LLPS-Ran-2851
Dync1i2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic; DH IC-2 |
| Gene Name: | Dync1i2, Dnci2, Dncic2 |
| Ensembl Gene: | ENSRNOG00000009781.8 |
| Ensembl Protein: | ENSRNOP00000042414.2 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Postsynaptic density, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000047243.4 | ENSRNOP00000042414.2 |
| Ensembl | ENSRNOT00000067729.4 | ENSRNOP00000060919.3 |
| Ensembl | ENSRNOT00000013400.6 | ENSRNOP00000013400.4 |
| UniProt | Q62871, DC1I2_RAT, Q62872, Q62873 | |
| GeneBank | U39045, U39046, U39044 | AAA89163.1, AAA89165.1, AAA89164.1 |
| Entrez | 116659 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAAVSVQEE SDLEKKRREA 60 61 EALLQSMGLT TDSPIVFSEH WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP 120 121 SALQLHSDSD LGRGPIKLGM AKITQVDFPP REIVTYTKET QTPVTAQPKE DEEEEDDVAA 180 181 PKPPVEPEEE KILKKDEEND SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ 240 241 INIFFDYSGR DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN 300 301 NNEEAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG GTYSGQIVLW 360 361 DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS ISTDGKICSW SLDMLSHPQD 420 421 SMELVHKQSK AVAVTSMSFP VGDVNNFVVG SEEGSVYTAC RHGSKAGISE MFEGHQGPIT 480 481 GIHCHAAVGA VDFSHLFVTS SFDWTVKLWT TKNNKPLYSF EDNSDYVYDV MWSPTHPALF 540 541 ACVDGMGRLD LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG 600 601 EQIAVPRNDE WARFGRTLAE INASRADAEE EAATRIPA 638 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCAGACA AAAGTGAATT AAAAGCTGAG TTGGAACGTA AGAAGCAACG GTTGGCCCAA 60 61 ATCAGAGAAG AAAAGAAGAG GAAAGAAGAG GAAAGGAAAA AAAAAGAAAC TGATCAGAAG 120 121 AAGGAAGCTG CAGTCTCTGT GCAGGAAGAG TCTGACCTTG AAAAGAAGAG AAGAGAAGCC 180 181 GAAGCCTTGC TTCAGAGCAT GGGGCTAACT ACAGACTCCC CAATTGTCCC TCCTCCCATG 240 241 TCTCCATCCT CCAAGTCGGT GAGCACGCCA AGTGAAGCTG GAAGCCAGGA CTCTGGAGAT 300 301 GGCGCCGTGG GATCTAGACG AGGACCTATT AAACTTGGAA TGGCCAAAAT TACTCAAGTC 360 361 GACTTTCCCC CTCGAGAAAT CGTCACATAT ACAAAGGAAA CTCAGACCCC GGTTACAGCT 420 421 CAACCCAAAG AAGATGAGGA GGAGGAAGAT GACGTAGCAG CTCCTAAGCC TCCTGTTGAA 480 481 CCTGAAGAAG AGAAAATTTT AAAAAAAGAC GAAGAGAATG ATAGCAAAGC TCCCCCTCAT 540 541 GAACTAACTG AAGAAGAAAA GCAACAAATT TTACACTCAG AAGAATTTTT AAGTTTCTTT 600 601 GACCATTCTA CAAGAATTGT AGAAAGAGCC CTCTCTGAGC AGATTAACAT CTTCTTTGAC 660 661 TACAGTGGGA GAGATTTGGA AGACAAAGAA GGGGAGATTC AAGCAGGTGC TAAGCTGTCA 720 721 TTAAATCGAC AGTTTTTTGA TGAGCGTTGG TCAAAGCATC GAGTTGTTAG TTGCTTGGAT 780 781 