DrLLPS - Data resource of LLPS

LLPS-Sac-1487
MSL1

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U2 small nuclear ribonucleoprotein B''
Gene Name:	MSL1, YIR009W, YIB9W
Ensembl Gene:	YIR009W
Ensembl Protein:	YIR009W_mRNA
Organism:	Saccharomyces cerevisiae
Taxa ID:	559292
LLPS Type:	Client

PDB: 5ZWO (A, K, L, N, J, E, M, C, z, q, r, x, t, y, s, F, B, O, d, a, b, c, e, f, g, I, D, G, 1, 2, 3, 4, 5, 6, X, Y, Z, H, o, p, u, w, v, W, 0, 9) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle, Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1937	P09012	Client	Nuclear speckle, Nucleolus, P-body	40.00	6e-133	422
Arabidopsis thaliana	LLPS-Art-0501	O22922	Client	Nucleolus	60.21	3e-126	371

▼ FUNCTION

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	YIR009W_mRNA	YIR009W_mRNA
UniProt		P40567, MSL1_YEAST, D6VVT9
GeneBank	BK006942, AY558237, X79743, Z37996	, AAS56563.1, DAA08555.1, CAA86079.1
RefSeq	NM_001179531.1	NP_012274.1
Entrez	854826

▼ SEQUENCE

Protein Sequence (FASTA)
1 MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL LFATFGEVLK 60 61 VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK VEFSKSETKT L 111
Nucleotide CDS Sequence (FASTA)
1 ATGGTTGAAC CAGCAAGGAA AAAGCAGAGG ATTGATCGCG ATACTCATCA CACTGTGGCT 60 61 GAACCAGTAA CGGAAGCTAA AAATACGCTG TACGTGAGCC AGCTTAATGA AAAAATTAAT 120 121 ATGCAACGAC TGCGAGTAAA CCTTTTTTTG CTCTTTGCTA CGTTTGGAGA GGTACTGAAG 180 181 GTTAGCATGA ATTTCAAGAA ACAGCGGGGC CAAGCCTTTA TCACCATGAG AACCATCGAC 240 241 CAGGCCAGTC TGGCCCAGAT TTCATTAAAC GGCGAGCGAT TCTTTGGTAA GCCTTTGAAA 300 301 GTTGAGTTCA GCAAGAGTGA AACTAAAACA CTATGA 336

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005685	Cellular Component	U1 snRNP
GO:0005686	Cellular Component	U2 snRNP
GO:0071004	Cellular Component	U2-type prespliceosome
GO:0035614	Molecular Function	SnRNA stem-loop binding
GO:0030619	Molecular Function	U1 snRNA binding
GO:0030620	Molecular Function	U2 snRNA binding
GO:0000398	Biological Process	MRNA splicing, via spliceosome

▼ KEGG

sce:YIR009W

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	InterPro	CDD	PROSITE	Gene3D

