• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scp-0603
cdc48

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cell division cycle protein 48; Transitional endoplasmic reticulum ATPase homolog
Gene Name: cdc48, SPAC1565.08, SPAC6F12.01
Ensembl Gene: SPAC1565.08
Ensembl Protein: SPAC1565.08.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER. Involved in spindle disassembly. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel. Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblSPAC1565.08.1SPAC1565.08.1
UniProtQ9P3A7, CDC48_SCHPO, O14221
GeneBankCU329670CAB99275.1
RefSeqNM_001018717.2NP_593287.2

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNAPSTMTDK  KPEVEHLQGE  NPPKDTYSAE  DTATAILRKK  RKPNSLVVDD  ATNDDNSVIT  60
61    LSSNTMETLQ  LFRGDTVVVK  GKRRKDTVLI  VLTDEEMEDG  VARINRVVRN  NLRVRLGDIV  120
121   TINPCPDIKY  AERISVLPLA  DTVEGLTGSL  FDVYLKPYFV  EAYRPIRKGD  LFVVRGSMRQ  180
181   VEFKVVDVAP  DEFGIVSQDT  IIHWEGEPIN  REDEESSLAE  VGYDDIGGCR  RQMAQIRELV  240
241   ELPLRHPQLF  KSIGIKPPRG  ILMYGPPGTG  KTLMARAVAN  ETGAFFFLIN  GPEIMSKMAG  300
301   ESESNLRKAF  EEAEKNSPAI  IFIDEIDSIA  PKREKTNGEV  ERRVVSQLLT  LMDGMKARSN  360
361   VVVMAATNRP  NSIDPALRRF  GRFDREVDVG  IPDPTGRLEI  LRIHTKNMKL  ADDVDLEQIA  420
421   AETHGYVGSD  LASLCSEAAM  QQIREKMDMI  DLDEDEIDAE  VLDSLGVTMD  NFRFALGSSN  480
481   PSALRETVVE  VPNVRWEDIG  GLEEVKRELR  ETVQMPVMYA  EKFLRFGVTP  SKGVLFFGPP  540
541   GTGKTLLAKA  IANECSANFI  SVKGPELLSM  WFGESESNVR  DIFDKARAAA  PCVVFLDELD  600
601   SIAKARGASA  GDSGGGDRVV  NQLLTEMDGV  NSKKNVFVIG  ATNRPDQIDP  ALMRPGRLDQ  660
661   LIYVPLPDEE  ARFSILQTQL  RHTPVAEDVD  LRAVAKATHG  FSGADLEFVV  QRAVKLAIKD  720
721   SIEEDIKREN  ETGEAPADDV  VMDEDASVSQ  VQRHHVEEAM  KMARRSVSDA  EVRRYEAYAH  780
781   QLLTSRGLTG  FQFDSADSNT  NGPSFGNDGA  DDLYA  815
Nucleotide CDS Sequence (FASTA)
1     ATGAACGCAC  CATCCACCAT  GACCGATAAG  AAACCAGAAG  TGGAACACCT  TCAGGGTGAA  60
61    AACCCTCCAA  AAGATACATA  TAGTGCAGAA  GACACAGCAA  CAGCTATTCT  TCGTAAAAAA  120
121   AGAAAACCAA  ATTCTCTAGT  GGTCGATGAC  GCTACCAACG  ATGATAACTC  AGTAATCACA  180
181   TTGTCGTCCA  ATACCATGGA  GACTTTACAA  CTTTTCCGTG  GTGACACAGT  TGTCGTTAAA  240
241   GGAAAGAGAC  GGAAAGACAC  TGTCTTGATT  GTTTTAACTG  ACGAAGAAAT  GGAAGATGGC  300
301   GTAGCAAGAA  TTAATCGTGT  TGTTCGTAAC  AACTTGCGCG  TAAGGTTAGG  CGATATTGTA  360
361   ACGATCAATC  CTTGTCCAGA  TATTAAATAT  GCTGAACGAA  TTTCAGTACT  ACCCTTGGCT  420
421   GATACCGTCG  AGGGTCTTAC  TGGTTCTCTC  TTTGATGTTT  ACCTTAAGCC  GTACTTTGTT  480
481   GAAGCGTATC  GTCCTATTCG  AAAGGGCGAT  CTTTTCGTTG  TACGGGGTAG  TATGCGTCAA  540
541   GTTGAATTTA  AAGTTGTTGA  TGTTGCTCCT  GATGAATTTG  GCATTGTTAG  CCAGGATACA  600
601   ATTATTCATT  GGGAAGGTGA  ACCCATTAAT  CGTGAGGATG  AAGAAAGTAG  CTTGGCAGAA  660
