LLPS-Sac-0978
SEC13
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear pore complex, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Functions as a component of the nuclear pore complex (NPC) and the COPII coat. It is one of 5 proteins constituting the COPII coat, which is involved in anterograde (ER to Golgi) double-membrane transport vesicle formation. First the small GTPase SAR1, activated by and binding to the integral ER membrane protein SEC12, exchanges GDP for GTP and recruits the heterodimer SEC23/24, which in turn recruits the heterotetramer SEC13-SEC31. The polymerization of COPII coat complexes then causes physically the deformation (budding) of the membrane, leading to the creation of a transport vesicle. The COPII complex is dissociated upon SAR1-GTP hydrolysis to SAR1-GDP. SEC23 functions as the SAR1 GTPase activating protein, whose activity is stimulated in the presence of SEC13/31. SEC13 is directly or indirectly required for normal ER membrane and nuclear envelope morphology. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YLR208W_mRNA | YLR208W_mRNA |
| UniProt | Q04491, SEC13_YEAST, D6VYK9 | |
| GeneBank | U14913, L05929, BK006945 | AAA35028.1, AAB67426.1, DAA09525.1 |
| RefSeq | NM_001182095.1 | NP_013309.1 |
| Entrez | 850905 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVVIANAHNE LIHDAVLDYY GKRLATCSSD KTIKIFEVEG ETHKLIDTLT GHEGPVWRVD 60 61 WAHPKFGTIL ASCSYDGKVL IWKEENGRWS QIAVHAVHSA SVNSVQWAPH EYGPLLLVAS 120 121 SDGKVSVVEF KENGTTSPII IDAHAIGVNS ASWAPATIEE DGEHNGTKES RKFVTGGADN 180 181 LVKIWKYNSD AQTYVLESTL EGHSDWVRDV AWSPTVLLRS YLASVSQDRT CIIWTQDNEQ 240 241 GPWKKTLLKE EKFPDVLWRA SWSLSGNVLA LSGGDNKVTL WKENLEGKWE PAGEVHQ 297 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTCGTCA TAGCTAATGC GCACAACGAA TTAATCCATG ACGCTGTTCT AGACTATTAT 60 61 GGGAAGCGCC TTGCAACCTG CTCTTCTGAC AAGACAATCA AGATCTTTGA AGTCGAAGGA 120 121 GAAACACACA AGTTAATAGA CACGTTGACT GGCCACGAAG GCCCAGTTTG GCGTGTTGAT 180 181 TGGGCACATC CTAAATTCGG AACCATTTTG GCATCGTGTT CTTATGATGG TAAAGTGTTG 240 241 ATTTGGAAGG AAGAAAACGG TAGATGGTCT CAAATTGCCG TTCATGCTGT CCACTCTGCT 300 301 TCTGTCAACT CTGTTCAATG GGCTCCTCAT GAATATGGCC CCCTACTGCT GGTTGCTTCC 360 361 TCTGATGGTA AGGTCTCCGT AGTAGAGTTC AAAGAAAACG GTACTACTTC CCCAATAATC 420 421 ATCGATGCTC ATGCCATTGG CGTTAACTCT GCTTCTTGGG CTCCAGCTAC CATCGAAGAA 480 481 GATGGTGAAC ACAACGGTAC TAAAGAATCT CGCAAGTTTG TTACTGGGGG TGCTGACAAT 540 541 TTGGTAAAGA TTTGGAAGTA CAATTCAGAT GCCCAAACTT ATGTTCTGGA AAGCACCTTA 600 601 GAAGGTCACA GCGATTGGGT TAGAGACGTA GCATGGTCAC CTACTGTTCT TCTACGTTCT 660 661 TATTTGGCCA GTGTTTCTCA AGATCGCACC TGTATTATTT GGACTCAAGA CAATGAACAA 720 721 GGCCCATGGA AAAAAACTTT ATTAAAAGAA GAAAAATTCC CAGATGTTTT ATGGAGAGCC 780 781 AGTTGGTCTT TGTCAGGTAA TGTACTAGCT CTTTCCGGTG GCGATAATAA AGTTACTTTA 840 841 TGGAAGGAAA ATCTTGAGGG TAAATGGGAA CCCGCTGGTG AAGTTCATCA GTGA 894 |
