LLPS-Ran-2793
Nedd4l

▼ OVERVIEW

Status: Unreviewed
Protein Name: Neural precursor cell-expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene Name: Nedd4l
Ensembl Gene: ENSRNOG00000017610.7
Ensembl Protein: ENSRNOP00000023890.7
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
OthersPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     QGESRILRVK  VVSGLTSPKS  EPFPCSDPYV  KLSLYVADEN  RELALVQTKT  IKKTLNPKWN  60
61    EEFYFRVNPS  NHRLLFEVFD  ENRLTRDDFL  GQVDVPLSHL  PTEDPTMERP  YTFKDFLLRP  120
121   RSHKSRVKGF  LRLKMAYMPK  NGGQDEENSE  QRDDMEHGWE  VVDSNDSASQ  HQEELPPPPL  180
181   PPGWEEKVDN  LGRTYYVNHN  NRSTQWHRPS  LMDVSSESDN  NIRQINQEAA  HRRFRSRRHI  240
241   SEDLEPEASE  GGGEGPEPWE  TISEEVNMAG  DSLSLALPPP  PASPVSRTSP  QELSEELSRR  300
301   LQITPDSNGE  QFSALIQREP  SSRLRSCSVT  DAVAEQAHLP  PPSTPTRRAR  SSTVTGGEES  360
361   TPSVAYVHTT  PGLPSGWEER  KDAKGRTYYV  NHNNRTTTWT  RPIMQLAEDG  ASGSATNSNN  420
421   HLVEPQIRRP  RSLSSPTVTL  SAPLEGAKDS  PIRRAVKDTL  SNPQSPQPSP  YNSPKPQHKV  480
481   TQSFLPPGWE  MRIAPNGRPF  FIDHNTKTTT  WEDPRLKFPV  HMRSKASLNP  NDLGPLPPGW  540
541   EERIHLDGRT  FYIDHNSKIT  QWEDPRLQNP  AITGPAVPYS  REFKQKYDYF  RKKLKKPADI  600
601   PNRFEMKLHR  NNIFEESYRR  IMSVKRPDVL  KARLWIEFES  EKGLDYGGVA  REWFFLLSKE  660
661   MFNPYYGLFE  YSATDNYTLQ  INPNSGLCNE  DHLSYFTFIG  RVAGLAVFHG  KLLDGFFIRP  720
721   FYKMMLGKQI  TLNDMESVDS  EYYNSLKWIL  ENDPTELDLM  FCIDEENFGQ  TYQVDLKPNG  780
781   SEIMVTNENK  REYIDLVIQW  RFVNRVQKQM  NAFLEGFTEL  LPIDLIKIFD  ENELELLMCG  840
841   LGDVDVNDWR  QHSIYKNGYC  PNHPVIQWFW  KAVLLMDAEK  RIRLLQFVTG  TSRVPMNGFA  900
901   ELYGSNGPQL  FTIEQWGSPE  KLPRAHTCFN  RLDLPPYETF  EDLREKLLMA  VENAQGFEGV  960
961   D  961
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCAGG  GAGAATCCCG  TATTCTCAGA  GTAAAAGTTT  TCTGGATTGA  CCTCGCCAAA  60
61    AAGCATATTG  CCAGTGACCC  ATACGTGAAG  CTCTCGTTGT  ACGTAGCTGA  CGAGAACAGA  120
121   GAACTCGCTC  TGGTTCAGAC  TAAGACAATT  AAAAAGACGC  TGAACCCAAA  GTGGAATGAA  180
181   GAGTTTTATT  TTAGAGTAAA  TCCATCTAAT  CACAGGCTCT  TATTTGAAGT  ATTTGACGAG  240
241   AACAGATTGA  CACGAGACGA  CTTTCTGGGC  CAGGTGGACG  TGCCTCTTAG  TCACCTTCCG  300
301   ACAGAAGATC  CAACCATGGA  GAGACCCTAT  ACATTTAAGG  ATTTTCTCCT  GCGACCTAGA  360
361   AGTCATAAAT  CACGCGTCAA  GGGGTTTTTG  AGGTTGAAAA  TGGCCTACAT  GCCGAAAAAC  420
421   GGAGGTCAGG  ATGAAGAAAA  CAGCGAGCAG  AGGGACGACA  TGGAGCATGG  ATGGGAAGTT  480
481   GTTGACTCAA  ACGACTCAGC  TTCCCAGCAC  CAGGAGGAGC  TCCCTCCTCC  TCCCCTGCCA  540
541   CCAGGATGGG  AAGAGAAAGT  GGACAATTTA  GGCCGAACTT  ACTATGTCAA  CCACAACAAC  600
601   AGGAGTACGC  AGTGGCACCG  ACCTAGCTTG  ATGGATGTAT  CGTCAGAGTC  AGACAATAAC  660
661   ATCAGGCAGA  TCAATCAGGA  GGCCGCACAC  CGGCGTTTCC  GCTCTCGGAG  GCACATTAGT  720
721   GAAGACTTGG  AGCCTGAGGC  CTCTGAAGGT  GGTGGAGAAG  GCCCTGAGCC  TTGGGAGACC  780
