LLPS-Icp-1031
nedd4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | E3 ubiquitin-protein ligase NEDD4 |
| Gene Name: | nedd4 |
| Ensembl Gene: | ENSIPUG00000015687.1 |
| Ensembl Protein: | ENSIPUP00000023237.1 |
| Organism: | Ictalurus punctatus |
| Taxa ID: | 7998 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle, Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSIPUT00000024235.1 | ENSIPUP00000023237.1 |
| UniProt | A0A2D0QT83, A0A2D0QT83_ICTPU | |
| RefSeq | , XM_017465447.1 | , XP_017320936.1, XP_017320936.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNNNMAGLVA EIRGLHVEED ESRILRVKVV AGIGLAKKDI LGASDPYTRL SLYDPVTGEL 60 61 VSLQTKTIKK TLDPKWNEEF FFKVHPRKHR LLLEVFDENR LTRDDFLGQV DVPLHQIPTE 120 121 APGSERPYTF KDFLLHPRSH KSRVKGHLRL KMTYLPKSGS EEEQTEQVEE VDPGWEFLES 180 181 QDVCGPCQPH QLPPLPPGWE ERQDNLGRTY YVNHENRTTQ WHRPTIQDVQ REAELTQSTH 240 241 VQLPFITRRQ ISDHDENNDR RESPESWEII TEDEGTLYSS QNQLSPPPPH SPLDYTAFTE 300 301 EFCRLQTGNE NRTSVTGHGS RRGSAPLLTV EERPVHPVML PTTPGLPPGW EEKQDSKGRV 360 361 YYINHKSRIS TWTRPLVQLI QPTDGSSSSA AGGACGRSPS PTVYAPPQAS PQASPLHSPG 420 421 PQQSHTFDFA GSMLPGWEVR VAPNGRPFFI DHNTKSTTWE DPRLRIPVHM RKQASLDPND 480 481 LGPLPVRARF YTLCMKLSAN EHVCVCVCVC VCVSAVPYSR DYKQKYEYFR KKLKKPGDIP 540 541 NRFEMSVRRN ALLEDSYRRI LSVKRPDLLK ARLWVEFAGE RGLDYGGVAR EWFFLISKEM 600 601 FNPYYGLFEY SALDNFTLQI NPNSGLCNED HFSYFKFIGR VAGMAVYHGK LLDAFFIRPF 660 661 YKMMLQKPIT LQDIESVDSE YFNSLKWILE NDPTDLDLRF TIDEELFGQT HQHELTPGGA 720 721 DVVVTDSNKK EYIHLVMQWR FVNRVQKQMS AFKEGFYELI PQDLIKIFDE NELELLMCGL 780 781 GDVDVNDWRE NTKYKNGYGP NQPVIQWFWK AVLLMDAEKR IRLLQFVTGT SRVPMNGFAE 840 841 LYGSNGPQLF TIEQWGTRDK LPRAHTCFNR LDLPPYESFE ELREKLNIAI ENTQGFDGVD 900 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATAATA ACATGGCTGG ACTTGTGGCG GAAATCCGAG GACTCCATGT CGAAGAGGAC 60 61 GAAAGCAGGA TCTTAAGAGT AAAAGTCGTC GCTGGGATTG GACTGGCTAA GAAGGATATT 120 121 CTTGGTGCAA GCGACCCGTA CACGAGACTT TCTCTGTACG ACCCCGTTAC CGGAGAACTG 180 181 GTCAGCCTTC AAACTAAAAC CATCAAAAAG ACGCTGGATC CAAAGTGGAA CGAGGAATTC 240 241 TTCTTCAAAG TTCATCCGAG GAAGCACCGT CTTCTGCTCG AAGTGTTCGA TGAGAATCGC 300 301 TTGACGCGTG ATGACTTTCT GGGTCAGGTG GACGTTCCTC TGCATCAGAT CCCCACAGAA 360 361 GCACCGGGCA GCGAGAGACC GTACACGTTC AAAGACTTTC TGCTCCATCC GAGAAGCCAC 420 421 AAGTCAAGGG TCAAAGGTCA CCTGAGGCTA AAGATGACCT ACCTGCCCAA GAGTGGTTCA 480 481 GAGGAGGAGC AGACCGAGCA GGTCGAGGAA GTGGACCCCG GCTGGGAGTT CCTGGAGAGT 540 541 CAGGATGTGT GCGGGCCGTG