▼ KEYWORD
ID | Family |
3D-structure | |
Complete proteome | |
Cytoplasmic vesicle | |
Direct protein sequencing | |
Endoplasmic reticulum | |
ER-Golgi transport | |
Membrane | |
mRNA transport | |
Nuclear pore complex | |
Nucleus | |
Protein transport | |
Reference proteome | |
Repeat | |
Translocation | |
Transport | |
Vacuole | |
WD repeat
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell periphery | |
Cellular Component | COPII vesicle coat | |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Nuclear pore outer ring | |
Cellular Component | Seh1-associated complex | |
Cellular Component | Vacuolar membrane | |
Molecular Function | Structural molecule activity | |
Biological Process | COPII-coated vesicle budding | |
Biological Process | MRNA transport | |
Biological Process | Nuclear pore distribution | |
Biological Process | Positive regulation of GTPase activity | |
Biological Process | Positive regulation of TORC1 signaling | |
Biological Process | Positive regulation of transcription, DNA-templated | |
Biological Process | Protein transport | |
Biological Process | Ubiquitin-dependent ERAD pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-0424 | Ashbya gossypii | 81.82 | 6e-173 | 488 |
| LLPS-Kop-0146 | Komagataella pastoris | 68.35 | 2e-144 | 415 |
| LLPS-Yal-0337 | Yarrowia lipolytica | 65.33 | 2e-134 | 390 |
| LLPS-Ved-0991 | Verticillium dahliae | 60.75 | 8e-111 | 330 |
| LLPS-Asni-0837 | Aspergillus niger | 60.39 | 2e-115 | 342 |
| LLPS-Nec-1057 | Neurospora crassa | 60.34 | 1e-108 | 325 |
| LLPS-Mao-0729 | Magnaporthe oryzae | 60.21 | 4e-105 | 315 |
| LLPS-Asfu-0432 | Aspergillus fumigatus | 60.2 | 4e-112 | 333 |
| LLPS-Pyt-0891 | Pyrenophora teres | 60.14 | 3e-103 | 311 |
| LLPS-Abg-0021 | Absidia glauca | 60.09 | 2e-84 | 261 |
| LLPS-Gag-0790 | Gaeumannomyces graminis | 59.86 | 2e-107 | 321 |
| LLPS-Pytr-0510 | Pyrenophora triticirepentis | 59.79 | 4e-103 | 311 |
| LLPS-Asc-1277 | Aspergillus clavatus | 59.53 | 5e-112 | 333 |
| LLPS-Lem-0760 | Leptosphaeria maculans | 59.52 | 4e-105 | 315 |
| LLPS-Aso-1170 | Aspergillus oryzae | 59.4 | 9e-112 | 332 |
| LLPS-Beb-0987 | Beauveria bassiana | 59.2 | 1e-106 | 319 |
| LLPS-Asn-0490 | Aspergillus nidulans | 59.09 | 9e-117 | 345 |
| LLPS-Asf-0092 | Aspergillus flavus | 58.77 | 1e-114 | 340 |
| LLPS-Ast-0311 | Aspergillus terreus | 58.77 | 2e-113 | 337 |
| LLPS-Trv-0677 | Trichoderma virens | 58.72 | 3e-108 | 324 |
| LLPS-Fuv-1031 | Fusarium verticillioides | 58.19 | 1e-107 | 322 |
| LLPS-Trr-0610 | Trichoderma reesei | 58.19 | 3e-107 | 321 |
| LLPS-Fuo-0898 | Fusarium oxysporum | 58.19 | 1e-107 | 322 |
