LLPS-Sac-0633
CBF5

▼ OVERVIEW

Status: Reviewed
Protein Name: H/ACA ribonucleoprotein complex subunit CBF5; Centromere-binding factor 5; Centromere/microtubule-binding protein CBF5; H/ACA snoRNP protein CBF5; Small nucleolar RNP protein CBF5; p64'
Gene Name: CBF5, YLR175W, L9470.11
Ensembl Gene: YLR175W
Ensembl Protein: YLR175W_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: LLPS regulator
PDB: 3UAI (A, B, C, D) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Out of the 142 yeast nucleolar proteins that have at least one human homologue, 124 are found in the updated nucleolar proteome."
Saccharomyces cerevisiae15635413
Cajal body, Stress granule, OthersPredicted from orthologsN/A(View)

▼ FUNCTION

Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909, PubMed:25219674). Catalyzes pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs (PubMed:25219674). It is a centromeric DNA-CBF3-binding factor which is involved in mitotic chromosome segregation (PubMed:8336724). Essential for cell growth (PubMed:8336724).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSKEDFVIKP  EAAGASTDTS  EWPLLLKNFD  KLLVRSGHYT  PIPAGSSPLK  RDLKSYISSG  60
61    VINLDKPSNP  SSHEVVAWIK  RILRCEKTGH  SGTLDPKVTG  CLIVCIDRAT  RLVKSQQGAG  120
121   KEYVCIVRLH  DALKDEKDLG  RSLENLTGAL  FQRPPLISAV  KRQLRVRTIY  ESNLIEFDNK  180
181   RNLGVFWASC  EAGTYMRTLC  VHLGMLLGVG  GHMQELRRVR  SGALSENDNM  VTLHDVMDAQ  240
241   WVYDNTRDES  YLRSIIQPLE  TLLVGYKRIV  VKDSAVNAVC  YGAKLMIPGL  LRYEEGIELY  300
301   DEIVLITTKG  EAIAVAIAQM  STVDLASCDH  GVVASVKRCI  MERDLYPRRW  GLGPVAQKKK  360
361   QMKADGKLDK  YGRVNENTPE  QWKKEYVPLD  NAEQSTSSSQ  ETKETEEEPK  KAKEDSLIKE  420
421   VETEKEEVKE  DDSKKEKKEK  KDKKEKKEKK  EKKDKKEKKE  KKEKKRKSED  GDSEEKKSKK  480
481   SKK  483
Nucleotide CDS Sequence (FASTA)
1     ATGTCAAAGG  AGGATTTCGT  TATTAAGCCT  GAAGCTGCAG  GTGCTTCCAC  TGACACTAGT  60
61    GAATGGCCAT  TACTTTTGAA  GAATTTTGAT  AAGTTATTAG  TCAGAAGTGG  TCATTATACC  120
121   CCTATCCCAG  CTGGTAGTTC  ACCACTAAAG  AGAGACCTGA  AATCATATAT  CAGCTCTGGT  180
181   GTCATTAATC  TAGATAAACC  TTCCAACCCA  TCATCGCACG  AAGTTGTAGC  TTGGATCAAA  240
241   AGAATCTTAC  GTTGTGAGAA  GACTGGTCAC  TCTGGTACAT  TGGATCCAAA  AGTTACAGGT  300
301   TGTTTGATTG  TTTGTATTGA  CAGAGCTACC  AGGTTGGTTA  AGTCTCAACA  AGGTGCTGGT  360
361   AAGGAGTATG  TGTGTATTGT  CAGATTGCAT  GATGCTTTGA  AGGATGAAAA  GGATTTGGGC  420
421   CGCTCACTAG  AAAACTTGAC  CGGTGCGCTT  TTCCAAAGAC  CTCCTTTAAT  CTCTGCTGTT  480
481   AAGAGACAAT  TACGTGTTCG  TACTATCTAT  GAGTCAAACT  TGATTGAGTT  CGATAACAAG  540
541   AGAAACTTAG  GTGTTTTCTG  GGCTTCCTGT  GAAGCTGGTA  CTTATATGCG  TACTTTGTGT  600
601   GTTCATTTAG  GTATGCTATT  AGGTGTTGGT  GGTCACATGC  AAGAATTGCG  TCGTGTTAGA  660
661   TCCGGTGCTC  TGTCTGAAAA  TGACAACATG  GTCACTTTAC  ATGATGTTAT  GGATGCCCAA  720
721   TGGGTTTACG  ACAATACAAG  AGATGAATCT  TACTTGAGAT  CCATTATTCA  ACCTTTAGAA  780
781   ACTCTATTGG  TTGGTTACAA  GAGAATTGTA  GTGAAGGATT  CTGCTGTCAA  TGCAGTATGT  840
841   TATGGTGCAA  AGTTGATGAT  CCCTGGTTTA  TTGCGTTACG  AAGAAGGTAT  TGAGTTATAT  900
