LLPS-Mum-0389
Tmub1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein |
| Gene Name: | Tmub1, Hops |
| Ensembl Gene: | ENSMUSG00000028958.14 |
| Ensembl Protein: | ENSMUSP00000122487.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Centrosome/Spindle pole body | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 18418082 |
▼ FUNCTION
| Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000123167.1 | ENSMUSP00000122487.1 |
| Ensembl | ENSMUST00000030799.14 | ENSMUSP00000030799.8 |
| Ensembl | ENSMUST00000115036.7 | ENSMUSP00000110688.1 |
| Ensembl | ENSMUST00000127194.1 | ENSMUSP00000123173.1 |
| Ensembl | ENSMUST00000115033.7 | ENSMUSP00000110685.1 |
| UniProt | Q9JMG3, TMUB1_MOUSE, Q53AQ3 | |
| GeneBank | BC019547, AK008109, AB030183, AY603379 | BAB25465.1, BAA92747.1, AAU00155.1, AAH19547.1 |
| RefSeq | NM_022418.3, XM_006535786.2 | NP_071863.1, XP_006535849.1 |
| Entrez | 64295 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGRDLLSTSG SSTGAMALIE GVGDEVTVLF AVLACLLVLA LAWVSTHTTE STDPQPQPPG 60 61 TTTPAQPSEA MSASDSIREE APGAESPSLR HRGPSAQPEP DTGVTASTPP DSPQEPLLLR 120 121 LKFLNDSEQV ARAWPQDTIG SLKRTQFPGQ EQQVRLIYQG QLLGDDTQTL GSLHLPPNCV 180 181 LHCHVSTRVG PPHPPCPPGS EPGPSGLEIG SLLLPLLLLL LLLLWYCQIQ YRPFFPLTAT 240 241 LGLAGFTLLL SLLAFAMYRP 260 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTTGA TTGAAGGCGT AGGCGATGAG GTGACTGTCC TTTTTGCGGT GCTTGCTTGC 60 61 CTTCTGGTGC TGGCCCTCGC CTGGGTCTCA ACACATACCA CTGAGAGTAC AGACCCCCAA 120 121 CCACAGCCGC CGGGGACCAC AACACCAGCA CAGCCCAGTG AAGCCATGTC AGCCTCTGAC 180 181 AGCATCAGAG AGGAGGCCCC AGGGGCTGAG AGTCCCAGCC TGAGACACAG AGGTCCATCT 240 241 GCACAGCCAG AGCCTGACAC AGGGGTCACA GCATCAACAC CTCCAGACTC TCCGCAGGAA 300 301 CCCCTACTTC TACGGTTGAA ATTTCTCAAT GACTCTGAGC AGGTAGCCAG GGCCTGGCCT 360 361 CAGGACACCA TTGGCTCCTT AAAAAGGACC CAGTTTCCAG GCCAGGAACA GCAGGTTCGG 420 421 CTCATCTACC AAGGTCAACT GCTAGGAGAC GACACTCAGA CACTAGGCAG TCTCCACCTG 480 481 CCCCCCAACT GCGTTCTCCA CTGCCACGTG TCCACGAGAG TCGGTCCCCC ACATCCTCCC 540 541 TGCCCACCGG GGTCAGAGCC CGGCCCCTCC GGGCTGGAAA TCGGCAGCCT TCTGTTGCCC 600 601 CTGCTGCTTC TGCTGCTGCT CCTGCTCTGG TACTGCCAGA TCCAGTACCG GCCCTTCTTT 660 661 CCCCTGACCG CTACCCTGGG TCTGGCCGGC TTCACCCTGC TCCTCAGTCT CCTGGCCTTT 720 721 GCCATGTATC GGCCGTAG 738 |
▼ KEYWORD
ID | Family |
Alternative initiation | |
Cell junction | |
Cell membrane | |
Complete proteome | |
Cytoplasm | |
Cytoskeleton | |
Endosome | |
Membrane | |
Nucleus | |
Phosphoprotein | |
Postsynaptic cell membrane | |
Reference proteome | |
Synapse | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Cytosol | |
Cellular Component | Integral component of membrane | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Cellular Component | Postsynaptic membrane | |
Cellular Component | Recycling endosome | |
Biological Process | Ubiquitin-dependent ERAD pathway |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0682 | Rattus norvegicus | 96.33 | 7e-101 | 301 |
| LLPS-Ict-0648 | Ictidomys tridecemlineatus | 91.06 | 7e-89 | 271 |
| LLPS-Mea-2183 | Mesocricetus auratus | 90.8 | 3e-98 | 295 |
| LLPS-Dio-4023 | Dipodomys ordii | 90.28 | 4e-85 | 261 |
| LLPS-Caf-2397 | Canis familiaris | 90.24 | 5e-89 | 271 |
| LLPS-Fec-4023 | Felis catus | 89.84 | 1e-88 | 270 |
| LLPS-Urm-3660 | Ursus maritimus | 89.84 | 3e-88 | 269 |
| LLPS-Chs-3963 | Chlorocebus sabaeus | 89.43 | 6e-90 | 273 |
