LLPS-Pug-1026
PGTG_07196
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidylethanolamine N-methyltransferase |
| Gene Name: | PGTG_07196 |
| Ensembl Gene: | PGTG_07196 |
| Ensembl Protein: | EFP80944 |
| Organism: | Puccinia graminis |
| Taxa ID: | 418459 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EFP80944 | EFP80944 |
| UniProt | E3K9T1, E3K9T1_PUCGT | |
| GeneBank | DS178277 | EFP80944.1 |
| RefSeq | XM_003325315.2 | XP_003325363.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQPSSTTSLK PGVVLVAPSP PADENPKKNS FQKDEADKED DQQQDEQGKS RQKSTYGKTM 60 61 DGTVFKIPET HNMISSLFDP RLPKSSLDLI TLSTLIAQTI PLMIFPRKKL KTFYMLSFLF 120 121 WRLTYNVGLG WVLKKQSENK FLIKIIKNLN LFNSKFNPRL SNWIEKQLKS KMSTNNLNYD 180 181 LNQYPIEFNV WLLFRQLVDI ILLNDFFSYF CLSYCSLNLP NQQQSQQDPL PNQSNLSLFL 240 241 IRCTAGVILV GFNIWVKLDA HRIVHDFAWY WGDAFFLSLQ ELVFDGVFEM APHPMYSIGY 300 301 AGFYGASLIT GSQSVFFVSL FAHLCQFGFL VYFENPHIQR TYGPQARPLT AASPRHALRS 360 361 RSHPRKKIQP LNFNSPNENP KAVSPDYRDT QHDTSSVHGS NTFHDPPQNP VDPAEVREEL 420 421 EHRLFRRKEM ILIDNFDKFR SIDFVTVLVI GYNFLILFIK EEDPSHIKKI YNNKGLLISS 480 481 LNAIAWRLWF SFGLGFRLKQ QSQNKMMVKH FLTNYYYPIG KFRHSQQKNE DEINDDDQND 540 541 LIDELKFEVI EECFQNWKGI YNLSLIMTYV SFAIMSIKFH KLGDQWELSS EVIRITFGLC 600 601 LVGIHVWTAI STYEVLGKFG WFYGDFFVDD YPMELTYAGI YRYLNNPERS MGGAGFVGMS 660 661 LMSGNKFVFA LALGSVLCHW WFLSFVETPH MKKVYGDRIR KEAGLTKVLK QNAQKLAARR 720 721 KKLDLRIDRE SCSSMGGGKS DEREGKGFER RFKEVQGTFE FIYDETVQAL DEFLEKSAPR 780 781 LSGVVRDTKV LLQSSGERLI LTRIANDLSS YDTTQYRLAI QESRYHRPRD PASNRLRFHM 840 841 GEPIRLQWNS PWNHSRADWV GCYRRGSNKS GLVTEVTSSG RWCGLFKEEW EGDMHIGKRR 900 901 QEGDAELDDA GKELKLENEA AKPRKTGWVE FKGERLPWEE GVYEFRYHHD GKYNVMAVTE 960 961 PFEIYVERIE QDVGNMKEIE DKLRNLVGYG LGMEANLIPM ILRKETARIL KDEFTKPSQN 1020 1021 GIHAANGHQP ATEGKVGENG LSDEGSQEEE DRFTVMSLDE AKRIQRLIGI GIGIELGIEI 1080 1081 ILEDCEINRL AKRIVFVKSL LKPFLNK 1107 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAACCTA GTAGTACCAC CTCACTCAAG CCTGGAGTAG TCCTAGTAGC ACCTTCTCCA 60 61 CCTGCCGATG AGAATCCGAA GAAGAATTCT TTCCAGAAAG ACGAGGCCGA CAAAGAGGAT 120 121 GATCAGCAAC AGGATGAACA AGGCAAAAGC CGTCAAAAAT CAACCTATGG GAAAACCATG 180 181 GATGGCACAG TCTTCAAGAT ACCCGAAACG CATAACATGA TTTCATCATT GTTTGATCCC 240 241 AGACTGCCCA AATCGAGTCT AGATTTAATC ACCCTATCAA CATTGATCGC CCAGACGATA 300 301 CCCTTGATGA TCTTTCCAAG GAAGAAACTC AAGACATTCT ACATGCTCTC ATTCTTATTC 360 