901   GACGAAATTG  TCTTGATAAC  TACCAAGGGT  GAAGCCATTG  CCGTTGCCAT  CGCACAAATG  960
961   TCAACCGTTG  ACTTAGCTTC  CTGTGATCAT  GGTGTTGTTG  CTAGTGTGAA  GAGATGTATC  1020
1021  ATGGAAAGAG  ATTTATACCC  AAGAAGATGG  GGTTTGGGTC  CAGTCGCACA  AAAGAAGAAG  1080
1081  CAAATGAAGG  CAGACGGCAA  ATTGGATAAA  TACGGCCGTG  TTAACGAAAA  CACCCCAGAA  1140
1141  CAATGGAAAA  AAGAATATGT  TCCATTAGAC  AATGCTGAAC  AGTCAACTTC  TAGCTCTCAG  1200
1201  GAAACTAAGG  AAACTGAAGA  AGAGCCTAAG  AAAGCTAAAG  AAGATTCTTT  AATCAAAGAA  1260
1261  GTCGAAACTG  AGAAGGAAGA  AGTGAAAGAG  GATGACAGCA  AAAAGGAAAA  GAAAGAGAAG  1320
1321  AAGGACAAGA  AGGAAAAGAA  GGAAAAGAAA  GAAAAGAAGG  ACAAGAAGGA  AAAGAAAGAG  1380
1381  AAAAAGGAGA  AGAAAAGAAA  GTCTGAAGAC  GGTGATTCTG  AGGAAAAGAA  ATCTAAGAAA  1440
1441  TCTAAGAAAT  GA  1452

▼ KEYWORD

ID
Family
3D-structure
Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
DNA-binding
Isomerase
Isopeptide bond
Microtubule
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ribonucleoprotein
Ribosome biogenesis
RNA-binding
rRNA processing
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
90S preribosome
Cellular Component
Box H/ACA snoRNP complex
Cellular Component
Chromosome, centromeric region
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Cellular Component
Nucleolus
Molecular Function
DNA binding
Molecular Function
MRNA binding
Molecular Function
Pseudouridine synthase activity
Biological Process
Box H/ACA snoRNA 3'-end processing
Biological Process
Cell cycle
Biological Process
Cell division
Biological Process
MRNA pseudouridine synthesis
Biological Process
RRNA modification
Biological Process
RRNA processing
Biological Process
RRNA pseudouridine synthesis
Biological Process
SnRNA pseudouridine synthesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-0197Ashbya gossypii94.010.0 717
LLPS-Kop-0011Komagataella pastoris86.450.0 688
LLPS-Yal-0035Yarrowia lipolytica86.160.0 665
LLPS-Blg-1352Blumeria graminis81.120.0 636
LLPS-Asni-0240Aspergillus niger80.420.0 629
LLPS-Scp-0612Schizosaccharomyces pombe80.210.0 614
LLPS-Asn-0161Aspergillus nidulans80.150.0 614
LLPS-Fuv-0644Fusarium verticillioides80.00.0 613
LLPS-Fuo-0245Fusarium oxysporum80.00.0 613
LLPS-Tum-0713Tuber melanosporum79.90.0 627
LLPS-Miv-0371Microbotryum violaceum79.90.0 627
LLPS-Asfu-0108Aspergillus fumigatus79.90.0 626
LLPS-Spr-0018Sporisorium reilianum79.790.0 620
LLPS-Zyt-0773Zymoseptoria tritici79.740.0 619
LLPS-Dos-0077Dothistroma septosporum79.740.0 625
LLPS-Asf-0206Aspergillus flavus79.630.0 621
LLPS-Aso-0117Aspergillus oryzae79.630.0 621
LLPS-Nef-0078Neosartorya fischeri79.630.0 623
LLPS-Scj-0391Schizosaccharomyces japonicus79.590.0 609
LLPS-Coo-0163Colletotrichum orbiculare79.550.0 574
LLPS-Beb-0278Beauveria bassiana79.530.0 626
LLPS-Usm-0108Ustilago maydis79.530.0 619
LLPS-Trv-0091Trichoderma virens79.480.0 627
LLPS-Crn-0520Cryptococcus neoformans79.430.0 614
LLPS-Asc-0048Aspergillus clavatus79.370.0 621
LLPS-Trr-0066Trichoderma reesei78.960.0 620
