LLPS-Ran-0682
Tmub1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein |
| Gene Name: | Tmub1, Hops |
| Ensembl Gene: | ENSRNOG00000013383.7 |
| Ensembl Protein: | ENSRNOP00000058703.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (PubMed:18665261). Acts as negative regulator of hepatocyte growth during regeneration (PubMed:22426572). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000061992.2 | ENSRNOP00000058703.1 |
| Ensembl | ENSRNOT00000088357.1 | ENSRNOP00000074242.1 |
| UniProt | Q53AQ4, TMUB1_RAT | |
| GeneBank | AY603378, CH474020 | AAU00154.1, EDL99355.1 |
| RefSeq | NM_001080153.2, NM_198781.3, XM_006235945.3 | NP_001073622.1, NP_942076.2, XP_006236007.1 |
| Entrez | 362301 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALIEGVGDE VTVLFSVLAC LLVLALAWVS THTTESTDPL PQSSGTTTPA QPSEAMTAID 60 61 SIREEAPGAE SPSLRHRGPS AQPEPEAGVT ASTPPDSPQE PLLLRLKFLN DSEQVARAWP 120 121 QDTIGSLKRT QFPGREQQVR LIYQGQLLGD DTQTLGSLHL PPNCVLHCHV STRVGPPHPP 180 181 CPPGSEPGPS GLEIGSLLLP LLLLLLLLLW YCQIQYRPFF PLTATLGLAG FTLLLSLLAF 240 241 AMYRP 245 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTTGA TTGAAGGCGT AGGGGATGAG GTGACTGTCC TTTTTTCGGT GCTTGCCTGC 60 61 CTTCTGGTGC TGGCCCTCGC CTGGGTCTCA ACACATACGA CTGAGAGTAC AGATCCCCTA 120 121 CCACAGTCGT CAGGGACCAC AACACCAGCA CAGCCCAGTG AAGCCATGAC AGCCATTGAT 180 181 AGCATCAGAG AGGAGGCCCC AGGAGCTGAG AGTCCCAGCC TGAGGCACAG AGGTCCATCT 240 241 GCACAGCCAG AGCCTGAGGC AGGGGTCACA GCATCAACAC CTCCAGACTC TCCACAGGAA 300 301 CCCTTACTGC TACGGTTGAA ATTTCTCAAT GACTCTGAAC AGGTGGCCAG GGCCTGGCCT 360 361 CAGGACACCA TTGGCTCCTT GAAAAGAACC CAGTTTCCAG GCCGGGAACA GCAGGTTCGA 420 421 CTCATCTACC AAGGCCAACT GCTAGGAGAC GACACCCAGA CACTGGGCAG TCTCCACCTT 480 481 CCCCCCAACT GCGTTCTCCA CTGCCACGTG TCCACAAGAG TCGGTCCCCC GCATCCTCCC 540 541 TGCCCACCGG GGTCAGAGCC CGGCCCCTCC GGGCTGGAAA TCGGCAGCCT TCTGTTGCCC 600 601 CTGCTGCTTC TGCTGCTGCT CCTGCTCTGG TACTGCCAGA TCCAGTACCG GCCCTTCTTT 660 661 CCCCTGACCG CTACCTTGGG CCTGGCCGGC TTCACCCTGC TCCTCAGTCT CCTGGCCTTT 720 721 GCCATGTATC GCCCGTAG 738 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Cytosol | |
Cellular Component | Integral component of membrane | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Cellular Component | Postsynaptic membrane | |
Cellular Component | Recycling endosome | |
Biological Process | Ubiquitin-dependent ERAD pathway |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-0389 | Mus musculus | 96.33 | 1e-111 | 328 |
| LLPS-Mea-2183 | Mesocricetus auratus | 93.9 | 2e-106 | 315 |
| LLPS-Dio-4023 | Dipodomys ordii | 90.69 | 1e-95 | 287 |
| LLPS-Ict-0648 | Ictidomys tridecemlineatus | 90.65 | 2e-99 | 296 |
| LLPS-Caf-2397 | Canis familiaris | 90.65 | 3e-101 | 301 |
| LLPS-Rhb-2269 | Rhinopithecus bieti | 90.24 | 2e-100 | 300 |
| LLPS-Fec-4023 | Felis catus | 90.24 | 4e-101 | 301 |
| LLPS-Pat-0954 | Pan troglodytes | 90.24 | 3e-100 | 299 |
| LLPS-Pap-4153 | Pan paniscus | 90.24 | 2e-100 | 299 |
| LLPS-Urm-3660 | Ursus maritimus | 90.24 | 2e-100 | 300 |
| LLPS-Hos-3352 | Homo sapiens | 90.24 | 3e-100 | 299 |
| LLPS-Cas-1751 | Carlito syrichta | 90.24 | 1e-99 | 298 |
