LLPS-Rhb-3695
TP73
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tumor protein p73 |
| Gene Name: | TP73 |
| Ensembl Gene: | ENSRBIG00000032568.1 |
| Ensembl Protein: | ENSRBIP00000017274.1 |
| Organism: | Rhinopithecus bieti |
| Taxa ID: | 61621 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRBIT00000041127.1 | ENSRBIP00000017274.1 |
| Ensembl | ENSRBIT00000041108.1 | ENSRBIP00000017255.1 |
| Ensembl | ENSRBIT00000041113.1 | ENSRBIP00000017260.1 |
| Ensembl | ENSRBIT00000041131.1 | ENSRBIP00000017278.1 |
| Ensembl | ENSRBIT00000041125.1 | ENSRBIP00000017272.1 |
| Ensembl | ENSRBIT00000041133.1 | ENSRBIP00000017280.1 |
| Ensembl | ENSRBIT00000041135.1 | ENSRBIP00000017282.1 |
| UniProt | A0A2K6L161, A0A2K6L161_RHIBE | |
| RefSeq | XM_017882441.1 | XP_017737930.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 60 61 VMAQFNLLSS TMDQMSSRAA SASPYTPEHT ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 120 121 YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 180 181 YKKAEHVTDI VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 240 241 EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLETR DGQVLGRRSF EGRICACPGR 300 301 DRKADEDHYR EQQALNESST KNGAASKRAF KQSPPAVPAL GPGVKKRRHG DEDTYYLQVR 360 361 GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQSPSYGPV LSPMNKVHGG 420 421 MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH GAQSMVSGSH 480 481 CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT 540 541 IWRGLQDLKQ GHDYGAAQQL LRSSNAAAIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 600 601 GPGAGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH 636 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTGTACG TCGGTGACCC CACACGGCAC CTGGCCACGG CCCAGTTCAA TTTGCTGAGC 60 61 AGCACCATGG ACCAGATGAG CAGCCGCGCG GCCTCGGCCA GCCCGTACAC CCCGGAGCAC 120 121 ACCGCCAGCG TGCCCACCCA CTCACCCTAC GCGCAGCCCA GCTCCACCTT CGACACCATG 180 181 TCGCCCGCGC CTGTCATTCC CTCCAACACC GACTATCCCG GACCCCACCA CTTCGAGGTC 240 241 ACTTTCCAGC AGTCCAGCAC GGCCAAGTCA GCCACCTGGA CGTACTCTCC ACTCTTGAAG 300 301 AAACTCTACT GCCAGATCGC CAAGACGTGC CCCATCCAGA TCAAGGTGTC CACCCCACCA 360 361 CCCCCGGGCA CCGCCATCCG GGCCATGCCT GTCTACAAGA AGGCGGAGCA CGTGACCGAC 420 421 ATCGTGAAGC GCTGCCCCAA CCACGAGCTC GGGAGAGACT TCAACGAAGG ACAGTCTGCC 480 481 CCAGCCAGCC ACCTCATCCG TGTGGAAGGC AATAATCTCT CGCAGTATGT GGACGACCCT 540 541 GTCACCGGCA GGCAGAGCGT CGTGGTGCCC TATGAGCCAC CACAGGTGGG GACAGAATTC 600 601 ACCACCATCC TGTACAACTT CATGTGTAAC AGCAGCTGTG TGGGGGGCAT GAACCGACGG 660 661 CCCATCCTCA TCATCATCAC CCTGGAGACG CGGGATGGGC AGGTGCTGGG CCGCCGGTCC 720 721 TTTGAGGGCC GCATCTGCGC CTGTCCTGGC CGCGACCGAA AAGCCGATGA GGACCACTAC 780 781 CGGGAGCAGC AGGCCTTGAA TGAGAGCTCT ACCAAGAACG GGGCTGCCAG CAAGCGCGCC 840 841 TTCAAGCAGA GCCCCCCTGC CGTCCCCGCC CTGGGTCCCG GCGTGAAGAA GCGGCGGCAC 900 901 GGAGACGAGG ACACGTACTA CCTGCAGGTG CGAGGCCGGG