LLPS-Nec-1348
chol-1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidylethanolamine N-methyltransferase |
| Gene Name: | chol-1, cho2, B2E7.130, NCU08045 |
| Ensembl Gene: | NCU08045 |
| Ensembl Protein: | EAA33479 |
| Organism: | Neurospora crassa |
| Taxa ID: | 367110 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAA33479 | EAA33479 |
| UniProt | Q7SAJ6, CHO2_NEUCR | |
| GeneBank | BX897675, CM002239 | CAE85544.1, EAA33479.1 |
| RefSeq | XM_957622.2 | XP_962715.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSSAADPFA ARLNSDVRQR HPTASATSKN VEGTSQQKQQ QQQQQSEANA AASRVKKTYG 60 61 KTPDGTVFVV PTTHDMVTQL LDPREPKNLS DVAVLAIIAL HFLAAYYLPW GVKRPLFAAI 120 121 FMFWRLAYNV GIGYLLTIQS KYKLLVTWAK RWKLFENPAT GKNPRPWLYN LLKKELETKI 180 181 PQDYKFEEAP IEYNTWLTFR RVVDLILMCD FISYCLFAIV CAHKPDGEGL FMCFARWAAG 240 241 ITLVGFNLWV KLDAHRVVKD YAWYWGDFFY LIEQELTFDG VFELAPHPMY SIGYAGYYGI 300 301 SMMAASYDVL FISIIAHAAQ FAFLVIVENP HIEKTYNPPQ PRVRCESEAG SQLQEFASEY 360 361 SVPSTTGRHD NTPLPVHNLI GLKNLDFFRI TDVAIVLLCA YLAVVTMVTP NTRFYQALFV 420 421 LHALAWRLWY SAGLGVILTM QSEEKMFTRH FLKYGESVGE AWRQWKGIYH LSNCLCHASF 480 481 IAASYKMYEF PADWTYGWAL LKHVVGLSLI ALQVWTATSI YESLGEFGWF YGDFFFDSKR 540 541 QLTYTSIYRF LNNPERVFGT AGLWGAALIT WSRAIFLMAL AGHFLTLAFL AYVEKPHMQK 600 601 VYGRNLRDDA GVTKFIKRSL PPPVTEWQQS IDKVLDETKH FIDEFVDAAR SRLATGSSTI 660 661 VKDTSALFNK YPARLTLSKI SPDLAGYDPK HYGLSLAGTR VVGTNEKATG KESPNARVLK 720 721 DVKTQAFEYG APIRVKWTAP ANHSKKDWVG LYMVTDNRSR EVTEVPSLGR WVPTNPGEYD 780 781 TTTDQGILVW DQPVEKKSED TDLVEGEMVF EGDKLWWTQG VFEFRYHHGG GHHVMSISEP 840 841 FEIQIPKFDD EHMGVDISGE VGERAVEAAL LPVIRNCLDR DPDIAPSNAE ERFGGHVERD 900 901 GKYARRVVYA IRHMFGIDFA PAVVLADGNV RRLAWRICHA KEVLAPFSMS HTNGRTTPVD 960 961 SKFSE 965 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCTCCT CGGCAGCAGA TCCCTTTGCC GCCAGGCTCA ACAGTGATGT CCGCCAACGG 60 61 CATCCTACCG CATCGGCGAC CAGCAAGAAT GTAGAGGGCA CTTCGCAGCA GAAGCAGCAG 120 121 CAGCAGCAGC AGCAATCAGA GGCCAATGCC GCTGCGTCAA GGGTCAAAAA GACATACGGC 180 181 AAAACGCCAG ATGGCACAGT CTTCGTCGTC CCCACGACCC ATGACATGGT CACCCAGCTG 240 241 CTCGACCCTC GCGAGCCCAA GAACTTATCA GATGTCGCCG TGCTCGCCAT CATCGCTCTA 300 301 CACTTCCTCG CCGCTTACTA CCTGCCGTGG