LLPS-Sac-0948
DBP5
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | ATP-dependent RNA helicase DBP5; DEAD box protein 5; Helicase CA5/6; Ribonucleic acid-trafficking protein 8 |
| Gene Name: | DBP5, RAT8, YOR046C |
| Ensembl Gene: | YOR046C |
| Ensembl Protein: | YOR046C_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear pore complex, Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. Contributes to the blocking of bulk poly(A)+ mRNA export in ethanol-stressed cells. May also be involved in early transcription. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YOR046C_mRNA | YOR046C_mRNA |
| UniProt | P20449, DBP5_YEAST, D6W2B2 | |
| GeneBank | U28135, BK006948, Z74954, Z74955 | CAA99239.1, AAB01679.1, CAA99237.1, DAA10828.1 |
| RefSeq | NM_001183465.1 | NP_014689.1 |
| Entrez | 854211 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSDTKRDPAD LLASLKIDNE KEDTSEVSTK ETVKSQPEKT ADSIKPAEKL VPKVEEKKTK 60 61 QEDSNLISSE YEVKVKLADI QADPNSPLYS AKSFDELGLA PELLKGIYAM KFQKPSKIQE 120 121 RALPLLLHNP PRNMIAQSQS GTGKTAAFSL TMLTRVNPED ASPQAICLAP SRELARQTLE 180 181 VVQEMGKFTK ITSQLIVPDS FEKNKQINAQ VIVGTPGTVL DLMRRKLMQL QKIKIFVLDE 240 241 ADNMLDQQGL GDQCIRVKRF LPKDTQLVLF SATFADAVRQ YAKKIVPNAN TLELQTNEVN 300 301 VDAIKQLYMD CKNEADKFDV LTELYGLMTI GSSIIFVATK KTANVLYGKL KSEGHEVSIL 360 361 HGDLQTQERD RLIDDFREGR SKVLITTNVL ARGIDIPTVS MVVNYDLPTL ANGQADPATY 420 421 IHRIGRTGRF GRKGVAISFV HDKNSFNILS AIQKYFGDIE MTRVPTDDWD EVEKIVKKVL 480 481 KD 482 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGTGATA CAAAGAGAGA TCCGGCCGAT TTACTAGCTT CTTTAAAGAT TGATAATGAG 60 61 AAAGAGGATA CAAGTGAAGT TTCAACAAAA GAGACTGTTA AGTCCCAACC AGAAAAGACT 120 121 GCTGATTCGA TCAAGCCTGC AGAAAAATTA GTTCCAAAAG TTGAGGAAAA AAAAACAAAA 180 181 CAGGAGGATA GTAATTTAAT CAGCTCAGAA TATGAAGTTA AGGTCAAACT TGCTGATATC 240 241 CAGGCTGACC CAAATTCTCC ATTGTACAGT GCTAAATCTT TTGATGAATT AGGATTAGCA 300 301 CCAGAACTAC TAAAGGGGAT ATATGCTATG AAATTTCAAA AACCATCCAA AATTCAAGAA 360 361 AGGGCGCTGC CATTATTATT ACATAATCCG CCTAGGAACA TGATTGCTCA GTCTCAATCA 420 421 GGTACAGGTA AAACTGCCGC CTTTTCTTTA ACGATGCTAA CAAGAGTAAA CCCAGAAGAC 480 481 GCATCTCCAC AGGCAATTTG CTTAGCCCCC TCCAGAGAAC TGGCCAGACA AACACTAGAA 540 541 GTCGTTCAGG AAATGGGTAA GTTCACAAAA ATAACCAGTC AGTTAATTGT TCCCGATTCT 600 601 TTTGAGAAAA ACAAGCAAAT TAATGCTCAA GTGATTGTTG GTACGCCGGG CACTGTTCTT 660 661 GACCTAATGC GTAGAAAATT GATGCAGCTA CAGAAAATTA AAATTTTTGT TTTGGATGAA 720 721 GCCGATAACA TGTTGGATCA GCAGGGTCTA GGTGACCAGT GTATTCGTGT TAAGAGATTT 780 781 TTACCCAAGG ATACTCAACT TGTTTTGTTT AGTGCTACTT TTGCCGATGC AGTTAGGCAG 840 841 TACGCAAAGA AGATCGTTCC AAATGCTAAT ACTTTAGAAT TACAAACAAA TGAAGTTAAT 900 901 GTTGATGCCA TCAAACAACT ATACATGGAC TGCAAAAACG AAGCAGATAA