361 TGGAGATTAA CCTATAACGT CGGTTTAGGT TGGGTATTAA AGAAACAATC TGAGAATAAA 420 421 TTCTTAATCA AGATCATCAA GAACTTGAAT CTGTTTAATT CCAAGTTTAA TCCACGATTG 480 481 TCGAACTGGA TCGAGAAACA ACTCAAGTCG AAAATGTCGA CGAATAACTT GAATTACGAT 540 541 CTCAATCAAT ATCCGATCGA ATTTAACGTG TGGTTACTAT TCAGACAACT AGTCGATATC 600 601 ATCCTCCTGA ACGATTTCTT CTCCTACTTC TGCCTCTCCT ACTGTTCCCT CAATCTTCCA 660 661 AATCAGCAGC AATCACAACA AGACCCCCTA CCAAATCAGT CAAACTTGAG CCTCTTCTTG 720 721 ATTCGTTGTA CCGCTGGGGT CATACTCGTC GGATTTAACA TATGGGTCAA ACTGGACGCG 780 781 CACCGAATTG TCCATGATTT CGCATGGTAT TGGGGTGATG CCTTCTTCCT ATCTTTACAG 840 841 GAGTTGGTTT TTGACGGAGT ATTTGAGATG GCTCCGCATC CAATGTATTC GATCGGCTAT 900 901 GCTGGATTTT ACGGTGCTAG TTTGATCACC GGTTCTCAAT CCGTATTTTT TGTGTCTCTA 960 961 TTCGCCCATC TCTGCCAATT CGGTTTCCTG GTTTACTTTG AAAACCCACA CATCCAACGT 1020 1021 ACCTATGGTC CTCAAGCTAG GCCACTGACG GCTGCCAGTC CCCGACATGC ACTTCGATCT 1080 1081 CGCTCTCATC CGCGCAAGAA AATTCAGCCC TTAAACTTCA ATTCTCCTAA CGAAAATCCC 1140 1141 AAAGCTGTTT CGCCTGATTA TCGAGACACC CAGCATGATA CGAGCTCGGT TCATGGATCA 1200 1201 AACACTTTTC ATGATCCTCC GCAGAACCCC GTCGATCCTG CCGAAGTTAG GGAAGAATTA 1260 1261 GAGCATAGAC TCTTTAGAAG AAAGGAGATG ATCTTGATCG ATAACTTTGA CAAGTTTCGA 1320 1321 TCGATCGATT TTGTCACAGT CTTGGTGATA GGATACAACT TTCTCATCTT ATTTATAAAG 1380 1381 GAGGAAGATC CGAGTCATAT CAAAAAGATC TATAACAATA AGGGCCTACT GATCAGTAGC 1440 1441 TTGAATGCTA TAGCTTGGAG GCTTTGGTTT AGCTTTGGAC TGGGCTTTAG ATTAAAACAA 1500 1501 CAATCGCAAA ATAAGATGAT GGTCAAACAT TTCTTAACGA ACTATTATTA TCCGATCGGA 1560 1561 AAGTTCCGTC ACTCTCAACA GAAAAATGAA GACGAGATCA ACGATGACGA TCAGAACGAT 1620 1621 TTGATCGACG AGCTGAAATT CGAGGTGATC GAAGAATGCT TCCAGAATTG GAAGGGAATC 1680 1681 TATAACTTAT CATTAATAAT GACTTATGTG TCTTTCGCAA TAATGTCGAT CAAGTTTCAC 1740 1741 AAGTTAGGAG ATCAATGGGA GTTAAGCTCT GAAGTCATCA GAATTACATT TGGATTATGT 1800 1801 TTAGTTGGTA TTCATGTTTG GACAGCTATT TCAACATACG AGGTATTGGG CAAATTTGGC 1860 1861 TGGTTCTATG GCGATTTTTT TGTGGATGAT TATCCCATGG AGTTGACTTA CGCGGGGATT 1920 1921 TATAGATACT TGAACAATCC TGAAAGATCT ATGGGCGGTG CTGGATTTGT TGGGATGAGC 1980 1981 TTAATGAGTG GGAATAAATT CGTATTTGCG TTGGCCTTAG GTTCGGTGCT ATGTCATTGG 2040 2041 TGGTTCCTAA GTTTTGTTGA AACTCCTCAC ATGAAGAAAG TGTATGGTGA CCGAATTAGA 2100 2101 AAGGAAGCCG GACTGACGAA AGTCCTGAAG CAAAATGCGC AAAAACTCGC TGCACGTCGA 2160 2161 AAGAAATTAG ATCTGCGCAT AGACCGTGAG AGCTGCAGCA GCATGGGCGG TGGGAAGAGC 2220 2221 GATGAGAGGG AAGGAAAAGG