• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Brr-1836

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit K
Ensembl Gene: Bra011430
Ensembl Protein: Bra011430.1-P
Organism: Brassica rapa
Taxa ID: 51351
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblBra011430.1Bra011430.1-P
UniProtM4D4M6, M4D4M6_BRARP

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDAGMNTSTH  LKAQARCPLQ  EHFLPRKSSK  ENLDRFIPNR  SAMDFDYAHY  ALTEGRNGKD  60
61    QVTAAVSSPS  REAYRKQLAE  TMNLNHTRIL  AFRNKPQAPV  ELLPTDHSAS  LLHQQPKSVK  120
121   PRRYIPQTSE  RTLDAPDIVD  DFYLNLLDWG  SANVLAIALG  HTVYLWDASS  GSTSELVTID  180
181   EEKGPVTSIN  WAPDGRHVAL  GLNNSEVQLW  DSGSNRQLRT  LKGCHQSRVG  SLAWNNHILT  240
241   TGGMDGQIVN  NDVRIRSHVV  ETYRGHTQEV  CGLKWSGSGQ  QLASGGNDNV  VHIWDRSAAS  300
301   SNSTTQYLHR  LEEHTSAVKA  LAWCPFQANL  LATGGGGGDR  TIKFWNTHTG  ACLNSVDTGS  360
361   QVCSLLWSKN  ERELLSSHGF  TQNQLTLWKY  PSMVKMAELT  GHTSRVLYMA  QSPDGCTVAS  420
421   AAGDETLRFW  NVFGVPETAK  KAAPKATHEP  FSHVNLIAQL  IKRRRFGTKT  LDPSPPSTVI  480
481   NRARKREMGK  EMESPKEQSS  YTVEQLVAVN  PFNPEILPDL  ENYVNEQVTS  QTYSLDANLC  540
541   LLRLYQFEPE  RMNTHIVARI  LLKALMAMPA  PDFSLCLFLI  PERVQMEEQF  KTLIVLSHYL  600
601   ETGRFQQFWD  EAAKNRHILE  SVPGFEQAIQ  AYASHLLSLS  YQKVPRSVLA  EAVNMDGASL  660
661   DKFIEHQVAN  SGWIVAKEDG  SIVLPQNEFN  RPELKKNPGE  NVSLEHIARI  FPILG  715
Nucleotide CDS Sequence (FASTA)
1     ATGGATGCAG  GTATGAACAC  ATCTACGCAC  TTGAAGGCTC  AAGCTCGGTG  CCCACTTCAA  60
61    GAACACTTCC  TTCCCCGGAA  GAGTTCCAAG  GAAAACCTTG  ACAGATTCAT  TCCCAACAGA  120
121   TCAGCCATGG  ACTTCGACTA  TGCTCACTAC  GCTCTTACCG  AAGGTAGGAA  CGGGAAAGAT  180
181   CAGGTAACAG  CAGCGGTAAG  CTCACCGTCC  AGAGAGGCCT  ACAGGAAGCA  ACTCGCTGAG  240
241   ACGATGAACC  TGAACCACAC  TCGGATTCTC  GCCTTCAGAA  ACAAACCTCA  AGCTCCAGTC  300
301   GAGTTGCTTC  CTACAGACCA  CTCTGCTTCT  CTTCTTCACC  AACAGCCCAA  ATCCGTTAAG  360
361   CCTCGCAGAT  ACATTCCTCA  GACTTCTGAG  AGAACATTGG  ATGCACCTGA  CATTGTGGAC  420
421   GACTTCTACC  TCAACTTGCT  TGACTGGGGC  AGTGCTAATG  TCCTTGCCAT  TGCGTTGGGA  480
481   CACACTGTTT  ATCTGTGGGA  TGCTTCCAGC  GGGTCCACTT  CTGAGCTTGT  CACCATTGAT  540
541   GAGGAGAAAG  GACCTGTCAC  GAGTATCAAC  TGGGCACCTG  ATGGTCGTCA  TGTCGCACTT  600
601   GGACTCAACA  ACTCCGAAGT  GCAGCTGTGG  GATTCTGGAT  CCAACCGTCA  ACTGAGGACA  660
661   TTGAAGGGTT  GCCACCAGTC  TAGAGTAGGA  TCATTGGCGT  GGAATAATCA  CATCCTGACG  720
721   ACGGGAGGGA  TGGATGGACA  GATCGTCAAC  AACGACGTGC  GAATCAGATC  ACACGTTGTG  780
781   GAAACTTACA  GAGGTCACAC  TCAAGAGGTC  TGCGGGCTAA  AGTGGTCAGG  ATCCGGACAG  840
841   CAACTAGCGA  GTGGTGGCAA  CGACAATGTT  GTACACATAT  GGGATCGTTC  AGCCGCCTCT  900
901   TCAAACTCGA  CCACTCAGTA  TTTGCACAGG  CTCGAAGAAC  ATACGTCTGC  AGTTAAAGCC  960
961   CTTGCGTGGT  GCCCTTTCCA  AGCGAATCTG  CTTGCTACTG  GTGGTGGTGG  AGGAGATAGG  1020
1021  ACGATAAAGT  TCTGGAACAC  TCACACAGGA  GCTTGCTTGA  ATTCAGTTGA  CACCGGCTCC  1080