GGTGTCAAGA GGCCTCTCTT TGCCGCCATC 360 361 TTCATGTTCT GGAGATTGGC TTACAACGTC GGCATTGGTT ACCTGTTGAC GATTCAGTCC 420 421 AAGTACAAGC TCCTGGTGAC TTGGGCCAAG AGGTGGAAGC TGTTTGAGAA CCCCGCGACT 480 481 GGCAAGAACC CGCGCCCATG GCTTTACAAT CTACTCAAGA AGGAACTCGA GACCAAGATC 540 541 CCTCAGGACT ACAAGTTTGA AGAAGCTCCG ATCGAGTACA ACACTTGGCT CACCTTCCGT 600 601 CGCGTCGTCG ACTTGATTCT CATGTGCGAC TTCATCTCCT ACTGCCTGTT CGCTATCGTC 660 661 TGCGCGCACA AGCCGGACGG AGAGGGTTTG TTCATGTGCT TTGCCCGTTG GGCTGCTGGA 720 721 ATCACGCTGG TTGGCTTCAA CCTATGGGTT AAGCTGGATG CTCATCGTGT TGTGAAGGAC 780 781 TATGCTTGGT ACTGGGGTGA CTTCTTCTAC CTCATTGAGC AGGAACTGAC CTTCGACGGT 840 841 GTTTTCGAGC TGGCTCCTCA CCCCATGTAC TCCATCGGAT ACGCTGGGTA CTATGGTATC 900 901 TCCATGATGG CCGCGAGCTA CGACGTCCTG TTTATCTCCA TTATCGCCCA TGCCGCCCAA 960 961 TTCGCCTTTT TGGTAATCGT TGAGAATCCT CATATCGAGA AGACCTATAA CCCGCCTCAG 1020 1021 CCACGTGTGA GGTGCGAGTC GGAGGCTGGT AGTCAGTTGC AGGAGTTTGC TTCCGAGTAC 1080 1081 TCTGTCCCTT CCACAACCGG AAGACATGAC AATACCCCGC TGCCCGTCCA CAACCTCATC 1140 1141 GGTCTCAAGA ACCTCGACTT CTTCCGTATC ACGGACGTTG CCATCGTGCT CCTCTGTGCT 1200 1201 TACCTTGCTG TCGTCACTAT GGTCACTCCC AACACCCGCT TTTACCAAGC CCTTTTCGTG 1260 1261 TTGCATGCTT TGGCTTGGCG TTTGTGGTAC TCTGCCGGTT TGGGAGTGAT TTTGACCATG 1320 1321 CAGTCTGAGG AGAAGATGTT CACTAGGCAC TTCTTGAAGT ACGGCGAGAG CGTGGGCGAG 1380 1381 GCCTGGCGCC AGTGGAAGGG CATCTACCAC CTGAGCAACT GCCTCTGCCA TGCCTCCTTT 1440 1441 ATCGCTGCCT CTTACAAGAT GTATGAATTT CCCGCCGATT GGACCTACGG CTGGGCGCTT 1500 1501 CTCAAGCACG TCGTTGGCCT GAGTTTGATT GCCCTCCAGG TCTGGACCGC CACCAGCATC 1560 1561 TACGAGTCGC TAGGCGAATT CGGATGGTTT TATGGCGATT TCTTCTTCGA CAGCAAGAGG 1620 1621 CAGCTGACTT ACACTTCTAT CTACCGCTTC CTCAACAACC CCGAGCGCGT CTTTGGTACT 1680 1681 GCTGGCTTAT GGGGCGCTGC CCTGATCACC TGGTCCCGCG CCATCTTCCT CATGGCTCTT 1740 1741 GCCGGCCACT TTCTCACTCT TGCGTTCCTC GCGTATGTTG AGAAGCCTCA CATGCAAAAG 1800 1801 GTCTATGGCC GTAATCTGCG TGATGATGCC GGCGTCACCA AGTTCATCAA GCGTTCTCTA 1860 1861 CCTCCCCCTG TTACTGAGTG GCAGCAGAGT ATCGACAAGG TCCTGGATGA GACAAAGCAC 1920 1921 TTCATCGACG AGTTCGTAGA TGCTGCTCGC TCCAGACTCG CCACTGGATC ATCTACCATT 1980 1981 GTCAAGGATA CTTCAGCCCT GTTCAACAAA TACCCCGCTC GTCTCACTCT CAGCAAGATT 2040 2041 TCACCCGACC TTGCGGGCTA