TTTCGAACGC AGGTTTAAAG AAGTCCAAGG AACTTTCGAG 2280 2281 TTTATTTACG ACGAAACCGT CCAAGCCCTT GATGAGTTCT TGGAGAAATC TGCTCCCCGA 2340 2341 CTATCTGGTG TTGTACGAGA TACTAAGGTA CTCTTGCAAA GCTCAGGCGA AAGATTGATC 2400 2401 CTGACGCGGA TTGCGAACGA TCTATCTAGT TACGATACAA CTCAATATCG TTTGGCCATA 2460 2461 CAAGAATCGA GATATCACCG TCCCAGAGAT CCAGCTTCGA ACCGATTAAG ATTCCATATG 2520 2521 GGTGAGCCGA TCAGGCTACA GTGGAACTCG CCCTGGAATC ATTCCCGAGC CGACTGGGTA 2580 2581 GGATGCTACC GCCGAGGCTC TAACAAGAGT GGCCTAGTGA CCGAGGTCAC CAGCTCCGGC 2640 2641 CGATGGTGTG GCTTGTTTAA AGAAGAATGG GAGGGCGATA TGCACATTGG GAAGCGGAGG 2700 2701 CAAGAGGGGG ACGCGGAGCT TGACGATGCA GGAAAAGAGC TCAAGCTGGA AAACGAAGCT 2760 2761 GCCAAGCCCC GAAAAACTGG GTGGGTTGAG TTCAAGGGTG AAAGATTGCC TTGGGAGGAG 2820 2821 GGGGTCTATG AGTTCAGATA TCATCATGAC GGAAAGTATA ACGTCATGGC TGTCACTGAA 2880 2881 CCTTTCGAAA TCTATGTTGA GAGGATCGAG CAAGACGTTG GAAACATGAA AGAGATCGAA 2940 2941 GATAAACTCA GGAACTTAGT TGGCTATGGA TTAGGCATGG AAGCGAACTT GATCCCGATG 3000 3001 ATCTTGAGGA AAGAGACTGC GAGGATTCTT AAGGACGAGT TCACGAAACC TAGCCAGAAT 3060 3061 GGGATCCACG CAGCGAACGG GCACCAGCCA GCCACAGAAG GGAAGGTAGG AGAGAATGGG 3120 3121 CTGAGCGATG AGGGGTCCCA AGAAGAAGAA GACAGATTCA CAGTGATGAG TTTGGACGAA 3180 3181 GCAAAACGGA TCCAACGGTT GATTGGGATC GGGATCGGGA TCGAACTGGG CATCGAAATC 3240 3241 ATCCTCGAAG ATTGCGAAAT CAATCGATTA GCTAAAAGGA TCGTCTTCGT CAAAAGTCTG 3300 3301 CTCAAGCCTT TTTTGAATAA ATGA 3324 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Endoplasmic reticulum | |
Lipid biosynthesis | |
Lipid metabolism | |
Membrane | |
Methyltransferase | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Reference proteome | |
S-adenosyl-L-methionine | |
Transferase | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | Phosphatidylcholine biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Put-0847 | Puccinia triticina | 87.75 | 0.0 | 1856 |
| LLPS-Mel-1400 | Melampsora laricipopulina | 49.54 | 0.0 | 938 |
| LLPS-Asg-0805 | Ashbya gossypii | 43.79 | 3e-59 | 223 |
| LLPS-Sac-0538 | Saccharomyces cerevisiae | 43.61 | 1e-59 | 224 |
| LLPS-Pytr-1273 | Pyrenophora triticirepentis | 42.62 | 1e-65 | 243 |
| LLPS-Kop-0636 | Komagataella pastoris | 41.69 | 3e-57 | 218 |
| LLPS-Miv-1393 | Microbotryum violaceum | 38.8 | 0.0 | 663 |
| LLPS-Crn-1111 | Cryptococcus neoformans | 38.67 | 0.0 | 676 |
| LLPS-Abg-1865 | Absidia glauca | 36.53 | 0.0 | 582 |
