LLPS-Sac-0120
MAK11
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein MAK11; Maintenance of killer protein 11 |
| Gene Name: | MAK11, YKL021C |
| Ensembl Gene: | YKL021C |
| Ensembl Protein: | YKL021C_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Out of the 142 yeast nucleolar proteins that have at least one human homologue, 124 are found in the updated nucleolar proteome." | Saccharomyces cerevisiae | 15635413 |
▼ FUNCTION
| Essential for cell growth. Plays a role in assembly of 60S pre-ribosomal particles in the nucleolus. Also required for replication of the M1 double-stranded RNA of the L-A virus. This latter function may reflect an enhanced requirement for free 60S ribosomal particles for the translation of viral mRNAs which lack poly-A tails. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YKL021C_mRNA | YKL021C_mRNA |
| UniProt | P20484, MAK11_YEAST, D6VXR4 | |
| GeneBank | BK006944, Z28021, J03506 | CAA81856.1, AAA34750.1, DAA09134.1 |
| RefSeq | NM_001179587.3 | NP_012904.3 |
| Entrez | 853847 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLLNTTYTVF IFFLLRIIKF KIKAENFLEH EKLKTHGTSS RKDPKGQVKN SCRKMSAIGD 60 61 KNQFRIIVGS YEHNILCLSL DIPNQKENDA AKTPHFMPIF HFQAHSLSIK CLAVSRRYLV 120 121 SGSNDEHIRI YDLQKRKELG TLLSHQGSIT ALQFSHPASS SEDAAVSKGS KNSKWLLSAS 180 181 EDHKIMVWRV KDWETVGTLK GHTARVNDVD IHPTNRIAIS VSDDHSIRLW NLMTLRNAAV 240 241 LKLRKYNTNG TCVRWLGAKG DYFAVGLRDR VLIYETGSAK VFKEIVFQRK TLMHIETHIL 300 301 PFDNKEYLSV GISDGNVHFY PCEELFEKVE ENEKQEDDDD KEDISPAFSL LGHTNRIKDF 360 361 KFYTNEFGTY LVTIGSDGKI VVWDMSTKEQ VAVYDCGERL NCLTLCDESI EKYNTMKKRD 420 421 AETADIGDQS EVESDTEELK KIMFGEKKKL NKKKRKQLKK SKVSVELE 468 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTACTGA ATACTACTTA TACTGTCTTC ATTTTTTTTT TGCTTAGAAT TATAAAGTTC 60 61 AAGATCAAGG CCGAAAATTT TTTAGAACAT GAAAAATTGA AAACTCATGG TACCTCATCT 120 121 CGAAAAGATC CTAAGGGCCA AGTCAAGAAT TCGTGTAGAA AAATGAGTGC TATAGGCGAC 180 181 AAGAACCAAT TTCGTATCAT TGTGGGCTCA TACGAGCACA ACATTTTGTG TTTATCCTTA 240 241 GATATCCCAA ATCAAAAGGA AAATGATGCA GCAAAGACAC CACATTTTAT GCCAATATTT 300 301 CATTTTCAAG CCCATTCGTT GAGTATTAAA TGTTTGGCTG TTTCAAGAAG ATACCTAGTT 360 361 TCTGGATCCA ATGACGAGCA CATCAGAATT TATGATTTGC AAAAGAGGAA GGAACTGGGT 420 421 ACTTTGTTAA GTCATCAGGG CTCTATTACT GCTCTACAAT TCTCACATCC AGCTTCTTCC 480 481 AGTGAGGATG CTGCTGTTTC AAAGGGGAGC AAGAATAGCA AATGGTTATT ATCAGCATCA 540 541 GAAGACCACA AAATTATGGT TTGGAGAGTA AAGGACTGGG AAACAGTGGG GACTTTAAAG 600 601 GGACACACGG CAAGGGTTAA TGATGTGGAT ATTCACCCCA CCAATAGAAT TGCCATCAGT 660 661 GTTAGTGATG ACCATTCTAT ACGTCTTTGG AATTTGATGA CTCTAAGAAA TGCTGCTGTA 720 721 CTAAAACTAA GAAAATATAA TACAAACGGG ACTTGTGTTA GATGGTTAGG CGCCAAAGGT 