LLPS-Ran-0953
Akap1

▼ OVERVIEW

Status: Unreviewed
Protein Name: A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 121 kDa; AKAP 121; Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Protein kinase A-anchoring protein 1; PRKA1; Spermatid A-kinase anchor protein 84; S-AKAP84
Gene Name: Akap1, Akap
Ensembl Gene: ENSRNOG00000002373.8
Ensembl Protein: ENSRNOP00000003251.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAIQFRSLFP  LALPGMLALL  GWWWFFSRKK  DRLSSNGKQV  GTLKVGPAIE  DRLPTEEACP  60
61    GVLSVTPSVT  QPPGKEEQRS  MDRPLTDPPA  LPRTRQVRRR  SESSGNLPSI  VDTRLQAGQC  120
121   RDENSKVVLS  LMGDEAKSIP  LGRPLFPKDL  SFPYEAVEGC  KQESALGRTP  GRGWLSQCAA  180
181   SGENARETGG  AEGTGDAVLG  ESVLEEGLLP  QECVSEVEKS  EFPILAPGGG  GGEKVRSGPP  240
241   QVDELLKKEE  YIVGKLPSSF  VGPVHSELVK  DEGALVPQVK  GSQDRSLARE  LDKDKTLPEK  300
301   DQIEQTAFQI  ISQVILEATE  EIRATTVGKT  VAQVHPTPGT  QPQGQEESCV  PASQETSLGQ  360
361   EIPDPASTRT  GATASPSAGA  PPPKTYVSCL  SSPLSGPTKD  QKPKNSAHHI  SLAPCPPPVT  420
421   PQRQSLDGAS  NPRGDDTFVT  CTSNNSQSVL  SVTSLGLCSD  PVSTSRLEDS  CTETISSSGD  480
481   KAVTPPLPDS  TEPFSNGVLK  EELSDLGTED  GWTMDTEADH  SGGSDGNSMD  SVDSCCGLTK  540
541   PDSPQTVQAG  SNPKKVDLII  WEIEVPKHLV  GRLIGKQGRY  VSFLKQTSGA  KIYISTLPYT  600
601   QNIQICHIEG  SQHHVDKALN  LIGKKFKELN  LTNIYAPPLP  SLALPSLPMT  SWLMLPDGIT  660
661   VEVIVVNQVN  AGHLFVQQHT  HPTFHALRSL  DQQMYLCYSQ  PGIPTLPTPV  EITVICAAPG  720
721   ADGAWWRAQV  VASYEETNEV  EIRYVDYGGY  KRVKVDVLRQ  IRSDFVTLPF  QGAEVLLDSV  780
781   VPLSDDDHFS  PEADAAMSEM  TGNTALLAQV  TSYSATGLPL  IQLWSVVGDE  VVLINRSLVE  840
841   RGLAQWVDSC  YASL  854
Nucleotide CDS Sequence (FASTA)
1     ATGGCAATCC  AGTTCCGTTC  ACTCTTCCCC  TTGGCCTTGC  CTGGAATGCT  AGCACTCCTT  60
61    GGCTGGTGGT  GGTTTTTCTC  TCGTAAAAAA  GATCGGCTCA  GCAGCAATGG  CAAGCAGGTG  120
121   GGGACATTGA  AGGTTGGCCC  TGCCATCGAG  GACCGACTGC  CCACTGAAGA  GGCCTGTCCT  180
181   GGAGTCCTGT  CTGTGACCCC  CAGTGTCACA  CAGCCTCCTG  GAAAGGAAGA  GCAGCGCTCT  240