GTTTGATGTT 960 961 TTAACTGAGC TATATGGTTT AATGACAATT GGATCTTCCA TTATTTTTGT TGCAACCAAA 1020 1021 AAAACCGCAA ACGTTTTATA TGGGAAATTG AAAAGTGAAG GTCATGAAGT TTCTATCTTG 1080 1081 CATGGTGATT TACAGACACA AGAAAGAGAC AGATTAATAG ACGACTTCAG AGAGGGTAGA 1140 1141 TCCAAAGTTT TGATTACTAC TAATGTCCTG GCCCGTGGTA TTGATATTCC TACTGTCTCA 1200 1201 ATGGTTGTCA ACTATGATCT TCCAACGCTT GCTAACGGAC AAGCAGATCC AGCTACTTAC 1260 1261 ATTCACAGAA TCGGTAGAAC CGGTAGATTC GGCAGAAAAG GTGTTGCCAT TTCCTTTGTA 1320 1321 CATGACAAAA ATTCTTTCAA TATTTTATCT GCAATTCAGA AATACTTCGG TGATATAGAA 1380 1381 ATGACTCGTG TTCCAACGGA TGATTGGGAT GAAGTCGAAA AAATAGTTAA GAAAGTGTTA 1440 1441 AAGGATTAG 1449 |
▼ KEYWORD
ID | Family |
3D-structure | |
ATP-binding | |
Complete proteome | |
Cytoplasm | |
Helicase | |
Hydrolase | |
Membrane | |
mRNA transport | |
Nuclear pore complex | |
Nucleotide-binding | |
Nucleus | |
Phosphoprotein | |
Protein transport | |
Reference proteome | |
RNA-binding | |
Translocation | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cellular bud tip | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic stress granule | |
Cellular Component | Nuclear membrane | |
Cellular Component | Nuclear pore cytoplasmic filaments | |
Cellular Component | Nucleus | |
Cellular Component | Polysome | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent RNA helicase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent ATPase activity | |
Biological Process | MRNA export from nucleus | |
Biological Process | Poly(A)+ mRNA export from nucleus | |
Biological Process | Translational termination |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-0736 | Ashbya gossypii | 75.31 | 0.0 | 740 |
| LLPS-Kop-0329 | Komagataella pastoris | 68.45 | 0.0 | 685 |
| LLPS-Tum-0277 | Tuber melanosporum | 63.4 | 0.0 | 559 |
| LLPS-Scp-0531 | Schizosaccharomyces pombe | 61.65 | 0.0 | 546 |
| LLPS-Abg-1019 | Absidia glauca | 59.47 | 2e-179 | 518 |
| LLPS-Usm-0101 | Ustilago maydis | 59.43 | 0.0 | 522 |
| LLPS-Scc-1114 | Schizosaccharomyces cryophilus | 59.22 | 0.0 | 563 |
| LLPS-Yal-1145 | Yarrowia lipolytica | 59.01 | 0.0 | 580 |
| LLPS-Phn-0701 | Phaeosphaeria nodorum | 58.81 | 3e-171 | 498 |
| LLPS-Spr-0140 | Sporisorium reilianum | 58.77 | 0.0 | 527 |
| LLPS-Pytr-1134 | Pyrenophora triticirepentis | 58.33 | 2e-175 | 509 |
| LLPS-Lem-0335 | Leptosphaeria maculans | 58.1 | 1e-168 | 492 |
| LLPS-Pyt-0854 | Pyrenophora teres | 58.1 | 1e-174 | 507 |
| LLPS-Scj-1110 | Schizosaccharomyces japonicus | 57.49 | 0.0 | 568 |
| LLPS-Nef-0393 | Neosartorya fischeri | 56.51 | 9e-168 | 490 |
| LLPS-Asfu-0424 | Aspergillus fumigatus | 56.51 | 6e-168 | 490 |
| LLPS-Miv-0432 | Microbotryum violaceum | 56.12 | 2e-165 | 484 |
