• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-0926
RUVBL1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RuvB-like helicase
Gene Name: RUVBL1
Ensembl Gene: ENSBTAG00000020998.6
Ensembl Protein: ENSBTAP00000027964.5
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Cajal body, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKIEEVKSTT  KTQRIASHSH  VKGLGLDESG  LAKQAASGLV  GQENAREACG  VIVELIKSKK  60
61    MAGRAVLLAG  PPGTGKTALA  LAIAQELGSK  VPFCPMVGSE  VYSTEIKKTE  VLMENFRRAI  120
121   GLRIKETKEV  YEGEVTELTP  CETENPMGGY  GKTISHVIIG  LKTAKGTKQL  KLDPSIFESL  180
181   QKERVEAGDV  IYIEANSGAV  KRQGRCDTYA  TEFDLEAEEY  VPLPKGDVHK  KKEIIQDVTL  240
241   HDLDVANARP  QGGQDILSMM  GQLMKPKKTE  ITDKLRGEIN  KVVNKYIDQG  VAELVPGVLF  300
301   VDEVHMLDIE  CFTYLHRALE  SSIAPIVIFA  SNRGNCVIRG  TEDVTSPHGI  PLDLLDRVMI  360
361   IRTMLYTPQE  MKQIIKIRAQ  TEGINISEEA  LNHLGEIGTK  TTLRYAVQLL  TPANLLAKIN  420
421   GKDGIEKEHV  EEISELFYDA  KSSAKILADQ  QDKYMK  456
Nucleotide CDS Sequence (FASTA)
1     ATGAAGATCG  AGGAGGTGAA  GAGCACCACT  AAGACTCAGC  GTATCGCCTC  CCACAGCCAC  60
61    GTGAAGGGGC  TGGGGCTGGA  CGAGAGCGGC  CTGGCCAAGC  AAGCGGCCTC  GGGACTCGTG  120
121   GGCCAGGAGA  ACGCGCGTGA  GGCATGTGGT  GTGATAGTAG  AATTAATCAA  AAGCAAGAAA  180
181   ATGGCTGGAA  GAGCTGTCCT  GTTGGCAGGA  CCTCCTGGAA  CTGGCAAGAC  GGCTCTAGCT  240
241   CTGGCTATTG  CTCAGGAGCT  GGGGAGTAAG  GTCCCCTTCT  GCCCGATGGT  GGGGAGTGAA  300
301   GTATACTCCA  CGGAGATCAA  GAAGACGGAA  GTGCTGATGG  AGAACTTCCG  CAGGGCCATT  360
361   GGGCTTCGGA  TAAAGGAGAC  CAAGGAGGTG  TACGAAGGAG  AGGTCACGGA  GCTCACCCCA  420
421   TGTGAGACGG  AGAATCCCAT  GGGGGGCTAC  GGCAAGACCA  TCAGCCACGT  GATCATTGGG  480
481   CTCAAGACGG  CCAAGGGGAC  CAAGCAGCTG  AAGCTGGACC  CCAGCATTTT  TGAAAGTTTG  540
541   CAAAAAGAGC  GAGTAGAAGC  TGGAGATGTG  ATTTACATCG  AAGCCAACAG  TGGGGCCGTG  600
601   AAGAGGCAGG  GCAGGTGTGA  CACCTATGCC  ACAGAATTTG  ACCTTGAAGC  CGAAGAGTAC  660
661   GTCCCCCTGC  CCAAGGGGGA  CGTGCACAAG  AAGAAGGAGA  TCATCCAGGA  CGTCACCTTG  720
721   CACGACTTGG  ACGTGGCCAA  CGCACGGCCC  CAGGGGGGAC  AAGACATCCT  GTCTATGATG  780
781   GGCCAGCTCA  TGAAGCCCAA  GAAGACGGAG  ATCACAGATA  AACTGCGGGG  GGAGATCAAC  840
841   AAGGTGGTGA  ACAAGTACAT  CGACCAGGGC  GTGGCCGAGC  TGGTCCCGGG  CGTGCTGTTC  900
901   GTGGACGAGG  TCCACATGCT  GGACATCGAG  TGCTTCACCT  ACCTGCACCG  CGCGCTCGAG  960
961   TCCTCCATCG  CGCCCATCGT  CATCTTCGCG  TCCAACCGAG  GCAACTGCGT  CATCAGGGGC  1020
1021  ACGGAGGACG  TCACCTCTCC  TCACGGCATC  CCTCTCGACC  TTCTGGACCG  AGTGATGATC  1080
1081  ATCCGGACCA  TGCTGTACAC  CCCGCAGGAG  ATGAAACAGA  TCATTAAGAT  CCGAGCCCAG  1140
1141  ACAGAGGGGA  TCAACATCAG  TGAGGAAGCG  CTGAACCACC  TGGGGGAGAT  TGGAACCAAG  1200
1201  ACCACCTTGA  GGTACGCCGT  GCAGCTGCTG  ACCCCGGCCA  ACCTGCTGGC  CAAGATCAAC  1260
1261  GGGAAGGACG  GCATCGAGAA  GGAGCACGTG  GAGGAGATCA  GCGAGCTCTT  CTACGACGCC  1320
