LLPS-Ran-4166
Safb
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Scaffold attachment factor B1 |
| Gene Name: | Safb, Safb1 |
| Ensembl Gene: | ENSRNOG00000050543.2 |
| Ensembl Protein: | ENSRNOP00000071054.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear stress body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000089164.1 | ENSRNOP00000071054.1 |
| Ensembl | ENSRNOT00000072868.1 | ENSRNOP00000066884.1 |
| Ensembl | ENSRNOT00000081770.1 | ENSRNOP00000069796.1 |
| UniProt | O88453, SAFB1_RAT | |
| GeneBank | AF056324 | AAC29479.1 |
| Entrez | 64196 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAETLSGLGD SGAASAAAVS SAASETGTRR LSDLRVIDLR AELRKRNLDS SGNKSVLMER 60 61 LKKAIEEEGG NPDEIEVISE GNKKMPKRPS KGKKPEDEGV EDNGLEENSG DGQEDVETSL 120 121 ENLQDMDMMD ISVLDEADID NGSVADCVEE EEEATLPEGL GDSTELVEGD SKGLPEQLQE 180 181 HAIDDKEAIN NVDTSSSDFT ILQEMEEASL EPENEKILDI LGETCKSEPV KEEGSELEQP 240 241 FAQATSSVGP DRKLAEEEDL FESCGHPEEE EEEEEEEEQE EEQEEEGDLA LASSSKSESS 300 301 STRCQWSEAD ALLAVVKREP AEAPGGGTGM DREPVGLEEP VEQSSTAAQL PETTSQELVR 360 361 APTAAPSPEP RDSKDDVKKF AFDACNDVPA APKESSASEG ADQKMSSVED DSDTKRLSRE 420 421 EKGRSSCGRN FWVSGLSSTT RATDLKNLFS RYGKVVGAKV VTNARSPGAR CYGFVTMSTA 480 481 EEATKCINHL HKTELHGKMI SVEKAKSEPA GKRVPDRRDG DSKKEKTSTS DRSANLKREE 540 541 KGDRKDDAKK TDDGSTEKSK DADDQKPGPS ERSRTTKSGS RGTERTVVMD KSKGVPVISV 600 601 KTSGSKERAS KSQDRKSVSR EKRSVVSFDK VKESRKSRDS ESRRERERER SEREQRLQAQ 660 661 WEREERERLE IARERLAFHR HRLERERMER ERLERERMHV EQERRREQER IHREREELRR 720 721 QQELRYEQER RPAVRRPYEV DGRRDDAYWP EAKRAALDDR YHSDFSRQDR FHDFDHRDRG 780 781 RYPNHSVDRR EGSRSMMGDR EGQHYPERHG GPERHGRDSR DGWGYGSNKR LSEGRGLPPP 840 841 PRRDWGEHGR RLEDDRAWQG TADGGMMERD HKRWQGGERS MSGHSGPGHM MNRGGMSGRG 900 901 SFAPGGASRG HVIPRGGMQA GFGGQSRGSR PSDARFTRRY 940 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGAGA CTCTGTCGGG TTTAGGAGAC TCGGGTGCGG CAAGCGCAGC GGCCGTGAGC 60 61 TCCGCGGCGT CAGAGACCGG GACGCGGCGG CTCAGCGACC TGCGGGTGAT CGACCTGCGG 120 121 GCGGAGCTGC GGAAGCGAAA CCTCGACTCG AGCGGCAACA AGAGCGTGCT GATGGAGCGG 180 181 CTTAAGAAGG CCATTGAAGA GGAAGGTGGG AATCCTGATG AAATTGAAGT CATCTCAGAA 240 241 GGCAACAAGA AGATGCCTAA GAGGCCCAGC AAAGGGAAGA AACCAGAAGA CGAGGGTGTG 300 301 GAGGACAACG GGCTCGAGGA GAATTCTGGG GATGGGCAGG AGGATGTGGA AACCAGCCTG 360 361 GAGAACCTGC AAGACATGGA TATGATGGAC ATCAGTGTGC TGGATGAGGC TGACATTGAT 420 421 AATGGCAGCG TGGCAGACTG TGTGGAGGAA GAAGAGGAGG CCACACTCCC TGAGGGCCTA 480 481 GGAGACAGCA CTGAACTGGT AGAAGGCGAC TCGAAGGGGC TCCCAGAACA GCTGCAGGAG 540 541 CATGCTATAG ATGACAAGGA AGCCATTAAC AATGTAGATA CATCATCATC TGACTTCACC 