DrLLPS - Data resource of LLPS

LLPS-Ran-2028
Grb2

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
Gene Name:	Grb2, Ash
Ensembl Gene:	ENSRNOG00000003990.6
Ensembl Protein:	ENSRNOP00000005347.4
Organism:	Rattus norvegicus
Taxa ID:	10116
LLPS Type:	Scaffold

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Droplet, Centrosome/Spindle pole body, Stress granule, Receptor cluster	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1126	P62993	Scaffold	Droplet, Centrosome/Spindle pole body, Stress granule, Receptor cluster	100.00	2e-162	455

▼ FUNCTION

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSRNOT00000005347.5	ENSRNOP00000005347.4
UniProt		P62994, GRB2_RAT, P29354, Q14450, Q5BKA7, Q63057, Q63059
GeneBank	D49846, X62853, BC091144, D49847	CAA44665.1, BAA08646.1, BAA08645.1, AAH91144.1
RefSeq	NM_030846.2	NP_110473.2
Entrez	81504

▼ SEQUENCE

Protein Sequence (FASTA)
1 MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60 61 FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120 121 WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 180 181 DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV 217
Nucleotide CDS Sequence (FASTA)
1 ATGGAAGCCA TCGCCAAATA TGACTTCAAA GCTACTGCTG ACGATGAGCT GAGCTTCAAG 60 61 AGGGGGGACA TCCTTAAGGT TTTGAATGAA GAGTGTGATC AGAACTGGTA TAAGGCAGAA 120 121 CTCAATGGGA AAGATGGCTT CATCCCCAAG AATTACATAG AAATGAAACC ACATCCGTGG 180 181 TTTTTTGGCA AAATCCCCAG AGCAAAGGCA GAAGAAATGC TTAGCAAACA GCGGCATGAC 240 241 GGGGCCTTCC TGATCCGAGA GAGCGAGAGC GCTCCTGGGG ATTTCTCCCT GTCAGTCAAG 300 301 TTTGGAAATG ATGTACAGCA CTTCAAGGTG CTTCGTGACG GAGCCGGGAA GTACTTCCTG 360 361 TGGGTGGTGA AGTTTAATTC TTTGAATGAG CTGGTAGATT ACCACAGATC AACATCCGTG 420 421 TCCAGGAACC AGCAGATATT CCTCCGGGAC ATAGAACAGG TGCCACAGCA GCCAACGTAC 480 481 GTCCAGGCAC TCTTTGACTT TGACCCCCAG GAGGATGGTG AGCTGGGCTT TCGCCGAGGA 540 541 GACTTCATTC ATGTCATGGA TAACTCAGAT CCCAATTGGT GGAAAGGGGC CTGCCATGGG 600 601 CAGACCGGCA TGTTTCCCCG CAATTATGTC ACCCCAGTGA ACCGGAACGT CTAA 654

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0967	Endosome
KW-0333	Golgi apparatus
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0677	Repeat
KW-0727	SH2 domain
KW-0728	SH3 domain

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005911	Cellular Component	Cell-cell junction
GO:0008180	Cellular Component	COP9 signalosome
GO:0005737	Cellular Component	Cytoplasm
GO:0005829	Cellular Component	Cytosol
GO:0005768	Cellular Component	Endosome
GO:0005794	Cellular Component	Golgi apparatus
GO:0070436	Cellular Component	Grb2-EGFR complex
GO:0005730	Cellular Component	Nucleolus
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0032991	Cellular Component	Protein-containing complex
GO:0012506	Cellular Component	Vesicle membrane
GO:0019899	Molecular Function	Enzyme binding
GO:0046875	Molecular Function	Ephrin receptor binding
GO:0005154	Molecular Function	Epidermal growth factor receptor binding
GO:0042802	Molecular Function	Identical protein binding
GO:0043560	Molecular Function	Insulin receptor substrate binding
GO:0005168	Molecular Function	Neurotrophin TRKA receptor binding
GO:0051219	Molecular Function	Phosphoprotein binding
GO:0001784	Molecular Function	Phosphotyrosine residue binding
GO:0019904	Molecular Function	Protein domain specific binding
GO:0019901	Molecular Function	Protein kinase binding
GO:0019903	Molecular Function	Protein phosphatase binding
GO:0017124	Molecular Function	SH3 domain binding
GO:0005070	Molecular Function	SH3/SH2 adaptor activity
GO:0007568	Biological Process	Aging
GO:0048646	Biological Process	Anatomical structure formation involved in morphogenesis
GO:0060670	Biological Process	Branching involved in labyrinthine layer morphogenesis
GO:0030154	Biological Process	Cell differentiation
GO:0071479	Biological Process	Cellular response to ionizing radiation
GO:0008286	Biological Process	Insulin receptor signaling pathway
GO:0030838	Biological Process	Positive regulation of actin filament polymerization
GO:2000379	Biological Process	Positive regulation of reactive oxygen species metabolic process
GO:0051291	Biological Process	Protein heterooligomerization
GO:0007265	Biological Process	Ras protein signal transduction
GO:0031623	Biological Process	Receptor internalization
GO:0043408	Biological Process	Regulation of MAPK cascade
GO:0042770	Biological Process	Signal transduction in response to DNA damage

