• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scm-2153
SMAX5B_014280

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein kinase C delta type; nPKC-delta
Gene Name: SMAX5B_014280
Ensembl Gene: ENSSMAG00000001563.1
Ensembl Protein: ENSSMAP00000002557.1
Organism: Scophthalmus maximus
Taxa ID: 52904
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPFLRITFN  SYELGILPTL  ADPPFCAIKM  KEALTTERGK  TLVQRKPTMY  PAWKASFDAH  60
61    IYEGRVLEVL  LMKTAEETLA  EVSVGVAVLA  ERCKKANGRA  EFWVDLQPSG  KVMMAVQYFL  120
121   EGGDTESKKA  AKEEEAPTLN  RRRGAIKQAK  IHFIKNHEFI  ATFFRQPTFC  SVCREFVWGL  180
181   NKQGYKCRQC  NAAIHKKCID  KIIGRCTGTA  ANSRDTVFQK  ERFKIDMPHR  FKINNYMSPT  240
241   FCDHCGSLLW  GLVKQGLKCE  DCAMNVHHKC  QDKVANLCGI  NQKMLAEALT  QVSQKSSTRH  300
301   SDPNLPNLPD  IGIYDEVNKL  AGLDINDPSH  YGRLWEGSSP  QPQSRITHLT  RINVDDFVFH  360
361   KVLGKGSFGK  VLLAELKGRG  EYFAVKALKK  DVVLMDDDVE  CTMVEKRVLA  LNWENPFLTH  420
421   LFSTFQTKEH  LFFVMEYLNG  GDLMFHIQEK  GRFELYRASF  YSAEIICGLQ  FLHSKGVIYR  480
481   DLKLDNVMLD  HEGHIKIADF  GMCKENVFGE  NRATTFCGTP  DYIAPEILLG  QKYSFSVDWW  540
541   SFGVLLYEML  IGQSPFHGDD  EDELFESIRM  DTPHYPRWIN  KEAKDLLERL  FERDPSRRLG  600
601   IVGNVRLHPF  FKAFNWQALE  NREVEPPFKP  KVKAPNDCSN  FDREFLSENP  RLSHSDKNFI  660
661   DSMDQSAFAG  FSFINPKMEH  LLEK  684
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCCTT  TCTTGAGGAT  CACCTTTAAC  TCATACGAGT  TGGGCATCCT  GCCCACACTG  60
61    GCAGACCCTC  CCTTCTGTGC  GATCAAGATG  AAGGAGGCCT  TGACGACTGA  ACGAGGTAAG  120
121   ACCCTGGTCC  AGCGGAAACC  CACCATGTAC  CCGGCTTGGA  AGGCCAGTTT  TGACGCACAC  180
181   ATCTATGAGG  GTCGTGTGCT  GGAGGTACTG  CTGATGAAGA  CAGCAGAGGA  GACACTGGCT  240
241   GAGGTCTCTG  TTGGTGTGGC  TGTCCTTGCA  GAGCGATGCA  AGAAAGCCAA  CGGCCGCGCT  300
301   GAATTCTGGG  TGGATCTTCA  ACCTTCTGGG  AAAGTGATGA  TGGCAGTGCA  GTATTTTCTG  360
361   GAGGGAGGGG  ATACAGAGAG  TAAAAAGGCT  GCAAAGGAGG  AAGAGGCTCC  TACTCTGAAC  420
421   CGCAGACGAG  GGGCCATCAA  GCAGGCCAAG  ATCCACTTCA  TAAAGAACCA  TGAGTTCATC  480
481   GCTACTTTCT  TCAGACAGCC  CACTTTCTGC  TCCGTGTGCA  GGGAGTTTGT  TTGGGGACTC  540
541   AACAAACAAG  GCTATAAATG  CAGACAATGC  AATGCGGCCA  TCCACAAGAA  ATGCATAGAT  600
601   AAAATAATCG  GCAGATGTAC  CGGTACTGCT  GCCAACAGTC  GGGACACTGT  GTTCCAGAAG  660
661   GAGCGCTTTA  AAATTGACAT  GCCGCACCGT  TTCAAGATCA  ACAACTACAT  GAGTCCCACC  720
721   TTCTGCGACC  ACTGTGGAAG  TCTGCTGTGG  GGTCTCGTCA  AACAAGGCCT  GAAGTGCGAA  780
781   GATTGTGCCA  TGAATGTCCA  TCACAAGTGT  CAGGATAAAG  TAGCCAACCT  TTGTGGTATC  840