Interaction
HINT	Mentha	PINA	IID	iRefIndex
MIST

Physicochemical
AAindex

Structure
PDB

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Asg-0673	Ashbya gossypii	50.45	3e-30	110
LLPS-Cogr-1290	Colletotrichum graminicola	47.56	4e-15	72.4
LLPS-Ved-0614	Verticillium dahliae	47.56	4e-15	72.4
LLPS-Cog-0418	Colletotrichum gloeosporioides	47.56	2e-14	70.5
LLPS-Coo-0145	Colletotrichum orbiculare	45.12	3e-15	72.8
LLPS-Trv-1339	Trichoderma virens	43.9	2e-14	70.5
LLPS-Fuo-1239	Fusarium oxysporum	43.9	3e-13	67.0
LLPS-Fuv-1431	Fusarium verticillioides	43.9	3e-13	67.0
LLPS-Osl-0067	Ostreococcus lucimarinus	42.86	4e-11	61.2
LLPS-Fus-1030	Fusarium solani	42.68	3e-12	64.3
LLPS-Beb-1458	Beauveria bassiana	41.46	1e-12	65.5
LLPS-Nec-1118	Neurospora crassa	41.46	1e-11	62.8
LLPS-Trr-1635	Trichoderma reesei	40.24	8e-14	68.6
LLPS-Scp-1226	Schizosaccharomyces pombe	39.53	6e-14	67.8
LLPS-Scc-0642	Schizosaccharomyces cryophilus	39.53	1e-13	67.4
LLPS-Usm-0687	Ustilago maydis	39.47	5e-09	55.8
LLPS-Phn-0492	Phaeosphaeria nodorum	39.29	5e-14	69.3
LLPS-Xet-0915	Xenopus tropicalis	39.08	4e-08	54.7
LLPS-Asfu-0840	Aspergillus fumigatus	38.67	1e-08	55.5
LLPS-Dar-3887	Danio rerio	38.67	5e-08	54.3
LLPS-Anp-0195	Anas platyrhynchos	38.46	7e-08	53.9
LLPS-Mod-3211	Monodelphis domestica	38.46	7e-08	53.9
LLPS-Pes-1392	Pelodiscus sinensis	38.46	8e-08	53.9
LLPS-Sah-0895	Sarcophilus harrisii	38.46	7e-08	53.9
LLPS-Mao-1201	Magnaporthe oryzae	38.37	6e-11	60.5
LLPS-Cae-1096	Caenorhabditis elegans	38.37	3e-13	67.0
LLPS-Map-0423	Magnaporthe poae	38.37	5e-11	60.5
LLPS-Abg-0858	Absidia glauca	38.27	2e-08	54.7
LLPS-Drm-1677	Drosophila melanogaster	38.27	3e-09	55.8
LLPS-Aso-0661	Aspergillus oryzae	38.1	2e-12	64.7
LLPS-Zyt-1539	Zymoseptoria tritici	38.1	6e-14	67.8
LLPS-Asn-0128	Aspergillus nidulans	38.1	6e-13	66.2
LLPS-Tar-1481	Takifugu rubripes	37.5	7e-08	53.9
LLPS-Tum-1334	Tuber melanosporum	37.11	2e-14	69.7
LLPS-Lac-0574	Latimeria chalumnae	37.08	3e-08	55.1
LLPS-Pytr-0937	Pyrenophora triticirepentis	36.9	8e-13	65.9
LLPS-Miv-1581	Microbotryum violaceum	36.78	2e-09	57.8
LLPS-Blg-1575	Blumeria graminis	36.47	2e-10	58.9
LLPS-Cii-0947	Ciona intestinalis	36.47	7e-09	54.7
LLPS-Spr-0098	Sporisorium reilianum	36.36	7e-10	58.2
LLPS-Pyt-0634	Pyrenophora teres	36.14	9e-13	65.5
LLPS-Dos-0127	Dothistroma septosporum	35.96	6e-13	66.2
LLPS-Lem-1334	Leptosphaeria maculans	35.71	7e-14	68.6
LLPS-Ast-0381	Aspergillus terreus	35.48	1e-12	65.5
LLPS-Pof-0342	Poecilia formosa	34.88	2e-11	62.8
LLPS-Xim-2750	Xiphophorus maculatus	34.78	1e-12	66.2