600 601 ATCCTGCAGG AGATGGAAGA GGCATCTTTG GAGCCAGAAA ATGAGAAAAT ACTCGACATT 660 661 TTGGGGGAAA CTTGTAAATC TGAGCCAGTA AAAGAAGAAG GTTCGGAGCT GGAGCAGCCC 720 721 TTTGCCCAGG CCACGAGTAG CGTGGGGCCA GACAGGAAGC TGGCGGAGGA AGAGGACCTA 780 781 TTTGAGAGCT GCGGCCACCC GGAAGAGGAA GAAGAAGAGG AGGAAGAAGA GGAGCAGGAA 840 841 GAGGAGCAGG AGGAGGAGGG AGATTTAGCT TTGGCCAGCA GCAGCAAGTC TGAGTCTTCA 900 901 AGCACTCGAT GTCAGTGGAG CGAGGCAGAC GCCCTGTTAG CAGTAGTGAA AAGGGAGCCG 960 961 GCAGAGGCGC CTGGCGGAGG CACTGGGATG GACCGCGAGC CTGTAGGGCT AGAGGAGCCA 1020 1021 GTTGAACAGA GTAGCACGGC TGCCCAGCTC CCGGAGACCA CCAGCCAGGA GCTGGTGCGA 1080 1081 GCGCCCACGG CAGCCCCGAG CCCTGAGCCC CGAGATAGCA AAGACGACGT GAAGAAGTTT 1140 1141 GCTTTTGACG CTTGTAATGA CGTCCCTGCG GCTCCTAAAG AGTCCTCAGC CAGTGAGGGC 1200 1201 GCTGATCAGA AAATGAGTTC TGTGGAAGAT GACTCGGATA CAAAAAGGCT TTCCAGAGAG 1260 1261 GAGAAGGGTC GCAGCAGCTG TGGTAGGAAT TTCTGGGTTA GTGGCCTTTC ATCTACGACC 1320 1321 AGAGCCACAG ATCTGAAGAA CCTTTTTAGC AGATACGGGA AGGTGGTGGG AGCTAAGGTT 1380 1381 GTGACGAACG CCCGGAGTCC CGGAGCTCGC TGTTACGGCT TTGTCACTAT GTCCACAGCT 1440 1441 GAAGAGGCAA CAAAGTGCAT TAACCATTTG CATAAGACTG AGCTGCATGG CAAGATGATC 1500 1501 TCGGTGGAAA AGGCCAAAAG TGAGCCCGCT GGCAAAAGAG TACCTGACAG GCGAGATGGC 1560 1561 GACAGCAAGA AAGAGAAGAC CAGCACCAGT GACAGATCTG CAAACCTTAA GAGGGAGGAG 1620 1621 AAAGGTGACA GAAAAGACGA TGCCAAGAAG ACGGATGATG GGAGCACAGA GAAGAGCAAG 1680 1681 GATGCAGATG ACCAAAAGCC TGGGCCTTCA GAGCGCTCTC GAACAACCAA GTCAGGAAGC 1740 1741 CGTGGCACTG AGCGTACTGT GGTGATGGAC AAGTCCAAAG GTGTGCCTGT CATCAGTGTG 1800 1801 AAGACTTCTG GTTCTAAAGA GAGAGCCTCC AAAAGTCAGG ACCGAAAGTC TGTCAGCCGG 1860 1861 GAGAAGCGGT CTGTTGTGTC CTTTGACAAG GTTAAAGAGT CTCGAAAGTC CAGAGACTCG 1920 1921 GAGTCACGGA GGGAGCGGGA GCGGGAGCGC AGTGAGCGGG AGCAAAGGCT GCAGGCCCAG 1980 1981 TGGGAGCGGG AGGAGCGAGA GCGGCTGGAG ATTGCCCGGG AGCGCCTGGC TTTCCACCGA 2040 2041 CATAGGCTGG AGCGTGAACG CATGGAGAGG GAACGGTTGG AGCGGGAGCG CATGCATGTG 2100 2101 GAACAGGAGC GGAGGCGTGA GCAAGAGCGC ATTCACCGAG AGCGAGAGGA GCTTCGGCGT 2160 2161 CAGCAGGAAC TGCGCTATGA ACAGGAGCGG AGGCCTGCTG TGCGCAGGCC CTATGAAGTA 2220 2221 GATGGCCGGC GAGATGATGC CTATTGGCCA GAAGCTAAAC GGGCTGCGCT GGATGACCGT 2280 2281 TACCACTCAG ACTTCAGTCG CCAGGACCGC TTTCATGACT TCGACCACAG AGACAGAGGC 2340 2341 CGCTATCCCA ACCACTCTGT GGATAGGAGA GAAGGTTCAC GGTCGATGAT GGGAGACAGA 2400 2401 GAAGGACAGC ATTACCCTGA GCGCCATGGA GGACCTGAAC GCCATGGCCG GGACTCTCGA 2460 2461 GATGGCTGGG GCTATGGCTC AAACAAGAGA CTGAGTGAAG GCCGGGGGCT GCCCCCTCCT 2520 2521 CCCAGGCGTG ACTGGGGAGA GCATGGCCGG AGACTTGAAG ATGACCGGGC ATGGCAGGGC 2580 2581 ACAGCTGATG GAGGCATGAT GGAGCGTGAT CACAAGAGAT GGCAAGGTGG