• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Php-1164
PHYPA_006783

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit A
Gene Name: PHYPA_006783
Ensembl Gene: Pp3c4_26450
Ensembl Protein: Pp3c4_26450V3.3
Organism: Physcomitrella patens
Taxa ID: 3218
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MATFAKPENA  LKRAEELMNV  GQKQAALQAL  HDLITSKRYR  AWQKTLEKIM  FKYVELCVDM  60
61    KKGRFAKDGL  IQYRIVCQQV  NVSSLEEVIK  YFLQLSSERA  EAAQVQAAAA  EVTLDIEDLE  120
121   AEKRPEDLML  SYVSGERGKE  RSDRETVTPW  FQFLWETYRT  VLEILRNNSK  LESLYSMTAH  180
181   RAFQFCLQYK  RTTEFRRLCE  ILRNHLINLN  KYRDQRDRPD  LTQPESLQLY  LETRFEQLKV  240
241   ATELELWQEA  FRSIEDIHGL  MFMVKRTPKP  QMMAVYYAKL  TQIYWVSDSH  LYHAYAWYKL  300
301   YNLQKSYNKN  LTAKDLQLMA  SSVVLATLAV  APYDRKYGAH  HFELEMEKDR  NIRMANILGF  360
361   NIDVKKDSRE  VLSRAALLSE  LVAKGVMTYV  SPEVKDLYTL  LENEFHPLDL  AARAEPFLSK  420
421   LPNLSDKLSS  ASPVPEVRLE  QYVPALERLT  ALRVLQQVSQ  VYSTIKIADL  TRMVTFFDFS  480
481   KVEKLIVEAV  KYNFVQMKVD  HLKEVVNFGS  QDLESEKVKT  HLTVLAKRLK  KACSMIFPPS  540
541   IERPSKQTLP  YPELLAVVEK  EHKKLLARKV  LIERRKEEQE  RQMLEMEREE  ESKRLKQQRL  600
601   TEEAEAKRLA  KESARREEAR  IRKEIEDKEL  EEARTLLAEA  EKRKGKKGKK  AAADGEVTKI  660
661   TKQLLLEEAL  SEQIKERQEM  ERKLQKLAKT  MDYLERAKRE  EERPLIEEAY  RNRLQDDERF  720
721   YKQQQEQAIE  QSKNQHETDV  VEKHRLLRMA  DDKDVFQRQV  VARRQGEFER  LQRLREERLA  780
781   EERAIRSQER  EIRRKKEFFR  RQEEQRLLRI  QEEEEARKRE  EIERKRREEA  ERLAKLEEIA  840
841   QKQREREAAA  EEREKREREE  ALRARLEEKP  GKFVLPSLRK  RLEGGDDMRR  PNMDDRRDVR  900
901   PSMEERRPLF  DVQGSATSRE  TDMQVEREAS  SPPSKRYQPP  RGRQVDSEAP  PPRAYEPPVR  960
961   RTHDALAARK  DVYDPPRAGA  YAHPGRSGGR  PLGGGRLVEE  RPERRDRW  1008
Nucleotide CDS Sequence (FASTA)
1     ATGACATATG  TTTCACCTGA  GGTTAAGGAT  TTGTACACAT  TGTTAGAGAA  TGAATTTCAT  60
61    CCGCTCGATC  TTGCTGCAAG  AGCTGAGCCT  TTCCTATCAA  AACTCCCAAA  TCTAAGCGAC  120
121   AAATTGTCGT  CAGCGTCACC  TGTCCCAGAA  GTGCGATTGG  AACAGTATGT  TCCAGCTCTT  180
181   GAAAGGCTTA  CTGCTCTTCG  AGTTCTTCAG  CAAGTTTCTC  AAGTGTATTC  TACTATTAAG  240
241   ATTGCAGACC  TTACTCGAAT  GGTTACCTTT  TTTGATTTCT  CAAAGGTTGA  GAAGTTAATT  300
301   GTTGAAGCTG  TGAAGTACAA  CTTTGTGCAA  ATGAAGGTTG  ATCATCTGAA  AGAAGTTGTC  360
361   AACTTCGGCA  GTCAGGATTT  GGAATCTGAG  AAAGTGAAAA  CCCATCTTAC  TGTTCTTGCC  420