AGAACTTCGA GATCCTGATG 960 961 AAGCTGAAGG AGAGCCTGGA GCTGATGGAG TTGGTGCCGC AGCCGCTGGT GGACTCCTAT 1020 1021 CGGCAGCAGC AGCAGCTCCT ACAGAGGCCG AGTCACCTAC AGTCCCCATC CTACGGGCCG 1080 1081 GTCCTCTCGC CCATGAACAA GGTGCACGGG GGCATGAACA AGCTGCCCTC CGTCAATCAG 1140 1141 CTGGTGGGCC AGCCTCCCCC GCACAGCTCG GCAGCTACAC CCAACCTGGG GCCTGTGGGC 1200 1201 CCTGGGATGC TCAACAACCA TGGCCACGCA GTGCCAGCCA ACGGCGAGAT GAGCAGCAGC 1260 1261 CACGGCGCCC AGTCCATGGT CTCGGGGTCC CACTGCACTC CGCCACCCCC CTACCACGCC 1320 1321 GACCCCAGCC TCGTCAGTTT TTTAACAGGA TTGGGGTGTC CAAACTGCAT CGAGTATTTC 1380 1381 ACGTCCCAAG GGTTACAGAG CATTTACCAC CTGCAGAACC TGACCATCGA GGACCTGGGG 1440 1441 GCCCTGAAGA TCCCCGAGCA GTACCGCATG ACCATCTGGC GGGGCCTGCA GGACCTGAAG 1500 1501 CAGGGCCACG ACTACGGCGC CGCGCAGCAG CTGCTCCGCT CCAGCAACGC GGCCGCCATC 1560 1561 TCCATCGGCG GCTCCGGGGA GCTGCAGCGC CAGCGGGTCA TGGAGGCCGT GCACTTCCGC 1620 1621 GTGCGCCACA CCATCACCAT CCCCAACCGC GGCGGCCCCG GCGCCGGCCC CGACGAGTGG 1680 1681 GCGGACTTCG GCTTCGACCT GCCCGACTGC AAGGCCCGCA AGCAGCCCAT CAAGGAGGAG 1740 1741 TTCACGGAGG CCGAGATCCA CTGA 1764 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Golgi apparatus | |
Cellular Component | Nucleoplasm | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | Identical protein binding | |
Molecular Function | MDM2/MDM4 family protein binding | |
Molecular Function | Metal ion binding | |
Molecular Function | P53 binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Molecular Function | Transcription factor binding | |
Biological Process | Cell cycle arrest | |
Biological Process | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
Biological Process | Negative regulation of cardiac muscle cell proliferation | |
Biological Process | Positive regulation of cell cycle arrest | |
Biological Process | Protein tetramerization | |
Biological Process | Regulation of mitotic cell cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-0169 | Macaca mulatta | 98.78 | 0.0 | 1096 |
| LLPS-Paa-3805 | Papio anubis | 98.74 | 0.0 | 1224 |
| LLPS-Cea-2447 | Cercocebus atys | 98.74 | 0.0 | 1225 |
| LLPS-Man-0717 | Macaca nemestrina | 98.74 | 0.0 | 1223 |
| LLPS-Maf-0746 | Macaca fascicularis | 98.58 | 0.0 | 1222 |
| LLPS-Chs-2741 | Chlorocebus sabaeus | 98.43 | 0.0 | 1217 |
| LLPS-Gog-0622 | Gorilla gorilla | 98.27 | 0.0 | 1206 |
| LLPS-Hos-1348 | Homo sapiens | 98.27 | 0.0 | 1206 |
| LLPS-Pat-1263 | Pan troglodytes | 97.96 | 0.0 | 1202 |
| LLPS-Poa-1500 | Pongo abelii | 97.85 | 6e-159 | 474 |
| LLPS-Caj-1175 | Callithrix jacchus | 96.23 | 0.0 | 1196 |
| LLPS-Aon-3911 | Aotus nancymaae | 95.75 | 0.0 | 1196 |
| LLPS-Mal-3086 | Mandrillus leucophaeus | 92.92 | 0.0 | 1146 |
| LLPS-Cas-2816 | Carlito syrichta | 92.46 | 0.0 | 1138 |
| LLPS-Eqc-1255 | Equus caballus | 90.44 | 0.0 | 1116 |
| LLPS-Ict-0063 | Ictidomys tridecemlineatus | 89.76 | 0.0 | 1098 |