1081  CAAGTTTGTT  CGTTGCTGTG  GAGCAAGAAC  GAAAGAGAGT  TGCTTAGCTC  ACACGGGTTT  1140
1141  ACACAGAACC  AGCTTACGTT  GTGGAAGTAC  CCATCTATGG  TGAAAATGGC  TGAGCTCACT  1200
1201  GGTCATACAT  CAAGAGTTCT  ATACATGGCC  CAGAGCCCAG  ATGGTTGTAC  CGTGGCTTCA  1260
1261  GCAGCAGGAG  ATGAAACTCT  GAGATTCTGG  AATGTTTTCG  GAGTACCAGA  GACGGCCAAA  1320
1321  AAAGCAGCTC  CAAAAGCAAC  TCATGAGCCG  TTTTCTCATG  TGAACCTTAT  AGCCCAGTTG  1380
1381  ATAAAGCGTC  GTCGTTTCGG  CACTAAAACC  CTAGATCCAT  CTCCACCCTC  CACAGTAATC  1440
1441  AATCGAGCAC  GGAAGAGAGA  GATGGGAAAA  GAGATGGAGT  CGCCGAAGGA  GCAGAGCTCG  1500
1501  TACACCGTTG  AGCAGCTCGT  CGCCGTCAAT  CCCTTCAACC  CCGAAATCTT  ACCCGATCTC  1560
1561  GAAAACTACG  TCAACGAGCA  GGTTACATCG  CAAACGTATA  GCCTGGATGC  GAATCTATGC  1620
1621  TTGCTTCGTC  TCTATCAGTT  TGAGCCTGAG  CGCATGAACA  CTCACATCGT  GGCTCGAATC  1680
1681  TTGCTCAAGG  CTCTTATGGC  TATGCCAGCT  CCAGACTTCA  GCCTTTGCCT  CTTCTTGATT  1740
1741  CCAGAAAGAG  TGCAAATGGA  GGAGCAGTTC  AAGACGCTTA  TTGTTCTCTC  ACACTACCTT  1800
1801  GAGACTGGGA  GGTTCCAACA  GTTCTGGGAT  GAAGCTGCCA  AGAACCGTCA  CATTCTTGAG  1860
1861  AGTGTTCCAG  GTTTTGAGCA  AGCTATCCAA  GCGTATGCAA  GTCACCTTCT  TAGCTTAAGC  1920
1921  TACCAAAAGG  TTCCAAGATC  TGTGCTTGCC  GAGGCTGTCA  ACATGGATGG  TGCATCTCTA  1980
1981  GACAAGTTCA  TTGAACACCA  AGTGGCTAAC  AGTGGATGGA  TTGTAGCGAA  GGAAGATGGA  2040
2041  AGTATCGTCT  TACCACAGAA  CGAATTTAAC  CGTCCGGAGC  TGAAGAAAAA  TCCAGGTGAG  2100
2101  AATGTTTCCT  TGGAACACAT  TGCCCGCATC  TTCCCCATCC  TTGGTTGA  2148

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Anaphase-promoting complex binding
Molecular Function
Ribosome binding
Molecular Function
Translation initiation factor activity
Molecular Function
Ubiquitin-protein transferase activator activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Positive regulation of ubiquitin protein ligase activity
Biological Process
Regulation of translational initiation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Brn-0424Brassica napus99.118e-158 462
LLPS-Bro-0630Brassica oleracea97.590.0 915
LLPS-Art-2632Arabidopsis thaliana94.10.0 876
LLPS-Gor-0684Gossypium raimondii84.280.0 799
LLPS-Pot-1523Populus trichocarpa82.970.0 795
LLPS-Mae-1502Manihot esculenta82.750.0 785
LLPS-Thc-0626Theobroma cacao82.530.0 787
LLPS-Coc-1228Corchorus capsularis81.650.0 728
LLPS-Glm-2314Glycine max79.910.0 755
LLPS-Phv-0845Phaseolus vulgaris79.480.0 755
LLPS-Vir-0340Vigna radiata79.480.0 759
LLPS-Via-0004Vigna angularis79.260.0 757
LLPS-Sol-1361Solanum lycopersicum78.90.0 754
LLPS-Viv-1461Vitis vinifera78.770.0 753
LLPS-Prp-0392Prunus persica78.60.0 747
LLPS-Sot-0137Solanum tuberosum78.460.0 750
LLPS-Dac-0281Daucus carota78.210.0 732
LLPS-Met-0287Medicago truncatula78.120.0 743
LLPS-Hea-1274Helianthus annuus76.430.0 699
LLPS-Nia-1338Nicotiana attenuata76.197e-125 378