TGGTCATCCC AGTATCCAGA ATTACTTGTG GCTTCCTATA ATAACAATGA AGAGGCTCCT 840 841 CATGAGCCTG ATGGTGTGGC CCTCGTATGG AATATGAAGT ACAAGAAAAC TACCCCAGAG 900 901 TACGTGTTCC ACTGCCAGTC AGCTGTAATG TCTGCTACAT TTGCAAAATT TCATCCAAAT 960 961 CTTGTTGTTG GAGGTACATA CTCAGGCCAA ATTGTGCTTT GGGATAACCG TAGCAATAAA 1020 1021 AGAACCCCCG TCCAGAGAAC ACCACTGTCA GCTGCTGCAC ACACACACCC TGTCTACTGT 1080 1081 GTAAATGTTG TTGGAACACA AAATGCTCAT AATCTGATTA GCATCTCTAC TGATGGAAAA 1140 1141 ATTTGCTCCT GGAGCTTAGA CATGCTTTCC CATCCACAGG ATAGCATGGA GTTGGTTCAT 1200 1201 AAACAGTCAA AGGCAGTAGC TGTAACATCT ATGTCTTTCC CTGTTGGAGA CGTCAACAAC 1260 1261 TTTGTTGTGG GCAGTGAAGA AGGTTCTGTG TATACAGCAT GCCGCCATGG CAGCAAAGCC 1320 1321 GGAATCAGTG AGATGTTTGA GGGACACCAG GGACCCATCA CGGGAATCCA CTGTCACGCA 1380 1381 GCTGTTGGCG CAGTAGACTT CTCACATCTG TTCGTCACTT CGTCTTTTGA CTGGACAGTA 1440 1441 AAACTTTGGA CAACTAAGAA TAACAAGCCT TTGTACTCAT TTGAAGATAA TTCAGACTAT 1500 1501 GTCTATGATG TTATGTGGTC ACCCACCCAC CCAGCCCTGT TTGCCTGTGT GGATGGCATG 1560 1561 GGGAGACTGG ATCTATGGAA TCTCAACAAT GACACAGAGG TGCCGACTGC CAGCATTTCT 1620 1621 GTGGAGGGCA ACCCTGCCCT TAACCGTGTG AGATGGACCC ACTCGGGAAG AGAGATCGCC 1680 1681 GTGGGTGATT CTGAAGGACA GATTGTCATA TATGATGTGG GCGAGCAGAT CGCTGTTCCC 1740 1741 CGAAATGATG AATGGGCAAG ATTTGGCCGA ACACTCGCAG AGATTAACGC AAGCCGAGCT 1800 1801 GATGCAGAGG AGGAAGCGGC TACCCGGATT CCTGCCTAG 1839 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic dynein complex | |
Cellular Component | Dynein complex | |
Cellular Component | Microtubule | |
Cellular Component | Vesicle | |
Molecular Function | Dynein heavy chain binding | |
Molecular Function | Dynein light chain binding | |
Molecular Function | Motor activity | |
Molecular Function | Protein-containing complex binding | |
Biological Process | Brain development | |
Biological Process | Cellular response to nerve growth factor stimulus | |
Biological Process | Microtubule-based movement | |
Biological Process | Negative regulation of neuron projection development |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-3534 | Mus musculus | 99.06 | 0.0 | 1194 |
| LLPS-Cas-2876 | Carlito syrichta | 98.58 | 0.0 | 1079 |
| LLPS-Mup-1045 | Mustela putorius furo | 97.81 | 0.0 | 1178 |
| LLPS-Aon-1773 | Aotus nancymaae | 97.81 | 0.0 | 1185 |
| LLPS-Loa-4071 | Loxodonta africana | 97.81 | 0.0 | 1181 |
| LLPS-Aim-2374 | Ailuropoda melanoleuca | 97.65 | 0.0 | 1179 |
| LLPS-Mal-3091 | Mandrillus leucophaeus | 97.65 | 0.0 | 1182 |
| LLPS-Maf-4543 | Macaca fascicularis | 97.65 | 0.0 | 1182 |