LLPS-Mao-0785Magnaporthe oryzae78.910.0 619
LLPS-Pug-0451Puccinia graminis78.850.0 621
LLPS-Scc-0536Schizosaccharomyces cryophilus78.550.0 612
LLPS-Fus-0270Fusarium solani78.550.0 612
LLPS-Mel-0421Melampsora laricipopulina78.330.0 612
LLPS-Gag-0173Gaeumannomyces graminis78.180.0 615
LLPS-Map-0314Magnaporthe poae77.920.0 616
LLPS-Cog-0619Colletotrichum gloeosporioides77.720.0 617
LLPS-Abg-0562Absidia glauca77.140.0 607
LLPS-Cogr-0221Colletotrichum graminicola76.360.0 580
LLPS-Lem-0152Leptosphaeria maculans76.180.0 597
LLPS-Nec-0508Neurospora crassa75.970.0 593
LLPS-Pyt-0896Pyrenophora teres75.920.0 586
LLPS-Pytr-0237Pyrenophora triticirepentis75.920.0 586
LLPS-Ved-0097Verticillium dahliae74.370.0 586
LLPS-Xet-0419Xenopus tropicalis73.890.0 581
LLPS-Tag-0670Taeniopygia guttata73.610.0 543
LLPS-Pes-1193Pelodiscus sinensis73.50.0 531
LLPS-Phn-0257Phaeosphaeria nodorum73.480.0 585
LLPS-Prp-0136Prunus persica73.180.0 573
LLPS-Mae-0249Manihot esculenta73.110.0 572
LLPS-Put-0446Puccinia triticina73.110.0 554
LLPS-Anp-0500Anas platyrhynchos73.060.0 541
LLPS-Meg-0620Meleagris gallopavo73.060.0 536
LLPS-Gaga-0058Gallus gallus72.920.0 572
LLPS-Osl-0515Ostreococcus lucimarinus72.880.0 529
LLPS-Brn-0842Brassica napus72.850.0 564
LLPS-Arl-0271Arabidopsis lyrata72.850.0 566
LLPS-Brr-1157Brassica rapa72.850.0 564
LLPS-Art-0211Arabidopsis thaliana72.850.0 569
LLPS-Bro-0242Brassica oleracea72.850.0 567
LLPS-Gas-0229Galdieria sulphuraria72.770.0 564
LLPS-Orb-1065Oryza barthii72.70.0 543
LLPS-Gor-1799Gossypium raimondii72.440.0 569
LLPS-Sob-0960Sorghum bicolor72.410.0 556
LLPS-Php-0267Physcomitrella patens72.220.0 564
LLPS-Amt-0393Amborella trichopoda72.180.0 560
LLPS-Orp-0500Oryza punctata72.150.0 555
LLPS-Cea-2583Cercocebus atys72.140.0 568
LLPS-Maf-0565Macaca fascicularis72.140.0 565
LLPS-Chs-2531Chlorocebus sabaeus72.140.0 568
LLPS-Mal-0941Mandrillus leucophaeus72.140.0 568
LLPS-Paa-0014Papio anubis72.140.0 568
LLPS-Rhb-0183Rhinopithecus bieti72.140.0 565
LLPS-Man-0026Macaca nemestrina72.140.0 568
LLPS-Mam-0266Macaca mulatta72.140.0 568
LLPS-Icp-0595Ictalurus punctatus72.060.0 560
LLPS-Leo-1115Lepisosteus oculatus72.060.0 571
LLPS-Ora-2161Ornithorhynchus anatinus72.060.0 568
LLPS-Tar-0615Takifugu rubripes72.060.0 564
LLPS-Dar-0247Danio rerio72.060.0 565
LLPS-Fia-0268Ficedula albicollis72.050.0 572
LLPS-Sem-0468Selaginella moellendorffii71.990.0 558
LLPS-Orm-0413Oryza meridionalis71.990.0 560
LLPS-Aon-1717Aotus nancymaae71.880.0 565
LLPS-Mum-0055Mus musculus71.880.0 570
LLPS-Otg-0578Otolemur garnettii71.880.0 565
LLPS-Pot-0331Populus trichocarpa71.880.0 567
LLPS-Ict-2516Ictidomys tridecemlineatus71.880.0 568
LLPS-Asm-0329Astyanax mexicanus71.80.0 563
LLPS-Scf-2354Scleropages formosus71.80.0 570
LLPS-Viv-1255Vitis vinifera71.80.0 561
LLPS-Thc-1355Theobroma cacao71.760.0 566
LLPS-Orgl-0643Oryza glumaepatula71.730.0 558
LLPS-Ors-0349Oryza sativa71.730.0 556
LLPS-Zem-0429Zea mays71.730.0 556
LLPS-Orr-1280Oryza rufipogon71.730.0 556