CCAACCTCAC CAGCTGCCCC CGCTGCCCCC TGGCTGGGAG 600 601 GAGAGGCAGG ACAACCTCGG CAGAACCTAC TACGTCAACC ACGAGAACCG CACCACACAG 660 661 TGGCACAGAC CCACAATCCA GGACGTGCAG AGGGAGGCGG AGCTGACGCA GAGCACGCAC 720 721 GTACAACTTC CTTTCATCAC GCGCAGACAG ATCTCTGACC ACGATGAGAA CAACGATCGC 780 781 AGGGAGTCTC CCGAGAGTTG GGAGATCATT ACTGAGGACG AGGGCACTCT GTACAGCAGT 840 841 CAGAATCAGC TCTCTCCCCC TCCTCCTCAT TCACCGCTGG ATTACACGGC TTTCACTGAG 900 901 GAGTTCTGCA GGTTACAGAC GGGCAACGAG AACCGCACCT CTGTCACAGG TCACGGGAGT 960 961 CGGAGAGGGA GCGCACCGTT GCTGACTGTA GAGGAACGTC CGGTTCATCC TGTGATGTTG 1020 1021 CCCACGACCC CGGGTTTGCC CCCTGGCTGG GAGGAGAAGC AGGACAGTAA GGGTCGAGTT 1080 1081 TATTACATCA ACCACAAGAG CAGAATCTCC ACCTGGACCC GGCCACTTGT CCAGTTGATC 1140 1141 CAGCCCACTG ACGGATCCTC CTCGTCTGCG GCGGGCGGAG CGTGTGGTCG CTCTCCGAGC 1200 1201 CCCACGGTGT ACGCACCGCC CCAAGCCTCG CCCCAAGCCT CGCCCCTGCA CTCGCCCGGC 1260 1261 CCGCAGCAAT CGCACACCTT CGACTTCGCT GGCTCCATGC TCCCGGGCTG GGAGGTCCGG 1320 1321 GTCGCTCCGA ACGGACGGCC GTTCTTCATC GACCACAACA CCAAGAGCAC TACGTGGGAA 1380 1381 GACCCCAGGT TGAGGATTCC TGTTCACATG AGGAAACAAG CCTCTCTCGA CCCCAACGAC 1440 1441 CTCGGCCCGC TGCCGGTAAG GGCAAGGTTT TACACCTTGT GTATGAAGCT GTCGGCGAAC 1500 1501 GAGCACGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTTT CAGCTGTGCC TTACTCCAGA 1560 1561 GACTACAAGC AGAAGTACGA GTATTTCCGC AAGAAGCTGA AGAAGCCAGG AGACATCCCG 1620 1621 AATCGTTTCG AGATGTCCGT GAGACGGAAC GCTCTTCTGG AGGACTCATA CCGCCGCATC 1680 1681 CTGTCCGTCA AGCGACCCGA CCTCCTCAAG GCCCGCCTCT GGGTGGAGTT TGCAGGGGAG 1740 1741 AGGGGGCTGG ACTACGGGGG CGTGGCCAGA GAGTGGTTCT TTCTCATCTC CAAGGAGATG 1800 1801 TTCAACCCTT ATTACGGGCT GTTTGAGTAC TCTGCTCTGG ACAACTTCAC GCTGCAGATC 1860 1861 AACCCAAACT CGGGCCTCTG CAACGAGGAT CATTTCTCCT ACTTCAAATT CATCGGGCGT 1920 1921 GTGGCGGGGA TGGCCGTCTA CCACGGCAAG CTGCTGGACG CGTTCTTCAT TCGACCGTTC 1980 1981 TACAAGATGA TGCTGCAGAA GCCGATCACG TTACAGGACA TCGAATCTGT GGACAGCGAG 2040 2041 TACTTTAACT CTCTGAAATG GATCCTGGAG AACGACCCCA CTGACCTGGA CCTCCGCTTC 2100 2101 ACCATCGACG AGGAGCTCTT TGGACAGACG CACCAGCACG AGTTAACACC AGGTGGCGCC 2160 2161 GACGTCGTCG TCACCGACTC CAACAAGAAA GAGTACATCC ACCTCGTGAT GCAGTGGAGA 2220 2221 TTTGTGAACC GGGTCCAGAA GCAAATGTCC GCCTTCAAGG AGGGCTTCTA CGAGCTCATC 2280 2281 CCGCAGGACC TGATCAAGAT CTTCGACGAG AACGAGCTGG AGCTGCTGAT GTGCGGTTTG 2340 2341 GGGGACGTGG ACGTCAACGA CTGGAGGGAA AACACCAAGT ATAAGAACGG CTACGGGCCG 2400 2401 AACCAGCCCG TCATCCAGTG GTTCTGGAAG GCTGTGCTGC TGATGGATGC TGAGAAGCGA 2460 2461 ATCCGGTTGC