| LLPS-Scs-0156 | Sclerotinia sclerotiorum | 55.92 | 3e-171 | 498 |
| LLPS-Ast-0930 | Aspergillus terreus | 55.81 | 3e-169 | 493 |
| LLPS-Asf-0906 | Aspergillus flavus | 55.56 | 2e-173 | 504 |
| LLPS-Mao-1505 | Magnaporthe oryzae | 55.45 | 2e-160 | 470 |
| LLPS-Aso-0612 | Aspergillus oryzae | 55.34 | 6e-173 | 503 |
| LLPS-Asc-1481 | Aspergillus clavatus | 55.14 | 4e-173 | 503 |
| LLPS-Asn-1043 | Aspergillus nidulans | 55.12 | 2e-172 | 501 |
| LLPS-Coo-0072 | Colletotrichum orbiculare | 54.93 | 8e-166 | 485 |
| LLPS-Nec-1561 | Neurospora crassa | 54.59 | 8e-173 | 503 |
| LLPS-Zyt-0507 | Zymoseptoria tritici | 54.57 | 2e-162 | 477 |
| LLPS-Cog-1045 | Colletotrichum gloeosporioides | 54.46 | 1e-163 | 479 |
| LLPS-Map-0276 | Magnaporthe poae | 54.37 | 5e-154 | 454 |
| LLPS-Trv-0080 | Trichoderma virens | 54.25 | 9e-164 | 479 |
| LLPS-Gag-0669 | Gaeumannomyces graminis | 53.9 | 2e-167 | 489 |
| LLPS-Blg-1479 | Blumeria graminis | 53.64 | 1e-168 | 492 |
| LLPS-Cogr-1145 | Colletotrichum graminicola | 53.56 | 7e-166 | 484 |
| LLPS-Beb-1108 | Beauveria bassiana | 53.54 | 2e-158 | 466 |
| LLPS-Asni-0365 | Aspergillus niger | 53.17 | 5e-169 | 493 |
| LLPS-Fus-1337 | Fusarium solani | 52.13 | 2e-157 | 464 |
| LLPS-Fuo-0442 | Fusarium oxysporum | 51.89 | 2e-157 | 463 |
| LLPS-Fuv-0117 | Fusarium verticillioides | 51.89 | 2e-157 | 463 |
| LLPS-Paa-2353 | Papio anubis | 51.88 | 1e-148 | 441 |
| LLPS-Ved-0666 | Verticillium dahliae | 51.81 | 2e-163 | 479 |
| LLPS-Mel-0683 | Melampsora laricipopulina | 51.72 | 7e-160 | 471 |
| LLPS-Dos-0475 | Dothistroma septosporum | 51.65 | 7e-144 | 430 |
| LLPS-Man-4520 | Macaca nemestrina | 51.63 | 2e-147 | 437 |
| LLPS-Dio-1062 | Dipodomys ordii | 51.57 | 4e-151 | 446 |
| LLPS-Crn-0125 | Cryptococcus neoformans | 51.22 | 3e-156 | 463 |
| LLPS-Loa-1149 | Loxodonta africana | 51.08 | 2e-149 | 442 |
| LLPS-Pap-1458 | Pan paniscus | 51.08 | 1e-149 | 444 |
| LLPS-Hos-0841 | Homo sapiens | 51.08 | 3e-150 | 444 |
| LLPS-Mod-2633 | Monodelphis domestica | 51.08 | 6e-149 | 441 |
| LLPS-Caf-1841 | Canis familiaris | 51.08 | 1e-149 | 443 |
| LLPS-Gog-3288 | Gorilla gorilla | 51.08 | 1e-149 | 444 |
| LLPS-Maf-1336 | Macaca fascicularis | 51.08 | 7e-150 | 444 |
| LLPS-Chs-3188 | Chlorocebus sabaeus | 51.08 | 7e-150 | 444 |
| LLPS-Mal-0442 | Mandrillus leucophaeus | 51.08 | 7e-150 | 444 |
| LLPS-Caj-3802 | Callithrix jacchus | 51.01 | 1e-143 | 428 |
| LLPS-Trr-0484 | Trichoderma reesei | 50.98 | 8e-164 | 479 |
| LLPS-Pug-0105 | Puccinia graminis | 50.87 | 1e-157 | 466 |
| LLPS-Orc-2267 | Oryctolagus cuniculus | 50.84 | 8e-148 | 440 |
| LLPS-Rhb-4083 | Rhinopithecus bieti | 50.84 | 1e-147 | 438 |
