LLPS-Ran-1897
Cdc20

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cell division cycle protein 20 homolog; p55CDC
Gene Name: Cdc20
Ensembl Gene: ENSRNOG00000028415.4
Ensembl Protein: ENSRNOP00000037772.3
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Interacts with NEK2 (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAQFVFESDL  HSLLQLDAPI  PNAPIARWQR  KAKEATGPAP  SPMRAANRSH  SAGRTPGRTP  60
61    GKSNSKVQTT  PSKPGGDRYI  PQRSASQMEV  ASFLLSKENQ  PEDGGTPTKK  EHQKAWARNL  120
121   NGFDVEEAKI  LRLSGKPQNA  PEGYQNRLKV  LYSQKATPGS  SRKACRYIPS  LPDRILDAPE  180
181   IRNDYYLNLV  DWSSGNVLAV  ALDNSVYLWN  AGSGDILQLL  QMEQPGDYIS  SVAWIKEGNY  240
241   LAVGTSNAEV  QLWDVQQQKR  LRNMTSHSAR  VSSLSWNSYI  LSSGSRSGHI  HHHDVRVAEH  300
301   HVATLSGHSQ  EVCGLRWAPD  GRHLASGGND  NIVNVWPSGP  GESGWVPLQT  FTQHQGAVKA  360
361   VAWCPWQSNI  LATGGGTSDR  HIRIWNVCSG  ACLSAVDVHS  QVCSILWSPH  YKELISGHGF  420
421   AQNQLVIWKY  PTMAKVAELK  GHTARVLSLT  MSPDGATVAS  AAADETLRLW  RCFELDPALR  480
481   REREKASTSK  SSLIHQGIR  499
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCAGT  TCGTGTTCGA  GAGCGATTTG  CATTCACTGC  TTCAACTGGA  CGCGCCCATC  60
61    CCCAATGCAC  CGATTGCTCG  CTGGCAGCGC  AAAGCAAAAG  AAGCCACAGG  CCCAGCCCCC  120
121   TCGCCTATGC  GGGCCGCCAA  CAGATCACAC  AGCGCCGGTC  GGACCCCGGG  CCGAACTCCT  180
181   GGCAAATCTA  ATTCTAAGGT  TCAGACCACC  CCTAGCAAAC  CTGGAGGTGA  CCGCTATATC  240
241   CCCCAACGTA  GTGCTTCCCA  AATGGAGGTG  GCCAGCTTCC  TCTTGAGCAA  GGAGAACCAG  300
301   CCGGAAGACG  GGGGTACGCC  CACCAAGAAG  GAGCATCAGA  AAGCCTGGGC  TCGGAACCTG  360
361   AACGGTTTTG  ATGTGGAGGA  AGCCAAGATC  CTCAGGCTCA  GTGGAAAACC  TCAGAATGCC  420
421   CCAGAAGGCT  ACCAGAACAG  ATTGAAAGTA  CTCTACAGCC  AGAAAGCCAC  GCCTGGCTCC  480
481   AGTCGGAAGG  CTTGCAGATA  CATTCCTTCC  CTGCCAGACA  GGATTCTTGA  TGCCCCTGAA  540
541   ATCCGGAATG  ACTACTACCT  GAATCTTGTC  GATTGGAGCT  CTGGAAATGT  ATTAGCTGTG  600
601   GCACTGGACA  ACAGTGTGTA  CTTATGGAAC  GCTGGTTCCG  GTGACATCCT  GCAGCTGTTG  660
661   CAAATGGAGC  AGCCTGGGGA  CTACATATCA  TCCGTGGCCT  GGATCAAAGA  GGGCAACTAC  720
721   CTGGCTGTGG  GCACCAGTAA  TGCTGAGGTG  CAGCTATGGG  ATGTGCAGCA  GCAGAAACGG  780
781   CTTCGAAACA  TGACCAGCCA  CTCTGCTCGA  GTAAGCTCCC  TGAGTTGGAA  CAGCTATATC  840
841   CTGTCAAGTG  GTTCACGATC  TGGCCACATC  CACCACCACG  ATGTTCGAGT  AGCAGAACAC  900
901   CATGTGGCCA  CACTGAGTGG  CCATAGCCAG  GAAGTATGTG  GGCTGCGCTG  GGCCCCAGAT  960
961   GGACGACATC  TGGCAAGCGG  TGGCAATGAT  AACATTGTCA  ACGTGTGGCC  TAGTGGTCCT  1020
1021  GGAGAAAGTG  GCTGGGTTCC  CCTGCAGACA  TTCACTCAAC  ATCAAGGTGC  TGTCAAGGCT  1080
1081  GTTGCATGGT  GTCCCTGGCA  GTCCAATATC  CTGGCAACAG  GAGGAGGTAC  CAGTGACCGA  1140
1141  CACATTCGCA  TTTGGAACGT  CTGCTCTGGA  GCCTGTCTGA  GTGCTGTGGA  TGTGCATTCC  1200
1201  CAGGTGTGCT  CCATCCTCTG  GTCTCCCCAC  TATAAGGAGC  TCATCTCAGG  CCATGGCTTT  1260