CGATCCCAAG CATTATGGTC TGTCTCTGGC TGGTACACGT 2100 2101 GTTGTGGGCA CGAATGAAAA GGCCACGGGC AAGGAAAGCC CCAACGCCCG CGTACTGAAG 2160 2161 GACGTCAAGA CCCAGGCGTT CGAGTACGGA GCCCCGATTC GCGTCAAGTG GACTGCGCCC 2220 2221 GCCAACCACA GCAAGAAGGA CTGGGTCGGT CTCTACATGG TCACGGACAA TCGCTCTAGG 2280 2281 GAGGTCACCG AGGTTCCATC TCTTGGCCGT TGGGTACCAA CCAACCCTGG GGAGTACGAC 2340 2341 ACCACCACCG ACCAGGGTAT TCTCGTCTGG GACCAGCCTG TCGAGAAGAA GTCTGAGGAT 2400 2401 ACAGATCTCG TCGAGGGTGA GATGGTCTTC GAGGGTGACA AGCTTTGGTG GACACAGGGT 2460 2461 GTGTTCGAAT TCCGTTACCA CCACGGTGGC GGACACCACG TCATGTCCAT CTCGGAGCCT 2520 2521 TTCGAAATCC AGATTCCCAA GTTCGACGAC GAGCACATGG GCGTCGATAT CAGCGGAGAA 2580 2581 GTTGGTGAGC GCGCCGTTGA GGCAGCTCTC CTGCCAGTCA TCCGTAACTG CCTGGACCGC 2640 2641 GACCCCGATA TTGCGCCCAG CAATGCGGAA GAGCGTTTCG GCGGCCATGT CGAAAGGGAT 2700 2701 GGCAAGTATG CCAGGCGTGT TGTGTACGCT ATTCGGCATA TGTTCGGTAT CGACTTTGCC 2760 2761 CCTGCGGTTG TGCTTGCGGA CGGAAACGTC CGCAGGTTGG CTTGGAGGAT ATGTCACGCC 2820 2821 AAGGAAGTTC TGGCTCCATT CAGTATGTCA CATACCAACG GCCGGACAAC ACCAGTCGAT 2880 2881 AGCAAGTTCT CTGAGTGA 2898 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Endoplasmic reticulum | |
Lipid biosynthesis | |
Lipid metabolism | |
Membrane | |
Methyltransferase | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Reference proteome | |
S-adenosyl-L-methionine | |
Transferase | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | Phosphatidylcholine biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pytr-1273 | Pyrenophora triticirepentis | 70.24 | 2e-122 | 401 |
| LLPS-Fuo-1330 | Fusarium oxysporum | 68.34 | 0.0 | 1256 |
| LLPS-Fuv-0433 | Fusarium verticillioides | 68.34 | 0.0 | 1258 |
| LLPS-Map-1064 | Magnaporthe poae | 68.27 | 0.0 | 1280 |
| LLPS-Gag-1422 | Gaeumannomyces graminis | 67.79 | 0.0 | 1276 |
| LLPS-Beb-1274 | Beauveria bassiana | 67.11 | 0.0 | 1262 |
| LLPS-Fus-1164 | Fusarium solani | 66.99 | 0.0 | 1290 |
| LLPS-Coo-1207 | Colletotrichum orbiculare | 66.74 | 0.0 | 1263 |
| LLPS-Trv-1494 | Trichoderma virens | 66.63 | 0.0 | 1274 |
| LLPS-Mao-0658 | Magnaporthe oryzae | 66.01 | 0.0 | 1258 |
| LLPS-Ved-1517 | Verticillium dahliae | 65.91 | 0.0 | 1301 |