1321  AAGTCCTCGG  CCAAGATTCT  GGCCGACCAG  CAGGACAAGT  ACATGAAGTG  A  1371

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
DNA damage
DNA recombination
DNA repair
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Proteomics identification
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Ino80 complex
Cellular Component
MLL1 complex
Cellular Component
NuA4 histone acetyltransferase complex
Cellular Component
R2TP complex
Cellular Component
Ribonucleoprotein complex
Cellular Component
Swr1 complex
Molecular Function
ADP binding
Molecular Function
ATP binding
Molecular Function
ATP-dependent 5'-3' DNA helicase activity
Molecular Function
ATP-dependent DNA helicase activity
Molecular Function
ATPase binding
Molecular Function
TBP-class protein binding
Molecular Function
TFIID-class transcription factor complex binding
Molecular Function
Transcription coactivator activity
Biological Process
Box C/D snoRNP assembly
Biological Process
Chromatin remodeling
Biological Process
DNA recombination
Biological Process
DNA repair
Biological Process
Histone acetylation
Biological Process
Histone H2A acetylation
Biological Process
Histone H4 acetylation
Biological Process
Positive regulation of canonical Wnt signaling pathway
Biological Process
Regulation of transcription by RNA polymerase II

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-2157Ovis aries99.510.0 834
LLPS-Eqc-0854Equus caballus99.50.0 821
LLPS-Mea-0498Mesocricetus auratus99.340.0 925
LLPS-Mum-1815Mus musculus99.340.0 925
LLPS-Ran-1397Rattus norvegicus99.340.0 925
LLPS-Orc-0226Oryctolagus cuniculus99.120.0 924
LLPS-Rhb-0406Rhinopithecus bieti99.120.0 924
LLPS-Man-0765Macaca nemestrina99.120.0 924
LLPS-Pat-1105Pan troglodytes99.120.0 924
LLPS-Urm-0869Ursus maritimus99.120.0 924
LLPS-Pap-1194Pan paniscus99.120.0 924
LLPS-Hos-1414Homo sapiens99.120.0 924
LLPS-Fec-1768Felis catus99.120.0 924
LLPS-Nol-2208Nomascus leucogenys99.120.0 924
LLPS-Cas-0391Carlito syrichta99.120.0 924
LLPS-Mam-0217Macaca mulatta99.120.0 924
LLPS-Poa-0075Pongo abelii99.120.0 924
LLPS-Caf-1010Canis familiaris99.120.0 924
LLPS-Cap-2198Cavia porcellus99.120.0 925
LLPS-Fud-2878Fukomys damarensis99.120.0 924
LLPS-Caj-0354Callithrix jacchus99.120.0 924
LLPS-Cea-0872Cercocebus atys99.120.0 924
LLPS-Aon-0496Aotus nancymaae99.120.0 924
LLPS-Sus-1563Sus scrofa99.120.0 925
LLPS-Chs-2339Chlorocebus sabaeus99.120.0 924
LLPS-Paa-3010Papio anubis99.120.0 924
LLPS-Mal-0311Mandrillus leucophaeus99.120.0 924
LLPS-Mup-1571Mustela putorius furo99.120.0 924
LLPS-Aim-1485Ailuropoda melanoleuca99.120.0 924
LLPS-Mod-0095Monodelphis domestica98.90.0 920
LLPS-Sah-1060Sarcophilus harrisii98.780.0 828
LLPS-Myl-1661Myotis lucifugus98.690.0 919
LLPS-Loa-1670Loxodonta africana98.680.0 920
LLPS-Ict-3405Ictidomys tridecemlineatus98.361e-124 375
LLPS-Ora-0202Ornithorhynchus anatinus97.980.0 799