TGCAGTTTGT GACGGGGACG TCTCGCGTGC CGATGAACGG TTTTGCAGAG 2520 2521 CTCTATGGGT CCAACGGGCC GCAGTTATTC ACCATCGAGC AGTGGGGGAC CCGAGACAAA 2580 2581 CTGCCCCGGG CTCACACGTG CTTTAACCGT CTGGACCTGC CTCCGTACGA GTCGTTCGAG 2640 2641 GAGCTCCGAG AGAAGCTGAA CATCGCCATC GAGAACACTC AGGGCTTCGA CGGCGTCGAC 2700 2701 TAG 2703 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Dar-1213 | Danio rerio | 77.89 | 0.0 | 774 |
| LLPS-Xim-3751 | Xiphophorus maculatus | 76.42 | 0.0 | 767 |
| LLPS-Tar-3074 | Takifugu rubripes | 76.21 | 0.0 | 766 |
| LLPS-Scf-4165 | Scleropages formosus | 76.04 | 0.0 | 767 |
| LLPS-Mea-3689 | Mesocricetus auratus | 73.61 | 0.0 | 725 |
| LLPS-Pof-1285 | Poecilia formosa | 69.41 | 0.0 | 1237 |
| LLPS-Fia-2130 | Ficedula albicollis | 68.41 | 0.0 | 1177 |
| LLPS-Ora-3335 | Ornithorhynchus anatinus | 68.28 | 0.0 | 1134 |
| LLPS-Tag-0692 | Taeniopygia guttata | 68.05 | 0.0 | 1191 |
| LLPS-Poa-1160 | Pongo abelii | 68.04 | 0.0 | 1179 |
| LLPS-Gaga-1785 | Gallus gallus | 67.63 | 0.0 | 1186 |
| LLPS-Nol-2704 | Nomascus leucogenys | 67.52 | 0.0 | 1058 |
| LLPS-Pat-3744 | Pan troglodytes | 67.4 | 0.0 | 1059 |
| LLPS-Aim-3561 | Ailuropoda melanoleuca | 67.36 | 0.0 | 1060 |
| LLPS-Myl-1428 | Myotis lucifugus | 67.36 | 0.0 | 1046 |
| LLPS-Mup-4404 | Mustela putorius furo | 67.32 | 0.0 | 1191 |
| LLPS-Pap-2274 | Pan paniscus | 67.28 | 0.0 | 1058 |
| LLPS-Ova-3877 | Ovis aries | 67.25 | 0.0 | 1113 |
| LLPS-Eqc-1565 | Equus caballus | 67.24 | 0.0 | 1061 |
| LLPS-Hos-4743 | Homo sapiens | 67.16 | 0.0 | 1056 |
| LLPS-Caf-3781 | Canis familiaris | 67.16 | 0.0 | 1064 |
| LLPS-Cas-2705 | Carlito syrichta | 67.11 | 0.0 | 1057 |
| LLPS-Gog-0578 | Gorilla gorilla | 67.03 | 0.0 | 1055 |
| LLPS-Fec-4650 | Felis catus | 66.83 | 0.0 | 1051 |
| LLPS-Caj-1066 | Callithrix jacchus | 66.79 | 0.0 | 1053 |
| LLPS-Ten-0465 | Tetraodon nigroviridis | 66.77 | 0.0 | 1156 |
| LLPS-Bot-3711 | Bos taurus | 66.75 | 0.0 | 1053 |
| LLPS-Pes-1871 | Pelodiscus sinensis | 66.71 | 0.0 | 1063 |
| LLPS-Chs-0154 | Chlorocebus sabaeus | 66.7 | 0.0 | 1169 |
| LLPS-Ict-1383 | Ictidomys tridecemlineatus | 66.48 | 0.0 | 1173 |
| LLPS-Mam-4423 | Macaca mulatta | 66.42 | 0.0 | 1036 |
| LLPS-Maf-4099 | Macaca fascicularis | 66.42 | 0.0 | 1036 |
| LLPS-Cea-0801 | Cercocebus atys | 66.42 | 0.0 | 1036 |
| LLPS-Paa-4073 | Papio anubis | 66.42 | 0.0 | 1036 |
| LLPS-Orc-3523 | Oryctolagus cuniculus | 66.38 | 0.0 | 1051 |
| LLPS-Sus-4766 | Sus scrofa | 65.5 | 0.0 | 1035 |
