LLPS-Cea-2447
TP73
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tumor protein p73 |
| Gene Name: | TP73 |
| Ensembl Gene: | ENSCATG00000038079.1 |
| Ensembl Protein: | ENSCATP00000029728.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 60 61 VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 120 121 YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 180 181 YKKAEHVTDI VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 240 241 EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLETR DGQVLGRRSF EGRICACPGR 300 301 DRKADEDHYR EQQALNESSA KNGAAGKRAF KQSPPAVPAL GPGVKKRRHG DEDTYYLQVR 360 361 GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG 420 421 MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PTNGEMNSSH STQSMVSGSH 480 481 CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT 540 541 IWRGLQDLKQ GHDYGAAQQL LRSSNAAAIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 600 601 GPGAGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH 636 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCCAGT CCACCGCCAC CTCCCCCGAT GGGGGCACCA CGTTTGAGCA CCTCTGGAGC 60 61 TCTCTGGAAC CAGACAGCAC CTACTTTGAC CTTCCCCAGT CAAGCCGGGG GAATAATGAG 120 121 GTGGTGGGCG GCACAGATTC CAGCATGGAC GTCTTCCACC TAGAGGGCAT GACCACATCT 180 181 GTCATGGCCC AGTTCAATTT GCTGAGCAGC ACCATGGACC AGATGAGCAG CCGCGCGGCC 240 241 TCGGCCAGCC CGTACACCCC GGAGCACGCC GCCAGCGTGC CCACCCACTC ACCCTACGCG 300 301 CAGCCCAGCT CCACCTTCGA CACCATGTCG CCCGCGCCTG TCATCCCCTC CAACACCGAC 360 361 TATCCCGGAC CCCACCACTT CGAGGTCACT TTCCAGCAGT CCAGCACGGC CAAGTCAGCC 420 421 ACCTGGACGT ACTCCCCACT CTTGAAGAAA CTCTACTGCC AGATCGCCAA GACGTGCCCC 480 481 ATCCAGATCA AGGTGTCCAC CCCACCGCCC CCGGGCACCG CCATCCGGGC CATGCCTGTC 540 541 TACAAGAAGG CAGAGCACGT GACCGACATC GTGAAGCGCT GCCCCAACCA CGAGCTCGGG 600 601 AGGGACTTCA ACGAAGGACA GTCTGCCCCA GCCAGCCACC TCATCCGTGT GGAAGGCAAT 660 661 AATCTCTCGC AGTATGTGGA CGACCCTGTC ACCGGCAGGC AGAGCGTCGT GGTGCCCTAT 720 721 GAGCCACCAC AGGTGGGGAC AGAATTCACC ACCATCCTGT ACAACTTCAT GTGTAACAGC 780 781 AGCTGTGTGG GGGGCATGAA CCGACGGCCC ATCCTCATTA TCATCACCCT GGAGACGCGG 840 841 GATGGGCAGG TGCTGGGCCG CCGGTCCTTT GAGGGCCGCA TCTGCGCCTG TCCTGGCCGC 900 901 GACCGAAAAG CCGACGAGGA CCACTACCGG GAGCAGCAGG CCTTGAATGA GAGCTCCGCC 960 961 AAGAACGGGG CTGCCGGCAA GCGCGCCTTC AAGCAGAGCC CCCCTGCCGT CCCCGCCCTG 1020 1021 GGCCCCGGCG TGAAGAAGCG GCGGCACGGA GACGAGGACA CGTACTACCT GCAGGTGCGA 1080 1081 GGCCGCGAGA ACTTCGAGAT CCTGATGAAG CTGAAGGAGA GCCTGGAGCT GATGGAGTTG 1140 1141 GTGCCGCAGC CGCTGGTGGA CTCCTATCGG CAGCAGCAGC AGCTCCTACA GAGGCCGAGT 1200 1201 CACCTACAGC CCCCATCCTA CGGGCCGGTC CTCTCGCCCA TGAACAAGGT GCACGGGGGC 1260 1261 ATGAACAAGC TGCCCTCCGT CAACCAGCTG GTGGGCCAGC CTCCCCCGCA CAGCTCGGCA 1320 1321 