| LLPS-Urm-2139 | Ursus maritimus | 50.84 | 2e-147 | 439 |
| LLPS-Mam-0985 | Macaca mulatta | 50.84 | 6e-148 | 439 |
| LLPS-Poa-0671 | Pongo abelii | 50.84 | 1e-148 | 441 |
| LLPS-Aon-2920 | Aotus nancymaae | 50.84 | 2e-149 | 442 |
| LLPS-Sus-2008 | Sus scrofa | 50.84 | 3e-148 | 439 |
| LLPS-Mum-1891 | Mus musculus | 50.84 | 1e-149 | 443 |
| LLPS-Aim-2139 | Ailuropoda melanoleuca | 50.84 | 8e-148 | 438 |
| LLPS-Anp-2277 | Anas platyrhynchos | 50.72 | 7e-146 | 434 |
| LLPS-Meg-0185 | Meleagris gallopavo | 50.72 | 3e-147 | 437 |
| LLPS-Fia-0454 | Ficedula albicollis | 50.6 | 2e-147 | 437 |
| LLPS-Fec-0136 | Felis catus | 50.6 | 2e-148 | 440 |
| LLPS-Gaga-1327 | Gallus gallus | 50.6 | 9e-149 | 441 |
| LLPS-Cas-3786 | Carlito syrichta | 50.6 | 6e-148 | 439 |
| LLPS-Eqc-0032 | Equus caballus | 50.6 | 2e-148 | 440 |
| LLPS-Leo-1397 | Lepisosteus oculatus | 50.6 | 2e-147 | 438 |
| LLPS-Mup-1728 | Mustela putorius furo | 50.6 | 3e-148 | 440 |
| LLPS-Myl-3553 | Myotis lucifugus | 50.6 | 9e-148 | 437 |
| LLPS-Ran-1524 | Rattus norvegicus | 50.6 | 1e-147 | 439 |
| LLPS-Dar-3155 | Danio rerio | 50.48 | 2e-146 | 435 |
| LLPS-Cap-0377 | Cavia porcellus | 50.48 | 5e-141 | 421 |
| LLPS-Drm-1103 | Drosophila melanogaster | 50.42 | 1e-117 | 361 |
| LLPS-Otg-4407 | Otolemur garnettii | 50.36 | 1e-145 | 433 |
| LLPS-Bot-0551 | Bos taurus | 50.36 | 1e-147 | 438 |
| LLPS-Tag-2729 | Taeniopygia guttata | 50.12 | 4e-144 | 428 |
| LLPS-Tut-1786 | Tursiops truncatus | 50.12 | 3e-147 | 437 |
| LLPS-Xet-2414 | Xenopus tropicalis | 50.0 | 6e-136 | 407 |
| LLPS-Icp-0146 | Ictalurus punctatus | 50.0 | 9e-142 | 423 |
| LLPS-Put-0301 | Puccinia triticina | 49.78 | 2e-146 | 435 |
| LLPS-Sah-0047 | Sarcophilus harrisii | 49.76 | 4e-132 | 399 |
| LLPS-Asm-2432 | Astyanax mexicanus | 49.64 | 1e-144 | 431 |
| LLPS-Gas-1116 | Galdieria sulphuraria | 49.63 | 2e-140 | 417 |
| LLPS-Lac-0034 | Latimeria chalumnae | 49.61 | 2e-136 | 406 |
| LLPS-Mea-4053 | Mesocricetus auratus | 49.52 | 2e-132 | 399 |
| LLPS-Ict-2484 | Ictidomys tridecemlineatus | 49.28 | 4e-131 | 396 |
| LLPS-Fud-0657 | Fukomys damarensis | 49.28 | 1e-138 | 415 |
| LLPS-Orl-1360 | Oryzias latipes | 49.28 | 3e-144 | 430 |
| LLPS-Orn-2511 | Oreochromis niloticus | 49.16 | 6e-144 | 429 |
| LLPS-Pof-2933 | Poecilia formosa | 49.16 | 2e-143 | 428 |
| LLPS-Ova-0179 | Ovis aries | 49.16 | 1e-128 | 389 |
| LLPS-Ten-2671 | Tetraodon nigroviridis | 48.92 | 3e-141 | 422 |
| LLPS-Pat-0182 | Pan troglodytes | 48.79 | 9e-129 | 390 |
| LLPS-Cea-1628 | Cercocebus atys | 48.79 | 7e-129 | 390 |
| LLPS-Pes-2653 | Pelodiscus sinensis | 48.56 | 7e-135 | 403 |
| LLPS-Nol-4078 | Nomascus leucogenys | 48.55 | 2e-128 | 389 |
