | 1e-139 | 400 |
| LLPS-Maf-3947 | Macaca fascicularis | 85.17 | 2e-139 | 399 |
| LLPS-Mam-2917 | Macaca mulatta | 84.75 | 5e-139 | 399 |
| LLPS-Poa-3683 | Pongo abelii | 84.75 | 3e-140 | 402 |
| LLPS-Chs-3749 | Chlorocebus sabaeus | 84.75 | 1e-138 | 397 |
| LLPS-Pat-0484 | Pan troglodytes | 84.32 | 7e-137 | 393 |
| LLPS-Aon-3841 | Aotus nancymaae | 84.21 | 5e-49 | 166 |
| LLPS-Hos-2807 | Homo sapiens | 84.19 | 1e-135 | 390 |
| LLPS-Ict-1684 | Ictidomys tridecemlineatus | 83.88 | 4e-138 | 396 |
| LLPS-Gog-2295 | Gorilla gorilla | 83.68 | 6e-136 | 392 |
| LLPS-Pap-2089 | Pan paniscus | 83.44 | 1e-85 | 262 |
| LLPS-Cap-2738 | Cavia porcellus | 82.95 | 1e-119 | 348 |
| LLPS-Nol-3610 | Nomascus leucogenys | 82.79 | 4e-67 | 213 |
| LLPS-Myl-2486 | Myotis lucifugus | 82.64 | 2e-132 | 382 |
| LLPS-Otg-4670 | Otolemur garnettii | 82.01 | 2e-135 | 390 |
| LLPS-Eqc-2785 | Equus caballus | 80.3 | 2e-133 | 385 |
| LLPS-Tag-3250 | Taeniopygia guttata | 69.35 | 2e-56 | 184 |
| LLPS-Mum-3737 | Mus musculus | 69.07 | 1e-109 | 324 |
| LLPS-Ran-4044 | Rattus norvegicus | 68.72 | 2e-113 | 334 |
| LLPS-Ora-3455 | Ornithorhynchus anatinus | 67.09 | 3e-106 | 315 |
| LLPS-Mea-1935 | Mesocricetus auratus | 67.02 | 5e-80 | 246 |
| LLPS-Sah-1454 | Sarcophilus harrisii | 66.24 | 6e-110 | 325 |
| LLPS-Gaga-3937 | Gallus gallus | 66.23 | 5e-97 | 301 |
| LLPS-Meg-2580 | Meleagris gallopavo | 64.96 | 6e-99 | 296 |
| LLPS-Fia-1037 | Ficedula albicollis | 64.26 | 2e-97 | 293 |
| LLPS-Xet-2403 | Xenopus tropicalis | 52.97 | 5e-78 | 244 |
| LLPS-Leo-0777 | Lepisosteus oculatus | 47.48 | 9e-72 | 227 |
| LLPS-Dar-3216 | Danio rerio | 45.33 | 1e-65 | 211 |
| LLPS-Scf-1689 | Scleropages formosus | 44.74 | 1e-60 | 199 |
| LLPS-Icp-2610 | Ictalurus punctatus | 43.23 | 7e-60 | 196 |
| LLPS-Tar-3589 | Takifugu rubripes | 42.11 | 3e-58 | 193 |
| LLPS-Ten-2159 | Tetraodon nigroviridis | 41.8 | 7e-56 | 187 |
| LLPS-Orl-0714 | Oryzias latipes | 41.56 | 2e-56 | 189 |
| LLPS-Orn-2834 | Oreochromis niloticus | 41.13 | 6e-56 | 187 |
| LLPS-Gaa-2232 | Gasterosteus aculeatus | 40.24 | 2e-54 | 183 |
| LLPS-Xim-1116 | Xiphophorus maculatus | 40.24 | 4e-55 | 185 |
| LLPS-Scm-1963 | Scophthalmus maximus | 40.16 | 1e-52 | 180 |
| LLPS-Caj-4269 | Callithrix jacchus | 38.03 | 1e-33 | 131 |
| LLPS-Drm-2399 | Drosophila melanogaster | 29.43 | 2e-15 | 79.0 |