780 781 GATTATTTTG CCGTGGGTTT AAGGGATAGG GTGCTTATTT ATGAAACTGG ATCGGCTAAA 840 841 GTTTTTAAAG AAATAGTCTT TCAAAGGAAA ACTCTTATGC ATATTGAAAC ACATATTTTA 900 901 CCATTCGATA ATAAGGAATA CCTTTCTGTT GGTATCAGCG ATGGTAATGT TCATTTCTAT 960 961 CCTTGTGAGG AGTTATTCGA AAAAGTTGAA GAAAATGAAA AGCAGGAAGA TGATGACGAC 1020 1021 AAGGAGGATA TCAGCCCCGC TTTTTCTTTA TTGGGTCACA CAAACCGTAT TAAAGATTTC 1080 1081 AAGTTTTATA CGAATGAATT TGGTACCTAC CTAGTCACCA TTGGTTCTGA TGGTAAAATT 1140 1141 GTCGTATGGG ATATGTCTAC AAAAGAACAA GTAGCAGTCT ACGACTGTGG CGAAAGGCTA 1200 1201 AATTGCTTAA CGCTATGCGA TGAAAGCATT GAGAAATACA ACACAATGAA GAAGAGGGAT 1260 1261 GCTGAAACAG CTGATATAGG TGACCAAAGT GAGGTGGAAA GTGATACCGA AGAATTAAAG 1320 1321 AAGATAATGT TTGGTGAGAA GAAGAAACTC AATAAAAAGA AGCGGAAGCA ATTGAAGAAG 1380 1381 AGTAAAGTAT CAGTAGAACT TGAATAA 1407 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Membrane | |
Cellular Component | Nuclear membrane | |
Cellular Component | Nucleolus | |
Biological Process | Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | Ribosomal large subunit assembly | |
Biological Process | Ribosomal large subunit biogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-0028 | Ashbya gossypii | 61.82 | 2e-152 | 447 |
| LLPS-Kop-0046 | Komagataella pastoris | 46.7 | 1e-101 | 317 |
| LLPS-Yal-0662 | Yarrowia lipolytica | 39.78 | 4e-69 | 233 |
| LLPS-Orn-2073 | Oreochromis niloticus | 33.54 | 4e-15 | 82.0 |
| LLPS-Scm-3993 | Scophthalmus maximus | 33.1 | 1e-10 | 68.2 |
| LLPS-Gaa-3438 | Gasterosteus aculeatus | 32.93 | 2e-14 | 79.7 |
| LLPS-Chc-0521 | Chondrus crispus | 32.5 | 1e-25 | 111 |
| LLPS-Urm-3332 | Ursus maritimus | 31.65 | 3e-13 | 75.9 |
| LLPS-Mua-0648 | Musa acuminata | 31.11 | 9e-11 | 67.8 |
| LLPS-Crn-0221 | Cryptococcus neoformans | 30.89 | 2e-40 | 156 |
| LLPS-Abg-0207 | Absidia glauca | 30.81 | 2e-41 | 157 |
| LLPS-Man-1777 | Macaca nemestrina | 30.49 | 4e-13 | 75.9 |
| LLPS-Caf-2580 | Canis familiaris | 30.49 | 2e-13 | 76.3 |
| LLPS-Anp-1368 | Anas platyrhynchos | 30.48 | 9e-36 | 140 |
| LLPS-Asm-0771 | Astyanax mexicanus | 30.47 | 5e-33 | 133 |
| LLPS-Gas-0296 | Galdieria sulphuraria | 30.32 | 6e-16 | 82.4 |
| LLPS-Xet-2036 | Xenopus tropicalis | 30.28 | 8e-11 | 68.6 |
| LLPS-Blg-0031 | Blumeria graminis | 30.26 | 4e-10 | 65.9 |
| LLPS-Chr-0429 | Chlamydomonas reinhardtii | 30.16 | 4e-10 | 66.6 |
| LLPS-Scj-0289 | Schizosaccharomyces japonicus | 30.06 | 1e-06 | 55.1 |
| LLPS-Glm-0900 | Glycine max | 29.79 | 5e-11 | 69.7 |
| LLPS-Amt-1384 | Amborella trichopoda | 29.67 | 3e-17 | 88.2 |
| LLPS-Art-0138 | Arabidopsis thaliana | 29.37 | 5e-10 | 66.2 |
| LLPS-Scp-0224 | Schizosaccharomyces pombe | 29.3 | 2e-10 | 66.6 |
