• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orn-3722
prkcd

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein kinase C delta type; nPKC-delta
Gene Name: prkcd
Ensembl Gene: ENSONIG00000019041.1
Ensembl Protein: ENSONIP00000023972.1
Organism: Oreochromis niloticus
Taxa ID: 8128
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPFLRIAFN  SYDLGILPPL  TDPPFCAIKM  KEALTTERGK  TLVQRKPTMY  PAWKSTFDAH  60
61    IYEGRVLEVL  LMKTAEEPLA  EVSVGVSVLA  ERCKKANGRA  EFWVDLHPSG  KVMMAVQYFL  120
121   EDADAESKQP  VKEEEAPTLN  RRRGAIKQAK  IHFIKNHEFI  ATFFRQPTFC  SVCREFVWGL  180
181   NKQGYKCRQC  NAAIHKKCID  KIIGRCTGTA  ANSRDTVFQK  ERFKIDMPHR  FKINNYMSPT  240
241   FCDHCGSLLW  GLVKQGLKCE  DCAMNVHHKC  QDKVANLCGI  NQKLLAEALT  QVSQKSSTRR  300
301   SDPNLPNLPD  IGIYDEVNKL  AGLEINDGST  YGKLWEGSIP  RAPSRLTHLT  KINMDNFIFH  360
361   KVLGKGSFGK  VLLAELKGRG  EYFAVKALKK  DVVLMDDDVE  CTMVEKRVLA  LAWENPFLTH  420
421   LYSTFQTKEH  LFFVMEYLNG  GDLMFHIQEK  GRFELYRATF  YSAEIICGLQ  FLHSKGIIYR  480
481   DLKLDNVMLD  CDGHIKIADF  GMCKENVFGD  NRATTFCGTP  DYIAPEILLG  QKYSFSVDWW  540
541   SFGVLLYEML  IGQSPFHGDD  EDELFESIRM  DTPHYPRWIS  KESKDLLERL  FERDPTRRIG  600
601   IVGNIRLHPF  FKSINWQALE  MREVEPPFKP  KVKAPNDCSN  FDREFLSEKA  RLSYSDKNFI  660
661   DSMDQSAFAG  FSFMNPKMEH  LLEK  684
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCCTT  TCTTGAGGAT  TGCCTTTAAC  TCGTACGACC  TGGGCATCCT  GCCTCCTCTA  60
61    ACTGACCCGC  CCTTCTGTGC  TATCAAGATG  AAGGAAGCCT  TGACAACTGA  AAGAGGGAAG  120
121   ACCCTGGTTC  AGCGTAAACC  CACCATGTAC  CCAGCCTGGA  AGTCCACTTT  TGATGCACAC  180
181   ATCTATGAAG  GTCGTGTGCT  CGAGGTACTG  CTGATGAAGA  CAGCGGAGGA  GCCGCTGGCT  240
241   GAAGTCTCTG  TCGGTGTGTC  TGTCCTTGCT  GAGCGTTGCA  AGAAAGCCAA  CGGGCGTGCT  300
301   GAATTCTGGG  TGGATCTCCA  TCCTTCAGGG  AAAGTGATGA  TGGCAGTGCA  GTATTTTCTG  360
361   GAGGATGCAG  ATGCAGAGAG  CAAGCAGCCT  GTGAAGGAGG  AAGAAGCGCC  TACTCTAAAC  420
421   CGTAGACGTG  GGGCCATAAA  GCAGGCCAAG  ATACACTTCA  TCAAGAACCA  TGAGTTCATT  480
481   GCAACTTTCT  TCAGACAGCC  CACTTTCTGC  TCTGTGTGCA  GAGAATTTGT  CTGGGGACTC  540
541   AACAAGCAAG  GCTATAAATG  CAGACAATGT  AATGCAGCCA  TCCACAAGAA  ATGTATAGAC  600
601   AAAATCATCG  GCAGATGTAC  CGGTACTGCT  GCCAACAGTC  GGGATACTGT  GTTCCAGAAG  660
661   GAGCGATTTA  AAATCGACAT  GCCGCATCGT  TTCAAGATCA  ACAACTACAT  GAGTCCCACC  720
721   TTCTGTGACC  ACTGTGGAAG  CCTTCTATGG  GGTCTGGTCA  AGCAAGGCCT  GAAGTGTGAA  780
781   GACTGCGCCA  TGAATGTCCA  TCACAAGTGT  CAGGACAAAG  TAGCCAACCT  TTGTGGTATC  840