▼ KEGG

rno:81504

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	PTMcode

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
iEKPD	CORUM

Localization
COMPARTMENTS

Expression
ArrayExpress	TISSUES

Element
miRTarBase	miRWalk	RAID

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-0055	Gorilla gorilla	100.0	2e-162	455
LLPS-Caj-2802	Callithrix jacchus	100.0	2e-162	455
LLPS-Fud-4366	Fukomys damarensis	100.0	2e-162	455
LLPS-Chs-3262	Chlorocebus sabaeus	100.0	2e-162	455
LLPS-Maf-3331	Macaca fascicularis	100.0	2e-162	455
LLPS-Sus-0356	Sus scrofa	100.0	2e-162	455
LLPS-Cea-0827	Cercocebus atys	100.0	2e-162	455
LLPS-Aon-1471	Aotus nancymaae	100.0	2e-162	455
LLPS-Mup-0708	Mustela putorius furo	100.0	2e-162	455
LLPS-Myl-4356	Myotis lucifugus	100.0	2e-162	455
LLPS-Paa-2270	Papio anubis	100.0	2e-162	455
LLPS-Bot-3287	Bos taurus	100.0	2e-162	455
LLPS-Dio-4311	Dipodomys ordii	100.0	2e-162	455
LLPS-Otg-2488	Otolemur garnettii	100.0	2e-162	455
LLPS-Rhb-1950	Rhinopithecus bieti	100.0	2e-162	455
LLPS-Orc-3409	Oryctolagus cuniculus	100.0	2e-162	455
LLPS-Fec-4440	Felis catus	100.0	2e-162	455
LLPS-Hos-1126	Homo sapiens	100.0	2e-162	455
LLPS-Pat-1955	Pan troglodytes	100.0	2e-162	455
LLPS-Urm-3048	Ursus maritimus	100.0	2e-162	455
LLPS-Pap-2127	Pan paniscus	100.0	2e-162	455
LLPS-Man-2683	Macaca nemestrina	100.0	2e-162	455
LLPS-Cas-3293	Carlito syrichta	100.0	2e-162	455
LLPS-Nol-1797	Nomascus leucogenys	100.0	2e-162	455
LLPS-Ict-2782	Ictidomys tridecemlineatus	100.0	2e-162	455
LLPS-Cap-3753	Cavia porcellus	100.0	2e-162	455
LLPS-Eqc-3391	Equus caballus	100.0	2e-162	455
LLPS-Poa-0227	Pongo abelii	100.0	2e-162	455
LLPS-Caf-2348	Canis familiaris	100.0	2e-162	455
LLPS-Mam-2993	Macaca mulatta	100.0	2e-162	455
LLPS-Mum-4436	Mus musculus	99.54	7e-162	453
LLPS-Mea-0768	Mesocricetus auratus	99.54	6e-162	453
LLPS-Mal-0689	Mandrillus leucophaeus	99.54	6e-162	453
LLPS-Aim-3644	Ailuropoda melanoleuca	99.48	1e-142	404
LLPS-Mod-1313	Monodelphis domestica	97.7	3e-159	447
LLPS-Meg-1203	Meleagris gallopavo	97.7	3e-159	447
LLPS-Gaga-3593	Gallus gallus	97.7	3e-159	447
LLPS-Anp-0508	Anas platyrhynchos	97.38	2e-139	395
LLPS-Pes-2879	Pelodiscus sinensis	97.24	1e-158	445
LLPS-Anc-3657	Anolis carolinensis	97.24	4e-159	446
LLPS-Fia-3669	Ficedula albicollis	96.77	3e-157	441
LLPS-Tag-1741	Taeniopygia guttata	96.31	7e-157	441
LLPS-Leo-2654	Lepisosteus oculatus	95.85	6e-157	441
LLPS-Lac-0703	Latimeria chalumnae	95.52	3e-88	269
LLPS-Icp-1162	Ictalurus punctatus	94.93	2e-155	437
LLPS-Scf-1099	Scleropages formosus	94.93	2e-154	434
LLPS-Dar-3113	Danio rerio	94.93	1e-155	437
LLPS-Gaa-3259	Gasterosteus aculeatus	94.47	8e-155	435
LLPS-Asm-3107	Astyanax mexicanus	94.01	2e-154	434
LLPS-Xim-0975	Xiphophorus maculatus	94.01	1e-154	435
LLPS-Pof-1785	Poecilia formosa	94.01	1e-154	435
LLPS-Orl-1653	Oryzias latipes	93.58	2e-152	429
LLPS-Scm-0763	Scophthalmus maximus	93.15	9e-153	430
LLPS-Ova-0545	Ovis aries	92.66	9e-148	417
LLPS-Xet-3767	Xenopus tropicalis	91.7	9e-154	433
LLPS-Orn-4004	Oreochromis niloticus	91.24	5e-150	423
LLPS-Loa-0716	Loxodonta africana	90.65	3e-145	411
LLPS-Tar-3979	Takifugu rubripes	83.98	8e-143	405
LLPS-Ten-2338	Tetraodon nigroviridis	74.36	2e-75	231
LLPS-Cis-1256	Ciona savignyi	67.11	5e-67	214
LLPS-Cii-2332	Ciona intestinalis	62.84	3e-57	185
LLPS-Ora-0049	Ornithorhynchus anatinus	52.67	2e-48	167
LLPS-Sah-3001	Sarcophilus harrisii	51.32	4e-45	158
LLPS-Tut-0280	Tursiops truncatus	42.37	2e-06	51.6

LLPS-Ran-2028Grb2

Protein Sequence

Nucleotide Sequence

LLPS-Ran-2028
Grb2