| LLPS-Cogr-0907 | Colletotrichum graminicola | 65.76 | 0.0 | 1272 |
| LLPS-Trr-1095 | Trichoderma reesei | 65.47 | 0.0 | 1300 |
| LLPS-Cog-1037 | Colletotrichum gloeosporioides | 64.7 | 0.0 | 1276 |
| LLPS-Asni-0930 | Aspergillus niger | 60.95 | 0.0 | 1135 |
| LLPS-Asf-0049 | Aspergillus flavus | 60.58 | 0.0 | 1128 |
| LLPS-Aso-0402 | Aspergillus oryzae | 60.58 | 0.0 | 1128 |
| LLPS-Asfu-1308 | Aspergillus fumigatus | 60.54 | 0.0 | 1069 |
| LLPS-Asc-1162 | Aspergillus clavatus | 60.48 | 0.0 | 1125 |
| LLPS-Ast-1319 | Aspergillus terreus | 59.82 | 0.0 | 1100 |
| LLPS-Nef-0792 | Neosartorya fischeri | 59.57 | 0.0 | 1113 |
| LLPS-Pyt-1456 | Pyrenophora teres | 58.85 | 0.0 | 1060 |
| LLPS-Blg-0539 | Blumeria graminis | 58.22 | 0.0 | 1051 |
| LLPS-Miv-1393 | Microbotryum violaceum | 57.06 | 3e-48 | 190 |
| LLPS-Lem-0456 | Leptosphaeria maculans | 56.35 | 0.0 | 1036 |
| LLPS-Dos-0973 | Dothistroma septosporum | 55.89 | 0.0 | 1029 |
| LLPS-Phn-0811 | Phaeosphaeria nodorum | 55.7 | 0.0 | 1023 |
| LLPS-Zyt-0976 | Zymoseptoria tritici | 55.35 | 0.0 | 1028 |
| LLPS-Tum-1495 | Tuber melanosporum | 50.53 | 0.0 | 864 |
| LLPS-Spr-1555 | Sporisorium reilianum | 46.81 | 1e-66 | 246 |
| LLPS-Crn-1111 | Cryptococcus neoformans | 44.34 | 8e-61 | 229 |
| LLPS-Scj-1398 | Schizosaccharomyces japonicus | 41.48 | 0.0 | 620 |
| LLPS-Yal-0985 | Yarrowia lipolytica | 41.06 | 0.0 | 643 |
| LLPS-Abg-1865 | Absidia glauca | 39.47 | 0.0 | 638 |
| LLPS-Scc-1317 | Schizosaccharomyces cryophilus | 39.32 | 0.0 | 587 |
| LLPS-Scp-1575 | Schizosaccharomyces pombe | 38.55 | 0.0 | 608 |
| LLPS-Mel-1400 | Melampsora laricipopulina | 38.13 | 0.0 | 578 |
| LLPS-Chc-0342 | Chondrus crispus | 37.01 | 2e-38 | 156 |
| LLPS-Put-0847 | Puccinia triticina | 34.92 | 9e-169 | 530 |
| LLPS-Usm-0901 | Ustilago maydis | 34.22 | 3e-47 | 187 |
| LLPS-Asg-0805 | Ashbya gossypii | 33.54 | 5e-106 | 355 |
| LLPS-Pug-1026 | Puccinia graminis | 33.49 | 9e-166 | 522 |
| LLPS-Sac-0538 | Saccharomyces cerevisiae | 32.27 | 8e-107 | 358 |
| LLPS-Cym-0800 | Cyanidioschyzon merolae | 31.37 | 7e-78 | 276 |
| LLPS-Kop-0636 | Komagataella pastoris | 30.56 | 2e-108 | 363 |
| LLPS-Gas-1063 | Galdieria sulphuraria | 28.95 | 2e-77 | 274 |