1261  GCCCAGAACC  AGCTGGTTAT  TTGGAAGTAC  CCAACCATGG  CCAAGGTGGC  AGAGCTCAAA  1320
1321  GGTCACACAG  CCCGGGTCCT  GAGTCTCACC  ATGAGTCCAG  ACGGGGCCAC  AGTGGCATCT  1380
1381  GCAGCAGCCG  ATGAGACTCT  GCGGCTCTGG  CGCTGCTTTG  AGCTGGACCC  TGCCCTTCGG  1440
1441  CGGGAGCGGG  AAAAAGCCAG  CACATCTAAA  AGTAGCCTCA  TCCACCAAGG  CATCCGGTGA  1500

▼ KEYWORD

ID
Family
Acetylation
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Isopeptide bond
Mitosis
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation
Ubl conjugation pathway
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Anaphase-promoting complex
Cellular Component
Centrosome
Cellular Component
Cytosol
Cellular Component
Nucleoplasm
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Protein-containing complex
Cellular Component
Spindle pole
Molecular Function
Anaphase-promoting complex binding
Molecular Function
Histone deacetylase binding
Molecular Function
Protein C-terminus binding
Molecular Function
Ubiquitin-protein transferase activator activity
Biological Process
Anaphase-promoting complex-dependent catabolic process
Biological Process
Cell division
Biological Process
Mitotic sister chromatid cohesion
Biological Process
Mitotic spindle assembly
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of synapse maturation
Biological Process
Positive regulation of synaptic plasticity
Biological Process
Positive regulation of ubiquitin protein ligase activity
Biological Process
Protein ubiquitination
Biological Process
Regulation of dendrite development
Biological Process
Regulation of meiotic nuclear division

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-1649Mus musculus97.60.0 958
LLPS-Mea-0393Mesocricetus auratus97.190.0 955
LLPS-Ict-1396Ictidomys tridecemlineatus96.390.0 945
LLPS-Eqc-0448Equus caballus96.20.0 896
LLPS-Cap-0628Cavia porcellus95.790.0 938
LLPS-Orc-1587Oryctolagus cuniculus95.590.0 936
LLPS-Dio-1481Dipodomys ordii95.590.0 935
LLPS-Cas-0353Carlito syrichta95.390.0 939
LLPS-Urm-1258Ursus maritimus95.390.0 936
LLPS-Aim-0795Ailuropoda melanoleuca95.190.0 935
LLPS-Sus-0552Sus scrofa95.190.0 936
LLPS-Pat-0235Pan troglodytes94.990.0 933
LLPS-Pap-1359Pan paniscus94.990.0 933
LLPS-Hos-0405Homo sapiens94.990.0 933
LLPS-Mup-1168Mustela putorius furo94.990.0 935
LLPS-Gog-0808Gorilla gorilla94.990.0 933
LLPS-Poa-0583Pongo abelii94.790.0 933
LLPS-Mam-1204Macaca mulatta94.790.0 933
LLPS-Fec-0145Felis catus94.790.0 931
LLPS-Man-0845Macaca nemestrina94.790.0 933
LLPS-Rhb-1289Rhinopithecus bieti94.790.0 933
LLPS-Mal-2807Mandrillus leucophaeus94.790.0 933
LLPS-Paa-0034Papio anubis94.790.0 933
LLPS-Maf-1009Macaca fascicularis94.790.0 933
LLPS-Chs-0782Chlorocebus sabaeus94.790.0 933
LLPS-Cea-3390Cercocebus atys94.790.0 933
LLPS-Caf-0605Canis familiaris94.590.0 929