661   GTTGGCTATG  ACGATATCGG  TGGTTGTCGT  CGCCAGATGG  CTCAAATCCG  TGAGCTTGTC  720
721   GAGCTTCCCC  TCCGTCATCC  CCAATTATTC  AAAAGTATAG  GTATCAAGCC  ACCTCGTGGT  780
781   ATCCTTATGT  ATGGTCCTCC  AGGTACCGGT  AAAACTTTAA  TGGCTCGCGC  AGTTGCTAAT  840
841   GAAACGGGCG  CTTTCTTTTT  CCTGATTAAT  GGTCCTGAGA  TTATGTCAAA  AATGGCAGGC  900
901   GAATCTGAGT  CTAATTTGCG  GAAGGCGTTT  GAAGAAGCCG  AAAAAAATTC  CCCTGCTATT  960
961   ATTTTTATTG  ATGAGATAGA  TTCTATTGCT  CCCAAGCGTG  AAAAAACGAA  TGGTGAAGTT  1020
1021  GAACGACGTG  TTGTTTCACA  ATTATTGACT  TTAATGGATG  GTATGAAAGC  TCGTAGTAAT  1080
1081  GTTGTAGTAA  TGGCCGCTAC  CAATCGTCCT  AACTCTATCG  ATCCGGCATT  GAGACGTTTT  1140
1141  GGTCGTTTTG  ATCGTGAAGT  CGATGTTGGT  ATTCCTGATC  CCACCGGCCG  CTTAGAGATC  1200
1201  CTTCGTATTC  ACACAAAGAA  CATGAAGCTT  GCTGATGACG  TTGATCTTGA  GCAAATTGCT  1260
1261  GCTGAGACTC  ATGGTTACGT  TGGATCTGAT  TTGGCATCTT  TGTGTTCTGA  AGCTGCCATG  1320
1321  CAACAGATTC  GTGAAAAGAT  GGATATGATT  GACTTGGATG  AAGATGAGAT  TGATGCCGAG  1380
1381  GTTTTAGACT  CTCTAGGTGT  TACAATGGAT  AACTTCAGAT  TTGCCCTTGG  TTCCAGCAAT  1440
1441  CCTTCTGCTT  TGCGTGAAAC  CGTTGTGGAA  GTTCCCAATG  TTCGTTGGGA  AGACATTGGT  1500
1501  GGATTGGAAG  AAGTTAAGCG  TGAATTACGT  GAAACTGTCC  AGATGCCTGT  TATGTATGCC  1560
1561  GAAAAGTTTT  TGCGTTTTGG  TGTCACTCCC  AGCAAAGGTG  TTTTGTTTTT  CGGACCCCCT  1620
1621  GGTACAGGTA  AGACATTGTT  GGCGAAAGCC  ATTGCCAACG  AATGTTCTGC  CAACTTTATT  1680
1681  TCAGTAAAGG  GACCCGAATT  GCTTAGCATG  TGGTTTGGTG  AGTCTGAATC  AAACGTTCGT  1740
1741  GATATATTTG  ACAAGGCTCG  TGCTGCAGCT  CCTTGTGTCG  TTTTCTTAGA  TGAGTTGGAT  1800
1801  TCTATTGCCA  AAGCACGTGG  CGCTTCTGCT  GGTGACTCTG  GTGGTGGTGA  TCGTGTTGTC  1860
1861  AACCAACTTC  TTACTGAGAT  GGATGGTGTT  AACAGCAAGA  AGAATGTATT  TGTTATTGGT  1920
1921  GCTACCAACC  GTCCCGATCA  GATTGATCCT  GCCTTGATGC  GTCCCGGTCG  TTTGGATCAA  1980
1981  TTAATCTACG  TTCCCTTACC  CGATGAAGAA  GCTCGCTTCA  GCATTTTGCA  AACTCAATTG  2040
2041  AGACATACGC  CTGTTGCTGA  AGATGTTGAC  TTGCGTGCAG  TTGCTAAGGC  GACCCATGGC  2100
2101  TTCTCAGGTG  CTGATTTGGA  GTTTGTTGTA  CAAAGAGCTG  TTAAATTGGC  CATCAAGGAC  2160
2161  AGCATTGAAG  AAGACATCAA  GCGCGAAAAT  GAGACTGGAG  AGGCTCCTGC  TGACGATGTT  2220
2221  GTTATGGACG  AAGATGCATC  TGTGTCTCAA  GTTCAGCGTC  ATCATGTGGA  GGAGGCCATG  2280
2281  AAAATGGCAC  GCCGCTCTGT  CAGTGATGCA  GAAGTCCGTC  GTTATGAAGC  TTATGCCCAT  2340
2341  CAACTCCTTA  CCTCGCGTGG  TCTTACAGGA  TTCCAGTTTG  ATTCGGCTGA  TAGTAATACT  2400
2401  AATGGACCAA  GCTTCGGAAA  TGATGGTGCT  GATGATTTGT  ATGCATAG  2448

▼ KEYWORD

ID
Family
ATP-binding
Cell cycle
Chaperone
Complete proteome
Cytoplasm
Hydrolase
Nucleotide-binding
Nucleus
Protein transport
Reference proteome
Repeat
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cdc48p-Npl4p-Vms1p AAA ATPase complex