| LLPS-Cea-2192 | Cercocebus atys | 97.65 | 0.0 | 1182 |
| LLPS-Cap-4032 | Cavia porcellus | 97.65 | 0.0 | 1162 |
| LLPS-Eqc-4342 | Equus caballus | 97.65 | 0.0 | 1164 |
| LLPS-Poa-3757 | Pongo abelii | 97.65 | 0.0 | 1182 |
| LLPS-Hos-0093 | Homo sapiens | 97.65 | 0.0 | 1182 |
| LLPS-Fud-3841 | Fukomys damarensis | 97.49 | 0.0 | 1181 |
| LLPS-Nol-2797 | Nomascus leucogenys | 97.49 | 0.0 | 1179 |
| LLPS-Ict-1342 | Ictidomys tridecemlineatus | 97.49 | 0.0 | 1183 |
| LLPS-Rhb-4557 | Rhinopithecus bieti | 97.49 | 0.0 | 1176 |
| LLPS-Man-3894 | Macaca nemestrina | 97.49 | 0.0 | 1180 |
| LLPS-Dio-3787 | Dipodomys ordii | 97.34 | 0.0 | 1163 |
| LLPS-Urm-0580 | Ursus maritimus | 96.55 | 0.0 | 1158 |
| LLPS-Tut-1793 | Tursiops truncatus | 96.51 | 0.0 | 1103 |
| LLPS-Bot-3592 | Bos taurus | 96.17 | 0.0 | 1078 |
| LLPS-Ova-3642 | Ovis aries | 96.08 | 0.0 | 1154 |
| LLPS-Paa-4467 | Papio anubis | 95.08 | 0.0 | 1160 |
| LLPS-Gog-0654 | Gorilla gorilla | 95.08 | 0.0 | 1160 |
| LLPS-Caj-4283 | Callithrix jacchus | 95.08 | 0.0 | 1160 |
| LLPS-Mam-1856 | Macaca mulatta | 95.08 | 0.0 | 1160 |
| LLPS-Pat-2818 | Pan troglodytes | 95.08 | 0.0 | 1160 |
| LLPS-Chs-0414 | Chlorocebus sabaeus | 95.05 | 0.0 | 1129 |
| LLPS-Otg-1866 | Otolemur garnettii | 94.83 | 0.0 | 1112 |
| LLPS-Ora-0184 | Ornithorhynchus anatinus | 94.04 | 0.0 | 1131 |
| LLPS-Caf-3087 | Canis familiaris | 93.57 | 0.0 | 1105 |
| LLPS-Sus-4314 | Sus scrofa | 93.42 | 0.0 | 1100 |
| LLPS-Fec-2957 | Felis catus | 93.42 | 0.0 | 1101 |
| LLPS-Tag-1584 | Taeniopygia guttata | 93.26 | 0.0 | 1086 |
| LLPS-Myl-0003 | Myotis lucifugus | 93.14 | 0.0 | 1129 |
| LLPS-Fia-0069 | Ficedula albicollis | 93.1 | 0.0 | 1088 |
| LLPS-Pap-0594 | Pan paniscus | 92.49 | 0.0 | 1089 |
| LLPS-Orc-3575 | Oryctolagus cuniculus | 92.48 | 0.0 | 1094 |
| LLPS-Sah-1444 | Sarcophilus harrisii | 92.01 | 0.0 | 1088 |
| LLPS-Pes-0374 | Pelodiscus sinensis | 91.49 | 0.0 | 1118 |
| LLPS-Meg-3253 | Meleagris gallopavo | 91.33 | 0.0 | 1091 |
| LLPS-Ere-0790 | Erinaceus europaeus | 91.24 | 0.0 | 1048 |
| LLPS-Mod-2673 | Monodelphis domestica | 91.05 | 0.0 | 1125 |
| LLPS-Anp-0580 | Anas platyrhynchos | 89.49 | 0.0 | 1090 |
| LLPS-Gaga-2204 | Gallus gallus | 89.18 | 0.0 | 1041 |
| LLPS-Anc-0423 | Anolis carolinensis | 89.03 | 0.0 | 1045 |
| LLPS-Lac-2897 | Latimeria chalumnae | 87.77 | 0.0 | 1050 |
| LLPS-Leo-1652 | Lepisosteus oculatus | 83.72 | 0.0 | 979 |
| LLPS-Xet-3528 | Xenopus tropicalis | 83.44 | 0.0 | 1043 |