421   AAGAGGTTGA  AGAAGGCCTG  CAGCATGATC  TTTCCACCGT  CTATTGAGAG  ACCATCTAAG  480
481   CAGACTTTGC  CTTACCCGGA  ACTTCTAGCG  GTTGTGGAAA  AGGAGCATAA  AAAGTTGTTA  540
541   GCTCGCAAGG  TTTTGATTGA  GCGTCGCAAA  GAAGAGCAAG  AACGACAAAT  GCTTGAAATG  600
601   GAAAGAGAAG  AGGAGTCAAA  GAGGCTGAAG  CAGCAACGTT  TGACAGAAGA  AGCTGAGGCA  660
661   AAGAGACTCG  CAAAAGAGTC  AGCCAGGCGA  GAGGAAGCCA  GAATTCGGAA  GGAAATCGAA  720
721   GACAAAGAAC  TGGAGGAAGC  GAGAACCTTG  CTTGCCGAAG  CTGAAAAACG  AAAGGGCAAG  780
781   AAGGGCAAGA  AAGCAGCTGC  AGATGGAGAA  GTTACCAAAA  TTACAAAGCA  GCTTCTTTTG  840
841   GAAGAGGCTT  TAAGTGAGCA  AATAAAAGAA  CGACAAGAGA  TGGAGCGGAA  GCTCCAGAAG  900
901   CTCGCGAAGA  CGATGGATTA  TTTGGAACGT  GCAAAGCGAG  AGGAGGAGAG  ACCATTGATT  960
961   GAGGAGGCTT  ACCGCAACCG  GCTTCAGGAT  GATGAGCGGT  TTTACAAGCA  ACAACAGGAG  1020
1021  CAAGCCATTG  AGCAGAGCAA  GAATCAGCAC  GAGACAGACG  TGGTTGAGAA  GCATCGGTTG  1080
1081  TTGCGGATGG  CAGACGACAA  GGATGTTTTC  CAACGACAAG  TTGTCGCCCG  TCGTCAAGGA  1140
1141  GAGTTTGAGA  GGTTGCAGCG  CTTGCGGGAA  GAGAGACTAG  CGGAGGAGCG  TGCTATTAGA  1200
1201  TCTCAAGAAC  GTGAGATCAG  ACGCAAGAAG  GAATTCTTTA  GGAGACAAGA  GGAGCAGCGA  1260
1261  CTTCTTAGGA  TTCAGGAAGA  AGAAGAAGCT  AGAAAGAGAG  AAGAAATAGA  GCGCAAACGC  1320
1321  AGAGAAGAAG  CTGAGCGTCT  CGCTAAGTTG  GAGGAAATTG  CTCAAAAGCA  ACGGGAGAGA  1380
1381  GAGGCTGCTG  CCGAAGAGAG  GGAGAAGCGT  GAGAGAGAAG  AGGCTTTGCG  AGCCAGGCTT  1440
1441  GAAGAAAAGC  CTGGAAAGTT  TGTACTCCCT  TCACTTCGAA  AGAGGTTGGA  GGGTGGTGAC  1500
1501  GATATGAGGC  GTCCTAACAT  GGATGATCGC  CGAGACGTAC  GTCCTTCAAT  GGAGGAACGC  1560
1561  CGGCCTCTTT  TTGATGTGCA  AGGATCGGCT  ACTTCCCGCG  AAACAGATAT  GCAGGTTGAA  1620
1621  AGGGAGGCTT  CCAGTCCTCC  CTCTAAACGC  TATCAACCAC  CGCGAGGTCG  CCAGGTTGAT  1680
1681  TCTGAAGCTC  CTCCACCGCG  GGCTTATGAA  CCTCCAGTTC  GACGCACGCA  TGATGCCCTA  1740
1741  GCTGCCCGCA  AGGATGTTTA  TGACCCTCCC  CGGGCTGGTG  CATATGCTCA  TCCAGGTCGC  1800
1801  TCAGGAGGTA  GACCCCTTGG  TGGTGGCCGA  CTTGTGGAAG  AGCGTCCAGA  GCGCCGAGAC  1860
1861  CGGTGGTAG  1869

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sem-0336Selaginella moellendorffii79.370.0 927
LLPS-Amt-0137Amborella trichopoda78.850.0 910
LLPS-Pot-0396Populus trichocarpa74.130.0 832
LLPS-Mae-1398Manihot esculenta73.780.0 855
LLPS-Viv-0885Vitis vinifera73.60.0 848
LLPS-Mua-1669Musa acuminata72.90.0 822