TGAGAGGAGC 2640 2641 ATGTCTGGCC ACTCAGGGCC CGGTCACATG ATGAATCGTG GTGGCATGTC AGGGCGAGGC 2700 2701 AGTTTTGCCC CCGGAGGAGC TTCCCGTGGC CATGTGATCC CACGTGGAGG GATGCAGGCA 2760 2761 GGCTTCGGCA CAGAGCCGGG GCAGCAGACC CAGTGA 2796 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | Chromatin binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Molecular Function | Sequence-specific DNA binding | |
Biological Process | Intracellular estrogen receptor signaling pathway | |
Biological Process | Regulation of mRNA processing | |
Biological Process | Regulation of transcription by RNA polymerase II |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-3784 | Mus musculus | 99.05 | 3e-111 | 372 |
| LLPS-Mea-3044 | Mesocricetus auratus | 95.51 | 1e-90 | 303 |
| LLPS-Sus-2843 | Sus scrofa | 92.38 | 7e-95 | 328 |
| LLPS-Poa-2871 | Pongo abelii | 92.38 | 7e-91 | 315 |
| LLPS-Man-3352 | Macaca nemestrina | 92.38 | 1e-90 | 314 |
| LLPS-Caf-4188 | Canis familiaris | 91.9 | 2e-93 | 325 |
| LLPS-Mal-2796 | Mandrillus leucophaeus | 91.51 | 9e-89 | 309 |
| LLPS-Paa-3599 | Papio anubis | 91.51 | 7e-89 | 310 |
| LLPS-Cea-3286 | Cercocebus atys | 91.51 | 4e-89 | 310 |
| LLPS-Maf-3805 | Macaca fascicularis | 91.51 | 4e-89 | 310 |
| LLPS-Chs-1116 | Chlorocebus sabaeus | 91.51 | 4e-89 | 310 |
| LLPS-Mam-4548 | Macaca mulatta | 91.51 | 4e-89 | 310 |
| LLPS-Eqc-2782 | Equus caballus | 91.47 | 8e-84 | 297 |
| LLPS-Fec-3932 | Felis catus | 91.47 | 8e-95 | 326 |
| LLPS-Aim-1944 | Ailuropoda melanoleuca | 91.04 | 1e-92 | 320 |
| LLPS-Mup-0904 | Mustela putorius furo | 91.04 | 1e-91 | 318 |
| LLPS-Gog-2762 | Gorilla gorilla | 91.04 | 2e-88 | 308 |
| LLPS-Hos-2609 | Homo sapiens | 91.04 | 2e-88 | 309 |
| LLPS-Cap-4349 | Cavia porcellus | 91.0 | 4e-97 | 333 |
| LLPS-Dio-3623 | Dipodomys ordii | 90.82 | 8e-83 | 293 |
| LLPS-Aon-1703 | Aotus nancymaae | 90.57 | 6e-88 | 307 |
| LLPS-Caj-4786 | Callithrix jacchus | 89.21 | 1e-121 | 395 |
| LLPS-Loa-1393 | Loxodonta africana | 88.73 | 1e-83 | 295 |
| LLPS-Myl-3606 | Myotis lucifugus | 88.68 | 3e-98 | 336 |
| LLPS-Otg-1961 | Otolemur garnettii | 86.19 | 6e-80 | 284 |
| LLPS-Fud-3422 | Fukomys damarensis | 84.18 | 0.0 | 858 |
| LLPS-Ova-3176 | Ovis aries | 82.09 | 2e-78 | 280 |
| LLPS-Pat-0634 | Pan troglodytes | 82.06 | 5e-76 | 273 |
| LLPS-Nol-3052 | Nomascus leucogenys | 81.8 | 0.0 | 862 |
| LLPS-Pap-3032 | Pan paniscus | 81.7 | 7e-76 | 273 |
| LLPS-Bot-0517 | Bos taurus | 81.6 | 2e-83 | 294 |
| LLPS-Urm-3538 | Ursus maritimus | 79.91 | 0.0 | 841 |
| LLPS-Ora-1187 | Ornithorhynchus anatinus | 79.41 | 7e-15 | 82.4 |