781   ATTTCAGAGG  AAGTGAACAT  GGCGGGAGAT  TCTCTCAGCC  TGGCTCTACC  CCCACCTCCT  840
841   GCCTCCCCAG  TGTCAAGGAC  CAGCCCCCAG  GAGCTGTCGG  AAGAACTGAG  CAGAAGGTTG  900
901   CAGATCACTC  CGGACTCCAA  TGGGGAACAG  TTCAGTGCTC  TGATTCAGAG  AGAGCCCTCG  960
961   TCTAGGCTCC  GGTCCTGCAG  TGTTACCGAC  GCGGTTGCTG  AACAAGCTCA  CCTTCCACCG  1020
1021  CCCAGCACCC  CAACTAGGCG  AGCCCGTTCG  TCAACTGTCA  CGGGTGGTGA  GGAATCAACG  1080
1081  CCATCAGTGG  CCTATGTACA  TACCACGCCG  GGCCTACCTT  CAGGCTGGGA  AGAAAGAAAA  1140
1141  GATGCTAAGG  GACGCACATA  CTATGTCAAT  CATAACAATC  GAACCACAAC  TTGGACTCGA  1200
1201  CCAATCATGC  AGCTTGCAGA  AGACGGTGCC  TCTGGATCAG  CCACAAACAG  TAACAACCAC  1260
1261  CTAGTCGAAC  CCCAGATCCG  CCGGCCTCGT  AGCCTCAGCT  CGCCAACAGT  AACCTTATCT  1320
1321  GCCCCACTGG  AGGGTGCCAA  GGATTCACCC  ATACGCCGTG  CTGTGAAAGA  TACCCTTTCC  1380
1381  AATCCACAGT  CCCCTCAGCC  ATCACCTTAC  AACTCCCCCA  AACCACAACA  CAAAGTCACA  1440
1441  CAGAGCTTCC  TGCCACCAGG  CTGGGAGATG  AGGATAGCGC  CAAACGGCCG  ACCCTTCTTC  1500
1501  ATTGACCATA  ACACAAAGAC  GACAACCTGG  GAAGATCCAC  GGCTGAAATT  TCCAGTACAT  1560
1561  ATGCGGTCAA  AAGCATCTTT  AAACCCCAAT  GACCTGGGCC  CTCTTCCTCC  TGGCTGGGAA  1620
1621  GAAAGGATCC  ACCTGGACGG  CCGCACATTT  TACATTGACC  ATAATAGCAA  AATTACTCAG  1680
1681  TGGGAAGATC  CAAGACTACA  GAATCCAGCC  ATAACTGGTC  CGGCTGTGCC  GTACTCCAGA  1740
1741  GAATTTAAGC  AGAAATACGA  CTACTTTAGG  AAGAAATTAA  AGAAACCTGC  TGATATTCCA  1800
1801  AACAGGTTTG  AAATGAAACT  CCACAGAAAC  AACATATTTG  AAGAATCCTA  TCGGAGGATC  1860
1861  ATGTCTGTAA  AGAGACCTGA  CGTCCTAAAG  GCTAGACTGT  GGATCGAGTT  TGAATCAGAG  1920
1921  AAAGGCCTGG  ACTATGGGGG  CGTGGCCAGA  GAGTGGTTCT  TCTTACTGTC  CAAAGAGATG  1980
1981  TTCAATCCCT  ACTATGGCCT  CTTCGAGTAC  TCTGCCACGG  ACAACTACAC  ACTTCAGATC  2040
2041  AATCCCAACT  CAGGCCTGTG  TAACGAAGAT  CACTTATCCT  ATTTCACTTT  CATTGGGAGA  2100
2101  GTTGCTGGCC  TGGCAGTGTT  TCATGGGAAA  CTCTTAGATG  GATTCTTCAT  TCGACCTTTC  2160
2161  TACAAGATGA  TGCTGGGGAA  GCAAATAACT  CTGAATGACA  TGGAGTCTGT  GGACAGCGAG  2220
2221  TACTACAACT  CTTTGAAGTG  GATCTTGGAA  AACGACCCCA  CGGAACTTGA  CCTCATGTTC  2280
2281  TGCATAGATG  AAGAGAACTT  TGGGCAGACT  TACCAAGTGG  ACCTGAAGCC  CAATGGGTCA  2340
2341  GAAATCATGG  TAACCAATGA  GAACAAGCGA  GAATATATTG  ACTTGGTCAT  CCAGTGGAGA  2400
2401  TTTGTGAACA  GGGTCCAGAA  GCAAATGAAT  GCCTTCTTGG  AGGGATTTAC  AGAACTTCTT  2460
2461  CCAATCGACT  TGATTAAAAT  TTTTGATGAA  AATGAGCTGG  AGTTGCTGAT  GTGCGGCCTT  2520
2521  GGTGATGTGG  ACGTGAATGA  TTGGAGACAG  CACTCCATTT  ACAAGAACGG  CTACTGCCCC  2580
2581  AACCACCCTG  TCATCCAGTG  GTTCTGGAAG  GCCGTGCTGC  TGATGGATGC  TGAGAAGCGG  2640
2641  ATCCGGTTAC  TACAGTTTGT  CACAGGCACC  TCCAGAGTAC  CCATGAATGG  ATTTGCCGAA  2700
2701  CTTTATGGTT  CCAATGGTCC  TCAGCTGTTT  ACAATAGAGC  AATGGGGTAG  TCCTGAAAAA  2760