LLPS-Nef-0653	Neosartorya fischeri	34.52	1e-08	54.3
LLPS-Gas-0799	Galdieria sulphuraria	34.15	1e-09	57.4
LLPS-Put-0920	Puccinia triticina	34.12	1e-08	55.5
LLPS-Bro-0668	Brassica oleracea	34.12	4e-12	64.3
LLPS-Brn-3322	Brassica napus	34.12	4e-12	64.3
LLPS-Scm-0829	Scophthalmus maximus	33.72	1e-11	62.8
LLPS-Orn-1224	Oreochromis niloticus	33.68	2e-12	65.5
LLPS-Coc-1783	Corchorus capsularis	33.33	4e-09	57.8
LLPS-Pug-0400	Puccinia graminis	33.33	6e-09	55.8
LLPS-Arl-0182	Arabidopsis lyrata	33.33	1e-10	59.7
LLPS-Asni-0667	Aspergillus niger	33.33	4e-12	63.5
LLPS-Asc-1671	Aspergillus clavatus	33.0	6e-12	63.2
LLPS-Via-2183	Vigna angularis	32.98	2e-11	62.0
LLPS-Glm-0462	Glycine max	32.98	8e-11	60.5
LLPS-Orl-2736	Oryzias latipes	32.97	3e-12	64.7
LLPS-Nia-1602	Nicotiana attenuata	32.94	1e-10	60.1
LLPS-Scf-0665	Scleropages formosus	32.94	9e-12	63.9
LLPS-Asm-2129	Astyanax mexicanus	32.94	1e-11	63.5
LLPS-Icp-3303	Ictalurus punctatus	32.94	2e-11	62.4
LLPS-Sei-0242	Setaria italica	32.93	1e-09	57.4
LLPS-Man-2455	Macaca nemestrina	32.65	1e-14	71.6
LLPS-Mal-0632	Mandrillus leucophaeus	32.65	1e-14	71.6
LLPS-Mea-1095	Mesocricetus auratus	32.63	1e-13	68.9
LLPS-Mum-2108	Mus musculus	32.63	9e-14	69.3
LLPS-Fud-0636	Fukomys damarensis	32.63	1e-13	68.9
LLPS-Amt-1683	Amborella trichopoda	32.14	1e-09	57.0
LLPS-Mae-1280	Manihot esculenta	32.14	7e-11	60.5
LLPS-Orbr-1453	Oryza brachyantha	32.14	9e-08	52.0
LLPS-Hea-0496	Helianthus annuus	32.14	9e-10	57.4
LLPS-Art-2884	Arabidopsis thaliana	32.1	2e-09	56.2
LLPS-Mup-0696	Mustela putorius furo	31.96	6e-14	69.7
LLPS-Mam-3763	Macaca mulatta	31.91	6e-13	67.0
LLPS-Poa-1260	Pongo abelii	31.91	6e-13	67.0
LLPS-Eqc-2324	Equus caballus	31.91	6e-13	67.0
LLPS-Cap-1023	Cavia porcellus	31.91	6e-13	67.0
LLPS-Cas-1675	Carlito syrichta	31.91	6e-13	67.0
LLPS-Pat-1670	Pan troglodytes	31.91	6e-13	67.0
LLPS-Pap-3583	Pan paniscus	31.91	6e-13	67.0
LLPS-Urm-1661	Ursus maritimus	31.91	6e-13	67.0
LLPS-Hos-1937	Homo sapiens	31.91	6e-13	67.0
LLPS-Fec-0946	Felis catus	31.91	6e-13	67.0
LLPS-Orc-0603	Oryctolagus cuniculus	31.91	6e-13	67.0
LLPS-Rhb-0139	Rhinopithecus bieti	31.91	5e-13	67.0
LLPS-Dio-3552	Dipodomys ordii	31.91	6e-13	67.0
LLPS-Bot-3197	Bos taurus	31.91	6e-13	67.0
LLPS-Paa-1040	Papio anubis	31.91	6e-13	67.0
LLPS-Ova-1853	Ovis aries	31.91	6e-13	67.0
LLPS-Ran-0365	Rattus norvegicus	31.91	6e-13	67.0
LLPS-Cea-3357	Cercocebus atys	31.91	6e-13	67.0
LLPS-Sus-4620	Sus scrofa	31.91	6e-13	67.0
LLPS-Maf-1916	Macaca fascicularis	31.91	6e-13	67.0
LLPS-Chs-0113	Chlorocebus sabaeus	31.91	6e-13	67.0