| LLPS-Php-0367 | Physcomitrella patens | 29.28 | 2e-19 | 94.4 |
| LLPS-Ten-0323 | Tetraodon nigroviridis | 29.27 | 6e-11 | 68.9 |
| LLPS-Cis-1877 | Ciona savignyi | 29.2 | 2e-10 | 67.4 |
| LLPS-Cii-1131 | Ciona intestinalis | 29.2 | 7e-11 | 68.9 |
| LLPS-Orl-3342 | Oryzias latipes | 29.17 | 2e-15 | 82.8 |
| LLPS-Put-0070 | Puccinia triticina | 28.97 | 1e-15 | 82.0 |
| LLPS-Trv-0143 | Trichoderma virens | 28.96 | 7e-26 | 114 |
| LLPS-Scf-3191 | Scleropages formosus | 28.83 | 1e-11 | 71.2 |
| LLPS-Ict-0127 | Ictidomys tridecemlineatus | 28.71 | 1e-30 | 125 |
| LLPS-Meg-1644 | Meleagris gallopavo | 28.65 | 3e-14 | 79.3 |
| LLPS-Nia-0500 | Nicotiana attenuata | 28.57 | 3e-22 | 101 |
| LLPS-Pot-0362 | Populus trichocarpa | 28.51 | 9e-15 | 79.3 |
| LLPS-Trr-0137 | Trichoderma reesei | 28.5 | 1e-25 | 113 |
| LLPS-Xim-0668 | Xiphophorus maculatus | 28.45 | 5e-33 | 133 |
| LLPS-Pof-0493 | Poecilia formosa | 28.45 | 7e-33 | 132 |
| LLPS-Beb-0909 | Beauveria bassiana | 28.44 | 5e-27 | 117 |
| LLPS-Brn-0312 | Brassica napus | 28.38 | 5e-17 | 86.3 |
| LLPS-Brr-0377 | Brassica rapa | 28.38 | 5e-17 | 85.9 |
| LLPS-Bro-1140 | Brassica oleracea | 28.38 | 4e-17 | 86.3 |
| LLPS-Vir-1672 | Vigna radiata | 28.37 | 7e-11 | 68.9 |
| LLPS-Cus-1766 | Cucumis sativus | 28.37 | 1e-10 | 68.2 |
| LLPS-Mae-2078 | Manihot esculenta | 28.37 | 3e-10 | 67.0 |
| LLPS-Gaga-1029 | Gallus gallus | 28.25 | 8e-36 | 141 |
| LLPS-Met-2115 | Medicago truncatula | 28.19 | 9e-06 | 52.8 |
| LLPS-Thc-1593 | Theobroma cacao | 28.17 | 2e-10 | 67.4 |
| LLPS-Coc-2348 | Corchorus capsularis | 28.17 | 9e-11 | 68.6 |
| LLPS-Tar-0407 | Takifugu rubripes | 28.16 | 1e-34 | 137 |
| LLPS-Sol-1085 | Solanum lycopersicum | 28.12 | 7e-15 | 81.3 |
| LLPS-Tag-3269 | Taeniopygia guttata | 28.12 | 4e-13 | 75.9 |
| LLPS-Cogr-0300 | Colletotrichum graminicola | 28.08 | 2e-23 | 106 |
| LLPS-Drm-1593 | Drosophila melanogaster | 28.01 | 1e-21 | 100 |
| LLPS-Lac-0612 | Latimeria chalumnae | 27.83 | 5e-33 | 133 |
| LLPS-Dar-0202 | Danio rerio | 27.8 | 2e-32 | 131 |
| LLPS-Aso-0807 | Aspergillus oryzae | 27.65 | 3e-23 | 106 |
| LLPS-Asf-0208 | Aspergillus flavus | 27.65 | 6e-23 | 105 |
| LLPS-Ova-4000 | Ovis aries | 27.6 | 1e-13 | 77.4 |
| LLPS-Anc-3263 | Anolis carolinensis | 27.57 | 4e-13 | 75.5 |
| LLPS-Mao-0786 | Magnaporthe oryzae | 27.52 | 2e-24 | 109 |
| LLPS-Fia-3556 | Ficedula albicollis | 27.52 | 9e-13 | 74.7 |
| LLPS-Sot-0082 | Solanum tuberosum | 27.31 | 5e-17 | 86.3 |
| LLPS-Miv-0741 | Microbotryum violaceum | 27.25 | 5e-31 | 129 |
| LLPS-Pyt-0045 | Pyrenophora teres | 27.23 | 1e-25 | 113 |
| LLPS-Icp-0318 | Ictalurus punctatus | 27.22 | 3e-33 | 133 |