LLPS-Anp-2062Anas platyrhynchos97.560.0 823
LLPS-Pes-0165Pelodiscus sinensis96.970.0 795
LLPS-Anc-0063Anolis carolinensis96.930.0 892
LLPS-Meg-0758Meleagris gallopavo96.710.0 905
LLPS-Gaga-0158Gallus gallus96.490.0 904
LLPS-Otg-1251Otolemur garnettii96.070.0 895
LLPS-Fia-0119Ficedula albicollis95.830.0 899
LLPS-Tag-1172Taeniopygia guttata95.830.0 899
LLPS-Leo-0709Lepisosteus oculatus94.531e-131 388
LLPS-Maf-2024Macaca fascicularis93.420.0 858
LLPS-Gog-0010Gorilla gorilla93.20.0 854
LLPS-Asm-0455Astyanax mexicanus92.760.0 878
LLPS-Dar-1168Danio rerio92.540.0 860
LLPS-Scf-0862Scleropages formosus91.670.0 876
LLPS-Orn-0389Oreochromis niloticus91.230.0 866
LLPS-Xim-0397Xiphophorus maculatus91.230.0 865
LLPS-Orl-1782Oryzias latipes91.010.0 862
LLPS-Pof-1299Poecilia formosa90.830.0 862
LLPS-Scm-0883Scophthalmus maximus90.570.0 860
LLPS-Icp-1449Ictalurus punctatus90.570.0 847
LLPS-Gaa-0900Gasterosteus aculeatus90.130.0 855
LLPS-Xet-0006Xenopus tropicalis89.760.0 843
LLPS-Tar-0399Takifugu rubripes89.250.0 850
LLPS-Dio-0597Dipodomys ordii88.540.0 722
LLPS-Lac-0446Latimeria chalumnae82.260.0 744
LLPS-Cis-0937Ciona savignyi81.80.0 787
LLPS-Cii-0243Ciona intestinalis81.360.0 790
LLPS-Drm-1250Drosophila melanogaster79.340.0 743
LLPS-Hov-1531Hordeum vulgare78.888e-140 408
LLPS-Pot-2683Populus trichocarpa77.290.0 553
LLPS-Sem-0242Selaginella moellendorffii76.260.0 721
LLPS-Php-0269Physcomitrella patens75.820.0 725
LLPS-Met-0395Medicago truncatula75.380.0 719
LLPS-Chr-0205Chlamydomonas reinhardtii75.380.0 726
LLPS-Gor-0512Gossypium raimondii75.160.0 716
LLPS-Coc-0206Corchorus capsularis75.160.0 716
LLPS-Mae-0835Manihot esculenta74.950.0 714
LLPS-Thc-0965Theobroma cacao74.950.0 715
LLPS-Abg-0745Absidia glauca74.950.0 723
LLPS-Ast-0332Aspergillus terreus74.750.0 627
LLPS-Phv-0897Phaseolus vulgaris74.730.0 717
LLPS-Glm-0827Glycine max74.730.0 713
LLPS-Amt-0560Amborella trichopoda74.510.0 713
LLPS-Via-0019Vigna angularis74.510.0 715
LLPS-Mua-1224Musa acuminata74.070.0 716
LLPS-Hea-0296Helianthus annuus74.070.0 708
LLPS-Nia-1336Nicotiana attenuata73.850.0 711
LLPS-Prp-1596Prunus persica73.850.0 704
LLPS-Cus-0680Cucumis sativus73.850.0 708
LLPS-Brr-1040Brassica rapa73.630.0 706
LLPS-Bro-0434Brassica oleracea73.630.0 706
LLPS-Brn-1551Brassica napus73.630.0 706
LLPS-Lep-0909Leersia perrieri73.630.0 708
LLPS-Sol-0927Solanum lycopersicum73.570.0 650
LLPS-Scj-0898Schizosaccharomyces japonicus73.540.0 698
LLPS-Orgl-0773Oryza glumaepatula73.510.0 702
LLPS-Orbr-0808Oryza brachyantha73.410.0 703
LLPS-Sob-0613Sorghum bicolor73.410.0 704
LLPS-Art-0130Arabidopsis thaliana73.410.0 703
LLPS-Ors-0339Oryza sativa73.410.0 704
LLPS-Orm-0526Oryza meridionalis73.410.0 707
LLPS-Orb-1348Oryza barthii73.410.0 706
LLPS-Ori-0193Oryza indica73.410.0 706
LLPS-Sot-0192Solanum tuberosum73.410.0 705