| LLPS-Gog-3755 | Gorilla gorilla | 89.43 | 4e-89 | 271 |
| LLPS-Pat-0954 | Pan troglodytes | 89.43 | 4e-89 | 271 |
| LLPS-Pap-4153 | Pan paniscus | 89.43 | 7e-89 | 271 |
| LLPS-Hos-3352 | Homo sapiens | 89.43 | 4e-89 | 271 |
| LLPS-Rhb-2269 | Rhinopithecus bieti | 89.43 | 1e-89 | 272 |
| LLPS-Cas-1751 | Carlito syrichta | 89.43 | 5e-90 | 274 |
| LLPS-Maf-0011 | Macaca fascicularis | 89.02 | 3e-89 | 271 |
| LLPS-Cea-2038 | Cercocebus atys | 89.02 | 3e-89 | 271 |
| LLPS-Mal-0548 | Mandrillus leucophaeus | 89.02 | 3e-89 | 271 |
| LLPS-Mam-4481 | Macaca mulatta | 89.02 | 3e-89 | 271 |
| LLPS-Nol-3786 | Nomascus leucogenys | 89.02 | 7e-88 | 268 |
| LLPS-Cap-4024 | Cavia porcellus | 88.66 | 6e-88 | 268 |
| LLPS-Man-1251 | Macaca nemestrina | 88.62 | 1e-88 | 270 |
| LLPS-Caj-0340 | Callithrix jacchus | 88.31 | 4e-87 | 266 |
| LLPS-Myl-3178 | Myotis lucifugus | 88.26 | 5e-86 | 263 |
| LLPS-Paa-1529 | Papio anubis | 88.16 | 2e-88 | 269 |
| LLPS-Aon-1094 | Aotus nancymaae | 87.9 | 4e-86 | 264 |
| LLPS-Mup-0018 | Mustela putorius furo | 87.5 | 2e-90 | 275 |
| LLPS-Sus-1302 | Sus scrofa | 87.4 | 5e-87 | 266 |
| LLPS-Aim-0525 | Ailuropoda melanoleuca | 87.11 | 6e-91 | 277 |
| LLPS-Orc-3289 | Oryctolagus cuniculus | 86.69 | 5e-81 | 251 |
| LLPS-Fud-2173 | Fukomys damarensis | 86.64 | 1e-83 | 257 |
| LLPS-Otg-1457 | Otolemur garnettii | 86.59 | 5e-84 | 258 |
| LLPS-Tut-2357 | Tursiops truncatus | 85.77 | 1e-78 | 244 |
| LLPS-Eqc-1810 | Equus caballus | 84.62 | 7e-83 | 256 |
| LLPS-Ova-1137 | Ovis aries | 84.06 | 3e-79 | 248 |
| LLPS-Bot-4410 | Bos taurus | 82.42 | 6e-81 | 252 |
| LLPS-Fia-1920 | Ficedula albicollis | 72.73 | 6e-13 | 67.8 |
| LLPS-Sah-2459 | Sarcophilus harrisii | 72.65 | 7e-69 | 219 |
| LLPS-Tag-3217 | Taeniopygia guttata | 70.67 | 2e-27 | 108 |
| LLPS-Mod-4250 | Monodelphis domestica | 70.59 | 2e-64 | 208 |
| LLPS-Scm-2411 | Scophthalmus maximus | 58.82 | 6e-19 | 88.6 |
| LLPS-Tar-0702 | Takifugu rubripes | 58.06 | 6e-36 | 134 |
| LLPS-Orn-1072 | Oreochromis niloticus | 55.74 | 2e-34 | 130 |
| LLPS-Lac-1171 | Latimeria chalumnae | 52.69 | 1e-37 | 140 |
| LLPS-Xim-0848 | Xiphophorus maculatus | 48.87 | 1e-39 | 144 |
| LLPS-Poa-0617 | Pongo abelii | 47.15 | 7e-22 | 96.7 |
| LLPS-Ten-3475 | Tetraodon nigroviridis | 47.06 | 1e-38 | 141 |
| LLPS-Ere-0910 | Erinaceus europaeus | 45.9 | 9e-22 | 96.3 |
| LLPS-Orl-0443 | Oryzias latipes | 45.31 | 5e-39 | 143 |
| LLPS-Icp-0803 | Ictalurus punctatus | 45.17 | 7e-41 | 148 |
| LLPS-Asm-1033 | Astyanax mexicanus | 44.23 | 6e-39 | 143 |
| LLPS-Leo-2090 | Lepisosteus oculatus | 44.13 | 2e-37 | 139 |
| LLPS-Anc-2698 | Anolis carolinensis | 44.13 | 7e-32 | 124 |
| LLPS-Gaa-0332 | Gasterosteus aculeatus | 43.67 | 2e-35 | 132 |
| LLPS-Scf-2521 | Scleropages formosus | 43.64 | 1e-34 | 132 |
| LLPS-Loa-3766 | Loxodonta africana | 43.35 | 2e-22 | 98.2 |
| LLPS-Pes-2867 | Pelodiscus sinensis | 42.86 | 6e-25 | 105 |
| LLPS-Dar-2352 | Danio rerio | 42.54 | 6e-36 | 135 |
| LLPS-Xet-3631 | Xenopus tropicalis | 40.36 | 6e-23 | 100 |
| LLPS-Cae-0497 | Caenorhabditis elegans | 39.81 | 4e-12 | 69.7 |
| LLPS-Pof-1025 | Poecilia formosa | 39.01 | 2e-19 | 89.4 |
| LLPS-Ora-0910 | Ornithorhynchus anatinus | 38.01 | 4e-19 | 87.4 |
| LLPS-Cii-2077 | Ciona intestinalis | 33.91 | 2e-11 | 66.6 |
| LLPS-Cis-1300 | Ciona savignyi | 33.59 | 4e-10 | 62.8 |