LLPS-Lep-1793Leersia perrieri72.90.0 845
LLPS-Orb-0329Oryza barthii72.730.0 843
LLPS-Ori-1613Oryza indica72.730.0 843
LLPS-Orni-0562Oryza nivara72.730.0 844
LLPS-Ors-0761Oryza sativa72.730.0 842
LLPS-Orr-0489Oryza rufipogon72.730.0 842
LLPS-Orm-0829Oryza meridionalis72.730.0 843
LLPS-Org-0875Oryza glaberrima72.730.0 840
LLPS-Orgl-0581Oryza glumaepatula72.550.0 843
LLPS-Orp-0081Oryza punctata72.550.0 842
LLPS-Hov-0369Hordeum vulgare72.380.0 846
LLPS-Tra-0743Triticum aestivum72.20.0 848
LLPS-Orbr-1098Oryza brachyantha72.20.0 837
LLPS-Coc-2146Corchorus capsularis72.20.0 848
LLPS-Tru-0894Triticum urartu72.20.0 850
LLPS-Cus-1019Cucumis sativus71.850.0 837
LLPS-Phv-0370Phaseolus vulgaris71.850.0 839
LLPS-Glm-1144Glycine max71.680.0 838
LLPS-Met-0081Medicago truncatula71.50.0 822
LLPS-Vir-0284Vigna radiata71.50.0 834
LLPS-Sob-1639Sorghum bicolor71.50.0 835
LLPS-Brd-1665Brachypodium distachyon71.330.0 832
LLPS-Thc-0247Theobroma cacao71.150.0 831
LLPS-Zem-1185Zea mays71.150.0 824
LLPS-Gor-0600Gossypium raimondii70.80.0 828
LLPS-Prp-1021Prunus persica70.80.0 794
LLPS-Hea-1470Helianthus annuus70.630.0 822
LLPS-Sol-0993Solanum lycopersicum70.450.0 807
LLPS-Sot-0022Solanum tuberosum70.450.0 807
LLPS-Sei-0630Setaria italica69.980.0 743
LLPS-Brn-0379Brassica napus69.280.0 803
LLPS-Bro-0581Brassica oleracea69.280.0 804
LLPS-Dac-0439Daucus carota69.060.0 804
LLPS-Brr-1395Brassica rapa68.940.0 801
LLPS-Arl-0341Arabidopsis lyrata68.590.0 803
LLPS-Art-2707Arabidopsis thaliana68.590.0 803
LLPS-Via-0841Vigna angularis67.830.0 765
LLPS-Nia-0434Nicotiana attenuata66.060.0 898
LLPS-Chr-0851Chlamydomonas reinhardtii51.640.0 567
LLPS-Osl-0946Ostreococcus lucimarinus50.090.0 563
LLPS-Mum-0015Mus musculus41.321e-132 440
LLPS-Mea-1773Mesocricetus auratus41.323e-134 441
LLPS-Chs-2477Chlorocebus sabaeus41.328e-134 441
LLPS-Cea-0090Cercocebus atys41.321e-132 441
LLPS-Gog-0965Gorilla gorilla41.322e-134 441
LLPS-Dio-0869Dipodomys ordii41.321e-132 440
LLPS-Bot-2842Bos taurus41.321e-132 441
LLPS-Orc-2967Oryctolagus cuniculus41.322e-132 440
LLPS-Cap-0952Cavia porcellus41.321e-132 440
LLPS-Mam-0588Macaca mulatta41.322e-132 440
LLPS-Cas-1796Carlito syrichta41.326e-132 439
LLPS-Loa-0625Loxodonta africana41.262e-131 436
LLPS-Asm-2057Astyanax mexicanus41.224e-135 446
LLPS-Aon-2312Aotus nancymaae41.153e-132 439