| LLPS-Sah-2941 | Sarcophilus harrisii | 78.5 | 3e-67 | 238 |
| LLPS-Rhb-3399 | Rhinopithecus bieti | 78.1 | 2e-61 | 229 |
| LLPS-Mod-3788 | Monodelphis domestica | 77.1 | 1e-65 | 242 |
| LLPS-Meg-1307 | Meleagris gallopavo | 69.77 | 3e-32 | 139 |
| LLPS-Tag-2181 | Taeniopygia guttata | 69.13 | 6e-40 | 164 |
| LLPS-Asm-1145 | Astyanax mexicanus | 67.86 | 1e-29 | 131 |
| LLPS-Dar-2103 | Danio rerio | 66.67 | 8e-30 | 131 |
| LLPS-Gaga-0579 | Gallus gallus | 66.36 | 9e-59 | 221 |
| LLPS-Anc-2160 | Anolis carolinensis | 66.22 | 6e-09 | 64.3 |
| LLPS-Icp-2333 | Ictalurus punctatus | 64.46 | 3e-27 | 123 |
| LLPS-Anp-0440 | Anas platyrhynchos | 63.37 | 6e-56 | 211 |
| LLPS-Tut-1716 | Tursiops truncatus | 63.27 | 4e-11 | 71.6 |
| LLPS-Ict-3333 | Ictidomys tridecemlineatus | 63.25 | 3e-31 | 129 |
| LLPS-Fia-1887 | Ficedula albicollis | 61.68 | 4e-47 | 186 |
| LLPS-Drm-0285 | Drosophila melanogaster | 61.36 | 7e-31 | 135 |
| LLPS-Gaa-2729 | Gasterosteus aculeatus | 61.22 | 5e-29 | 129 |
| LLPS-Orc-3422 | Oryctolagus cuniculus | 59.62 | 2e-32 | 140 |
| LLPS-Leo-2539 | Lepisosteus oculatus | 58.82 | 7e-30 | 132 |
| LLPS-Lac-1791 | Latimeria chalumnae | 57.89 | 2e-12 | 75.9 |
| LLPS-Orl-1087 | Oryzias latipes | 57.69 | 2e-11 | 72.4 |
| LLPS-Scm-2011 | Scophthalmus maximus | 57.69 | 3e-31 | 136 |
| LLPS-Orn-2420 | Oreochromis niloticus | 56.67 | 3e-24 | 114 |
| LLPS-Xim-2582 | Xiphophorus maculatus | 56.0 | 6e-09 | 64.3 |
| LLPS-Pof-2839 | Poecilia formosa | 56.0 | 6e-09 | 64.3 |
| LLPS-Scf-3590 | Scleropages formosus | 55.24 | 2e-57 | 217 |
| LLPS-Tar-1614 | Takifugu rubripes | 53.82 | 1e-55 | 210 |
| LLPS-Ten-1425 | Tetraodon nigroviridis | 52.34 | 2e-11 | 72.0 |
| LLPS-Mel-1411 | Melampsora laricipopulina | 49.35 | 1e-08 | 58.9 |
| LLPS-Brd-1653 | Brachypodium distachyon | 46.84 | 1e-14 | 79.7 |
| LLPS-Tra-3046 | Triticum aestivum | 46.75 | 2e-15 | 81.3 |
| LLPS-Tru-1540 | Triticum urartu | 46.75 | 4e-15 | 79.0 |
| LLPS-Php-1492 | Physcomitrella patens | 45.57 | 7e-15 | 80.1 |
| LLPS-Coc-1905 | Corchorus capsularis | 45.16 | 1e-14 | 82.8 |
| LLPS-Amt-1864 | Amborella trichopoda | 44.87 | 3e-08 | 60.1 |
| LLPS-Mua-1148 | Musa acuminata | 44.3 | 6e-13 | 73.9 |
| LLPS-Zem-1786 | Zea mays | 44.3 | 7e-12 | 71.6 |
| LLPS-Orbr-0090 | Oryza brachyantha | 44.3 | 2e-14 | 79.3 |
| LLPS-Sob-2102 | Sorghum bicolor | 44.3 | 1e-11 | 71.2 |
| LLPS-Lep-2362 | Leersia perrieri | 43.04 | 3e-11 | 70.9 |
| LLPS-Sei-1156 | Setaria italica | 43.04 | 8e-12 | 71.6 |
| LLPS-Orb-1229 | Oryza barthii | 43.04 | 2e-10 | 68.6 |