GCTACACCCA ACCTGGGGCC TGTGGGCCCT GGGATGCTCA ACAACCATGG CCACGCAGTG 1380 1381 CCAACCAACG GCGAGATGAA CAGCAGCCAC AGCACTCAGT CCATGGTCTC GGGGTCCCAC 1440 1441 TGCACTCCGC CACCCCCCTA CCACGCCGAC CCCAGCCTCG TCAGTTTTTT AACAGGATTG 1500 1501 GGGTGTCCAA ACTGCATCGA GTATTTCACG TCCCAGGGGT TACAGAGCAT TTACCACCTG 1560 1561 CAGAACCTGA CCATCGAGGA CCTGGGGGCC CTGAAGATCC CCGAGCAGTA CCGCATGACC 1620 1621 ATCTGGCGAG GCCTGCAGGA CCTGAAGCAG GGCCACGACT ACGGCGCCGC GCAGCAGCTG 1680 1681 CTCCGCTCCA GCAACGCGGC CGCCATCTCC ATCGGCGGCT CCGGGGAGCT GCAGCGCCAG 1740 1741 CGGGTCATGG AGGCCGTGCA CTTCCGCGTG CGCCACACCA TCACCATCCC CAACCGCGGC 1800 1801 GGCCCCGGCG CCGGCCCCGA CGAGTGGGCG GACTTCGGCT TCGACCTGCC CGACTGCAAG 1860 1861 GCCCGCAAAC AGCCCATCAA GGAGGAGTTC ACGGAGGCCG AGATCCACTG A 1911 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Golgi apparatus | |
Cellular Component | Nucleoplasm | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | Identical protein binding | |
Molecular Function | MDM2/MDM4 family protein binding | |
Molecular Function | Metal ion binding | |
Molecular Function | P53 binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Molecular Function | Transcription factor binding | |
Biological Process | Cell cycle arrest | |
Biological Process | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
Biological Process | Negative regulation of cardiac muscle cell proliferation | |
Biological Process | Positive regulation of cell cycle arrest | |
Biological Process | Protein tetramerization | |
Biological Process | Regulation of mitotic cell cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-0717 | Macaca nemestrina | 99.37 | 0.0 | 1232 |
| LLPS-Paa-3805 | Papio anubis | 99.37 | 0.0 | 1233 |
| LLPS-Maf-0746 | Macaca fascicularis | 99.21 | 0.0 | 1231 |
| LLPS-Mam-0169 | Macaca mulatta | 99.13 | 0.0 | 1101 |
| LLPS-Rhb-3695 | Rhinopithecus bieti | 98.74 | 0.0 | 1225 |
| LLPS-Chs-2741 | Chlorocebus sabaeus | 98.59 | 0.0 | 1219 |
| LLPS-Gog-0622 | Gorilla gorilla | 98.58 | 0.0 | 1211 |
| LLPS-Hos-1348 | Homo sapiens | 98.27 | 0.0 | 1207 |
| LLPS-Pat-1263 | Pan troglodytes | 98.11 | 0.0 | 1204 |
| LLPS-Poa-1500 | Pongo abelii | 96.77 | 3e-157 | 470 |
| LLPS-Caj-1175 | Callithrix jacchus | 96.54 | 0.0 | 1201 |
| LLPS-Aon-3911 | Aotus nancymaae | 95.75 | 0.0 | 1197 |
| LLPS-Mal-3086 | Mandrillus leucophaeus | 93.55 | 0.0 | 1155 |
| LLPS-Cas-2816 | Carlito syrichta | 92.78 | 0.0 | 1142 |
| LLPS-Eqc-1255 | Equus caballus | 90.91 | 0.0 | 1120 |
| LLPS-Otg-0209 | Otolemur garnettii | 90.03 | 0.0 | 1107 |
| LLPS-Mup-2305 | Mustela putorius furo | 89.95 | 0.0 | 999 |
| LLPS-Ict-0063 | Ictidomys tridecemlineatus | 89.92 | 0.0 | 1099 |
| LLPS-Ran-3276 | Rattus norvegicus | 89.81 | 0.0 | 1106 |