| LLPS-Ran-3276 | Rattus norvegicus | 89.65 | 0.0 | 1103 |
| LLPS-Otg-0209 | Otolemur garnettii | 89.41 | 0.0 | 1099 |
| LLPS-Mup-2305 | Mustela putorius furo | 89.25 | 0.0 | 991 |
| LLPS-Mum-2253 | Mus musculus | 89.17 | 0.0 | 1093 |
| LLPS-Caf-2323 | Canis familiaris | 88.75 | 0.0 | 1104 |
| LLPS-Fec-3576 | Felis catus | 88.52 | 0.0 | 1103 |
| LLPS-Fud-0834 | Fukomys damarensis | 88.44 | 0.0 | 1115 |
| LLPS-Dio-2414 | Dipodomys ordii | 88.32 | 0.0 | 1101 |
| LLPS-Bot-3461 | Bos taurus | 88.09 | 0.0 | 1085 |
| LLPS-Pap-1893 | Pan paniscus | 87.77 | 0.0 | 1017 |
| LLPS-Sus-1102 | Sus scrofa | 87.62 | 0.0 | 1083 |
| LLPS-Ova-1628 | Ovis aries | 86.83 | 0.0 | 1080 |
| LLPS-Cap-1430 | Cavia porcellus | 86.63 | 0.0 | 1089 |
| LLPS-Loa-1199 | Loxodonta africana | 85.71 | 0.0 | 1040 |
| LLPS-Mea-0890 | Mesocricetus auratus | 84.67 | 2e-148 | 438 |
| LLPS-Meg-2050 | Meleagris gallopavo | 83.03 | 0.0 | 775 |
| LLPS-Anp-0977 | Anas platyrhynchos | 81.59 | 0.0 | 989 |
| LLPS-Gaga-0247 | Gallus gallus | 80.97 | 0.0 | 981 |
| LLPS-Pes-1705 | Pelodiscus sinensis | 80.81 | 0.0 | 978 |
| LLPS-Tag-2696 | Taeniopygia guttata | 80.5 | 0.0 | 998 |
| LLPS-Fia-2990 | Ficedula albicollis | 80.16 | 0.0 | 969 |
| LLPS-Xet-2409 | Xenopus tropicalis | 78.28 | 0.0 | 985 |
| LLPS-Ora-1899 | Ornithorhynchus anatinus | 76.54 | 0.0 | 626 |
| LLPS-Lac-0233 | Latimeria chalumnae | 76.01 | 0.0 | 924 |
| LLPS-Leo-3138 | Lepisosteus oculatus | 75.54 | 0.0 | 921 |
| LLPS-Nol-1131 | Nomascus leucogenys | 75.48 | 0.0 | 870 |
| LLPS-Scf-3780 | Scleropages formosus | 74.49 | 0.0 | 897 |
| LLPS-Icp-0498 | Ictalurus punctatus | 73.53 | 0.0 | 799 |
| LLPS-Urm-3237 | Ursus maritimus | 73.45 | 0.0 | 644 |
| LLPS-Orl-1373 | Oryzias latipes | 71.12 | 0.0 | 689 |
| LLPS-Asm-1634 | Astyanax mexicanus | 71.07 | 0.0 | 854 |
| LLPS-Dar-0393 | Danio rerio | 70.81 | 0.0 | 860 |
| LLPS-Pof-0064 | Poecilia formosa | 70.08 | 0.0 | 791 |
| LLPS-Xim-0401 | Xiphophorus maculatus | 69.92 | 0.0 | 790 |
| LLPS-Orn-1689 | Oreochromis niloticus | 69.08 | 0.0 | 849 |
| LLPS-Scm-0397 | Scophthalmus maximus | 68.24 | 0.0 | 835 |
| LLPS-Gaa-0220 | Gasterosteus aculeatus | 68.1 | 1e-141 | 424 |
| LLPS-Mod-2437 | Monodelphis domestica | 67.52 | 0.0 | 688 |
| LLPS-Ten-2187 | Tetraodon nigroviridis | 66.52 | 0.0 | 824 |
| LLPS-Tar-1745 | Takifugu rubripes | 65.55 | 0.0 | 771 |
| LLPS-Orc-0164 | Oryctolagus cuniculus | 58.59 | 0.0 | 616 |
| LLPS-Myl-1480 | Myotis lucifugus | 54.55 | 0.0 | 628 |
| LLPS-Aim-2920 | Ailuropoda melanoleuca | 54.55 | 0.0 | 625 |
| LLPS-Tut-1687 | Tursiops truncatus | 54.24 | 0.0 | 624 |
| LLPS-Anc-1449 | Anolis carolinensis | 50.41 | 2e-26 | 110 |
| LLPS-Cii-1707 | Ciona intestinalis | 44.56 | 1e-64 | 227 |
| LLPS-Cis-0319 | Ciona savignyi | 40.82 | 1e-60 | 216 |
| LLPS-Drm-1424 | Drosophila melanogaster | 29.38 | 2e-10 | 67.4 |