| LLPS-Gog-3755 | Gorilla gorilla | 90.24 | 3e-100 | 299 |
| LLPS-Chs-3963 | Chlorocebus sabaeus | 90.24 | 6e-101 | 301 |
| LLPS-Nol-3786 | Nomascus leucogenys | 89.84 | 2e-99 | 297 |
| LLPS-Mam-4481 | Macaca mulatta | 89.84 | 5e-100 | 298 |
| LLPS-Maf-0011 | Macaca fascicularis | 89.84 | 5e-100 | 298 |
| LLPS-Cea-2038 | Cercocebus atys | 89.84 | 5e-100 | 298 |
| LLPS-Mup-0018 | Mustela putorius furo | 89.84 | 2e-99 | 298 |
| LLPS-Mal-0548 | Mandrillus leucophaeus | 89.84 | 5e-100 | 298 |
| LLPS-Caj-0340 | Callithrix jacchus | 89.52 | 1e-98 | 295 |
| LLPS-Man-1251 | Macaca nemestrina | 89.43 | 2e-99 | 297 |
| LLPS-Aim-0525 | Ailuropoda melanoleuca | 89.43 | 4e-101 | 302 |
| LLPS-Aon-1094 | Aotus nancymaae | 89.11 | 4e-97 | 291 |
| LLPS-Paa-1529 | Papio anubis | 88.98 | 2e-99 | 297 |
| LLPS-Cap-4024 | Cavia porcellus | 88.66 | 9e-96 | 288 |
| LLPS-Myl-3178 | Myotis lucifugus | 88.16 | 3e-93 | 281 |
| LLPS-Otg-1457 | Otolemur garnettii | 87.8 | 5e-93 | 281 |
| LLPS-Sus-1302 | Sus scrofa | 87.8 | 4e-95 | 286 |
| LLPS-Fud-2173 | Fukomys damarensis | 87.76 | 7e-93 | 280 |
| LLPS-Orc-3289 | Oryctolagus cuniculus | 87.1 | 5e-92 | 278 |
| LLPS-Eqc-1810 | Equus caballus | 86.59 | 2e-90 | 275 |
| LLPS-Ova-1137 | Ovis aries | 86.18 | 1e-90 | 276 |
| LLPS-Tut-2357 | Tursiops truncatus | 86.18 | 1e-89 | 272 |
| LLPS-Bot-4410 | Bos taurus | 85.77 | 8e-91 | 277 |
| LLPS-Sah-2459 | Sarcophilus harrisii | 72.4 | 4e-74 | 233 |
| LLPS-Mod-4250 | Monodelphis domestica | 71.04 | 6e-71 | 224 |
| LLPS-Fia-1920 | Ficedula albicollis | 70.45 | 1e-12 | 66.6 |
| LLPS-Tag-3217 | Taeniopygia guttata | 69.33 | 6e-27 | 107 |
| LLPS-Scm-2411 | Scophthalmus maximus | 60.29 | 8e-20 | 90.5 |
| LLPS-Xim-0848 | Xiphophorus maculatus | 49.09 | 6e-43 | 152 |
| LLPS-Ten-3475 | Tetraodon nigroviridis | 47.96 | 3e-42 | 150 |
| LLPS-Leo-2090 | Lepisosteus oculatus | 46.56 | 3e-41 | 148 |
| LLPS-Orl-0443 | Oryzias latipes | 46.37 | 1e-43 | 154 |
| LLPS-Icp-0803 | Ictalurus punctatus | 45.95 | 4e-45 | 159 |
| LLPS-Gaa-0332 | Gasterosteus aculeatus | 44.72 | 2e-38 | 140 |
| LLPS-Asm-1033 | Astyanax mexicanus | 44.62 | 3e-43 | 154 |
| LLPS-Tar-0702 | Takifugu rubripes | 44.35 | 6e-39 | 142 |
| LLPS-Scf-2521 | Scleropages formosus | 43.64 | 3e-38 | 142 |
| LLPS-Anc-2698 | Anolis carolinensis | 43.32 | 3e-34 | 130 |
| LLPS-Dar-2352 | Danio rerio | 43.28 | 1e-40 | 147 |
| LLPS-Orn-1072 | Oreochromis niloticus | 42.06 | 9e-36 | 134 |
| LLPS-Lac-1171 | Latimeria chalumnae | 40.57 | 6e-40 | 145 |
| LLPS-Ora-0910 | Ornithorhynchus anatinus | 40.0 | 1e-20 | 91.3 |
| LLPS-Cae-0497 | Caenorhabditis elegans | 39.81 | 2e-12 | 70.1 |
| LLPS-Pof-1025 | Poecilia formosa | 39.72 | 4e-20 | 91.7 |
| LLPS-Xet-3631 | Xenopus tropicalis | 39.64 | 1e-22 | 99.0 |
| LLPS-Loa-3766 | Loxodonta africana | 39.34 | 4e-24 | 102 |
| LLPS-Ere-0910 | Erinaceus europaeus | 38.95 | 2e-21 | 95.1 |
| LLPS-Poa-0617 | Pongo abelii | 36.16 | 8e-22 | 96.3 |
| LLPS-Pes-2867 | Pelodiscus sinensis | 33.93 | 3e-27 | 111 |
| LLPS-Cii-2077 | Ciona intestinalis | 31.28 | 1e-15 | 77.8 |
| LLPS-Cis-1300 | Ciona savignyi | 29.02 | 5e-12 | 67.8 |