| LLPS-Cog-0483 | Colletotrichum gloeosporioides | 58.02 | 9e-107 | 319 |
| LLPS-Cogr-0982 | Colletotrichum graminicola | 58.02 | 1e-108 | 324 |
| LLPS-Phn-1115 | Phaeosphaeria nodorum | 57.82 | 6e-104 | 313 |
| LLPS-Fus-1108 | Fusarium solani | 57.81 | 2e-103 | 311 |
| LLPS-Tum-0569 | Tuber melanosporum | 57.01 | 1e-114 | 343 |
| LLPS-Blg-1001 | Blumeria graminis | 56.85 | 2e-106 | 319 |
| LLPS-Coo-1116 | Colletotrichum orbiculare | 56.75 | 7e-104 | 312 |
| LLPS-Nef-0022 | Neosartorya fischeri | 56.59 | 9e-85 | 262 |
| LLPS-Scj-1343 | Schizosaccharomyces japonicus | 56.57 | 3e-112 | 334 |
| LLPS-Dos-0739 | Dothistroma septosporum | 56.19 | 1e-103 | 312 |
| LLPS-Scp-0617 | Schizosaccharomyces pombe | 55.18 | 9e-109 | 325 |
| LLPS-Scc-0959 | Schizosaccharomyces cryophilus | 54.7 | 5e-105 | 315 |
| LLPS-Map-1000 | Magnaporthe poae | 54.67 | 6e-88 | 270 |
| LLPS-Put-0191 | Puccinia triticina | 53.53 | 1e-103 | 312 |
| LLPS-Pug-0262 | Puccinia graminis | 52.81 | 1e-103 | 313 |
| LLPS-Eqc-0066 | Equus caballus | 52.72 | 1e-89 | 276 |
| LLPS-Meg-1358 | Meleagris gallopavo | 52.4 | 2e-87 | 270 |
| LLPS-Anp-0757 | Anas platyrhynchos | 52.4 | 2e-87 | 270 |
| LLPS-Sah-1019 | Sarcophilus harrisii | 51.83 | 9e-92 | 282 |
| LLPS-Aim-0586 | Ailuropoda melanoleuca | 51.83 | 1e-91 | 283 |
| LLPS-Ict-0437 | Ictidomys tridecemlineatus | 51.83 | 2e-91 | 281 |
| LLPS-Pes-0087 | Pelodiscus sinensis | 51.7 | 2e-87 | 270 |
| LLPS-Fia-1274 | Ficedula albicollis | 51.7 | 3e-88 | 273 |
| LLPS-Cas-0802 | Carlito syrichta | 51.62 | 1e-91 | 283 |
| LLPS-Mea-1005 | Mesocricetus auratus | 51.5 | 3e-91 | 281 |
| LLPS-Sus-3751 | Sus scrofa | 51.5 | 2e-90 | 279 |
| LLPS-Loa-1735 | Loxodonta africana | 51.5 | 7e-91 | 280 |
| LLPS-Gaga-2486 | Gallus gallus | 51.32 | 6e-87 | 278 |
| LLPS-Aon-0591 | Aotus nancymaae | 51.3 | 4e-90 | 280 |
| LLPS-Caj-0018 | Callithrix jacchus | 51.3 | 5e-90 | 279 |
| LLPS-Ova-0625 | Ovis aries | 51.3 | 9e-91 | 280 |
| LLPS-Mup-1751 | Mustela putorius furo | 51.3 | 5e-91 | 280 |
| LLPS-Urm-1702 | Ursus maritimus | 51.3 | 5e-91 | 280 |
| LLPS-Mod-0062 | Monodelphis domestica | 51.3 | 2e-91 | 281 |
| LLPS-Otg-0998 | Otolemur garnettii | 51.3 | 5e-91 | 281 |
| LLPS-Caf-0867 | Canis familiaris | 51.3 | 5e-91 | 280 |
| LLPS-Cap-0749 | Cavia porcellus | 51.3 | 1e-91 | 282 |
| LLPS-Fud-0670 | Fukomys damarensis | 51.16 | 2e-90 | 278 |
| LLPS-Myl-0578 | Myotis lucifugus | 51.16 | 8e-90 | 278 |
| LLPS-Fec-1932 | Felis catus | 51.16 | 1e-89 | 278 |
| LLPS-Mum-0875 | Mus musculus | 50.99 | 3e-91 | 281 |
| LLPS-Maf-1908 | Macaca fascicularis | 50.97 | 1e-89 | 278 |
| LLPS-Chs-1005 | Chlorocebus sabaeus | 50.97 | 1e-89 | 278 |
| LLPS-Cea-0363 | Cercocebus atys | 50.97 | 4e-90 | 278 |