LLPS-Ori-0696Oryza indica71.620.0 553
LLPS-Org-0726Oryza glaberrima71.620.0 553
LLPS-Fud-1410Fukomys damarensis71.610.0 566
LLPS-Caj-0203Callithrix jacchus71.610.0 564
LLPS-Gog-0793Gorilla gorilla71.610.0 565
LLPS-Aim-1951Ailuropoda melanoleuca71.610.0 566
LLPS-Orc-2856Oryctolagus cuniculus71.610.0 566
LLPS-Hos-0558Homo sapiens71.610.0 565
LLPS-Pap-0346Pan paniscus71.610.0 564
LLPS-Pat-0345Pan troglodytes71.610.0 565
LLPS-Fec-1441Felis catus71.610.0 565
LLPS-Nol-0111Nomascus leucogenys71.610.0 564
LLPS-Poa-0508Pongo abelii71.610.0 563
LLPS-Cap-1932Cavia porcellus71.610.0 568
LLPS-Eqc-1606Equus caballus71.610.0 564
LLPS-Sol-1802Solanum lycopersicum71.580.0 558
LLPS-Chr-0327Chlamydomonas reinhardtii71.540.0 549
LLPS-Orn-0045Oreochromis niloticus71.540.0 561
LLPS-Ast-0053Aspergillus terreus71.540.0 566
LLPS-Pof-1256Poecilia formosa71.540.0 564
LLPS-Sei-0137Setaria italica71.470.0 555
LLPS-Ova-0725Ovis aries71.390.0 568
LLPS-Tra-0014Triticum aestivum71.390.0 554
LLPS-Tru-0165Triticum urartu71.390.0 553
LLPS-Mup-1615Mustela putorius furo71.350.0 564
LLPS-Loa-0322Loxodonta africana71.350.0 566
LLPS-Anc-0034Anolis carolinensis71.350.0 570
LLPS-Cas-2384Carlito syrichta71.350.0 565
LLPS-Caf-0122Canis familiaris71.350.0 565
LLPS-Lep-1168Leersia perrieri71.280.0 553
LLPS-Sot-0265Solanum tuberosum71.280.0 559
LLPS-Nia-0609Nicotiana attenuata71.280.0 559
LLPS-Hea-1638Helianthus annuus71.240.0 565
LLPS-Coc-0311Corchorus capsularis71.240.0 566
LLPS-Orni-0123Oryza nivara71.20.0 554
LLPS-Cym-0319Cyanidioschyzon merolae71.20.0 538
LLPS-Bot-0093Bos taurus71.130.0 565
LLPS-Sus-1415Sus scrofa71.090.0 563
LLPS-Via-1565Vigna angularis71.090.0 560
LLPS-Urm-1426Ursus maritimus71.090.0 555
LLPS-Orl-1463Oryzias latipes71.020.0 561
LLPS-Orbr-0167Oryza brachyantha70.940.0 552
LLPS-Brd-1135Brachypodium distachyon70.820.0 550
LLPS-Dac-0194Daucus carota70.760.0 562
LLPS-Cus-0048Cucumis sativus70.760.0 556
LLPS-Xim-1197Xiphophorus maculatus70.760.0 560
LLPS-Phv-0291Phaseolus vulgaris70.570.0 555
LLPS-Scm-0638Scophthalmus maximus70.50.0 558
LLPS-Met-0956Medicago truncatula70.390.0 556
LLPS-Ran-2002Rattus norvegicus70.390.0 545
LLPS-Mua-0160Musa acuminata70.310.0 552
LLPS-Lac-0642Latimeria chalumnae70.230.0 556
LLPS-Gaa-0034Gasterosteus aculeatus69.970.0 560
LLPS-Glm-0281Glycine max69.870.0 555
LLPS-Sah-0749Sarcophilus harrisii69.790.0 555
LLPS-Drm-0094Drosophila melanogaster69.710.0 543
LLPS-Mod-0207Monodelphis domestica69.710.0 556
LLPS-Vir-0297Vigna radiata69.610.0 542
LLPS-Ere-0063Erinaceus europaeus69.190.0 545
LLPS-Chc-0316Chondrus crispus69.030.0 547
LLPS-Cis-0307Ciona savignyi68.070.0 530
LLPS-Myl-0886Myotis lucifugus67.620.0 528
LLPS-Cii-0652Ciona intestinalis67.550.0 526
LLPS-Cae-0447Caenorhabditis elegans66.490.0 528
LLPS-Dio-0958Dipodomys ordii63.672e-115 347
LLPS-Mea-1353Mesocricetus auratus63.35e-115 346
LLPS-Ten-2285Tetraodon nigroviridis56.637e-140 419
LLPS-Hov-0130Hordeum vulgare33.04e-1685.1
LLPS-Tut-2265Tursiops truncatus28.043e-0962.0