• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sus-1563
RUVBL1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RuvB-like helicase
Gene Name: RUVBL1
Ensembl Gene: ENSSSCG00000011620.3
Ensembl Protein: ENSSSCP00000012383.3
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Cajal body, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKIEEVKSTT  KTQRIASHSH  VKGLGLDENG  LAKQAASGLV  GQENAREACG  VIVELIKSKK  60
61    MAGRAVLLAG  PPGTGKTALA  LAIAQELGSK  VPFCPMVGSE  VYSTEIKKTE  VLMENFRRAI  120
121   GLRIKETKEV  YEGEVTELTP  CETENPMGGY  GKTISHVVIG  LKTAKGTKQL  KLDPSIFESL  180
181   QKERVEAGDV  IYIEANSGAV  KRQGRCDTYA  TEFDLEAEEY  VPLPKGDVHK  KKEIIQDVTL  240
241   HDLDVANARP  QGGQDILSMM  GQLMKPKKTE  ITDKLRGEIN  KVVNKYIDQG  VAELVPGVLF  300
301   VDEVHMLDIE  CFTYLHRALE  SSIAPIVIFA  SNRGNCVIRG  TEDITSPHGI  PLDLLDRVMI  360
361   IRTMLYTPQE  MKQIIKIRAQ  TEGINISEEA  LNHLGEIGTK  TTLRYSVQLL  TPANLLAKIN  420
421   GKDGIEKEHV  EEISELFYDA  KSSAKILADQ  QDKYMK  456
Nucleotide CDS Sequence (FASTA)
1     ATGAAGATCG  AGGAGGTGAA  GAGCACGACC  AAGACGCAGC  GCATTGCCTC  CCACAGCCAC  60
61    GTGAAGGGGC  TAGGGCTAGA  CGAGAATGGT  CTGGCCAAGC  AGGCGGCCTC  GGGGCTCGTG  120
121   GGCCAGGAGA  ACGCGCGTGA  GGCATGTGGT  GTGATAGTAG  AATTAATCAA  AAGCAAGAAA  180
181   ATGGCTGGAA  GAGCTGTCTT  GTTGGCAGGA  CCTCCTGGAA  CTGGCAAGAC  AGCTCTAGCT  240
241   CTGGCTATTG  CTCAAGAGCT  GGGTAGTAAG  GTCCCTTTTT  GCCCGATGGT  GGGGAGTGAA  300
301   GTTTACTCCA  CGGAGATCAA  GAAGACAGAA  GTGCTGATGG  AGAACTTCCG  CAGGGCCATT  360
361   GGGCTGCGGA  TAAAGGAGAC  CAAGGAGGTC  TATGAAGGCG  AGGTCACGGA  GCTGACGCCT  420
421   TGCGAGACGG  AGAACCCGAT  GGGGGGCTAT  GGCAAGACTA  TCAGCCACGT  GGTTATCGGG  480
481   CTCAAGACGG  CCAAGGGCAC  CAAGCAGTTG  AAACTGGACC  CCAGCATTTT  TGAAAGTTTG  540
541   CAGAAAGAGC  GAGTAGAGGC  TGGCGATGTG  ATTTACATTG  AAGCCAACAG  TGGGGCTGTG  600
601   AAGAGGCAGG  GCAGGTGCGA  TACCTACGCC  ACAGAATTCG  ACCTTGAAGC  TGAGGAGTAT  660
661   GTCCCCCTGC  CCAAGGGGGA  TGTGCACAAG  AAGAAGGAAA  TCATCCAGGA  TGTGACCTTG  720
721   CATGACTTGG  ATGTGGCCAA  CGCACGGCCC  CAGGGGGGAC  AAGATATCCT  GTCTATGATG  780
781   GGTCAGCTCA  TGAAGCCAAA  GAAGACTGAG  ATCACAGATA  AACTCCGAGG  GGAGATTAAC  840
841   AAAGTGGTGA  ACAAGTACAT  CGACCAGGGC  GTGGCCGAGC  TGGTCCCGGG  GGTGCTCTTT  900
901   GTTGATGAGG  TCCACATGCT  GGACATCGAG  TGCTTTACCT  ACTTGCACCG  GGCCCTGGAG  960
961   TCTTCCATCG  CCCCCATTGT  CATCTTTGCA  TCCAACCGAG  GCAACTGTGT  CATCAGGGGA  1020
1021  ACGGAGGACA  TCACCTCTCC  TCACGGCATC  CCTCTTGACC  TCCTGGACCG  AGTGATGATC  1080
1081  ATCCGGACCA  TGCTGTACAC  CCCACAGGAG  ATGAAACAGA  TCATTAAAAT  ACGAGCCCAG  1140
1141  ACAGAAGGAA  TCAACATCAG  TGAGGAGGCG  CTGAACCACC  TTGGGGAGAT  TGGTACTAAG  1200
1201  ACCACTCTGA  GGTACTCGGT  GCAGCTGCTG  ACCCCAGCCA  ACCTGCTGGC  CAAGATCAAC  1260
1261  GGGAAAGATG  GCATTGAGAA  GGAGCATGTC  GAGGAGATCA  GTGAGCTCTT  CTATGATGCC  1320