841   AACCAGAAAA  TGCTAGCTGA  AGCACTTACA  CAAGTCAGCC  AGAAATCGTC  CACCCGCCAT  900
901   TCAGATCCAA  ACCTGCCTAA  TCTGCCTGAT  ATTGGAATCT  ATGATGAAGT  AAACAAACTT  960
961   GCCGGACTGG  ATATCAATGA  CCCATCTCAC  TACGGCAGAC  TGTGGGAAGG  GTCCAGTCCT  1020
1021  CAGCCTCAGT  CTCGTATTAC  CCATCTGACT  CGCATCAACG  TGGATGACTT  CGTCTTCCAC  1080
1081  AAGGTTTTGG  GAAAAGGCAG  CTTTGGCAAG  GTTCTCCTAG  CAGAGCTGAA  GGGTCGTGGA  1140
1141  GAGTACTTTG  CTGTGAAGGC  TCTGAAGAAA  GACGTGGTGC  TGATGGACGA  CGATGTGGAG  1200
1201  TGCACCATGG  TCGAGAAGAG  AGTCTTGGCA  TTGAACTGGG  AAAACCCCTT  TCTCACACAC  1260
1261  CTGTTCTCCA  CCTTCCAGAC  TAAGGAGCAT  CTGTTCTTTG  TGATGGAGTA  TCTGAACGGA  1320
1321  GGAGACTTGA  TGTTTCATAT  TCAGGAGAAA  GGGCGCTTTG  AACTCTACAG  AGCCTCGTTC  1380
1381  TACTCGGCCG  AGATTATTTG  TGGTCTCCAG  TTTTTACACT  CCAAAGGGGT  CATCTACAGA  1440
1441  GATCTCAAGT  TAGACAATGT  GATGCTGGAT  CATGAGGGAC  ACATAAAGAT  CGCTGACTTT  1500
1501  GGGATGTGCA  AGGAGAATGT  GTTTGGAGAG  AATCGCGCCA  CGACTTTCTG  TGGAACTCCT  1560
1561  GACTACATCG  CTCCGGAGAT  CCTGCTGGGA  CAGAAATACT  CATTCTCAGT  CGACTGGTGG  1620
1621  TCCTTCGGGG  TGTTGCTCTA  TGAGATGCTG  ATTGGACAGT  CGCCTTTCCA  TGGAGATGAT  1680
1681  GAGGATGAGT  TGTTTGAGTC  CATCCGCATG  GATACTCCCC  ACTATCCTCG  CTGGATCAAC  1740
1741  AAAGAGGCCA  AGGACCTGCT  CGAGCGGTTG  TTCGAGAGAG  ACCCCAGCCG  CAGGCTAGGA  1800
1801  ATCGTGGGTA  ATGTTCGTTT  ACACCCCTTC  TTCAAGGCCT  TTAACTGGCA  GGCCTTGGAG  1860
1861  AATAGGGAAG  TTGAACCCCC  TTTCAAACCA  AAAGTGAAAG  CACCGAATGA  TTGCAGCAAC  1920
1921  TTTGATCGGG  AGTTCCTCAG  TGAGAATCCT  CGTCTCTCAC  ACAGCGACAA  GAACTTCATA  1980
1981  GACTCCATGG  ACCAGTCAGC  ATTTGCTGGT  TTTTCATTCA  TCAACCCCAA  GATGGAGCAC  2040
2041  CTTTTAGAAA  AGTGA  2055

▼ KEYWORD

ID
Family
Apoptosis
ATP-binding
Cell cycle
Complete proteome
Cytoplasm
Kinase
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Repeat
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Protein kinase C activity
Biological Process
Apoptotic process
Biological Process
Cell cycle
Biological Process
Intracellular signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-3722Oreochromis niloticus92.840.01293
LLPS-Tar-2751Takifugu rubripes91.970.01277
LLPS-Xim-3107Xiphophorus maculatus91.080.01261
LLPS-Pof-3817Poecilia formosa91.00.01260
LLPS-Gaa-2353Gasterosteus aculeatus90.960.01263
LLPS-Orl-0847Oryzias latipes90.480.01263
LLPS-Ten-1276Tetraodon nigroviridis90.120.01241
LLPS-Scf-3074Scleropages formosus86.130.01191
LLPS-Leo-2566Lepisosteus oculatus83.720.01167