841   AATCAGAAAC  TACTAGCCGA  AGCCCTCACA  CAAGTCAGTC  AGAAATCATC  CACTCGCCGT  900
901   TCAGATCCAA  ATCTGCCTAA  TCTCCCCGAT  ATTGGAATCT  ATGACGAAGT  GAATAAACTT  960
961   GCTGGACTTG  AGATCAATGA  TGGGTCGACA  TACGGCAAAC  TTTGGGAAGG  TTCCATCCCA  1020
1021  CGGGCACCGT  CTCGTCTTAC  CCACTTAACC  AAGATCAACA  TGGACAACTT  CATCTTCCAC  1080
1081  AAAGTCTTAG  GAAAAGGCAG  TTTTGGCAAG  GTCCTGCTGG  CAGAGCTGAA  GGGGCGTGGA  1140
1141  GAGTATTTTG  CTGTGAAGGC  TCTGAAGAAA  GATGTAGTGC  TTATGGATGA  TGATGTGGAG  1200
1201  TGCACGATGG  TAGAGAAAAG  AGTCTTGGCT  TTAGCCTGGG  AAAACCCTTT  CCTCACACAC  1260
1261  CTTTACTCCA  CCTTTCAGAC  CAAGGAGCAT  CTGTTCTTTG  TGATGGAGTA  TCTGAATGGA  1320
1321  GGTGACTTGA  TGTTTCACAT  TCAGGAAAAA  GGGCGCTTTG  AGCTCTACAG  AGCCACGTTC  1380
1381  TACTCTGCCG  AGATCATTTG  TGGTCTTCAG  TTTTTACATT  CCAAAGGCAT  CATCTACAGG  1440
1441  GATCTTAAGT  TAGACAATGT  GATGTTGGAC  TGCGACGGGC  ACATAAAGAT  TGCTGACTTT  1500
1501  GGTATGTGCA  AGGAGAATGT  ATTTGGCGAC  AATCGCGCCA  CAACTTTCTG  CGGCACCCCT  1560
1561  GATTACATCG  CTCCAGAGAT  CCTGCTGGGA  CAGAAGTACT  CATTCTCAGT  TGACTGGTGG  1620
1621  TCATTTGGGG  TGTTGCTGTA  TGAGATGCTG  ATTGGTCAGT  CACCTTTTCA  TGGAGATGAT  1680
1681  GAGGATGAGC  TGTTTGAGTC  CATTCGCATG  GACACTCCCC  ATTATCCCCG  ATGGATCAGC  1740
1741  AAGGAGTCGA  AAGACCTGCT  CGAGCGGTTG  TTTGAGAGAG  ACCCAACTCG  CAGGATAGGA  1800
1801  ATTGTGGGTA  ATATCCGATT  ACACCCCTTT  TTCAAGAGCA  TTAACTGGCA  GGCGTTGGAG  1860
1861  ATGAGAGAGG  TTGAGCCCCC  CTTCAAACCC  AAAGTGAAAG  CACCGAATGA  CTGCAGCAAC  1920
1921  TTTGACCGGG  AGTTCCTCAG  CGAGAAGGCG  CGTCTTTCCT  ACAGCGATAA  GAACTTCATA  1980
1981  GATTCCATGG  ACCAGTCGGC  ATTTGCTGGG  TTTTCATTCA  TGAACCCCAA  GATGGAGCAT  2040
2041  CTTTTAGAAA  AATGA  2055

▼ KEYWORD

ID
Family
Apoptosis
ATP-binding
Cell cycle
Complete proteome
Cytoplasm
Kinase
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Repeat
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Protein kinase C activity
Biological Process
Apoptotic process
Biological Process
Cell cycle
Biological Process
Intracellular signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scm-2153Scophthalmus maximus92.840.01307
LLPS-Xim-3107Xiphophorus maculatus92.110.01295
LLPS-Pof-3817Poecilia formosa91.730.01291
LLPS-Tar-2751Takifugu rubripes91.390.01281
LLPS-Gaa-2353Gasterosteus aculeatus91.250.01283
LLPS-Orl-0847Oryzias latipes91.220.01283
LLPS-Ten-1276Tetraodon nigroviridis89.10.01243
LLPS-Scf-3074Scleropages formosus87.30.01219
LLPS-Leo-2566Lepisosteus oculatus86.050.01209
LLPS-Asm-3667Astyanax mexicanus83.380.01184