LLPS-Caj-0977	Callithrix jacchus	31.91	6e-13	67.0
LLPS-Gog-3379	Gorilla gorilla	31.91	6e-13	67.0
LLPS-Prp-0117	Prunus persica	31.82	1e-10	60.1
LLPS-Orm-1695	Oryza meridionalis	31.76	2e-08	55.8
LLPS-Orr-0430	Oryza rufipogon	31.76	2e-08	55.8
LLPS-Caf-1441	Canis familiaris	31.76	9e-12	63.2
LLPS-Ict-3450	Ictidomys tridecemlineatus	31.76	1e-11	62.8
LLPS-Anc-0322	Anolis carolinensis	31.76	7e-11	60.5
LLPS-Org-1970	Oryza glaberrima	31.76	2e-08	55.8
LLPS-Nol-3663	Nomascus leucogenys	31.76	1e-11	62.8
LLPS-Tag-2340	Taeniopygia guttata	31.76	1e-11	62.8
LLPS-Gaga-2994	Gallus gallus	31.76	1e-11	62.8
LLPS-Loa-1568	Loxodonta africana	31.76	9e-12	63.2
LLPS-Orp-1675	Oryza punctata	31.76	2e-08	55.5
LLPS-Viv-0855	Vitis vinifera	31.76	4e-11	61.2
LLPS-Meg-0844	Meleagris gallopavo	31.76	1e-11	62.8
LLPS-Gor-0414	Gossypium raimondii	31.76	5e-09	55.8
LLPS-Brr-0242	Brassica rapa	31.76	1e-10	60.5
LLPS-Ors-0194	Oryza sativa	31.76	7e-09	55.5
LLPS-Fia-1822	Ficedula albicollis	31.76	1e-11	62.4
LLPS-Otg-1366	Otolemur garnettii	31.76	1e-11	62.8
LLPS-Sot-1999	Solanum tuberosum	31.76	2e-10	59.7
LLPS-Orgl-1508	Oryza glumaepatula	31.76	2e-08	55.8
LLPS-Tut-0910	Tursiops truncatus	31.76	1e-11	62.8
LLPS-Aim-0966	Ailuropoda melanoleuca	31.76	1e-11	62.8
LLPS-Myl-0327	Myotis lucifugus	31.76	1e-11	62.8
LLPS-Cus-1765	Cucumis sativus	31.76	4e-10	58.5
LLPS-Orb-0289	Oryza barthii	31.76	2e-08	55.8
LLPS-Aon-3973	Aotus nancymaae	31.76	1e-11	62.8
LLPS-Ori-0514	Oryza indica	31.76	7e-09	55.5
LLPS-Leo-2150	Lepisosteus oculatus	31.76	1e-11	63.5
LLPS-Sol-1651	Solanum lycopersicum	31.76	8e-10	59.3
LLPS-Ora-2459	Ornithorhynchus anatinus	31.76	1e-11	62.4
LLPS-Thc-0229	Theobroma cacao	31.76	9e-09	55.1
LLPS-Orni-2127	Oryza nivara	31.76	2e-08	55.8
LLPS-Pot-1583	Populus trichocarpa	31.71	5e-09	55.8
LLPS-Sob-0282	Sorghum bicolor	31.71	3e-08	53.9
LLPS-Gaa-2855	Gasterosteus aculeatus	31.58	2e-11	62.8
LLPS-Zem-0362	Zea mays	30.95	3e-08	53.5
LLPS-Chr-0133	Chlamydomonas reinhardtii	30.95	3e-08	53.1
LLPS-Mua-1692	Musa acuminata	30.95	2e-09	57.0
LLPS-Met-1296	Medicago truncatula	30.85	3e-10	58.9
LLPS-Ten-1571	Tetraodon nigroviridis	30.77	6e-12	64.3
LLPS-Tru-0572	Triticum urartu	30.59	9e-09	55.1
LLPS-Hov-1141	Hordeum vulgare	30.59	2e-08	54.3
LLPS-Brd-0669	Brachypodium distachyon	30.59	2e-08	53.9
LLPS-Tra-1845	Triticum aestivum	30.59	1e-08	55.1
LLPS-Dac-1388	Daucus carota	30.34	8e-10	57.8
LLPS-Phv-0462	Phaseolus vulgaris	29.76	3e-09	56.2
LLPS-Vir-0010	Vigna radiata	28.57	9e-09	54.7

LLPS-Sac-1487MSL1

Protein Sequence

Nucleotide Sequence

LLPS-Sac-1487
MSL1