LLPS-Asm-3667Astyanax mexicanus82.510.01165
LLPS-Icp-2271Ictalurus punctatus81.160.01140
LLPS-Dar-0962Danio rerio79.220.01132
LLPS-Anc-3746Anolis carolinensis78.960.01100
LLPS-Xet-2931Xenopus tropicalis78.080.01103
LLPS-Mod-2311Monodelphis domestica77.970.01093
LLPS-Sah-0631Sarcophilus harrisii77.970.01092
LLPS-Fud-0864Fukomys damarensis76.960.01085
LLPS-Eqc-2912Equus caballus76.810.01075
LLPS-Pes-3753Pelodiscus sinensis76.530.01086
LLPS-Ict-4625Ictidomys tridecemlineatus76.520.01073
LLPS-Lac-3024Latimeria chalumnae76.520.01090
LLPS-Anp-2899Anas platyrhynchos76.420.01085
LLPS-Mam-0296Macaca mulatta76.230.01067
LLPS-Cap-3276Cavia porcellus76.230.01076
LLPS-Rhb-3203Rhinopithecus bieti76.230.01067
LLPS-Pat-4928Pan troglodytes76.230.01076
LLPS-Maf-3817Macaca fascicularis76.230.01067
LLPS-Chs-0833Chlorocebus sabaeus76.230.01067
LLPS-Gaga-1095Gallus gallus76.140.01087
LLPS-Otg-0023Otolemur garnettii76.120.01068
LLPS-Tag-3078Taeniopygia guttata76.090.01065
LLPS-Pap-3536Pan paniscus76.090.01074
LLPS-Man-1926Macaca nemestrina76.060.0 980
LLPS-Meg-0661Meleagris gallopavo76.060.01083
LLPS-Nol-3507Nomascus leucogenys75.940.01066
LLPS-Ran-4255Rattus norvegicus75.940.01067
LLPS-Gog-0463Gorilla gorilla75.940.01066
LLPS-Fec-1246Felis catus75.830.01070
LLPS-Cas-2786Carlito syrichta75.80.01066
LLPS-Poa-3726Pongo abelii75.80.01065
LLPS-Hos-3694Homo sapiens75.80.01065
LLPS-Paa-2363Papio anubis75.80.01066
LLPS-Mal-4672Mandrillus leucophaeus75.80.01066
LLPS-Cea-4242Cercocebus atys75.80.01066
LLPS-Aon-3788Aotus nancymaae75.80.01064
LLPS-Caj-3688Callithrix jacchus75.650.01064
LLPS-Caf-2978Canis familiaris75.510.01067
LLPS-Urm-2936Ursus maritimus75.510.01071
LLPS-Aim-3199Ailuropoda melanoleuca75.510.01069
LLPS-Dio-3441Dipodomys ordii75.250.01067
LLPS-Myl-4436Myotis lucifugus75.220.01064
LLPS-Fia-2681Ficedula albicollis75.00.01069
LLPS-Sus-1945Sus scrofa74.960.0 971
LLPS-Loa-4424Loxodonta africana74.690.01060
LLPS-Orc-4179Oryctolagus cuniculus73.680.0 986
LLPS-Bot-2907Bos taurus73.560.01044
LLPS-Ova-4240Ovis aries73.230.01030
LLPS-Mea-3433Mesocricetus auratus73.00.01038
LLPS-Mum-0530Mus musculus72.770.01054
LLPS-Ora-2098Ornithorhynchus anatinus61.670.0 881
LLPS-Mup-1848Mustela putorius furo61.112e-1584.0
LLPS-Drm-1985Drosophila melanogaster60.32e-122 387
LLPS-Cis-1665Ciona savignyi50.710.0 704
LLPS-Cae-0947Caenorhabditis elegans47.390.0 625
LLPS-Tum-0067Tuber melanosporum38.67e-117 379
LLPS-Scj-1525Schizosaccharomyces japonicus36.362e-120 390
LLPS-Abg-1134Absidia glauca36.331e-116 379