241   ATGGACAGGC  CTCTTACAGA  TCCCCCAGCC  TTGCCAAGGA  CCCGTCAAGT  TCGCCGAAGA  300
301   TCAGAGTCCT  CAGGCAACCT  CCCCAGCATT  GTAGACACAA  GGTTGCAGGC  AGGACAGTGC  360
361   AGAGATGAGA  ATTCAAAAGT  GGTACTCTCC  CTGATGGGGG  ACGAAGCCAA  ATCTATTCCT  420
421   CTTGGACGTC  CGCTTTTCCC  AAAGGATCTG  TCCTTCCCCT  ATGAAGCAGT  GGAAGGGTGT  480
481   AAGCAAGAGT  CTGCCCTGGG  CAGAACTCCT  GGGAGAGGCT  GGCTAAGCCA  GTGTGCAGCC  540
541   TCTGGAGAGA  ACGCGAGAGA  GACGGGTGGG  GCGGAAGGGA  CTGGAGATGC  TGTGTTGGGG  600
601   GAAAGTGTAC  TTGAGGAAGG  CCTATTGCCC  CAGGAGTGTG  TTTCAGAAGT  AGAGAAGAGT  660
661   GAGTTTCCGA  TCCTAGCTCC  CGGGGGAGGC  GGGGGAGAGA  AGGTGAGAAG  TGGCCCACCA  720
721   CAGGTAGATG  AGCTTTTAAA  GAAGGAAGAA  TATATTGTTG  GGAAGTTGCC  AAGTAGCTTT  780
781   GTGGGGCCAG  TTCACTCGGA  GCTGGTTAAG  GATGAGGGTG  CGCTGGTACC  CCAAGTCAAA  840
841   GGTAGCCAGG  ACAGAAGCCT  GGCTAGAGAA  CTGGACAAAG  ACAAGACCTT  GCCTGAAAAG  900
901   GACCAGATTG  AGCAGACTGC  CTTCCAGATC  ATCTCCCAGG  TGATCTTGGA  AGCGACTGAA  960
961   GAGATACGGG  CCACCACAGT  GGGCAAGACT  GTGGCACAAG  TGCATCCAAC  CCCGGGCACT  1020
1021  CAGCCTCAGG  GGCAGGAGGA  GAGCTGTGTC  CCAGCCAGCC  AGGAAACTAG  CTTGGGACAA  1080
1081  GAAATCCCAG  ATCCTGCTTC  CACCAGAACA  GGTGCCACTG  CCAGCCCTTC  AGCAGGAGCC  1140
1141  CCACCACCAA  AGACCTATGT  GAGCTGTCTC  AGCAGTCCTC  TGTCAGGCCC  CACCAAGGAC  1200
1201  CAGAAGCCAA  AGAACTCTGC  ACACCACATC  TCCCTGGCTC  CCTGCCCACC  GCCAGTTACC  1260
1261  CCCCAGAGGC  AGTCTCTGGA  TGGGGCAAGT  AACCCGAGAG  GTGATGACAC  CTTTGTCACC  1320
1321  TGTACGTCCA  ACAACAGCCA  GAGTGTCCTT  TCAGTTACCT  CCTTGGGGCT  GTGCTCAGAC  1380
1381  CCTGTCAGTA  CTTCGAGGCT  TGAAGACTCT  TGCACAGAGA  CCATCTCAAG  CTCCGGAGAC  1440
1441  AAAGCTGTCA  CCCCACCACT  GCCAGACAGT  ACTGAGCCCT  TCAGCAATGG  GGTGCTGAAG  1500
1501  GAGGAGTTGT  CAGACTTGGG  GACCGAGGAT  GGATGGACCA  TGGATACAGA  AGCAGATCAT  1560
1561  TCAGGAGTTG  CAGCTCCACC  CCAGGAAAGA  GGGCACTTTG  GTAACGGAGG  GTGCGCTGGG  1620
1621  TTTTTCGAGT  GCTGA  1635

