LLPS-Scm-0443
SMAX5B_010511
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA polymerase |
| Gene Name: | SMAX5B_010511 |
| Ensembl Gene: | ENSSMAG00000006536.1 |
| Ensembl Protein: | ENSSMAP00000010638.1 |
| Organism: | Scophthalmus maximus |
| Taxa ID: | 52904 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin | Predicted from orthologs | (View) |
▼ FUNCTION
| DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSSMAT00000010781.1 | ENSSMAP00000010638.1 |
| UniProt | A0A2U9BVI0, A0A2U9BVI0_SCOMX | |
| GeneBank | CP026251 | AWP07416.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSKRKAPQES LNEGITDFLV ELANYEKNVN RAIHKYNAYR KAASTIAKYP QKIKSGEEAK 60 61 KLDGVGAKIA EKIDEFLQTG KLRKLEKIRN DDTSSSINFL TRVTGIGPAA ARKFFEEGVK 120 121 TLDDLKKIEH KLNHHQQIGL KYFEEFEKRI PRAEMEKMET LILGELGKID EEYIGTICGS 180 181 YRRGAASSGD IDILLTHPDY TSETEKQPKL LNAVVEHLVS IGFVTDTLSK GDTKFMGVCQ 240 241 LQQSDDDEEE YLHRRIDIRL IPKDQYYCGV LYFTGSDIFN KNMRTHALEK GFTLNEYTIR 300 301 PVGVTGVAGE PLLVDSERDI FEYIHYKYRE PKERSE 336 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCAAGA GGAAGGCGCC GCAGGAATCC CTCAACGAGG GAATAACAGA CTTCCTTGTG 60 61 GAGCTGGCCA ATTACGAGAA AAATGTCAAC AGGGCAATAC ACAAGTACAA TGCGTACAGG 120 121 AAAGCAGCAT CTACCATTGC TAAATACCCT CAGAAGATCA AAAGTGGTGA AGAGGCCAAG 180 181 AAACTGGATG GTGTTGGAGC TAAAATAGCA GAAAAGATTG ACGAGTTCTT GCAAACTGGC 240 241 AAACTACGGA AACTGGAAAA GATCCGAAAT GATGACACCA GCTCTTCCAT CAATTTCCTC 300 301 ACCAGAGTTA CCGGAATTGG CCCTGCTGCT GCCAGGAAGT TTTTTGAAGA AGGGGTGAAG 360 361 ACATTAGACG ATCTGAAAAA GATAGAACAC AAACTAAACC ATCATCAACA GATTGGACTC 420 421 AAGTACTTTG AAGAGTTTGA GAAAAGGATC CCACGTGCTG AAATGGAAAA GATGGAGACG 480 481 CTGATTCTTG GAGAGTTGGG GAAAATTGAT GAAGAATATA TTGGAACAAT TTGTGGAAGT 540 541 TACAGGAGAG GCGCTGCATC GAGTGGTGAT ATTGATATTT TGCTGACCCA CCCAGACTAC 600 601 ACCTCTGAGA CTGAGAAGCA GCCAAAGCTG CTCAATGCCG TCGTCGAACA TTTGGTGTCC 660 661 ATTGGGTTTG TGACTGACAC TCTGTCCAAA GGAGACACCA AGTTCATGGG AGTCTGCCAA 720 721 CTGCAGCAGA GCGATGACGA TGAGGAAGAA TACCTTCACA GGCGTATTGA TATTAGGTTA 780 781 ATTCCTAAGG ACCAGTACTA CTGTGGAGTC CTGTATTTCA CTGGAAGTGA TATCTTCAAT 840 841 AAGAATATGA GAACTCATGC TCTTGAGAAG GGCTTCACGC TTAATGAGTA TACCATCCGA 900 901 CCAGTTGGGG TCACCGGTGT GGCAGGGGAG CCTCTTCTGG TGGATAGTGA GAGAGACATC 960 961 TTTGAATACA TCCACTACAA ATATCGAGAG CCAAAGGAGC GCAGCGAGTG A 1011 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Biological Process | DNA repair |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orn-3680 | Oreochromis niloticus | 94.35 | 0.0 | 656 |