LLPS-Mod-0435Monodelphis domestica41.158e-134 438
LLPS-Nef-1170Neosartorya fischeri41.033e-124 411
LLPS-Gaa-2181Gasterosteus aculeatus40.988e-134 441
LLPS-Ast-0339Aspergillus terreus40.966e-125 413
LLPS-Xet-1944Xenopus tropicalis40.814e-131 437
LLPS-Leo-0013Lepisosteus oculatus40.716e-135 445
LLPS-Tar-3448Takifugu rubripes40.711e-132 439
LLPS-Scf-0964Scleropages formosus40.719e-134 441
LLPS-Scm-1761Scophthalmus maximus40.719e-134 441
LLPS-Pap-0435Pan paniscus40.75e-125 419
LLPS-Sus-0395Sus scrofa40.642e-132 440
LLPS-Fud-0634Fukomys damarensis40.641e-127 426
LLPS-Paa-0066Papio anubis40.642e-132 440
LLPS-Aim-0186Ailuropoda melanoleuca40.642e-132 439
LLPS-Hos-1018Homo sapiens40.641e-132 441
LLPS-Fec-0067Felis catus40.647e-133 441
LLPS-Otg-1062Otolemur garnettii40.645e-132 439
LLPS-Poa-3313Pongo abelii40.642e-132 441
LLPS-Caf-1416Canis familiaris40.649e-133 441
LLPS-Eqc-1710Equus caballus40.649e-133 441
LLPS-Ova-0256Ovis aries40.592e-125 421
LLPS-Pes-0891Pelodiscus sinensis40.592e-126 422
LLPS-Blg-0618Blumeria graminis40.541e-121 404
LLPS-Pof-1144Poecilia formosa40.542e-132 438
LLPS-Asfu-0717Aspergillus fumigatus40.544e-124 411
LLPS-Caj-2102Callithrix jacchus40.522e-124 418
LLPS-Beb-1221Beauveria bassiana40.483e-120 400
LLPS-Ran-0623Rattus norvegicus40.473e-132 439
LLPS-Sah-1478Sarcophilus harrisii40.412e-125 421
LLPS-Rhb-2196Rhinopithecus bieti40.382e-122 412
LLPS-Xim-0895Xiphophorus maculatus40.378e-133 439
LLPS-Dar-0159Danio rerio40.371e-132 439
LLPS-Myl-2518Myotis lucifugus40.31e-129 432
LLPS-Scs-0678Sclerotinia sclerotiorum40.224e-123 408
LLPS-Ved-0012Verticillium dahliae40.223e-122 406
LLPS-Orl-1930Oryzias latipes40.24e-132 437
LLPS-Nol-2298Nomascus leucogenys40.171e-122 412
LLPS-Mup-2552Mustela putorius furo40.14e-127 425
LLPS-Gaga-1420Gallus gallus40.11e-131 438
LLPS-Asn-0846Aspergillus nidulans40.064e-122 405
LLPS-Asni-0491Aspergillus niger40.061e-122 407
LLPS-Orn-0451Oreochromis niloticus40.031e-129 431
LLPS-Coo-1154Colletotrichum orbiculare39.96e-120 400
LLPS-Cog-0227Colletotrichum gloeosporioides39.95e-120 399
LLPS-Lem-0000Leptosphaeria maculans39.741e-124 413
LLPS-Pytr-0849Pyrenophora triticirepentis39.749e-125 414
LLPS-Trv-0529Trichoderma virens39.743e-116 390
LLPS-Tag-0426Taeniopygia guttata39.722e-126 424
LLPS-Anc-0781Anolis carolinensis39.592e-129 433
LLPS-Asc-0268Aspergillus clavatus39.581e-124 412