2761  CTGCCCAGAG  CTCATACATG  CTTTAACCGC  CTTGATTTAC  CTCCGTATGA  AACCTTTGAA  2820
2821  GATCTACGGG  AGAAGCTTCT  CATGGCCGTG  GAGAATGCTC  AAGGCTTCGA  AGGTGTGGAT  2880
2881  TAA  2883

▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINIIDMIST
Physicochemical
Compute pI/MwAAindex
Function
iEKPD
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-3946Mus musculus98.540.01774
LLPS-Caj-2204Callithrix jacchus97.610.01621
LLPS-Paa-3664Papio anubis97.490.01622
LLPS-Gog-0068Gorilla gorilla97.380.01618
LLPS-Mal-0687Mandrillus leucophaeus97.380.01619
LLPS-Man-4045Macaca nemestrina97.380.01619
LLPS-Pat-0150Pan troglodytes97.380.01622
LLPS-Hos-3417Homo sapiens97.380.01622
LLPS-Maf-1969Macaca fascicularis97.260.01618
LLPS-Fud-4393Fukomys damarensis97.090.01761
LLPS-Rhb-4179Rhinopithecus bieti97.040.01613
LLPS-Fec-2159Felis catus96.810.01613
LLPS-Poa-4493Pongo abelii96.670.01758
LLPS-Mam-2760Macaca mulatta96.450.01749
LLPS-Caf-2959Canis familiaris96.360.01739
LLPS-Mup-2974Mustela putorius furo96.350.01752
LLPS-Sah-3853Sarcophilus harrisii96.150.01596
LLPS-Ova-1049Ovis aries95.840.01743
LLPS-Aim-3333Ailuropoda melanoleuca95.020.01698
LLPS-Loa-2298Loxodonta africana95.010.01729
LLPS-Myl-4427Myotis lucifugus94.890.01572
LLPS-Orc-1787Oryctolagus cuniculus94.180.01725
LLPS-Ict-1569Ictidomys tridecemlineatus93.580.01665
LLPS-Anp-0583Anas platyrhynchos93.430.01672
LLPS-Eqc-4489Equus caballus93.410.01583
LLPS-Cas-2849Carlito syrichta93.00.01615
LLPS-Tag-1761Taeniopygia guttata92.720.01693
LLPS-Otg-1108Otolemur garnettii92.70.01543
LLPS-Pes-3724Pelodiscus sinensis92.510.01701
LLPS-Xet-3742Xenopus tropicalis89.070.01617
LLPS-Gaga-1049Gallus gallus88.110.01613
LLPS-Lac-3767Latimeria chalumnae86.380.01459
LLPS-Aon-1614Aotus nancymaae82.330.0 835
LLPS-Fia-2130Ficedula albicollis81.780.0 823
LLPS-Leo-3878Lepisosteus oculatus80.10.01469
LLPS-Scf-4165Scleropages formosus78.850.01320
LLPS-Gaa-1985Gasterosteus aculeatus78.80.01425
LLPS-Tar-3074Takifugu rubripes77.450.01311
LLPS-Dar-1213Danio rerio77.40.01451
LLPS-Xim-3751Xiphophorus maculatus77.180.01442
LLPS-Asm-1632Astyanax mexicanus76.690.01296
LLPS-Mea-3689Mesocricetus auratus75.630.0 702
LLPS-Cea-0801Cercocebus atys71.380.0 872
LLPS-Sus-4766Sus scrofa70.710.0 872
LLPS-Chs-0154Chlorocebus sabaeus70.410.0 862
LLPS-Cap-1795Cavia porcellus69.350.0 849
LLPS-Icp-1031Ictalurus punctatus66.890.0 790
LLPS-Cii-2133Ciona intestinalis62.050.0 763
LLPS-Bot-3711Bos taurus61.50.01033
LLPS-Nol-2704Nomascus leucogenys61.50.01028
LLPS-Pap-2274Pan paniscus61.390.01029
LLPS-Scp-0104Schizosaccharomyces pombe61.115e-0654.7
LLPS-Pof-1285Poecilia formosa60.910.01118
LLPS-Ten-0465Tetraodon nigroviridis59.590.01058
LLPS-Aso-0034Aspergillus oryzae58.054e-115 362
LLPS-Dio-2813Dipodomys ordii56.890.01002