| LLPS-Pof-2548 | Poecilia formosa | 93.2 | 0.0 | 625 |
| LLPS-Xim-1732 | Xiphophorus maculatus | 92.58 | 0.0 | 629 |
| LLPS-Gaa-3113 | Gasterosteus aculeatus | 91.96 | 0.0 | 639 |
| LLPS-Tar-3611 | Takifugu rubripes | 91.67 | 0.0 | 643 |
| LLPS-Orl-2798 | Oryzias latipes | 91.12 | 0.0 | 637 |
| LLPS-Ten-3235 | Tetraodon nigroviridis | 89.02 | 0.0 | 615 |
| LLPS-Dar-2919 | Danio rerio | 88.79 | 0.0 | 612 |
| LLPS-Asm-2376 | Astyanax mexicanus | 88.69 | 0.0 | 604 |
| LLPS-Icp-3313 | Ictalurus punctatus | 88.39 | 0.0 | 619 |
| LLPS-Sus-2146 | Sus scrofa | 86.92 | 2e-57 | 187 |
| LLPS-Scf-3361 | Scleropages formosus | 83.73 | 0.0 | 553 |
| LLPS-Lac-3764 | Latimeria chalumnae | 83.04 | 0.0 | 576 |
| LLPS-Leo-0916 | Lepisosteus oculatus | 82.74 | 0.0 | 576 |
| LLPS-Anc-3012 | Anolis carolinensis | 80.95 | 0.0 | 567 |
| LLPS-Loa-2650 | Loxodonta africana | 79.76 | 0.0 | 563 |
| LLPS-Otg-0579 | Otolemur garnettii | 79.76 | 0.0 | 560 |
| LLPS-Urm-2344 | Ursus maritimus | 79.46 | 0.0 | 561 |
| LLPS-Aim-3165 | Ailuropoda melanoleuca | 79.46 | 0.0 | 560 |
| LLPS-Myl-1410 | Myotis lucifugus | 79.46 | 0.0 | 559 |
| LLPS-Caf-4613 | Canis familiaris | 79.17 | 0.0 | 558 |
| LLPS-Mod-3239 | Monodelphis domestica | 79.17 | 0.0 | 563 |
| LLPS-Fec-4344 | Felis catus | 79.17 | 0.0 | 558 |
| LLPS-Mup-3073 | Mustela putorius furo | 79.17 | 0.0 | 558 |
| LLPS-Mea-2762 | Mesocricetus auratus | 79.17 | 0.0 | 560 |
| LLPS-Ran-4334 | Rattus norvegicus | 78.87 | 0.0 | 556 |
| LLPS-Mum-1134 | Mus musculus | 78.87 | 0.0 | 556 |
| LLPS-Nol-0064 | Nomascus leucogenys | 78.57 | 0.0 | 554 |
| LLPS-Man-4444 | Macaca nemestrina | 78.57 | 0.0 | 553 |
| LLPS-Pat-2688 | Pan troglodytes | 78.57 | 0.0 | 554 |
| LLPS-Pap-1083 | Pan paniscus | 78.57 | 0.0 | 554 |
| LLPS-Hos-4990 | Homo sapiens | 78.57 | 0.0 | 554 |
| LLPS-Orc-2399 | Oryctolagus cuniculus | 78.57 | 0.0 | 556 |
| LLPS-Rhb-0787 | Rhinopithecus bieti | 78.57 | 0.0 | 553 |
| LLPS-Maf-3218 | Macaca fascicularis | 78.57 | 0.0 | 553 |
| LLPS-Chs-3636 | Chlorocebus sabaeus | 78.57 | 0.0 | 553 |
| LLPS-Gog-0062 | Gorilla gorilla | 78.57 | 0.0 | 554 |
| LLPS-Ova-0337 | Ovis aries | 78.3 | 0.0 | 521 |