| LLPS-Gaa-2954 | Gasterosteus aculeatus | 82.97 | 0.0 | 1012 |
| LLPS-Asm-2340 | Astyanax mexicanus | 82.6 | 0.0 | 1012 |
| LLPS-Scf-0546 | Scleropages formosus | 82.45 | 0.0 | 1008 |
| LLPS-Scm-0597 | Scophthalmus maximus | 81.82 | 0.0 | 1009 |
| LLPS-Tar-1474 | Takifugu rubripes | 81.29 | 0.0 | 985 |
| LLPS-Dar-2936 | Danio rerio | 81.18 | 0.0 | 1000 |
| LLPS-Icp-0706 | Ictalurus punctatus | 80.41 | 0.0 | 1001 |
| LLPS-Xim-1356 | Xiphophorus maculatus | 79.32 | 0.0 | 970 |
| LLPS-Ten-0577 | Tetraodon nigroviridis | 79.19 | 0.0 | 966 |
| LLPS-Orn-1018 | Oreochromis niloticus | 78.32 | 0.0 | 950 |
| LLPS-Pof-3579 | Poecilia formosa | 78.21 | 0.0 | 932 |
| LLPS-Mea-1925 | Mesocricetus auratus | 73.27 | 0.0 | 919 |
| LLPS-Orl-2205 | Oryzias latipes | 72.47 | 0.0 | 914 |
| LLPS-Drm-1374 | Drosophila melanogaster | 62.07 | 0.0 | 598 |
| LLPS-Cii-0197 | Ciona intestinalis | 56.21 | 0.0 | 604 |
| LLPS-Cis-0685 | Ciona savignyi | 48.36 | 0.0 | 614 |
| LLPS-Abg-1522 | Absidia glauca | 47.85 | 9e-154 | 465 |
| LLPS-Crn-0115 | Cryptococcus neoformans | 46.58 | 5e-134 | 416 |
| LLPS-Cae-0172 | Caenorhabditis elegans | 43.65 | 1e-125 | 392 |
| LLPS-Spr-0776 | Sporisorium reilianum | 43.63 | 4e-125 | 394 |
| LLPS-Miv-0905 | Microbotryum violaceum | 43.45 | 4e-128 | 404 |
| LLPS-Put-0378 | Puccinia triticina | 43.01 | 8e-124 | 390 |
| LLPS-Mel-1124 | Melampsora laricipopulina | 42.41 | 6e-125 | 387 |
| LLPS-Pug-0976 | Puccinia graminis | 42.15 | 2e-123 | 389 |
| LLPS-Asni-1568 | Aspergillus niger | 41.98 | 7e-116 | 367 |
| LLPS-Trr-0747 | Trichoderma reesei | 41.47 | 1e-115 | 368 |
| LLPS-Tum-0994 | Tuber melanosporum | 41.22 | 7e-124 | 388 |
| LLPS-Trv-0727 | Trichoderma virens | 40.82 | 9e-115 | 366 |
| LLPS-Asf-1532 | Aspergillus flavus | 40.68 | 7e-113 | 360 |
| LLPS-Aso-1452 | Aspergillus oryzae | 40.68 | 7e-113 | 360 |
| LLPS-Usm-0814 | Ustilago maydis | 40.62 | 1e-116 | 371 |
| LLPS-Phn-1258 | Phaeosphaeria nodorum | 40.38 | 9e-113 | 360 |
| LLPS-Pytr-0202 | Pyrenophora triticirepentis | 40.36 | 1e-109 | 352 |
| LLPS-Nec-0872 | Neurospora crassa | 40.17 | 4e-116 | 369 |
| LLPS-Fuo-0870 | Fusarium oxysporum | 40.17 | 1e-111 | 357 |
| LLPS-Fuv-0596 | Fusarium verticillioides | 40.13 | 1e-111 | 358 |
| LLPS-Ast-1283 | Aspergillus terreus | 39.92 | 3e-113 | 362 |
| LLPS-Asc-0902 | Aspergillus clavatus | 39.87 | 6e-114 | 364 |
| LLPS-Scs-0408 | Sclerotinia sclerotiorum | 39.71 | 2e-118 | 375 |
| LLPS-Pyt-0531 | Pyrenophora teres | 39.7 | 4e-113 | 362 |