| LLPS-Ori-1749 | Oryza indica | 43.04 | 4e-14 | 78.2 |
| LLPS-Orni-0323 | Oryza nivara | 43.04 | 1e-12 | 74.7 |
| LLPS-Org-2264 | Oryza glaberrima | 43.04 | 3e-14 | 78.2 |
| LLPS-Ors-0726 | Oryza sativa | 43.04 | 4e-14 | 78.2 |
| LLPS-Viv-2300 | Vitis vinifera | 43.01 | 1e-15 | 82.0 |
| LLPS-Orp-0258 | Oryza punctata | 42.86 | 3e-12 | 72.4 |
| LLPS-Sem-2174 | Selaginella moellendorffii | 42.17 | 6e-14 | 76.3 |
| LLPS-Met-0775 | Medicago truncatula | 41.77 | 9e-12 | 71.2 |
| LLPS-Glm-2200 | Glycine max | 41.77 | 2e-12 | 72.0 |
| LLPS-Sol-0410 | Solanum lycopersicum | 41.77 | 2e-11 | 69.3 |
| LLPS-Xet-0712 | Xenopus tropicalis | 41.44 | 8e-11 | 70.5 |
| LLPS-Orgl-1228 | Oryza glumaepatula | 40.74 | 2e-12 | 73.6 |
| LLPS-Orr-0678 | Oryza rufipogon | 40.74 | 2e-12 | 73.2 |
| LLPS-Orm-0812 | Oryza meridionalis | 40.74 | 5e-13 | 74.3 |
| LLPS-Thc-1479 | Theobroma cacao | 40.62 | 1e-13 | 75.9 |
| LLPS-Gor-2522 | Gossypium raimondii | 40.62 | 4e-14 | 77.0 |
| LLPS-Abg-0255 | Absidia glauca | 40.43 | 2e-09 | 63.9 |
| LLPS-Mae-0613 | Manihot esculenta | 39.58 | 2e-14 | 78.2 |
| LLPS-Spr-1436 | Sporisorium reilianum | 39.53 | 1e-10 | 68.2 |
| LLPS-Crn-1441 | Cryptococcus neoformans | 39.47 | 3e-10 | 66.2 |
| LLPS-Put-0179 | Puccinia triticina | 39.45 | 2e-12 | 72.0 |
| LLPS-Sot-0548 | Solanum tuberosum | 39.02 | 4e-11 | 68.2 |
| LLPS-Nia-0712 | Nicotiana attenuata | 39.02 | 3e-11 | 68.2 |
| LLPS-Pug-0723 | Puccinia graminis | 38.71 | 1e-10 | 67.8 |
| LLPS-Brr-0927 | Brassica rapa | 38.46 | 7e-09 | 63.5 |
| LLPS-Hov-1128 | Hordeum vulgare | 37.97 | 2e-11 | 69.7 |
| LLPS-Hea-1883 | Helianthus annuus | 37.66 | 2e-08 | 59.7 |
| LLPS-Dac-1814 | Daucus carota | 37.6 | 6e-11 | 69.3 |
| LLPS-Cus-0469 | Cucumis sativus | 36.71 | 6e-10 | 64.7 |
| LLPS-Scc-0022 | Schizosaccharomyces cryophilus | 36.71 | 5e-11 | 68.9 |
| LLPS-Prp-0087 | Prunus persica | 36.71 | 6e-10 | 64.7 |
| LLPS-Brn-0708 | Brassica napus | 35.44 | 1e-08 | 61.2 |
| LLPS-Pot-1676 | Populus trichocarpa | 35.44 | 5e-09 | 62.0 |
| LLPS-Art-0530 | Arabidopsis thaliana | 35.44 | 2e-09 | 63.2 |
| LLPS-Phv-0442 | Phaseolus vulgaris | 35.23 | 1e-09 | 64.7 |
| LLPS-Miv-1142 | Microbotryum violaceum | 34.23 | 4e-11 | 68.6 |
| LLPS-Yal-1493 | Yarrowia lipolytica | 33.33 | 2e-08 | 62.0 |
| LLPS-Scp-0490 | Schizosaccharomyces pombe | 32.94 | 5e-12 | 72.0 |
| LLPS-Vir-1011 | Vigna radiata | 31.2 | 9e-11 | 67.4 |
| LLPS-Asfu-0534 | Aspergillus fumigatus | 29.79 | 2e-08 | 60.8 |
| LLPS-Nef-1337 | Neosartorya fischeri | 29.79 | 2e-08 | 60.8 |
| LLPS-Bro-0583 | Brassica oleracea | 29.17 | 1e-09 | 63.9 |