| LLPS-Ran-1697 | Rattus norvegicus | 50.97 | 8e-91 | 280 |
| LLPS-Paa-0279 | Papio anubis | 50.97 | 1e-89 | 278 |
| LLPS-Mal-0038 | Mandrillus leucophaeus | 50.97 | 1e-89 | 278 |
| LLPS-Man-0112 | Macaca nemestrina | 50.97 | 1e-89 | 278 |
| LLPS-Rhb-1998 | Rhinopithecus bieti | 50.97 | 8e-90 | 279 |
| LLPS-Mam-1683 | Macaca mulatta | 50.97 | 1e-89 | 278 |
| LLPS-Xim-1527 | Xiphophorus maculatus | 50.83 | 1e-89 | 276 |
| LLPS-Pof-0696 | Poecilia formosa | 50.83 | 3e-89 | 276 |
| LLPS-Miv-0381 | Microbotryum violaceum | 50.78 | 2e-90 | 300 |
| LLPS-Mel-1130 | Melampsora laricipopulina | 50.76 | 1e-100 | 305 |
| LLPS-Gog-3134 | Gorilla gorilla | 50.65 | 7e-89 | 276 |
| LLPS-Bot-0315 | Bos taurus | 50.65 | 4e-90 | 278 |
| LLPS-Hos-0976 | Homo sapiens | 50.65 | 2e-88 | 275 |
| LLPS-Pap-2344 | Pan paniscus | 50.65 | 7e-89 | 276 |
| LLPS-Pat-0951 | Pan troglodytes | 50.65 | 8e-89 | 276 |
| LLPS-Orl-1836 | Oryzias latipes | 50.5 | 6e-89 | 275 |
| LLPS-Dio-0432 | Dipodomys ordii | 50.5 | 1e-90 | 280 |
| LLPS-Orn-0791 | Oreochromis niloticus | 50.5 | 2e-90 | 279 |
| LLPS-Tag-0110 | Taeniopygia guttata | 50.5 | 3e-89 | 276 |
| LLPS-Ora-1314 | Ornithorhynchus anatinus | 50.32 | 7e-90 | 277 |
| LLPS-Scf-1893 | Scleropages formosus | 50.32 | 2e-89 | 276 |
| LLPS-Lac-0978 | Latimeria chalumnae | 50.32 | 8e-89 | 275 |
| LLPS-Poa-0234 | Pongo abelii | 50.32 | 8e-88 | 273 |
| LLPS-Nol-2007 | Nomascus leucogenys | 50.32 | 1e-88 | 276 |
| LLPS-Tar-2712 | Takifugu rubripes | 50.17 | 5e-81 | 254 |
| LLPS-Scm-0467 | Scophthalmus maximus | 50.17 | 5e-89 | 275 |
| LLPS-Ten-1495 | Tetraodon nigroviridis | 50.17 | 5e-90 | 278 |
| LLPS-Viv-0752 | Vitis vinifera | 50.0 | 2e-82 | 257 |
| LLPS-Orc-2586 | Oryctolagus cuniculus | 50.0 | 8e-89 | 275 |
| LLPS-Dar-1399 | Danio rerio | 49.5 | 6e-87 | 270 |
| LLPS-Asm-0167 | Astyanax mexicanus | 49.35 | 1e-89 | 276 |
| LLPS-Icp-2364 | Ictalurus punctatus | 49.35 | 2e-88 | 274 |
| LLPS-Xet-1489 | Xenopus tropicalis | 49.35 | 2e-87 | 271 |
| LLPS-Anc-2019 | Anolis carolinensis | 49.35 | 3e-87 | 272 |
| LLPS-Cis-0646 | Ciona savignyi | 49.33 | 1e-86 | 269 |
| LLPS-Sem-0059 | Selaginella moellendorffii | 49.32 | 3e-82 | 258 |
| LLPS-Dac-0318 | Daucus carota | 49.32 | 2e-80 | 253 |
| LLPS-Drm-0606 | Drosophila melanogaster | 49.32 | 3e-80 | 254 |
| LLPS-Art-1450 | Arabidopsis thaliana | 49.32 | 8e-79 | 248 |
| LLPS-Pot-1052 | Populus trichocarpa | 49.32 | 5e-80 | 251 |
| LLPS-Amt-0715 | Amborella trichopoda | 49.32 | 2e-83 | 260 |
| LLPS-Sot-0875 | Solanum tuberosum | 49.16 | 2e-81 | 255 |
| LLPS-Met-0361 | Medicago truncatula | 49.14 | 9e-80 | 251 |
| LLPS-Coc-0568 | Corchorus capsularis | 49.14 | 5e-80 | 251 |
| LLPS-Cii-1147 | Ciona intestinalis | 48.86 | 2e-87 | 271 |