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Hrd1p ubiquitin ligase complex
Cellular Component
Mitotic spindle midzone
Cellular Component
Nuclear chromatin
Cellular Component
Nucleus
Cellular Component
RQC complex
Cellular Component
VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function
ATP binding
Molecular Function
ATPase activity
Molecular Function
Molecular adaptor activity
Molecular Function
Polyubiquitin modification-dependent protein binding
Biological Process
Autophagosome maturation
Biological Process
ER-associated misfolded protein catabolic process
Biological Process
Establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
Biological Process
Macroautophagy
Biological Process
Mitotic sister chromatid separation
Biological Process
Mitotic spindle disassembly
Biological Process
Protein localization to Golgi apparatus
Biological Process
Retrograde protein transport, ER to cytosol
Biological Process
Ribosome-associated ubiquitin-dependent protein catabolic process
Biological Process
Sterol regulatory element binding protein cleavage
Biological Process
Ubiquitin-dependent ERAD pathway
Biological Process
Ubiquitin-dependent protein catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0770Schizosaccharomyces cryophilus94.070.01460
LLPS-Scj-1330Schizosaccharomyces japonicus91.410.01409
LLPS-Phn-0853Phaeosphaeria nodorum83.740.01130
LLPS-Ast-0837Aspergillus terreus80.330.01199
LLPS-Nef-0641Neosartorya fischeri80.280.01205
LLPS-Asfu-0409Aspergillus fumigatus80.150.01205
LLPS-Asni-0139Aspergillus niger80.050.01198
LLPS-Asc-0054Aspergillus clavatus79.90.01196
LLPS-Asn-0996Aspergillus nidulans78.790.01186
LLPS-Nec-0633Neurospora crassa78.590.01183
LLPS-Map-1380Magnaporthe poae78.570.01182
LLPS-Scs-0443Sclerotinia sclerotiorum78.390.01179
LLPS-Coo-0032Colletotrichum orbiculare78.350.01181
LLPS-Cog-0557Colletotrichum gloeosporioides78.350.01181
LLPS-Trr-0973Trichoderma reesei78.310.01182
LLPS-Tum-0621Tuber melanosporum78.240.01181
LLPS-Fus-0060Fusarium solani78.090.01182
LLPS-Cogr-0617Colletotrichum graminicola77.970.01178
LLPS-Trv-0405Trichoderma virens77.960.01164
LLPS-Lem-0655Leptosphaeria maculans77.930.01181
LLPS-Yal-0766Yarrowia lipolytica77.920.01179
LLPS-Fuv-1200Fusarium verticillioides77.830.01178
LLPS-Fuo-0125Fusarium oxysporum77.830.01178
LLPS-Zyt-0327Zymoseptoria tritici77.760.01173
LLPS-Ved-0929Verticillium dahliae77.680.01178
LLPS-Aso-0754Aspergillus oryzae77.660.01191
LLPS-Asf-0755Aspergillus flavus77.660.01191
LLPS-Blg-1375Blumeria graminis77.510.01169
LLPS-Pyt-1181Pyrenophora teres77.450.01185
LLPS-Gag-0137Gaeumannomyces graminis76.890.01191
LLPS-Mao-0820Magnaporthe oryzae76.780.01192
LLPS-Pytr-1461Pyrenophora triticirepentis76.520.01186
LLPS-Sac-0118Saccharomyces cerevisiae75.760.01177