LLPS-Nol-1243Nomascus leucogenys94.590.0 926
LLPS-Tut-0690Tursiops truncatus94.590.0 926
LLPS-Bot-3451Bos taurus94.390.0 929
LLPS-Loa-0155Loxodonta africana93.990.0 924
LLPS-Caj-1701Callithrix jacchus93.990.0 927
LLPS-Aon-1881Aotus nancymaae93.660.0 905
LLPS-Otg-0169Otolemur garnettii93.60.0 920
LLPS-Fud-0456Fukomys damarensis92.530.0 911
LLPS-Ova-0831Ovis aries89.110.0 855
LLPS-Myl-3317Myotis lucifugus88.020.0 855
LLPS-Sah-2155Sarcophilus harrisii87.60.0 860
LLPS-Mod-2862Monodelphis domestica86.850.0 746
LLPS-Anp-0961Anas platyrhynchos80.230.0 712
LLPS-Meg-0344Meleagris gallopavo80.160.0 804
LLPS-Pes-1214Pelodiscus sinensis80.160.0 805
LLPS-Fia-1493Ficedula albicollis80.160.0 796
LLPS-Tag-0185Taeniopygia guttata79.560.0 796
LLPS-Gaga-1299Gallus gallus79.330.0 799
LLPS-Anc-1228Anolis carolinensis76.230.0 753
LLPS-Ora-0458Ornithorhynchus anatinus75.50.0 709
LLPS-Xet-0294Xenopus tropicalis73.880.0 763
LLPS-Orn-1972Oreochromis niloticus62.970.0 629
LLPS-Xim-2509Xiphophorus maculatus62.970.0 619
LLPS-Scm-0790Scophthalmus maximus62.850.0 622
LLPS-Lac-0959Latimeria chalumnae62.770.0 608
LLPS-Leo-1664Lepisosteus oculatus62.720.0 627
LLPS-Gaa-1247Gasterosteus aculeatus62.620.0 608
LLPS-Scf-3321Scleropages formosus62.550.0 614
LLPS-Orl-0031Oryzias latipes62.250.0 607
LLPS-Asm-2306Astyanax mexicanus62.150.0 609
LLPS-Ten-1599Tetraodon nigroviridis61.190.0 607
LLPS-Icp-1444Ictalurus punctatus60.960.0 600
LLPS-Dar-0590Danio rerio60.560.0 596
LLPS-Pof-0520Poecilia formosa59.960.0 573
LLPS-Tar-0947Takifugu rubripes54.082e-139 417
LLPS-Kop-0656Komagataella pastoris52.73e-97 311
LLPS-Cym-0041Cyanidioschyzon merolae51.912e-112 350
LLPS-Scp-0049Schizosaccharomyces pombe51.725e-95 303
LLPS-Zem-0720Zea mays51.621e-94 303
LLPS-Brd-0875Brachypodium distachyon51.628e-94 303
LLPS-Tra-1668Triticum aestivum51.629e-95 303
LLPS-Cii-0646Ciona intestinalis51.253e-164 483
LLPS-Orm-0264Oryza meridionalis50.974e-94 302
LLPS-Orr-0232Oryza rufipogon50.976e-94 302
LLPS-Org-0822Oryza glaberrima50.975e-94 302
LLPS-Ors-0181Oryza sativa50.975e-94 302
LLPS-Orp-0010Oryza punctata50.974e-94 302
LLPS-Orbr-1838Oryza brachyantha50.971e-93 302
LLPS-Orgl-1476Oryza glumaepatula50.976e-94 301
LLPS-Orni-0171Oryza nivara50.975e-94 302
LLPS-Cis-1472Ciona savignyi50.942e-169 496
LLPS-Nec-1044Neurospora crassa50.632e-93 303
LLPS-Amt-0571Amborella trichopoda50.486e-95 305
LLPS-Yal-0381Yarrowia lipolytica50.454e-103 326
LLPS-Chr-0277Chlamydomonas reinhardtii50.232e-129 392
LLPS-Ast-0845Aspergillus terreus50.162e-100 321
LLPS-Drm-0025Drosophila melanogaster50.02e-159 471
LLPS-Sem-0080Selaginella moellendorffii49.691e-93 300
LLPS-Tum-1282Tuber melanosporum49.367e-96 307
LLPS-Asni-0673Aspergillus niger49.236e-98 314
LLPS-Osl-0199Ostreococcus lucimarinus49.194e-129 390
LLPS-Aso-1109Aspergillus oryzae49.072e-97 313