| LLPS-Cea-4750 | Cercocebus atys | 78.3 | 0.0 | 522 |
| LLPS-Poa-2255 | Pongo abelii | 78.27 | 0.0 | 551 |
| LLPS-Tag-3451 | Taeniopygia guttata | 78.27 | 0.0 | 548 |
| LLPS-Fud-4184 | Fukomys damarensis | 78.27 | 0.0 | 554 |
| LLPS-Caj-2322 | Callithrix jacchus | 78.27 | 0.0 | 552 |
| LLPS-Dio-1957 | Dipodomys ordii | 78.26 | 2e-100 | 301 |
| LLPS-Xet-0923 | Xenopus tropicalis | 78.11 | 0.0 | 547 |
| LLPS-Aon-1832 | Aotus nancymaae | 77.78 | 3e-176 | 498 |
| LLPS-Mal-2348 | Mandrillus leucophaeus | 77.72 | 1e-98 | 296 |
| LLPS-Fia-2707 | Ficedula albicollis | 77.68 | 0.0 | 543 |
| LLPS-Bot-3056 | Bos taurus | 77.56 | 9e-175 | 498 |
| LLPS-Ora-2557 | Ornithorhynchus anatinus | 76.61 | 2e-120 | 353 |
| LLPS-Meg-1755 | Meleagris gallopavo | 76.28 | 6e-153 | 438 |
| LLPS-Pes-3279 | Pelodiscus sinensis | 76.05 | 9e-171 | 485 |
| LLPS-Cap-1290 | Cavia porcellus | 75.37 | 0.0 | 535 |
| LLPS-Sah-1572 | Sarcophilus harrisii | 75.15 | 0.0 | 521 |
| LLPS-Cas-1074 | Carlito syrichta | 75.0 | 0.0 | 515 |
| LLPS-Eqc-4659 | Equus caballus | 74.56 | 1e-180 | 510 |
| LLPS-Ict-3481 | Ictidomys tridecemlineatus | 72.92 | 2e-177 | 501 |
| LLPS-Anp-2695 | Anas platyrhynchos | 72.49 | 2e-120 | 353 |
| LLPS-Paa-2328 | Papio anubis | 71.16 | 0.0 | 536 |
| LLPS-Gaga-2095 | Gallus gallus | 70.33 | 3e-90 | 275 |
| LLPS-Cii-0841 | Ciona intestinalis | 64.29 | 2e-157 | 451 |
| LLPS-Yal-0989 | Yarrowia lipolytica | 36.16 | 1e-48 | 178 |
| LLPS-Phn-0154 | Phaeosphaeria nodorum | 35.92 | 2e-49 | 181 |
| LLPS-Dac-0347 | Daucus carota | 35.86 | 2e-52 | 187 |
| LLPS-Pyt-1107 | Pyrenophora teres | 35.6 | 2e-50 | 183 |
| LLPS-Asni-1388 | Aspergillus niger | 35.18 | 1e-50 | 184 |
| LLPS-Zyt-1019 | Zymoseptoria tritici | 34.93 | 6e-49 | 178 |
| LLPS-Nia-0389 | Nicotiana attenuata | 34.9 | 8e-53 | 188 |
| LLPS-Met-1779 | Medicago truncatula | 34.88 | 9e-54 | 190 |
| LLPS-Mao-1344 | Magnaporthe oryzae | 34.77 | 1e-55 | 199 |
| LLPS-Pot-1817 | Populus trichocarpa | 34.62 | 4e-54 | 191 |
| LLPS-Asfu-0375 | Aspergillus fumigatus | 34.53 | 6e-44 | 165 |
| LLPS-Fuv-1312 | Fusarium verticillioides | 34.42 | 1e-55 | 192 |
| LLPS-Pytr-0062 | Pyrenophora triticirepentis | 34.32 | 1e-48 | 178 |
| LLPS-Lem-1403 | Leptosphaeria maculans | 33.97 | 5e-46 | 171 |
| LLPS-Ast-1316 | Aspergillus terreus | 33.88 | 6e-46 | 170 |