1321  AAGTCCTCGG  CCAAGATCCT  GGCTGACCAG  CAGGACAAGT  ACATGAAGTG  A  1371

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
DNA damage
DNA recombination
DNA repair
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Proteomics identification
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Ino80 complex
Cellular Component
MLL1 complex
Cellular Component
NuA4 histone acetyltransferase complex
Cellular Component
R2TP complex
Cellular Component
Ribonucleoprotein complex
Cellular Component
Swr1 complex
Molecular Function
ADP binding
Molecular Function
ATP binding
Molecular Function
ATP-dependent 5'-3' DNA helicase activity
Molecular Function
ATP-dependent DNA helicase activity
Molecular Function
ATPase binding
Molecular Function
TBP-class protein binding
Molecular Function
TFIID-class transcription factor complex binding
Molecular Function
Transcription coactivator activity
Biological Process
Box C/D snoRNP assembly
Biological Process
Chromatin remodeling
Biological Process
DNA recombination
Biological Process
DNA repair
Biological Process
Histone acetylation
Biological Process
Histone H2A acetylation
Biological Process
Histone H4 acetylation
Biological Process
Positive regulation of canonical Wnt signaling pathway
Biological Process
Regulation of transcription by RNA polymerase II

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1397Rattus norvegicus99.340.0 925
LLPS-Mea-0498Mesocricetus auratus99.340.0 925
LLPS-Mum-1815Mus musculus99.340.0 925
LLPS-Eqc-0854Equus caballus99.260.0 820
LLPS-Nol-2208Nomascus leucogenys99.120.0 924
LLPS-Cas-0391Carlito syrichta99.120.0 924
LLPS-Mam-0217Macaca mulatta99.120.0 924
LLPS-Caf-1010Canis familiaris99.120.0 924
LLPS-Poa-0075Pongo abelii99.120.0 924
LLPS-Cap-2198Cavia porcellus99.120.0 925
LLPS-Orc-0226Oryctolagus cuniculus99.120.0 924
LLPS-Rhb-0406Rhinopithecus bieti99.120.0 924
LLPS-Man-0765Macaca nemestrina99.120.0 924
LLPS-Urm-0869Ursus maritimus99.120.0 924
LLPS-Pap-1194Pan paniscus99.120.0 924
LLPS-Pat-1105Pan troglodytes99.120.0 924
LLPS-Hos-1414Homo sapiens99.120.0 924
LLPS-Fec-1768Felis catus99.120.0 924
LLPS-Paa-3010Papio anubis99.120.0 924
LLPS-Mal-0311Mandrillus leucophaeus99.120.0 924
LLPS-Mup-1571Mustela putorius furo99.120.0 924
LLPS-Aim-1485Ailuropoda melanoleuca99.120.0 924
LLPS-Bot-0926Bos taurus99.120.0 925
LLPS-Fud-2878Fukomys damarensis99.120.0 924
LLPS-Caj-0354Callithrix jacchus99.120.0 924
LLPS-Cea-0872Cercocebus atys99.120.0 924
LLPS-Aon-0496Aotus nancymaae99.120.0 924
LLPS-Chs-2339Chlorocebus sabaeus99.120.0 924
LLPS-Ova-2157Ovis aries98.780.0 831
LLPS-Myl-1661Myotis lucifugus98.690.0 918
LLPS-Sah-1060Sarcophilus harrisii98.530.0 828
LLPS-Mod-0095Monodelphis domestica98.460.0 919
LLPS-Ict-3405Ictidomys tridecemlineatus98.366e-125 375
LLPS-Loa-1670Loxodonta africana98.250.0 919
LLPS-Ora-0202Ornithorhynchus anatinus97.730.0 799