| LLPS-Chc-0342 | Chondrus crispus | 36.11 | 2e-42 | 169 |
| LLPS-Spr-1555 | Sporisorium reilianum | 35.22 | 0.0 | 654 |
| LLPS-Tum-1495 | Tuber melanosporum | 34.79 | 1e-157 | 500 |
| LLPS-Aso-0402 | Aspergillus oryzae | 34.67 | 1e-173 | 543 |
| LLPS-Asf-0049 | Aspergillus flavus | 34.67 | 1e-173 | 543 |
| LLPS-Ast-1319 | Aspergillus terreus | 34.61 | 3e-168 | 528 |
| LLPS-Trv-1494 | Trichoderma virens | 34.02 | 3e-168 | 529 |
| LLPS-Gag-1422 | Gaeumannomyces graminis | 34.0 | 5e-149 | 478 |
| LLPS-Yal-0985 | Yarrowia lipolytica | 33.91 | 3e-154 | 491 |
| LLPS-Mao-0658 | Magnaporthe oryzae | 33.85 | 3e-150 | 481 |
| LLPS-Dos-0973 | Dothistroma septosporum | 33.81 | 5e-159 | 505 |
| LLPS-Nec-1348 | Neurospora crassa | 33.8 | 9e-173 | 540 |
| LLPS-Asni-0930 | Aspergillus niger | 33.73 | 2e-169 | 535 |
| LLPS-Nef-0792 | Neosartorya fischeri | 33.72 | 3e-170 | 534 |
| LLPS-Map-1064 | Magnaporthe poae | 33.71 | 3e-153 | 489 |
| LLPS-Usm-0901 | Ustilago maydis | 33.62 | 0.0 | 577 |
| LLPS-Coo-1207 | Colletotrichum orbiculare | 33.5 | 8e-159 | 504 |
| LLPS-Asfu-1308 | Aspergillus fumigatus | 33.37 | 4e-171 | 535 |
| LLPS-Cogr-0907 | Colletotrichum graminicola | 33.37 | 9e-164 | 517 |
| LLPS-Blg-0539 | Blumeria graminis | 33.33 | 2e-152 | 487 |
| LLPS-Cog-1037 | Colletotrichum gloeosporioides | 33.27 | 7e-154 | 491 |
| LLPS-Fus-1164 | Fusarium solani | 33.16 | 3e-164 | 518 |
| LLPS-Ved-1517 | Verticillium dahliae | 33.09 | 6e-163 | 514 |
| LLPS-Fuv-0433 | Fusarium verticillioides | 32.98 | 2e-153 | 488 |
| LLPS-Asc-1162 | Aspergillus clavatus | 32.88 | 4e-165 | 521 |
| LLPS-Zyt-0976 | Zymoseptoria tritici | 32.83 | 2e-153 | 490 |
| LLPS-Fuo-1330 | Fusarium oxysporum | 32.78 | 2e-152 | 484 |
| LLPS-Trr-1095 | Trichoderma reesei | 32.53 | 2e-171 | 537 |
| LLPS-Lem-0456 | Leptosphaeria maculans | 32.46 | 1e-156 | 498 |
| LLPS-Scp-1575 | Schizosaccharomyces pombe | 32.35 | 3e-144 | 463 |
| LLPS-Beb-1274 | Beauveria bassiana | 32.1 | 6e-164 | 517 |
| LLPS-Pyt-1456 | Pyrenophora teres | 31.5 | 5e-152 | 486 |
| LLPS-Scj-1398 | Schizosaccharomyces japonicus | 31.41 | 3e-146 | 468 |
| LLPS-Phn-0811 | Phaeosphaeria nodorum | 30.98 | 1e-130 | 428 |
| LLPS-Scc-1317 | Schizosaccharomyces cryophilus | 30.4 | 9e-144 | 462 |
| LLPS-Cym-0800 | Cyanidioschyzon merolae | 30.14 | 2e-07 | 59.3 |
| LLPS-Gas-1063 | Galdieria sulphuraria | 28.57 | 2e-63 | 234 |