| LLPS-Sol-1321 | Solanum lycopersicum | 48.83 | 1e-80 | 253 |
| LLPS-Nia-1486 | Nicotiana attenuata | 48.83 | 3e-81 | 254 |
| LLPS-Zem-0746 | Zea mays | 48.81 | 3e-84 | 263 |
| LLPS-Brn-1122 | Brassica napus | 48.64 | 8e-77 | 243 |
| LLPS-Mua-1820 | Musa acuminata | 48.64 | 4e-80 | 251 |
| LLPS-Brr-0258 | Brassica rapa | 48.64 | 1e-76 | 243 |
| LLPS-Bro-1591 | Brassica oleracea | 48.64 | 5e-77 | 244 |
| LLPS-Sob-0146 | Sorghum bicolor | 48.47 | 5e-84 | 261 |
| LLPS-Glm-2564 | Glycine max | 48.45 | 2e-80 | 252 |
| LLPS-Thc-1759 | Theobroma cacao | 48.45 | 5e-80 | 251 |
| LLPS-Via-1870 | Vigna angularis | 48.45 | 2e-81 | 255 |
| LLPS-Gor-0229 | Gossypium raimondii | 48.45 | 2e-80 | 252 |
| LLPS-Mae-0803 | Manihot esculenta | 48.45 | 3e-80 | 252 |
| LLPS-Phv-0300 | Phaseolus vulgaris | 48.45 | 2e-80 | 252 |
| LLPS-Leo-0801 | Lepisosteus oculatus | 48.38 | 1e-88 | 274 |
| LLPS-Prp-0053 | Prunus persica | 48.31 | 2e-78 | 247 |
| LLPS-Arl-0630 | Arabidopsis lyrata | 48.29 | 3e-77 | 244 |
| LLPS-Usm-0181 | Ustilago maydis | 48.25 | 1e-97 | 298 |
| LLPS-Brd-0449 | Brachypodium distachyon | 48.14 | 1e-82 | 258 |
| LLPS-Hea-2064 | Helianthus annuus | 48.12 | 3e-76 | 242 |
| LLPS-Cus-1182 | Cucumis sativus | 48.11 | 3e-79 | 249 |
| LLPS-Sei-1480 | Setaria italica | 47.8 | 1e-82 | 258 |
| LLPS-Tra-2164 | Triticum aestivum | 47.8 | 5e-83 | 259 |
| LLPS-Orbr-1994 | Oryza brachyantha | 47.46 | 6e-83 | 259 |
| LLPS-Tru-1064 | Triticum urartu | 47.46 | 4e-82 | 257 |
| LLPS-Orb-1875 | Oryza barthii | 47.42 | 2e-75 | 240 |
| LLPS-Org-1716 | Oryza glaberrima | 47.42 | 2e-75 | 240 |
| LLPS-Ori-0394 | Oryza indica | 47.12 | 2e-81 | 255 |
| LLPS-Orni-1346 | Oryza nivara | 47.12 | 2e-81 | 255 |
| LLPS-Orgl-0587 | Oryza glumaepatula | 47.12 | 2e-81 | 255 |
| LLPS-Hov-0727 | Hordeum vulgare | 47.12 | 4e-82 | 257 |
| LLPS-Ors-0581 | Oryza sativa | 47.12 | 2e-81 | 255 |
| LLPS-Orp-0321 | Oryza punctata | 47.12 | 3e-81 | 254 |
| LLPS-Orm-1480 | Oryza meridionalis | 47.12 | 2e-81 | 255 |
| LLPS-Orr-0591 | Oryza rufipogon | 47.12 | 2e-81 | 255 |
| LLPS-Lep-2226 | Leersia perrieri | 46.96 | 2e-75 | 240 |
| LLPS-Crn-0511 | Cryptococcus neoformans | 46.86 | 6e-87 | 270 |
| LLPS-Spr-1197 | Sporisorium reilianum | 46.82 | 8e-95 | 291 |
| LLPS-Php-0038 | Physcomitrella patens | 46.67 | 3e-79 | 249 |
| LLPS-Gas-0885 | Galdieria sulphuraria | 45.85 | 2e-77 | 245 |
| LLPS-Chr-0702 | Chlamydomonas reinhardtii | 45.05 | 8e-79 | 248 |
| LLPS-Osl-0370 | Ostreococcus lucimarinus | 44.83 | 5e-73 | 233 |
| LLPS-Chc-1141 | Chondrus crispus | 44.66 | 8e-68 | 222 |
| LLPS-Cae-0232 | Caenorhabditis elegans | 40.75 | 6e-65 | 213 |
| LLPS-Cym-0576 | Cyanidioschyzon merolae | 35.34 | 1e-49 | 180 |
| LLPS-Gaa-0374 | Gasterosteus aculeatus | 31.53 | 1e-34 | 134 |