LLPS-Asf-0759Aspergillus flavus49.072e-97 313
LLPS-Pug-1152Puccinia graminis49.063e-94 305
LLPS-Hea-1957Helianthus annuus48.961e-95 305
LLPS-Asfu-1113Aspergillus fumigatus48.778e-98 314
LLPS-Nef-0516Neosartorya fischeri48.776e-98 314
LLPS-Asc-1429Aspergillus clavatus48.772e-98 314
LLPS-Mel-1441Melampsora laricipopulina48.332e-93 302
LLPS-Fus-1367Fusarium solani48.33e-93 302
LLPS-Asn-1409Aspergillus nidulans48.061e-98 316
LLPS-Fuo-1370Fusarium oxysporum47.994e-93 293
LLPS-Fuv-0104Fusarium verticillioides47.992e-93 298
LLPS-Scj-0160Schizosaccharomyces japonicus47.856e-93 298
LLPS-Sol-1570Solanum lycopersicum47.592e-97 309
LLPS-Map-0782Magnaporthe poae47.382e-101 323
LLPS-Gas-0174Galdieria sulphuraria47.051e-137 413
LLPS-Miv-0054Microbotryum violaceum47.043e-93 301
LLPS-Arl-1349Arabidopsis lyrata47.021e-117 361
LLPS-Lep-0364Leersia perrieri46.972e-114 353
LLPS-Orb-0859Oryza barthii46.973e-114 352
LLPS-Ori-1072Oryza indica46.971e-114 353
LLPS-Nia-0597Nicotiana attenuata46.564e-97 308
LLPS-Coo-1173Colletotrichum orbiculare46.538e-97 311
LLPS-Phv-0845Phaseolus vulgaris46.491e-116 358
LLPS-Vir-0340Vigna radiata46.491e-117 361
LLPS-Gor-0684Gossypium raimondii46.281e-114 353
LLPS-Via-0004Vigna angularis46.254e-117 359
LLPS-Glm-0880Glycine max46.252e-114 352
LLPS-Coc-1228Corchorus capsularis46.195e-112 345
LLPS-Bro-0630Brassica oleracea46.13e-114 352
LLPS-Prp-0392Prunus persica46.057e-113 348
LLPS-Thc-0626Theobroma cacao46.043e-113 349
LLPS-Scs-0284Sclerotinia sclerotiorum46.011e-98 316
LLPS-Cus-0056Cucumis sativus45.899e-113 348
LLPS-Mua-0525Musa acuminata45.826e-120 367
LLPS-Sei-1121Setaria italica45.816e-116 357
LLPS-Met-0287Medicago truncatula45.83e-115 355
LLPS-Pot-2001Populus trichocarpa45.633e-112 347
LLPS-Dac-0281Daucus carota45.567e-116 356
LLPS-Viv-1461Vitis vinifera45.452e-110 342
LLPS-Brr-1836Brassica rapa44.91e-111 353
LLPS-Hov-0240Hordeum vulgare44.813e-109 342
LLPS-Tru-0515Triticum urartu44.522e-118 363
LLPS-Brn-2181Brassica napus43.999e-99 313
LLPS-Lem-0323Leptosphaeria maculans43.119e-101 322
LLPS-Pytr-0300Pyrenophora triticirepentis42.62e-100 321
LLPS-Pyt-1253Pyrenophora teres42.62e-100 321
LLPS-Sot-2036Solanum tuberosum42.252e-100 317
LLPS-Cogr-0287Colletotrichum graminicola41.877e-99 317
LLPS-Trv-1118Trichoderma virens41.454e-101 323
LLPS-Phn-0437Phaeosphaeria nodorum41.363e-102 325
LLPS-Zyt-0289Zymoseptoria tritici41.28e-99 317
LLPS-Blg-1287Blumeria graminis40.832e-97 313
LLPS-Gag-0195Gaeumannomyces graminis40.623e-103 328
LLPS-Cog-0806Colletotrichum gloeosporioides40.562e-99 319
LLPS-Trr-0480Trichoderma reesei40.493e-100 317
LLPS-Ved-0086Verticillium dahliae40.351e-98 316
LLPS-Beb-0614Beauveria bassiana40.35e-99 317
LLPS-Mao-0218Magnaporthe oryzae39.817e-101 322
LLPS-Dos-0362Dothistroma septosporum39.561e-97 314