| LLPS-Ere-0433 | Erinaceus europaeus | 48.55 | 3e-123 | 375 |
| LLPS-Scf-0491 | Scleropages formosus | 48.32 | 1e-153 | 453 |
| LLPS-Cym-1053 | Cyanidioschyzon merolae | 48.13 | 2e-136 | 412 |
| LLPS-Anc-3070 | Anolis carolinensis | 47.7 | 2e-134 | 404 |
| LLPS-Chc-0018 | Chondrus crispus | 47.56 | 3e-137 | 411 |
| LLPS-Ora-2146 | Ornithorhynchus anatinus | 46.86 | 3e-129 | 390 |
| LLPS-Scm-0081 | Scophthalmus maximus | 45.89 | 3e-139 | 417 |
| LLPS-Gaa-3162 | Gasterosteus aculeatus | 45.55 | 3e-142 | 425 |
| LLPS-Xim-0262 | Xiphophorus maculatus | 45.53 | 2e-146 | 436 |
| LLPS-Tar-2451 | Takifugu rubripes | 44.86 | 3e-143 | 427 |
| LLPS-Cis-0966 | Ciona savignyi | 44.79 | 2e-127 | 386 |
| LLPS-Cii-1549 | Ciona intestinalis | 44.11 | 3e-133 | 401 |
| LLPS-Cae-1158 | Caenorhabditis elegans | 42.72 | 7e-98 | 323 |
| LLPS-Coc-1240 | Corchorus capsularis | 42.53 | 1e-97 | 310 |
| LLPS-Nia-0215 | Nicotiana attenuata | 42.49 | 4e-100 | 317 |
| LLPS-Pot-0846 | Populus trichocarpa | 42.12 | 3e-102 | 322 |
| LLPS-Met-2127 | Medicago truncatula | 42.03 | 1e-98 | 312 |
| LLPS-Gor-1004 | Gossypium raimondii | 41.85 | 9e-98 | 310 |
| LLPS-Vir-1524 | Vigna radiata | 41.54 | 5e-101 | 317 |
| LLPS-Mae-0248 | Manihot esculenta | 41.5 | 2e-103 | 325 |
| LLPS-Sei-1315 | Setaria italica | 41.46 | 9e-88 | 281 |
| LLPS-Brr-0697 | Brassica rapa | 41.41 | 2e-99 | 314 |
| LLPS-Glm-1761 | Glycine max | 41.41 | 8e-101 | 318 |
| LLPS-Viv-0687 | Vitis vinifera | 41.34 | 4e-99 | 314 |
| LLPS-Brd-1132 | Brachypodium distachyon | 41.19 | 3e-88 | 283 |
| LLPS-Art-0447 | Arabidopsis thaliana | 41.04 | 1e-99 | 315 |
| LLPS-Php-1084 | Physcomitrella patens | 41.01 | 1e-100 | 318 |
| LLPS-Thc-1199 | Theobroma cacao | 40.92 | 1e-88 | 283 |
| LLPS-Tra-0428 | Triticum aestivum | 40.92 | 7e-88 | 281 |
| LLPS-Brn-1294 | Brassica napus | 40.78 | 3e-101 | 319 |
| LLPS-Sem-2420 | Selaginella moellendorffii | 40.77 | 3e-105 | 329 |
| LLPS-Phv-0254 | Phaseolus vulgaris | 40.75 | 1e-99 | 315 |
| LLPS-Osl-0892 | Ostreococcus lucimarinus | 40.67 | 8e-97 | 307 |
| LLPS-Sol-0396 | Solanum lycopersicum | 40.45 | 1e-97 | 310 |
| LLPS-Sot-0218 | Solanum tuberosum | 40.45 | 6e-98 | 311 |
| LLPS-Hea-1260 | Helianthus annuus | 40.34 | 8e-96 | 305 |
| LLPS-Dac-1259 | Daucus carota | 40.3 | 1e-93 | 299 |
| LLPS-Bro-2794 | Brassica oleracea | 40.26 | 5e-88 | 282 |
| LLPS-Arl-1304 | Arabidopsis lyrata | 40.26 | 7e-98 | 310 |
| LLPS-Cus-0464 | Cucumis sativus | 40.22 | 3e-88 | 283 |
| LLPS-Chr-0798 | Chlamydomonas reinhardtii | 40.1 | 8e-98 | 310 |
| LLPS-Prp-2068 | Prunus persica | 39.44 | 4e-94 | 301 |
| LLPS-Mua-0460 | Musa acuminata | 38.74 | 4e-89 | 287 |
| LLPS-Amt-1283 | Amborella trichopoda | 37.23 | 3e-95 | 303 |