LLPS-Icp-2271Ictalurus punctatus83.190.01169
LLPS-Dar-0962Danio rerio80.380.01147
LLPS-Anc-3746Anolis carolinensis80.260.01116
LLPS-Sah-0631Sarcophilus harrisii80.00.01119
LLPS-Xet-2931Xenopus tropicalis79.710.01122
LLPS-Mod-2311Monodelphis domestica79.710.01117
LLPS-Pap-3536Pan paniscus78.70.01106
LLPS-Pat-4928Pan troglodytes78.70.01106
LLPS-Lac-3024Latimeria chalumnae78.580.01112
LLPS-Mam-0296Macaca mulatta78.550.01094
LLPS-Rhb-3203Rhinopithecus bieti78.550.01094
LLPS-Maf-3817Macaca fascicularis78.550.01094
LLPS-Chs-0833Chlorocebus sabaeus78.550.01094
LLPS-Eqc-2912Equus caballus78.470.01098
LLPS-Pes-3753Pelodiscus sinensis78.380.01110
LLPS-Tag-3078Taeniopygia guttata78.280.01093
LLPS-Anp-2899Anas platyrhynchos78.270.01111
LLPS-Nol-3507Nomascus leucogenys78.260.01093
LLPS-Poa-3726Pongo abelii78.260.01093
LLPS-Mal-4672Mandrillus leucophaeus78.260.01093
LLPS-Paa-2363Papio anubis78.260.01093
LLPS-Gog-0463Gorilla gorilla78.260.01094
LLPS-Cea-4242Cercocebus atys78.260.01093
LLPS-Hos-3694Homo sapiens78.120.01093
LLPS-Fec-1246Felis catus78.120.01096
LLPS-Man-1926Macaca nemestrina78.090.01003
LLPS-Gaga-1095Gallus gallus77.980.01116
LLPS-Cas-2786Carlito syrichta77.970.01092
LLPS-Aon-3788Aotus nancymaae77.970.01090
LLPS-Fud-0864Fukomys damarensis77.890.01093
LLPS-Cap-3276Cavia porcellus77.860.01086
LLPS-Orc-4179Oryctolagus cuniculus77.860.01006
LLPS-Caj-3688Callithrix jacchus77.830.01090
LLPS-Caf-2978Canis familiaris77.680.01095
LLPS-Meg-0661Meleagris gallopavo77.620.01105
LLPS-Otg-0023Otolemur garnettii77.570.01088
LLPS-Urm-2936Ursus maritimus77.540.01094
LLPS-Aim-3199Ailuropoda melanoleuca77.540.01094
LLPS-Ict-4625Ictidomys tridecemlineatus77.390.01085
LLPS-Dio-3441Dipodomys ordii77.20.01089
LLPS-Ran-4255Rattus norvegicus77.170.01085
LLPS-Sus-1945Sus scrofa77.00.0 992
LLPS-Fia-2681Ficedula albicollis76.550.01093
LLPS-Myl-4436Myotis lucifugus76.450.01079
LLPS-Loa-4424Loxodonta africana76.290.01083
LLPS-Bot-2907Bos taurus75.140.01061
LLPS-Ova-4240Ovis aries74.820.01048
LLPS-Mea-3433Mesocricetus auratus74.580.01055
LLPS-Mum-0530Mus musculus73.820.01068
LLPS-Ora-2098Ornithorhynchus anatinus61.970.0 887
LLPS-Mup-1848Mustela putorius furo61.112e-1584.0
LLPS-Drm-1985Drosophila melanogaster60.912e-124 392
LLPS-Cis-1665Ciona savignyi50.990.0 708
LLPS-Cae-0947Caenorhabditis elegans48.140.0 640
LLPS-Abg-1134Absidia glauca36.291e-118 385
LLPS-Tum-0067Tuber melanosporum36.215e-117 380
LLPS-Scj-1525Schizosaccharomyces japonicus35.568e-118 383