LLPS-Dos-0041Dothistroma septosporum75.490.01176
LLPS-Abg-1695Absidia glauca75.470.01169
LLPS-Asg-0841Ashbya gossypii75.430.01164
LLPS-Spr-1211Sporisorium reilianum74.460.01124
LLPS-Usm-0109Ustilago maydis74.270.01124
LLPS-Kop-0019Komagataella pastoris74.220.01169
LLPS-Put-0137Puccinia triticina74.130.01137
LLPS-Pug-0193Puccinia graminis73.820.01135
LLPS-Mel-0495Melampsora laricipopulina73.660.01134
LLPS-Miv-0242Microbotryum violaceum73.10.01112
LLPS-Xet-0910Xenopus tropicalis73.020.01036
LLPS-Lac-3801Latimeria chalumnae72.890.0 912
LLPS-Ova-1264Ovis aries72.080.01076
LLPS-Tut-0689Tursiops truncatus71.410.01072
LLPS-Urm-1807Ursus maritimus71.390.01033
LLPS-Sus-2026Sus scrofa71.30.01078
LLPS-Crn-0411Cryptococcus neoformans71.220.01109
LLPS-Anc-0237Anolis carolinensis71.190.01078
LLPS-Pes-0788Pelodiscus sinensis71.170.01034
LLPS-Sah-0814Sarcophilus harrisii70.710.01077
LLPS-Mod-0606Monodelphis domestica70.710.01078
LLPS-Dio-0057Dipodomys ordii70.590.01075
LLPS-Ran-0792Rattus norvegicus70.590.01075
LLPS-Mal-0762Mandrillus leucophaeus70.590.01075
LLPS-Chs-0638Chlorocebus sabaeus70.590.01075
LLPS-Mum-0997Mus musculus70.590.01075
LLPS-Maf-3408Macaca fascicularis70.590.01075
LLPS-Mea-0209Mesocricetus auratus70.590.01074
LLPS-Cea-2649Cercocebus atys70.590.01075
LLPS-Gog-1311Gorilla gorilla70.590.01075
LLPS-Caj-0929Callithrix jacchus70.590.01075
LLPS-Fud-2089Fukomys damarensis70.590.01075
LLPS-Cap-0590Cavia porcellus70.590.01075
LLPS-Poa-0368Pongo abelii70.590.01075
LLPS-Mam-2019Macaca mulatta70.590.01075
LLPS-Cas-1422Carlito syrichta70.590.01075
LLPS-Ict-0904Ictidomys tridecemlineatus70.590.01075
LLPS-Hos-1698Homo sapiens70.590.01075
LLPS-Pap-1534Pan paniscus70.590.01075
LLPS-Pat-0632Pan troglodytes70.590.01075
LLPS-Loa-1132Loxodonta africana70.590.01075
LLPS-Rhb-1139Rhinopithecus bieti70.590.01075
LLPS-Orc-0712Oryctolagus cuniculus70.590.01075
LLPS-Icp-0746Ictalurus punctatus70.550.01082
LLPS-Bot-2920Bos taurus70.460.01075
LLPS-Myl-0276Myotis lucifugus70.460.01095
LLPS-Aim-1479Ailuropoda melanoleuca70.460.01076
LLPS-Mup-1577Mustela putorius furo70.460.01075
LLPS-Caf-1852Canis familiaris70.460.01073
LLPS-Fec-3017Felis catus70.460.01075
LLPS-Nol-1013Nomascus leucogenys70.450.01071
LLPS-Paa-0740Papio anubis70.410.01070
LLPS-Gaga-0545Gallus gallus70.410.01077
LLPS-Fia-0305Ficedula albicollis70.410.01077
LLPS-Scf-1468Scleropages formosus70.380.01081
LLPS-Cis-0849Ciona savignyi70.380.01065
LLPS-Orl-2769Oryzias latipes70.30.01079
LLPS-Dar-2143Danio rerio70.30.01078
LLPS-Ten-1386Tetraodon nigroviridis70.260.01097
LLPS-Zem-1715Zea mays70.250.01067
LLPS-Anp-2307Anas platyrhynchos70.240.01071
LLPS-Brn-2392Brassica napus70.210.01066
LLPS-Aon-0373Aotus nancymaae70.190.01071
LLPS-Xim-0465Xiphophorus maculatus70.180.01080