| LLPS-Aon-1614 | Aotus nancymaae | 65.04 | 0.0 | 1017 |
| LLPS-Dio-2813 | Dipodomys ordii | 65.02 | 0.0 | 1100 |
| LLPS-Cap-1795 | Cavia porcellus | 64.99 | 0.0 | 1139 |
| LLPS-Man-2232 | Macaca nemestrina | 64.5 | 0.0 | 989 |
| LLPS-Mum-2160 | Mus musculus | 64.17 | 0.0 | 1102 |
| LLPS-Ran-2332 | Rattus norvegicus | 64.01 | 0.0 | 1106 |
| LLPS-Mal-3969 | Mandrillus leucophaeus | 63.69 | 0.0 | 981 |
| LLPS-Sah-1231 | Sarcophilus harrisii | 62.79 | 0.0 | 983 |
| LLPS-Fud-2895 | Fukomys damarensis | 62.56 | 0.0 | 1083 |
| LLPS-Loa-2298 | Loxodonta africana | 61.27 | 0.0 | 1069 |
| LLPS-Otg-2043 | Otolemur garnettii | 60.98 | 0.0 | 915 |
| LLPS-Xet-3742 | Xenopus tropicalis | 60.84 | 0.0 | 1078 |
| LLPS-Leo-3878 | Lepisosteus oculatus | 59.58 | 0.0 | 1061 |
| LLPS-Rhb-4179 | Rhinopithecus bieti | 59.36 | 0.0 | 962 |
| LLPS-Lac-3767 | Latimeria chalumnae | 59.23 | 0.0 | 956 |
| LLPS-Gaa-1985 | Gasterosteus aculeatus | 59.23 | 0.0 | 1053 |
| LLPS-Anp-0583 | Anas platyrhynchos | 59.2 | 0.0 | 1042 |
| LLPS-Urm-3665 | Ursus maritimus | 58.98 | 0.0 | 982 |
| LLPS-Asm-1632 | Astyanax mexicanus | 58.14 | 0.0 | 953 |
| LLPS-Aso-0034 | Aspergillus oryzae | 55.7 | 1e-109 | 346 |
| LLPS-Cii-2133 | Ciona intestinalis | 51.58 | 0.0 | 854 |
| LLPS-Cae-1542 | Caenorhabditis elegans | 49.15 | 9e-178 | 539 |
| LLPS-Drm-0518 | Drosophila melanogaster | 49.09 | 8e-112 | 375 |
| LLPS-Cis-0222 | Ciona savignyi | 48.04 | 3e-107 | 345 |
| LLPS-Zyt-0373 | Zymoseptoria tritici | 47.71 | 2e-142 | 450 |
| LLPS-Yal-0673 | Yarrowia lipolytica | 47.12 | 2e-147 | 464 |
| LLPS-Scs-0053 | Sclerotinia sclerotiorum | 46.99 | 6e-142 | 449 |
| LLPS-Map-0232 | Magnaporthe poae | 46.69 | 1e-137 | 443 |
| LLPS-Scc-0696 | Schizosaccharomyces cryophilus | 46.23 | 4e-161 | 497 |
| LLPS-Miv-0848 | Microbotryum violaceum | 45.91 | 7e-153 | 478 |
| LLPS-Abg-0289 | Absidia glauca | 45.85 | 7e-99 | 348 |
| LLPS-Gas-0834 | Galdieria sulphuraria | 45.72 | 1e-94 | 331 |
| LLPS-Scp-0104 | Schizosaccharomyces pombe | 45.63 | 4e-160 | 494 |
| LLPS-Asg-0490 | Ashbya gossypii | 45.43 | 1e-95 | 338 |
| LLPS-Tum-0196 | Tuber melanosporum | 45.34 | 8e-99 | 347 |
| LLPS-Phn-0719 | Phaeosphaeria nodorum | 45.3 | 6e-157 | 489 |
| LLPS-Spr-0895 | Sporisorium reilianum | 45.24 | 1e-154 | 483 |
| LLPS-Kop-0927 | Komagataella pastoris | 45.22 | 1e-161 | 499 |
| LLPS-Asn-1238 | Aspergillus nidulans | 44.84 | 5e-157 | 488 |