LLPS-Amt-0178Amborella trichopoda75.326e-122 371
LLPS-Tru-0515Triticum urartu74.690.0 639
LLPS-Zem-0211Zea mays73.920.0 645
LLPS-Lep-0725Leersia perrieri73.452e-114 351
LLPS-Tra-0330Triticum aestivum73.334e-112 345
LLPS-Ori-0184Oryza indica72.571e-113 349
LLPS-Brd-1663Brachypodium distachyon72.572e-112 345
LLPS-Sei-1562Setaria italica72.573e-114 350
LLPS-Mua-1744Musa acuminata72.293e-112 345
LLPS-Sob-1774Sorghum bicolor72.123e-113 348
LLPS-Orp-0665Oryza punctata72.121e-112 346
LLPS-Ors-1206Oryza sativa72.125e-113 347
LLPS-Org-0299Oryza glaberrima72.125e-113 347
LLPS-Orr-0601Oryza rufipogon72.125e-113 347
LLPS-Orni-1678Oryza nivara72.125e-113 347
LLPS-Orb-1703Oryza barthii72.125e-113 347
LLPS-Orgl-2152Oryza glumaepatula72.125e-113 347
LLPS-Orm-0682Oryza meridionalis71.790.0 648
LLPS-Hov-1707Hordeum vulgare71.053e-111 343
LLPS-Orbr-0111Oryza brachyantha70.550.0 652
LLPS-Sem-0404Selaginella moellendorffii61.170.0 547
LLPS-Osl-0199Ostreococcus lucimarinus55.114e-157 470
LLPS-Ora-0458Ornithorhynchus anatinus54.118e-116 365
LLPS-Gag-0797Gaeumannomyces graminis52.565e-108 348
LLPS-Yal-0451Yarrowia lipolytica52.452e-112 360
LLPS-Ved-0887Verticillium dahliae52.246e-108 348
LLPS-Scs-0813Sclerotinia sclerotiorum52.245e-108 347
LLPS-Map-0837Magnaporthe poae52.025e-108 348
LLPS-Asni-0673Aspergillus niger51.776e-109 350
LLPS-Mao-1375Magnaporthe oryzae51.712e-107 346
LLPS-Beb-0001Beauveria bassiana51.44e-107 345
LLPS-Trr-1026Trichoderma reesei51.287e-106 341
LLPS-Chr-0277Chlamydomonas reinhardtii51.086e-137 418
LLPS-Trv-1348Trichoderma virens50.787e-106 341
LLPS-Fus-1367Fusarium solani50.645e-106 342
LLPS-Asf-0759Aspergillus flavus50.64e-111 356
LLPS-Aso-1109Aspergillus oryzae50.64e-111 356
LLPS-Fuo-1370Fusarium oxysporum50.477e-108 338
LLPS-Fuv-0104Fusarium verticillioides50.472e-107 342
LLPS-Nec-1044Neurospora crassa50.459e-107 345
LLPS-Kop-0656Komagataella pastoris50.329e-106 340
LLPS-Asc-1429Aspergillus clavatus50.34e-111 354
LLPS-Nef-0516Neosartorya fischeri50.04e-110 353
LLPS-Asfu-1113Aspergillus fumigatus50.04e-110 353
LLPS-Asn-1409Aspergillus nidulans49.75e-110 352
LLPS-Ast-0456Aspergillus terreus49.48e-109 350
LLPS-Gas-0174Galdieria sulphuraria49.311e-137 421
LLPS-Dos-0362Dothistroma septosporum48.81e-106 344
LLPS-Cym-0041Cyanidioschyzon merolae48.724e-112 355
LLPS-Xet-0294Xenopus tropicalis48.091e-125 390
LLPS-Cogr-0341Colletotrichum graminicola48.073e-109 351
LLPS-Coo-0159Colletotrichum orbiculare48.072e-110 349
LLPS-Gaga-1299Gallus gallus47.834e-122 381
LLPS-Meg-0344Meleagris gallopavo47.829e-123 383
LLPS-Cog-0167Colletotrichum gloeosporioides47.795e-108 348
LLPS-Phn-0437Phaeosphaeria nodorum47.713e-106 343
LLPS-Drm-0025Drosophila melanogaster47.61e-127 396
LLPS-Cii-0646Ciona intestinalis47.374e-130 403
LLPS-Anp-0961Anas platyrhynchos47.337e-124 384
LLPS-Lem-0323Leptosphaeria maculans47.21e-105 341