| LLPS-Ast-1080 | Aspergillus terreus | 27.21 | 4e-21 | 99.8 |
| LLPS-Coo-0616 | Colletotrichum orbiculare | 27.17 | 1e-20 | 98.6 |
| LLPS-Ora-1715 | Ornithorhynchus anatinus | 27.08 | 4e-13 | 75.5 |
| LLPS-Aim-3637 | Ailuropoda melanoleuca | 27.08 | 4e-13 | 75.9 |
| LLPS-Scc-0395 | Schizosaccharomyces cryophilus | 27.07 | 1e-13 | 75.9 |
| LLPS-Tut-0875 | Tursiops truncatus | 27.04 | 6e-33 | 133 |
| LLPS-Pytr-0051 | Pyrenophora triticirepentis | 27.01 | 2e-25 | 113 |
| LLPS-Mum-0410 | Mus musculus | 26.99 | 1e-32 | 132 |
| LLPS-Spr-0675 | Sporisorium reilianum | 26.92 | 1e-31 | 131 |
| LLPS-Via-1204 | Vigna angularis | 26.91 | 9e-21 | 97.1 |
| LLPS-Zyt-0033 | Zymoseptoria tritici | 26.9 | 3e-22 | 103 |
| LLPS-Pes-0253 | Pelodiscus sinensis | 26.88 | 2e-18 | 90.1 |
| LLPS-Pug-0328 | Puccinia graminis | 26.85 | 6e-21 | 99.4 |
| LLPS-Sem-0051 | Selaginella moellendorffii | 26.83 | 7e-21 | 97.1 |
| LLPS-Eqc-1006 | Equus caballus | 26.8 | 2e-31 | 129 |
| LLPS-Gor-0683 | Gossypium raimondii | 26.76 | 4e-10 | 66.6 |
| LLPS-Bot-0181 | Bos taurus | 26.72 | 8e-33 | 132 |
| LLPS-Otg-1016 | Otolemur garnettii | 26.7 | 4e-32 | 130 |
| LLPS-Cog-0688 | Colletotrichum gloeosporioides | 26.65 | 1e-20 | 98.6 |
| LLPS-Ved-0651 | Verticillium dahliae | 26.64 | 3e-20 | 97.1 |
| LLPS-Fec-0536 | Felis catus | 26.59 | 1e-30 | 126 |
| LLPS-Phv-0159 | Phaseolus vulgaris | 26.57 | 6e-20 | 94.4 |
| LLPS-Mup-0333 | Mustela putorius furo | 26.55 | 2e-29 | 122 |
| LLPS-Ere-0207 | Erinaceus europaeus | 26.48 | 4e-30 | 122 |
| LLPS-Phn-0365 | Phaeosphaeria nodorum | 26.46 | 3e-22 | 103 |
| LLPS-Asni-0781 | Aspergillus niger | 26.35 | 5e-10 | 65.5 |
| LLPS-Gag-1069 | Gaeumannomyces graminis | 26.32 | 1e-23 | 107 |
| LLPS-Rhb-0906 | Rhinopithecus bieti | 26.3 | 7e-31 | 127 |
| LLPS-Ran-0758 | Rattus norvegicus | 26.29 | 2e-28 | 119 |
| LLPS-Map-1161 | Magnaporthe poae | 25.9 | 3e-23 | 106 |
| LLPS-Loa-0393 | Loxodonta africana | 25.87 | 1e-30 | 126 |
| LLPS-Arl-0286 | Arabidopsis lyrata | 25.85 | 1e-16 | 84.7 |
| LLPS-Asfu-0361 | Aspergillus fumigatus | 25.78 | 3e-20 | 97.4 |
| LLPS-Fuo-0415 | Fusarium oxysporum | 25.73 | 1e-21 | 101 |
| LLPS-Cea-1244 | Cercocebus atys | 25.72 | 9e-31 | 127 |
| LLPS-Chs-0382 | Chlorocebus sabaeus | 25.72 | 9e-31 | 126 |
| LLPS-Maf-0712 | Macaca fascicularis | 25.72 | 9e-31 | 126 |
| LLPS-Mal-0585 | Mandrillus leucophaeus | 25.72 | 7e-31 | 127 |
| LLPS-Paa-0052 | Papio anubis | 25.72 | 9e-31 | 127 |
| LLPS-Mam-0771 | Macaca mulatta | 25.72 | 9e-31 | 126 |
| LLPS-Dos-0085 | Dothistroma septosporum | 25.65 | 1e-17 | 89.4 |
| LLPS-Leo-2953 | Lepisosteus oculatus | 25.64 | 3e-10 | 66.6 |
| LLPS-Viv-1595 | Vitis vinifera | 25.64 | 1e-19 | 93.6 |