| LLPS-Nef-0660 | Neosartorya fischeri | 44.82 | 8e-158 | 490 |
| LLPS-Asfu-0575 | Aspergillus fumigatus | 44.82 | 2e-157 | 490 |
| LLPS-Sac-0388 | Saccharomyces cerevisiae | 44.67 | 7e-156 | 485 |
| LLPS-Trr-1420 | Trichoderma reesei | 44.62 | 2e-97 | 343 |
| LLPS-Asni-0795 | Aspergillus niger | 44.54 | 2e-153 | 479 |
| LLPS-Ast-1325 | Aspergillus terreus | 44.48 | 3e-156 | 486 |
| LLPS-Crn-0084 | Cryptococcus neoformans | 44.48 | 2e-153 | 480 |
| LLPS-Trv-0010 | Trichoderma virens | 44.36 | 2e-96 | 340 |
| LLPS-Asf-0947 | Aspergillus flavus | 44.31 | 1e-155 | 484 |
| LLPS-Nec-1508 | Neurospora crassa | 44.24 | 6e-97 | 342 |
| LLPS-Pytr-0235 | Pyrenophora triticirepentis | 44.23 | 2e-154 | 482 |
| LLPS-Pyt-0220 | Pyrenophora teres | 44.23 | 2e-154 | 482 |
| LLPS-Asc-0963 | Aspergillus clavatus | 44.2 | 4e-156 | 487 |
| LLPS-Fuv-1577 | Fusarium verticillioides | 44.13 | 2e-97 | 343 |
| LLPS-Mao-0493 | Magnaporthe oryzae | 44.07 | 1e-95 | 338 |
| LLPS-Mod-1605 | Monodelphis domestica | 44.05 | 1e-150 | 474 |
| LLPS-Orl-3620 | Oryzias latipes | 43.87 | 1e-152 | 479 |
| LLPS-Cogr-1032 | Colletotrichum graminicola | 43.84 | 1e-153 | 479 |
| LLPS-Gag-1530 | Gaeumannomyces graminis | 43.81 | 1e-96 | 341 |
| LLPS-Fus-0792 | Fusarium solani | 43.74 | 1e-150 | 471 |
| LLPS-Meg-0718 | Meleagris gallopavo | 43.69 | 1e-149 | 471 |
| LLPS-Anc-0824 | Anolis carolinensis | 43.69 | 8e-149 | 470 |
| LLPS-Dos-0166 | Dothistroma septosporum | 43.51 | 2e-155 | 484 |
| LLPS-Cog-1074 | Colletotrichum gloeosporioides | 43.46 | 4e-149 | 468 |
| LLPS-Orn-2155 | Oreochromis niloticus | 43.39 | 8e-149 | 469 |
| LLPS-Scm-1302 | Scophthalmus maximus | 43.34 | 2e-144 | 457 |
| LLPS-Coo-1325 | Colletotrichum orbiculare | 43.04 | 4e-97 | 342 |
| LLPS-Beb-0263 | Beauveria bassiana | 43.0 | 2e-147 | 463 |
| LLPS-Ved-1490 | Verticillium dahliae | 42.89 | 3e-95 | 337 |
| LLPS-Blg-1136 | Blumeria graminis | 42.44 | 9e-148 | 464 |
| LLPS-Usm-0057 | Ustilago maydis | 42.41 | 9e-155 | 483 |
| LLPS-Pug-0738 | Puccinia graminis | 40.99 | 1e-158 | 489 |
| LLPS-Mel-1264 | Melampsora laricipopulina | 40.48 | 3e-157 | 490 |
| LLPS-Fuo-0286 | Fusarium oxysporum | 40.17 | 3e-155 | 483 |
| LLPS-Ere-0264 | Erinaceus europaeus | 40.07 | 1e-128 | 410 |
| LLPS-Put-1287 | Puccinia triticina | 38.0 | 1e-124 | 402 |
| LLPS-Tut-1124 | Tursiops truncatus | 37.15 | 2e-99 | 331 |
| LLPS-Scj-0560 | Schizosaccharomyces japonicus | 34.98 | 1e-153 | 478 |