| LLPS-Mum-2253 | Mus musculus | 89.33 | 0.0 | 1096 |
| LLPS-Caf-2323 | Canis familiaris | 89.06 | 0.0 | 1109 |
| LLPS-Dio-2414 | Dipodomys ordii | 88.63 | 0.0 | 1107 |
| LLPS-Fud-0834 | Fukomys damarensis | 88.59 | 0.0 | 1119 |
| LLPS-Bot-3461 | Bos taurus | 88.56 | 0.0 | 1092 |
| LLPS-Fec-3576 | Felis catus | 88.52 | 0.0 | 1104 |
| LLPS-Sus-1102 | Sus scrofa | 87.93 | 0.0 | 1087 |
| LLPS-Pap-1893 | Pan paniscus | 87.74 | 0.0 | 1016 |
| LLPS-Ova-1628 | Ovis aries | 87.15 | 0.0 | 1085 |
| LLPS-Cap-1430 | Cavia porcellus | 86.78 | 0.0 | 1092 |
| LLPS-Loa-1199 | Loxodonta africana | 86.36 | 0.0 | 1048 |
| LLPS-Mea-0890 | Mesocricetus auratus | 85.37 | 3e-150 | 443 |
| LLPS-Meg-2050 | Meleagris gallopavo | 83.83 | 0.0 | 783 |
| LLPS-Anp-0977 | Anas platyrhynchos | 82.06 | 0.0 | 996 |
| LLPS-Gaga-0247 | Gallus gallus | 81.44 | 0.0 | 987 |
| LLPS-Pes-1705 | Pelodiscus sinensis | 81.44 | 0.0 | 986 |
| LLPS-Tag-2696 | Taeniopygia guttata | 80.97 | 0.0 | 1001 |
| LLPS-Fia-2990 | Ficedula albicollis | 80.62 | 0.0 | 974 |
| LLPS-Xet-2409 | Xenopus tropicalis | 78.59 | 0.0 | 987 |
| LLPS-Ora-1899 | Ornithorhynchus anatinus | 76.77 | 0.0 | 627 |
| LLPS-Lac-0233 | Latimeria chalumnae | 76.63 | 0.0 | 933 |
| LLPS-Leo-3138 | Lepisosteus oculatus | 76.01 | 0.0 | 926 |
| LLPS-Nol-1131 | Nomascus leucogenys | 75.16 | 0.0 | 868 |
| LLPS-Scf-3780 | Scleropages formosus | 74.81 | 0.0 | 901 |
| LLPS-Icp-0498 | Ictalurus punctatus | 73.7 | 0.0 | 801 |
| LLPS-Urm-3237 | Ursus maritimus | 73.65 | 0.0 | 647 |
| LLPS-Asm-1634 | Astyanax mexicanus | 71.7 | 0.0 | 860 |
| LLPS-Orl-1373 | Oryzias latipes | 71.32 | 0.0 | 691 |
| LLPS-Dar-0393 | Danio rerio | 70.81 | 0.0 | 860 |
| LLPS-Pof-0064 | Poecilia formosa | 70.25 | 0.0 | 791 |
| LLPS-Xim-0401 | Xiphophorus maculatus | 69.92 | 0.0 | 788 |
| LLPS-Orn-1689 | Oreochromis niloticus | 69.38 | 0.0 | 852 |
| LLPS-Gaa-0220 | Gasterosteus aculeatus | 68.4 | 1e-142 | 427 |
| LLPS-Scm-0397 | Scophthalmus maximus | 68.39 | 0.0 | 837 |
| LLPS-Mod-2437 | Monodelphis domestica | 67.86 | 0.0 | 691 |
| LLPS-Ten-2187 | Tetraodon nigroviridis | 66.67 | 0.0 | 825 |
| LLPS-Tar-1745 | Takifugu rubripes | 65.7 | 0.0 | 776 |
| LLPS-Orc-0164 | Oryctolagus cuniculus | 58.59 | 0.0 | 617 |
| LLPS-Aim-2920 | Ailuropoda melanoleuca | 54.7 | 0.0 | 629 |
| LLPS-Myl-1480 | Myotis lucifugus | 54.55 | 0.0 | 630 |
| LLPS-Tut-1687 | Tursiops truncatus | 54.55 | 0.0 | 629 |
| LLPS-Anc-1449 | Anolis carolinensis | 50.41 | 4e-26 | 110 |
| LLPS-Cii-1707 | Ciona intestinalis | 42.81 | 2e-64 | 226 |
| LLPS-Cis-0319 | Ciona savignyi | 40.82 | 3e-60 | 215 |
| LLPS-Drm-1424 | Drosophila melanogaster | 29.38 | 2e-10 | 67.8 |