| LLPS-Hea-0503 | Helianthus annuus | 25.61 | 2e-19 | 93.2 |
| LLPS-Usm-0480 | Ustilago maydis | 25.54 | 7e-31 | 129 |
| LLPS-Orc-1201 | Oryctolagus cuniculus | 25.46 | 2e-33 | 134 |
| LLPS-Scs-0285 | Sclerotinia sclerotiorum | 25.44 | 1e-22 | 104 |
| LLPS-Fuv-0485 | Fusarium verticillioides | 25.43 | 8e-22 | 102 |
| LLPS-Gog-0600 | Gorilla gorilla | 25.43 | 8e-31 | 127 |
| LLPS-Hos-0828 | Homo sapiens | 25.43 | 3e-30 | 125 |
| LLPS-Pat-1818 | Pan troglodytes | 25.43 | 2e-30 | 125 |
| LLPS-Pap-1386 | Pan paniscus | 25.43 | 2e-30 | 125 |
| LLPS-Sus-3357 | Sus scrofa | 25.41 | 2e-14 | 79.7 |
| LLPS-Myl-0589 | Myotis lucifugus | 25.39 | 6e-30 | 124 |
| LLPS-Nol-1876 | Nomascus leucogenys | 25.33 | 3e-30 | 125 |
| LLPS-Fud-4157 | Fukomys damarensis | 25.1 | 1e-14 | 80.5 |
| LLPS-Prp-0240 | Prunus persica | 25.07 | 1e-17 | 88.2 |
| LLPS-Fus-0015 | Fusarium solani | 24.88 | 8e-22 | 102 |
| LLPS-Caj-0130 | Callithrix jacchus | 24.87 | 1e-30 | 126 |
| LLPS-Sah-1425 | Sarcophilus harrisii | 24.84 | 3e-26 | 113 |
| LLPS-Nef-0634 | Neosartorya fischeri | 24.83 | 1e-20 | 99.0 |
| LLPS-Mel-0167 | Melampsora laricipopulina | 24.82 | 3e-15 | 82.0 |
| LLPS-Cap-1972 | Cavia porcellus | 24.74 | 8e-31 | 127 |
| LLPS-Poa-1937 | Pongo abelii | 24.73 | 1e-30 | 126 |
| LLPS-Aon-1785 | Aotus nancymaae | 24.71 | 5e-14 | 78.6 |
| LLPS-Mea-2262 | Mesocricetus auratus | 24.71 | 3e-14 | 79.0 |
| LLPS-Dio-0610 | Dipodomys ordii | 24.71 | 4e-14 | 79.0 |
| LLPS-Cas-2604 | Carlito syrichta | 24.71 | 4e-14 | 79.0 |
| LLPS-Orm-1080 | Oryza meridionalis | 24.7 | 2e-15 | 81.3 |
| LLPS-Org-0016 | Oryza glaberrima | 24.68 | 2e-12 | 72.0 |
| LLPS-Asc-0683 | Aspergillus clavatus | 24.67 | 2e-20 | 97.8 |
| LLPS-Orni-0337 | Oryza nivara | 24.39 | 3e-11 | 68.9 |
| LLPS-Ori-1207 | Oryza indica | 24.26 | 1e-12 | 73.2 |
| LLPS-Zem-0208 | Zea mays | 24.26 | 4e-15 | 80.5 |
| LLPS-Dac-0200 | Daucus carota | 24.14 | 2e-18 | 90.5 |
| LLPS-Hov-0353 | Hordeum vulgare | 23.95 | 3e-14 | 77.8 |
| LLPS-Mod-3752 | Monodelphis domestica | 23.94 | 2e-13 | 76.6 |
| LLPS-Asn-0315 | Aspergillus nidulans | 23.92 | 7e-21 | 99.4 |
| LLPS-Orp-0197 | Oryza punctata | 23.08 | 3e-12 | 72.0 |
| LLPS-Tra-1636 | Triticum aestivum | 22.84 | 1e-14 | 79.0 |
| LLPS-Tum-1407 | Tuber melanosporum | 22.81 | 3e-18 | 91.7 |
| LLPS-Sei-0256 | Setaria italica | 22.75 | 5e-15 | 79.7 |
| LLPS-Orgl-0952 | Oryza glumaepatula | 22.71 | 1e-11 | 70.1 |
| LLPS-Sob-0661 | Sorghum bicolor | 22.59 | 2e-14 | 77.8 |
| LLPS-Osl-0429 | Ostreococcus lucimarinus | 22.59 | 7e-12 | 71.2 |
| LLPS-Orr-0985 | Oryza rufipogon | 21.85 | 5e-11 | 67.8 |
| LLPS-Brd-0763 | Brachypodium distachyon | 21.73 | 5e-13 | 73.9 |