LLPS-Lac-0085Latimeria chalumnae39.562e-122 411
LLPS-Ora-0586Ornithorhynchus anatinus39.556e-125 417
LLPS-Aso-0629Aspergillus oryzae39.421e-124 412
LLPS-Abg-0914Absidia glauca39.42e-124 410
LLPS-Fia-0193Ficedula albicollis39.396e-121 405
LLPS-Meg-1968Meleagris gallopavo39.381e-124 419
LLPS-Mal-2977Mandrillus leucophaeus39.361e-114 391
LLPS-Maf-0125Macaca fascicularis39.354e-114 389
LLPS-Man-0022Macaca nemestrina39.355e-114 389
LLPS-Gag-0109Gaeumannomyces graminis39.332e-116 390
LLPS-Map-0507Magnaporthe poae39.332e-116 390
LLPS-Cogr-0497Colletotrichum graminicola39.263e-118 395
LLPS-Pyt-0036Pyrenophora teres39.11e-124 413
LLPS-Trr-0690Trichoderma reesei39.13e-117 392
LLPS-Nec-1029Neurospora crassa39.072e-117 393
LLPS-Tum-1297Tuber melanosporum39.031e-121 405
LLPS-Pat-0419Pan troglodytes39.029e-0654.3
LLPS-Usm-0700Ustilago maydis39.021e-127 419
LLPS-Spr-0531Sporisorium reilianum39.027e-126 416
LLPS-Ict-0861Ictidomys tridecemlineatus39.026e-0654.7
LLPS-Mao-1429Magnaporthe oryzae38.688e-115 386
LLPS-Fus-1159Fusarium solani38.41e-114 385
LLPS-Fuv-0009Fusarium verticillioides38.32e-115 387
LLPS-Scj-0577Schizosaccharomyces japonicus38.268e-114 380
LLPS-Dos-0694Dothistroma septosporum38.227e-122 405
LLPS-Yal-0777Yarrowia lipolytica38.144e-101 346
LLPS-Fuo-0554Fusarium oxysporum38.141e-114 385
LLPS-Zyt-0164Zymoseptoria tritici37.949e-120 400
LLPS-Cae-0073Caenorhabditis elegans37.673e-97 338
LLPS-Gas-0051Galdieria sulphuraria37.362e-0655.8
LLPS-Drm-0296Drosophila melanogaster37.254e-104 358
LLPS-Chc-0832Chondrus crispus37.242e-106 361
LLPS-Cii-0363Ciona intestinalis36.812e-113 382
LLPS-Scc-0341Schizosaccharomyces cryophilus36.624e-115 384
LLPS-Scp-0823Schizosaccharomyces pombe36.522e-110 370
LLPS-Miv-0040Microbotryum violaceum36.525e-96 333
LLPS-Asf-0691Aspergillus flavus36.047e-92 322
LLPS-Asg-0027Ashbya gossypii35.951e-76 276
LLPS-Put-0093Puccinia triticina35.754e-100 347
LLPS-Pug-0601Puccinia graminis35.11e-96 337
LLPS-Phn-1167Phaeosphaeria nodorum35.03e-85 303
LLPS-Kop-0603Komagataella pastoris34.985e-83 293
LLPS-Ten-1186Tetraodon nigroviridis34.948e-65 241
LLPS-Sac-0156Saccharomyces cerevisiae34.443e-76 275
LLPS-Mel-0352Melampsora laricipopulina34.249e-94 328
LLPS-Crn-0205Cryptococcus neoformans32.845e-69 253
LLPS-Cym-0030Cyanidioschyzon merolae24.013e-40 166