LLPS-Orr-0389Oryza rufipogon73.330.0 695
LLPS-Orni-0286Oryza nivara73.330.0 697
LLPS-Org-2012Oryza glaberrima73.250.0 701
LLPS-Orp-0918Oryza punctata73.190.0 701
LLPS-Arl-0922Arabidopsis lyrata73.190.0 703
LLPS-Sei-0149Setaria italica72.970.0 699
LLPS-Nef-0154Neosartorya fischeri72.590.0 702
LLPS-Zem-1540Zea mays72.590.0 684
LLPS-Asc-0083Aspergillus clavatus72.590.0 706
LLPS-Brd-0223Brachypodium distachyon72.530.0 700
LLPS-Asni-0145Aspergillus niger72.430.0 701
LLPS-Viv-0943Vitis vinifera72.310.0 695
LLPS-Dac-1348Daucus carota72.080.0 697
LLPS-Tra-1835Triticum aestivum71.870.0 681
LLPS-Tum-0004Tuber melanosporum71.810.0 671
LLPS-Asfu-0804Aspergillus fumigatus71.710.0 697
LLPS-Asn-0302Aspergillus nidulans71.710.0 693
LLPS-Asf-0436Aspergillus flavus71.710.0 695
LLPS-Aso-0641Aspergillus oryzae71.710.0 695
LLPS-Fuv-0079Fusarium verticillioides71.50.0 605
LLPS-Chc-0297Chondrus crispus71.490.0 677
LLPS-Sac-0367Saccharomyces cerevisiae71.430.0 653
LLPS-Scc-0458Schizosaccharomyces cryophilus71.080.0 681
LLPS-Scp-0233Schizosaccharomyces pombe70.920.0 681
LLPS-Blg-0376Blumeria graminis70.690.0 673
LLPS-Asg-0473Ashbya gossypii70.50.0 653
LLPS-Lem-0294Leptosphaeria maculans70.380.0 635
LLPS-Mao-0243Magnaporthe oryzae70.310.0 667
LLPS-Scs-0672Sclerotinia sclerotiorum70.250.0 666
LLPS-Phn-0630Phaeosphaeria nodorum70.00.0 658
LLPS-Kop-0117Komagataella pastoris69.960.0 670
LLPS-Cog-0148Colletotrichum gloeosporioides69.930.0 659
LLPS-Osl-0746Ostreococcus lucimarinus69.890.0 684
LLPS-Nec-0316Neurospora crassa69.40.0 672
LLPS-Trr-0724Trichoderma reesei69.330.0 661
LLPS-Map-0292Magnaporthe poae69.250.0 663
LLPS-Pyt-0055Pyrenophora teres69.150.0 651
LLPS-Fus-0682Fusarium solani69.110.0 672
LLPS-Beb-0392Beauveria bassiana69.110.0 662
LLPS-Trv-0073Trichoderma virens69.110.0 662
LLPS-Mel-0970Melampsora laricipopulina69.00.0 666
LLPS-Ved-0650Verticillium dahliae68.890.0 662
LLPS-Coo-0623Colletotrichum orbiculare68.870.0 667
LLPS-Miv-0116Microbotryum violaceum68.860.0 685
LLPS-Pytr-0908Pyrenophora triticirepentis68.710.0 647
LLPS-Fuo-0099Fusarium oxysporum68.650.0 670
LLPS-Gag-0473Gaeumannomyces graminis68.580.0 662
LLPS-Gas-0029Galdieria sulphuraria68.20.0 651
LLPS-Cogr-0543Colletotrichum graminicola67.990.0 660
LLPS-Yal-1239Yarrowia lipolytica67.560.0 643
LLPS-Usm-0034Ustilago maydis67.490.0 650
LLPS-Spr-0909Sporisorium reilianum67.260.0 650
LLPS-Crn-0490Cryptococcus neoformans66.810.0 632
LLPS-Zyt-0486Zymoseptoria tritici66.240.0 636
LLPS-Pug-0433Puccinia graminis65.740.0 657
LLPS-Tru-0447Triticum urartu65.620.0 627
LLPS-Dos-0980Dothistroma septosporum63.350.0 630
LLPS-Vir-0049Vigna radiata62.783e-154 448
LLPS-Cae-0224Caenorhabditis elegans61.880.0 570
LLPS-Put-0781Puccinia triticina57.870.0 551
LLPS-Cym-0418Cyanidioschyzon merolae56.810.0 561
LLPS-Ten-0934Tetraodon nigroviridis44.525e-131 394