LLPS-Caj-1701Callithrix jacchus47.091e-122 383
LLPS-Dio-1481Dipodomys ordii47.094e-122 381
LLPS-Mum-1649Mus musculus46.861e-121 380
LLPS-Orc-1587Oryctolagus cuniculus46.844e-120 380
LLPS-Ict-1396Ictidomys tridecemlineatus46.843e-121 379
LLPS-Cas-0353Carlito syrichta46.841e-121 380
LLPS-Poa-0583Pongo abelii46.843e-121 379
LLPS-Sah-2155Sarcophilus harrisii46.751e-120 377
LLPS-Pytr-0300Pyrenophora triticirepentis46.654e-106 343
LLPS-Pyt-1253Pyrenophora teres46.654e-106 343
LLPS-Rhb-1289Rhinopithecus bieti46.63e-121 379
LLPS-Man-0845Macaca nemestrina46.63e-121 379
LLPS-Mam-1204Macaca mulatta46.63e-121 379
LLPS-Aon-1881Aotus nancymaae46.62e-121 380
LLPS-Cea-3390Cercocebus atys46.63e-121 379
LLPS-Sus-0552Sus scrofa46.63e-120 376
LLPS-Chs-0782Chlorocebus sabaeus46.63e-121 379
LLPS-Mea-0393Mesocricetus auratus46.61e-121 380
LLPS-Maf-1009Macaca fascicularis46.63e-121 379
LLPS-Aim-0795Ailuropoda melanoleuca46.69e-121 377
LLPS-Mal-2807Mandrillus leucophaeus46.63e-121 379
LLPS-Paa-0034Papio anubis46.63e-121 379
LLPS-Tut-0690Tursiops truncatus46.65e-121 378
LLPS-Eqc-0448Equus caballus46.512e-121 379
LLPS-Xim-2509Xiphophorus maculatus46.451e-118 374
LLPS-Pap-1359Pan paniscus46.364e-121 379
LLPS-Pat-0235Pan troglodytes46.364e-121 379
LLPS-Hos-0405Homo sapiens46.364e-121 379
LLPS-Nol-1243Nomascus leucogenys46.368e-119 372
LLPS-Cap-0628Cavia porcellus46.364e-120 376
LLPS-Caf-0605Canis familiaris46.363e-120 376
LLPS-Gog-0808Gorilla gorilla46.364e-121 379
LLPS-Myl-3317Myotis lucifugus46.369e-120 375
LLPS-Mup-1168Mustela putorius furo46.369e-121 377
LLPS-Ran-1897Rattus norvegicus46.361e-121 380
LLPS-Asm-2306Astyanax mexicanus46.322e-116 366
LLPS-Fia-1493Ficedula albicollis46.125e-119 375
LLPS-Loa-0155Loxodonta africana46.126e-120 375
LLPS-Fec-0145Felis catus46.121e-120 377
LLPS-Urm-1258Ursus maritimus46.121e-120 377
LLPS-Tag-0185Taeniopygia guttata46.125e-120 376
LLPS-Anc-1228Anolis carolinensis46.081e-115 364
LLPS-Cis-1472Ciona savignyi46.063e-130 403
LLPS-Pes-1214Pelodiscus sinensis46.04e-119 374
LLPS-Ova-0831Ovis aries46.09e-117 367
LLPS-Scm-0790Scophthalmus maximus45.972e-120 377
LLPS-Otg-0169Otolemur garnettii45.761e-116 367
LLPS-Scf-3321Scleropages formosus45.761e-113 359
LLPS-Bot-3451Bos taurus45.632e-119 374
LLPS-Orl-0031Oryzias latipes45.546e-121 378
LLPS-Fud-0456Fukomys damarensis45.52e-117 369
LLPS-Scj-0160Schizosaccharomyces japonicus45.417e-107 341
LLPS-Orn-1972Oreochromis niloticus45.238e-115 363
LLPS-Scp-0049Schizosaccharomyces pombe45.222e-106 340
LLPS-Tum-1179Tuber melanosporum45.11e-106 343
LLPS-Ten-1599Tetraodon nigroviridis44.152e-112 356
LLPS-Icp-1444Ictalurus punctatus43.847e-114 361
LLPS-Gaa-1247Gasterosteus aculeatus43.636e-113 357
LLPS-Dar-0590Danio rerio43.192e-115 363
LLPS-Mod-2417Monodelphis domestica41.24e-105 337
LLPS-Lac-0756Latimeria chalumnae40.958e-106 338