LLPS-Anp-2062Anas platyrhynchos96.820.0 820
LLPS-Pes-0165Pelodiscus sinensis96.720.0 793
LLPS-Anc-0063Anolis carolinensis96.710.0 891
LLPS-Otg-1251Otolemur garnettii96.290.0 895
LLPS-Meg-0758Meleagris gallopavo95.830.0 901
LLPS-Gaga-0158Gallus gallus95.610.0 900
LLPS-Tag-1172Taeniopygia guttata95.390.0 897
LLPS-Fia-0119Ficedula albicollis95.390.0 897
LLPS-Leo-0709Lepisosteus oculatus94.035e-131 387
LLPS-Maf-2024Macaca fascicularis93.420.0 858
LLPS-Gog-0010Gorilla gorilla92.980.0 852
LLPS-Asm-0455Astyanax mexicanus92.540.0 876
LLPS-Dar-1168Danio rerio92.320.0 858
LLPS-Scf-0862Scleropages formosus91.450.0 874
LLPS-Orn-0389Oreochromis niloticus91.010.0 863
LLPS-Xim-0397Xiphophorus maculatus91.010.0 863
LLPS-Orl-1782Oryzias latipes90.790.0 860
LLPS-Pof-1299Poecilia formosa90.610.0 860
LLPS-Scm-0883Scophthalmus maximus90.350.0 858
LLPS-Icp-1449Ictalurus punctatus90.350.0 845
LLPS-Gaa-0900Gasterosteus aculeatus89.910.0 853
LLPS-Xet-0006Xenopus tropicalis89.760.0 845
LLPS-Tar-0399Takifugu rubripes89.040.0 848
LLPS-Dio-0597Dipodomys ordii88.780.0 723
LLPS-Cis-0937Ciona savignyi82.240.0 788
LLPS-Lac-0446Latimeria chalumnae81.840.0 744
LLPS-Cii-0243Ciona intestinalis81.80.0 790
LLPS-Drm-1250Drosophila melanogaster79.560.0 742
LLPS-Hov-1531Hordeum vulgare79.284e-140 409
LLPS-Pot-2683Populus trichocarpa76.70.0 551
LLPS-Php-0269Physcomitrella patens76.040.0 726
LLPS-Sem-0242Selaginella moellendorffii76.040.0 721
LLPS-Chr-0205Chlamydomonas reinhardtii75.820.0 728
LLPS-Gor-0512Gossypium raimondii74.730.0 714
LLPS-Met-0395Medicago truncatula74.730.0 716
LLPS-Abg-0745Absidia glauca74.730.0 722
LLPS-Coc-0206Corchorus capsularis74.510.0 713
LLPS-Mae-0835Manihot esculenta74.290.0 712
LLPS-Thc-0965Theobroma cacao74.290.0 712
LLPS-Amt-0560Amborella trichopoda74.070.0 711
LLPS-Phv-0897Phaseolus vulgaris74.070.0 714
LLPS-Glm-0827Glycine max74.070.0 710
LLPS-Ast-0332Aspergillus terreus73.990.0 625
LLPS-Via-0019Vigna angularis73.850.0 712
LLPS-Mua-1224Musa acuminata73.850.0 717
LLPS-Prp-1596Prunus persica73.630.0 704
LLPS-Nia-1336Nicotiana attenuata73.630.0 711
LLPS-Hea-0296Helianthus annuus73.630.0 706
LLPS-Scj-0898Schizosaccharomyces japonicus73.540.0 699
LLPS-Art-0130Arabidopsis thaliana73.410.0 702
LLPS-Lep-0909Leersia perrieri73.410.0 709
LLPS-Orgl-0773Oryza glumaepatula73.290.0 702
LLPS-Bro-0434Brassica oleracea73.190.0 704
LLPS-Orm-0526Oryza meridionalis73.190.0 708
LLPS-Orbr-0808Oryza brachyantha73.190.0 704
LLPS-Sob-0613Sorghum bicolor73.190.0 705
LLPS-Ors-0339Oryza sativa73.190.0 706
LLPS-Brr-1040Brassica rapa73.190.0 704
LLPS-Arl-0922Arabidopsis lyrata73.190.0 702
LLPS-Cus-0680Cucumis sativus73.190.0 705
LLPS-Sot-0192Solanum tuberosum73.190.0 705
LLPS-Brn-0346Brassica napus73.190.0 704
LLPS-Orb-1348Oryza barthii73.190.0 707
LLPS-Ori-0193Oryza indica73.190.0 707