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Reference proteome
RNA-binding
Transit peptide
Transmembrane

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Lipid droplet
Cellular Component
Mitochondrial crista
Cellular Component
Mitochondrial outer membrane
Cellular Component
Neuromuscular junction
Cellular Component
Postsynaptic membrane
Molecular Function
Beta-tubulin binding
Molecular Function
Microtubule binding
Molecular Function
Protein kinase A regulatory subunit binding
Molecular Function
Protein kinase binding
Molecular Function
Protein phosphatase 2B binding
Molecular Function
Protein phosphatase binding
Molecular Function
Protein-containing complex scaffold activity
Molecular Function
RNA binding
Biological Process
Cellular response to cAMP
Biological Process
Cellular response to peptide hormone stimulus
Biological Process
Negative regulation of cardiac muscle hypertrophy
Biological Process
Negative regulation of protein dephosphorylation
Biological Process
Negative regulation of protein import into nucleus
Biological Process
Regulation of protein kinase A signaling

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-2039Mus musculus90.320.01389
LLPS-Mod-4182Monodelphis domestica85.280.0 535
LLPS-Mea-2686Mesocricetus auratus81.620.01182
LLPS-Ova-3502Ovis aries77.360.0 791
LLPS-Orl-2421Oryzias latipes72.493e-79 262
LLPS-Caj-3144Callithrix jacchus72.290.01048
LLPS-Icp-2161Ictalurus punctatus72.197e-151 472
LLPS-Scf-2155Scleropages formosus71.921e-157 491
LLPS-Anc-2528Anolis carolinensis71.917e-145 437
LLPS-Tar-0689Takifugu rubripes71.641e-146 457
LLPS-Otg-1716Otolemur garnettii71.570.0 981
LLPS-Aon-4210Aotus nancymaae71.250.01053
LLPS-Fud-4100Fukomys damarensis70.950.0 973
LLPS-Scm-2775Scophthalmus maximus70.755e-149 467
LLPS-Eqc-2003Equus caballus70.410.01020
LLPS-Asm-2038Astyanax mexicanus70.43e-151 473
LLPS-Dio-0989Dipodomys ordii70.350.0 963
LLPS-Ten-0470Tetraodon nigroviridis70.291e-150 467
LLPS-Orc-2550Oryctolagus cuniculus69.970.0 998
LLPS-Loa-4493Loxodonta africana69.80.01019
LLPS-Sus-2067Sus scrofa69.740.0 991
LLPS-Orn-3916Oreochromis niloticus69.633e-150 467
LLPS-Mal-1744Mandrillus leucophaeus69.60.01029
LLPS-Poa-3257Pongo abelii68.960.01026
LLPS-Myl-1828Myotis lucifugus68.880.01003
LLPS-Chs-4305Chlorocebus sabaeus68.730.01018
LLPS-Paa-2259Papio anubis68.640.01025
LLPS-Cea-1853Cercocebus atys68.640.01024
LLPS-Rhb-2780Rhinopithecus bieti68.580.01013
LLPS-Maf-2889Macaca fascicularis68.530.01028
LLPS-Cap-4674Cavia porcellus68.490.0 961
LLPS-Man-3092Macaca nemestrina68.20.01017
LLPS-Aim-4360Ailuropoda melanoleuca68.190.0 979
LLPS-Nol-1411Nomascus leucogenys68.170.01012
LLPS-Fec-3704Felis catus68.030.0 966
LLPS-Mam-3229Macaca mulatta67.930.0 993
LLPS-Mup-2622Mustela putorius furo67.690.0 954
LLPS-Pap-2865Pan paniscus67.550.0 993
LLPS-Gog-0701Gorilla gorilla67.550.0 986
LLPS-Pat-0734Pan troglodytes67.440.0 991
LLPS-Caf-1962Canis familiaris67.340.0 990
LLPS-Hos-4688Homo sapiens67.330.0 982
LLPS-Pof-4177Poecilia formosa67.142e-143 452
LLPS-Bot-4794Bos taurus67.010.0 925
LLPS-Xim-2860Xiphophorus maculatus65.723e-140 443
LLPS-Ict-3025Ictidomys tridecemlineatus65.420.0 773
LLPS-Tag-2021Taeniopygia guttata62.035e-153 463
LLPS-Anp-2945Anas platyrhynchos59.070.0 580
LLPS-Meg-2044Meleagris gallopavo58.240.0 587
LLPS-Dar-0763Danio rerio58.224e-95 317
LLPS-Sah-1259Sarcophilus harrisii53.770.0 759
LLPS-Cas-1909Carlito syrichta53.652e-126 399
LLPS-Leo-3859Lepisosteus oculatus52.819e-163 503
LLPS-Urm-2434Ursus maritimus52.279e-117 372
LLPS-Lac-3739Latimeria chalumnae51.541e-160 498
LLPS-Fia-3710Ficedula albicollis51.412e-154 482
LLPS-Gaa-1760Gasterosteus aculeatus51.271e-84 293
LLPS-Ora-0638Ornithorhynchus anatinus51.160.0 657
LLPS-Pes-2968Pelodiscus sinensis48.120.0 623
LLPS-Gaga-2575Gallus gallus46.920.0 598
LLPS-Cii-1527Ciona intestinalis37.884e-38 147
LLPS-Drm-0318Drosophila melanogaster31.651e-38 156
LLPS-Tut-2105Tursiops truncatus28.579e-0963.5