| LLPS-Gag-0066 | Gaeumannomyces graminis | 39.69 | 1e-109 | 352 |
| LLPS-Asn-0117 | Aspergillus nidulans | 39.62 | 2e-112 | 359 |
| LLPS-Coo-0435 | Colletotrichum orbiculare | 39.57 | 8e-110 | 353 |
| LLPS-Beb-0064 | Beauveria bassiana | 39.52 | 3e-111 | 357 |
| LLPS-Fus-0881 | Fusarium solani | 39.31 | 3e-109 | 351 |
| LLPS-Cogr-0802 | Colletotrichum graminicola | 39.19 | 5e-109 | 350 |
| LLPS-Blg-0915 | Blumeria graminis | 39.05 | 4e-112 | 359 |
| LLPS-Map-0959 | Magnaporthe poae | 38.81 | 8e-111 | 355 |
| LLPS-Mao-0620 | Magnaporthe oryzae | 38.65 | 7e-113 | 361 |
| LLPS-Cog-0269 | Colletotrichum gloeosporioides | 38.56 | 5e-107 | 345 |
| LLPS-Dos-1501 | Dothistroma septosporum | 37.18 | 4e-101 | 329 |
| LLPS-Zyt-0339 | Zymoseptoria tritici | 36.78 | 1e-98 | 323 |
| LLPS-Asfu-0618 | Aspergillus fumigatus | 36.68 | 1e-113 | 363 |
| LLPS-Nef-1455 | Neosartorya fischeri | 36.61 | 8e-113 | 361 |
| LLPS-Yal-0171 | Yarrowia lipolytica | 36.21 | 4e-77 | 264 |
| LLPS-Lem-1123 | Leptosphaeria maculans | 35.24 | 1e-91 | 305 |
| LLPS-Ved-0723 | Verticillium dahliae | 32.53 | 3e-33 | 132 |
| LLPS-Scp-0875 | Schizosaccharomyces pombe | 31.13 | 7e-51 | 190 |
| LLPS-Scc-1198 | Schizosaccharomyces cryophilus | 29.1 | 2e-44 | 171 |
| LLPS-Php-0889 | Physcomitrella patens | 28.05 | 8e-19 | 95.1 |
| LLPS-Nia-0566 | Nicotiana attenuata | 27.64 | 7e-06 | 53.1 |
| LLPS-Scj-1187 | Schizosaccharomyces japonicus | 26.26 | 1e-32 | 137 |
| LLPS-Sem-0637 | Selaginella moellendorffii | 25.08 | 3e-20 | 96.3 |
| LLPS-Kop-0776 | Komagataella pastoris | 24.95 | 6e-28 | 123 |
| LLPS-Chr-0489 | Chlamydomonas reinhardtii | 24.53 | 2e-26 | 118 |
| LLPS-Chc-0319 | Chondrus crispus | 23.97 | 2e-13 | 77.4 |
| LLPS-Orm-0543 | Oryza meridionalis | 22.92 | 3e-07 | 57.8 |
| LLPS-Tra-0445 | Triticum aestivum | 22.4 | 6e-07 | 56.6 |
| LLPS-Hov-1586 | Hordeum vulgare | 22.4 | 7e-07 | 56.6 |
| LLPS-Orgl-2224 | Oryza glumaepatula | 22.4 | 1e-07 | 58.9 |
| LLPS-Lep-1532 | Leersia perrieri | 22.4 | 4e-07 | 57.4 |
| LLPS-Orni-2354 | Oryza nivara | 22.4 | 1e-07 | 58.9 |
| LLPS-Orbr-1449 | Oryza brachyantha | 22.4 | 2e-07 | 58.5 |
| LLPS-Ors-2078 | Oryza sativa | 22.4 | 1e-07 | 58.9 |
| LLPS-Brd-1992 | Brachypodium distachyon | 21.88 | 5e-06 | 53.9 |
| LLPS-Zem-1149 | Zea mays | 21.88 | 5e-07 | 57.0 |
| LLPS-Orr-2090 | Oryza rufipogon | 21.88 | 6e-07 | 56.6 |
| LLPS-Sob-1132 | Sorghum bicolor | 21.88 | 7e-07 | 56.6 |
| LLPS-Sei-1616 | Setaria italica | 21.35 | 2e-06 | 55.1 |