LLPS-Orr-0389Oryza rufipogon73.110.0 696
LLPS-Orni-0286Oryza nivara73.110.0 697
LLPS-Org-2012Oryza glaberrima73.030.0 701
LLPS-Orp-0918Oryza punctata72.970.0 702
LLPS-Sei-0149Setaria italica72.750.0 700
LLPS-Brd-0223Brachypodium distachyon72.750.0 701
LLPS-Zem-1540Zea mays72.370.0 684
LLPS-Sol-0927Solanum lycopersicum72.370.0 651
LLPS-Asni-0145Aspergillus niger72.210.0 701
LLPS-Viv-0943Vitis vinifera72.090.0 696
LLPS-Tra-1835Triticum aestivum72.090.0 682
LLPS-Nef-0154Neosartorya fischeri71.930.0 701
LLPS-Asc-0083Aspergillus clavatus71.930.0 704
LLPS-Dac-1348Daucus carota71.860.0 698
LLPS-Fuv-0079Fusarium verticillioides71.760.0 605
LLPS-Chc-0297Chondrus crispus71.710.0 679
LLPS-Tum-0004Tuber melanosporum71.590.0 671
LLPS-Asfu-0804Aspergillus fumigatus71.490.0 697
LLPS-Asf-0436Aspergillus flavus71.490.0 694
LLPS-Aso-0641Aspergillus oryzae71.490.0 694
LLPS-Asn-0302Aspergillus nidulans71.490.0 692
LLPS-Scp-0233Schizosaccharomyces pombe71.140.0 681
LLPS-Scc-0458Schizosaccharomyces cryophilus71.080.0 681
LLPS-Sac-0367Saccharomyces cerevisiae70.510.0 650
LLPS-Blg-0376Blumeria graminis70.470.0 672
LLPS-Mao-0243Magnaporthe oryzae70.310.0 668
LLPS-Cog-0148Colletotrichum gloeosporioides70.160.0 660
LLPS-Lem-0294Leptosphaeria maculans70.160.0 634
LLPS-Scs-0672Sclerotinia sclerotiorum70.020.0 666
LLPS-Osl-0746Ostreococcus lucimarinus69.890.0 683
LLPS-Asg-0473Ashbya gossypii69.820.0 651
LLPS-Phn-0630Phaeosphaeria nodorum69.780.0 657
LLPS-Kop-0117Komagataella pastoris69.520.0 668
LLPS-Nec-0316Neurospora crassa69.40.0 672
LLPS-Fus-0682Fusarium solani69.330.0 673
LLPS-Beb-0392Beauveria bassiana69.330.0 662
LLPS-Map-0292Magnaporthe poae69.250.0 663
LLPS-Mel-0970Melampsora laricipopulina69.210.0 667
LLPS-Ved-0650Verticillium dahliae69.110.0 663
LLPS-Trr-0724Trichoderma reesei69.110.0 661
LLPS-Coo-0623Colletotrichum orbiculare69.090.0 668
LLPS-Pyt-0055Pyrenophora teres68.930.0 650
LLPS-Trv-0073Trichoderma virens68.890.0 661
LLPS-Fuo-0099Fusarium oxysporum68.870.0 671
LLPS-Miv-0116Microbotryum violaceum68.640.0 684
LLPS-Gag-0473Gaeumannomyces graminis68.580.0 661
LLPS-Pytr-0908Pyrenophora triticirepentis68.490.0 647
LLPS-Cogr-0543Colletotrichum graminicola68.210.0 661
LLPS-Gas-0029Galdieria sulphuraria68.20.0 653
LLPS-Yal-1239Yarrowia lipolytica67.780.0 644
LLPS-Usm-0034Ustilago maydis67.710.0 651
LLPS-Spr-0909Sporisorium reilianum67.490.0 652
LLPS-Crn-0490Cryptococcus neoformans66.590.0 632
LLPS-Pug-0433Puccinia graminis65.960.0 657
LLPS-Tru-0447Triticum urartu65.830.0 629
LLPS-Zyt-0486Zymoseptoria tritici65.810.0 635
LLPS-Dos-0980Dothistroma septosporum63.150.0 630
LLPS-Vir-0049Vigna radiata62.55e-154 447
LLPS-Cae-0224Caenorhabditis elegans61.880.0 569
LLPS-Put-0781Puccinia triticina58.30.0 553
LLPS-Cym-0418Cyanidioschyzon merolae56.810.0 560
LLPS-Ten-0934Tetraodon nigroviridis44.33e-130 392