| LLPS-Fus-1353 | Fusarium solani | 33.83 | 2e-53 | 192 |
| LLPS-Prp-0496 | Prunus persica | 33.82 | 5e-51 | 182 |
| LLPS-Miv-1469 | Microbotryum violaceum | 33.8 | 9e-31 | 126 |
| LLPS-Nef-0861 | Neosartorya fischeri | 33.69 | 3e-35 | 140 |
| LLPS-Aso-0365 | Aspergillus oryzae | 33.53 | 5e-44 | 165 |
| LLPS-Asf-0738 | Aspergillus flavus | 33.24 | 1e-43 | 163 |
| LLPS-Fuo-1443 | Fusarium oxysporum | 33.23 | 9e-52 | 187 |
| LLPS-Cog-0371 | Colletotrichum gloeosporioides | 33.23 | 2e-49 | 181 |
| LLPS-Cogr-1408 | Colletotrichum graminicola | 33.13 | 6e-50 | 182 |
| LLPS-Mua-1392 | Musa acuminata | 32.86 | 1e-50 | 182 |
| LLPS-Gor-2190 | Gossypium raimondii | 32.85 | 2e-52 | 187 |
| LLPS-Ere-1001 | Erinaceus europaeus | 32.79 | 1e-50 | 179 |
| LLPS-Asn-1181 | Aspergillus nidulans | 32.79 | 2e-39 | 151 |
| LLPS-Mam-1595 | Macaca mulatta | 32.78 | 5e-51 | 177 |
| LLPS-Dos-1523 | Dothistroma septosporum | 32.67 | 1e-42 | 162 |
| LLPS-Trv-1059 | Trichoderma virens | 32.37 | 1e-44 | 166 |
| LLPS-Trr-0509 | Trichoderma reesei | 32.36 | 7e-51 | 184 |
| LLPS-Coo-0120 | Colletotrichum orbiculare | 32.35 | 6e-46 | 171 |
| LLPS-Ved-1454 | Verticillium dahliae | 32.32 | 8e-46 | 171 |
| LLPS-Asc-1615 | Aspergillus clavatus | 32.25 | 3e-43 | 162 |
| LLPS-Beb-1473 | Beauveria bassiana | 32.1 | 3e-45 | 169 |
| LLPS-Nec-0115 | Neurospora crassa | 31.87 | 2e-45 | 170 |
| LLPS-Map-1267 | Magnaporthe poae | 31.83 | 2e-34 | 139 |
| LLPS-Sem-1033 | Selaginella moellendorffii | 31.79 | 2e-47 | 169 |
| LLPS-Abg-1778 | Absidia glauca | 31.61 | 2e-47 | 173 |
| LLPS-Crn-0471 | Cryptococcus neoformans | 31.29 | 1e-42 | 163 |
| LLPS-Gag-1131 | Gaeumannomyces graminis | 31.25 | 1e-39 | 154 |
| LLPS-Tum-1576 | Tuber melanosporum | 30.88 | 7e-41 | 157 |
| LLPS-Usm-1274 | Ustilago maydis | 30.68 | 1e-23 | 106 |
| LLPS-Spr-1429 | Sporisorium reilianum | 29.66 | 6e-26 | 113 |
| LLPS-Kop-0147 | Komagataella pastoris | 28.05 | 5e-27 | 115 |
| LLPS-Asg-1415 | Ashbya gossypii | 27.98 | 2e-13 | 74.7 |
| LLPS-Scc-1285 | Schizosaccharomyces cryophilus | 27.49 | 1e-30 | 125 |
| LLPS-Sac-0332 | Saccharomyces cerevisiae | 25.93 | 1e-12 | 72.8 |
| LLPS-Cis-1804 | Ciona savignyi | 24.32 | 7e-22 | 100 |
| LLPS-Scp-1632 | Schizosaccharomyces pombe | 24.07 | 1e-24 | 108 |
| LLPS-Chc-0704 | Chondrus crispus | 23.28 | 1e-15 | 81.3 |