LLPS-Ora-3335Ornithorhynchus anatinus56.380.0 969
LLPS-Urm-3665Ursus maritimus54.010.0 930
LLPS-Tum-0286Tuber melanosporum53.856e-0654.7
LLPS-Yal-0673Yarrowia lipolytica52.739e-0757.4
LLPS-Pug-0738Puccinia graminis52.494e-164 505
LLPS-Cae-1542Caenorhabditis elegans52.360.0 619
LLPS-Zyt-0373Zymoseptoria tritici50.938e-161 501
LLPS-Map-0232Magnaporthe poae50.822e-156 494
LLPS-Drm-0518Drosophila melanogaster49.482e-112 378
LLPS-Nef-0660Neosartorya fischeri49.164e-180 550
LLPS-Asfu-0575Aspergillus fumigatus49.161e-179 550
LLPS-Mel-1264Melampsora laricipopulina48.65e-176 541
LLPS-Crn-0084Cryptococcus neoformans48.583e-175 538
LLPS-Asc-0963Aspergillus clavatus48.50.0 553
LLPS-Asni-0795Aspergillus niger48.492e-178 546
LLPS-Ast-1325Aspergillus terreus48.490.0 553
LLPS-Scc-0696Schizosaccharomyces cryophilus48.43e-180 549
LLPS-Kop-0927Komagataella pastoris48.40.0 551
LLPS-Asn-1238Aspergillus nidulans48.331e-178 546
LLPS-Phn-0719Phaeosphaeria nodorum48.280.0 555
LLPS-Sac-0388Saccharomyces cerevisiae48.240.0 553
LLPS-Pyt-0220Pyrenophora teres48.172e-178 546
LLPS-Pytr-0235Pyrenophora triticirepentis48.172e-178 546
LLPS-Asf-0947Aspergillus flavus48.091e-178 546
LLPS-Asg-0016Ashbya gossypii47.92e-179 548
LLPS-Scm-1302Scophthalmus maximus47.93e-145 461
LLPS-Scj-0560Schizosaccharomyces japonicus47.561e-175 537
LLPS-Cog-1074Colletotrichum gloeosporioides47.515e-172 529
LLPS-Scs-0053Sclerotinia sclerotiorum47.272e-0655.8
LLPS-Nec-1247Neurospora crassa47.255e-175 537
LLPS-Dos-0166Dothistroma septosporum47.241e-176 541
LLPS-Trv-1090Trichoderma virens46.961e-171 528
LLPS-Gag-0565Gaeumannomyces graminis46.883e-0655.8
LLPS-Beb-0263Beauveria bassiana46.687e-169 521
LLPS-Mao-0563Magnaporthe oryzae46.661e-173 533
LLPS-Ved-0496Verticillium dahliae46.662e-173 533
LLPS-Fuv-1348Fusarium verticillioides46.636e-174 534
LLPS-Fuo-0286Fusarium oxysporum46.636e-174 534
LLPS-Spr-0895Sporisorium reilianum46.581e-171 530
LLPS-Blg-1136Blumeria graminis46.562e-172 530
LLPS-Cis-0222Ciona savignyi46.485e-104 338
LLPS-Fus-0792Fusarium solani46.397e-170 524
LLPS-Coo-0973Colletotrichum orbiculare46.327e-172 529
LLPS-Miv-0848Microbotryum violaceum46.293e-170 525
LLPS-Trr-1005Trichoderma reesei46.181e-169 523
LLPS-Gas-0834Galdieria sulphuraria46.038e-98 342
LLPS-Usm-0057Ustilago maydis45.722e-171 529
LLPS-Meg-0718Meleagris gallopavo45.634e-162 506
LLPS-Anc-0824Anolis carolinensis45.552e-159 500
LLPS-Put-1287Puccinia triticina45.542e-144 456
LLPS-Mod-1605Monodelphis domestica45.422e-159 499
LLPS-Orn-1221Oreochromis niloticus44.645e-157 488
LLPS-Abg-0289Absidia glauca44.565e-99 350
LLPS-Orl-3620Oryzias latipes44.432e-158 496
LLPS-Cogr-1587Colletotrichum graminicola43.963e-100 353
LLPS-Ere-0264Erinaceus europaeus43.511e-141 446
LLPS-Tut-1124Tursiops truncatus39.91e-112 368