LLPS-Pof-0776Poecilia formosa70.180.01080
LLPS-Orn-0745Oreochromis niloticus70.180.01082
LLPS-Orbr-0008Oryza brachyantha70.170.01073
LLPS-Scm-0718Scophthalmus maximus70.140.01082
LLPS-Leo-0922Lepisosteus oculatus70.120.01080
LLPS-Sob-1238Sorghum bicolor70.120.01066
LLPS-Otg-0202Otolemur garnettii70.090.01073
LLPS-Gaa-1179Gasterosteus aculeatus70.050.01083
LLPS-Orp-2009Oryza punctata69.970.01077
LLPS-Eqc-1552Equus caballus69.960.01072
LLPS-Org-0362Oryza glaberrima69.850.01073
LLPS-Bro-2750Brassica oleracea69.80.01055
LLPS-Brd-0279Brachypodium distachyon69.780.01063
LLPS-Ora-0296Ornithorhynchus anatinus69.760.01072
LLPS-Orm-0487Oryza meridionalis69.710.01072
LLPS-Orgl-0154Oryza glumaepatula69.620.01068
LLPS-Ori-0118Oryza indica69.620.01068
LLPS-Orb-0399Oryza barthii69.620.01068
LLPS-Orni-0423Oryza nivara69.620.01068
LLPS-Orr-1312Oryza rufipogon69.620.01070
LLPS-Ors-0321Oryza sativa69.620.01068
LLPS-Chc-0426Chondrus crispus69.590.01034
LLPS-Brr-1721Brassica rapa69.540.01052
LLPS-Viv-0788Vitis vinifera69.530.01054
LLPS-Lep-1460Leersia perrieri69.340.01061
LLPS-Hea-0261Helianthus annuus69.280.01056
LLPS-Sot-1499Solanum tuberosum69.230.01061
LLPS-Cii-0589Ciona intestinalis69.230.01069
LLPS-Tra-1500Triticum aestivum69.150.01061
LLPS-Art-0402Arabidopsis thaliana69.130.01066
LLPS-Arl-0850Arabidopsis lyrata69.070.01067
LLPS-Dac-0865Daucus carota69.030.01053
LLPS-Sem-2355Selaginella moellendorffii69.020.01062
LLPS-Tru-1253Triticum urartu69.00.01047
LLPS-Sei-0858Setaria italica68.990.01074
LLPS-Hov-0551Hordeum vulgare68.870.01045
LLPS-Prp-1161Prunus persica68.720.01065
LLPS-Drm-0157Drosophila melanogaster68.620.01073
LLPS-Meg-1745Meleagris gallopavo68.540.0 921
LLPS-Sol-0419Solanum lycopersicum68.510.01063
LLPS-Php-0299Physcomitrella patens68.490.01053
LLPS-Gor-2281Gossypium raimondii68.470.01053
LLPS-Glm-0533Glycine max68.420.01064
LLPS-Amt-0721Amborella trichopoda68.410.01057
LLPS-Mae-0646Manihot esculenta68.350.01065
LLPS-Nia-0662Nicotiana attenuata68.30.01065
LLPS-Cus-2287Cucumis sativus68.290.01040
LLPS-Met-0156Medicago truncatula68.260.01068
LLPS-Chr-0100Chlamydomonas reinhardtii68.130.01031
LLPS-Cae-0346Caenorhabditis elegans68.10.01035
LLPS-Mua-2473Musa acuminata67.970.01053
LLPS-Thc-0163Theobroma cacao67.880.01052
LLPS-Tag-0701Taeniopygia guttata67.830.01013
LLPS-Cym-0087Cyanidioschyzon merolae67.810.01053
LLPS-Osl-0532Ostreococcus lucimarinus67.80.01033
LLPS-Pot-0063Populus trichocarpa67.790.01053
LLPS-Tar-1879Takifugu rubripes67.650.0 596
LLPS-Phv-0688Phaseolus vulgaris67.50.01053
LLPS-Via-1117Vigna angularis67.410.01059
LLPS-Gas-0515Galdieria sulphuraria67.20.01053
LLPS-Vir-0466Vigna radiata67.080.01056
LLPS-Asm-1636Astyanax mexicanus65.920.0 942
LLPS-Man-2697Macaca nemestrina64.090.0 884