LLPS-Php-1050
TOP6B
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA topoisomerase 6 subunit B |
| Gene Name: | TOP6B, PHYPA_027060 |
| Ensembl Gene: | Pp3c22_12720 |
| Ensembl Protein: | Pp3c22_12720V3.3 |
| Organism: | Physcomitrella patens |
| Taxa ID: | 3218 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Pp3c22_12720V3.3 | Pp3c22_12720V3.3 |
| Ensembl | Pp3c22_12720V3.1 | Pp3c22_12720V3.1 |
| Ensembl | Pp3c22_12720V3.2 | Pp3c22_12720V3.2 |
| UniProt | A0A2K1IN99, A0A2K1IN99_PHYPA | |
| GeneBank | ABEU02000022 | PNR30744.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEASKEKKKP KGKGATATES VLKQKSPAEF FSENKNIAGF DNPGKSLYTT VRELVENALD 60 61 SAESIAELPV IEVTIEEISK SAFNAMIGLV DRERIDAALY DDFESEKAKE KRLAKEAKEQ 120 121 EKVAKALAAG KKVKDPHAKT GKGRGDTCFF KVTCKDNGKG MPHVDIPNML GRVLSGTKYG 180 181 LKQTRGKFGL GAKMALIWSK MSTGLPIDIW SSTKGQDFIS FCKLDLNIHQ NIPNIHVHEK 240 241 RPNPEKWRGA ELQVTIEGNW TTYRAKIINY LRQMAVITPY AQFNFSYIGP IPEKNLAIRF 300 301 ARRTDVMPPV PEETKHHPSA VDLLLIKRLI AESKEIHLQA FLQKEFVSIN KAHAERLIGE 360 361 MGPEFQPKML VKSLSDEQIV RLHQLFRQAK FDDPSGQCLS PAGEYNLRLG IMKELNPDLV 420 421 ATYEGSAQVF EGHPFIVEAG VSLGGKDVKP GINIFRFANR IPLLFEQGGD VVTRTAMKRI 480 481 NWGSYKINQQ QDKIGVFVSI VSTKIPFKGT GKEYIGDDIS EIAAAVKSSL QNCCIQLKAK 540 541 IVRQQQAKER QQRKRNLSKY IPDVSRAIYD VLQLMAGPAA KRQKFGFEYQ DMLEKVAKRE 600 601 ITEATLKQKL TQHVQQVDSE MALEFATQSG MVDTARENVY LTALDAKREF AVEFHNSVGV 660 661 FKLFTGL 667 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCTT CTAAGGAGAA GAAGAAGCCC AAGGGGAAGG GAGCTACTGC CACTGAATCT 60 61 GTCCTCAAAC AAAAGTCTCC TGCCGAATTT TTCTCCGAGA ATAAAAATAT TGCCGGATTC 120 121 GACAATCCTG GAAAGAGTCT TTATACAACA GTACGTGAGC TGGTTGAAAA TGCCCTTGAT 180 181 TCAGCAGAGT CCATTGCTGA GCTTCCTGTC ATTGAAGTGA CTATTGAGGA GATTAGCAAA 240 241 TCTGCATTTA ATGCTATGAT TGGGCTTGTT GACCGGGAGC GTATTGATGC AGCTTTATAT 300 301 GACGATTTCG AATCCGAGAA GGCCAAGGAG AAACGACTTG CCAAGGAAGC CAAGGAGCAA 360 361 GAAAAGGTAG CTAAGGCCTT AGCTGCTGGA AAGAAGGTTA AGGATCCTCA TGCTAAAACT 420 421 GGTAAAGGGC GTGGCGACAC ATGCTTCTTC AAGGTTACTT GCAAGGATAA TGGGAAAGGT 480 481 ATGCCACATG TTGATATTCC GAACATGCTC GGTCGAGTTC TGTCAGGAAC AAAATATGGA 540 541 TTGAAGCAAA CTCGCGGTAA ATTCGGGCTG GGTGCTAAAA TGGCTTTAAT CTGGTCGAAA 600 601 ATGAGCACTG GTCTGCCGAT CGACATCTGG AGTTCTACGA AAGGGCAGGA CTTTATTTCT 660 661 TTCTGCAAGC TTGATCTTAA TATTCACCAA AACATTCCAA ATATCCATGT ACATGAGAAA 720 721 CGGCCTAATC CTGAGAAATG GCGTGGAGCG GAACTTCAGG TTACTATAGA AGGCAATTGG 780 781 ACAACTTATC GCGCGAAGAT AATAAACTAC TTGCGGCAGA TGGCTGTAAT TACACCTTAC 840 841 GCACAATTCA ACTTTTCTTA TATTGGACCA ATACCAGAGA AGAATTTGGC CATTCGGTTT 900 901 GCGAGGCGAA CAGATGTAAT GCCTCCTGTG CCAGAGGAAA CCAAGCATCA CCCTTCAGCT 960 961 GTAGATCTGC TGCTTATCAA AAGACTTATT GCAGAATCAA AAGAAATACA CCTCCAAGCT 1020 1021 TTTCTGCAGA AGGAATTTGT TTCCATTAAT AAAGCACATG CCGAACGACT TATTGGTGAA 1080 1081 ATGGGCCCTG AGTTTCAACC TAAGATGCTA GTGAAATCAC TCAGCGATGA GCAGATTGTT 1140 1141 CGTCTTCACC AGTTATTCAG ACAAGCCAAA TTTGATGATC CGAGTGGACA GTGCCTCAGC 1200 1201 CCTGCTGGAG AATACAATCT ACGCCTTGGT ATCATGAAAG AGCTGAATCC AGACCTCGTT 1260 1261 GCTACTTATG AGGGCAGTGC TCAAGTCTTT GAGGGACATC CATTTATAGT GGAGGCTGGG 1320 1321 GTTAGTCTTG GCGGTAAAGA TGTGAAGCCT GGCATCAATA TTTTTCGCTT TGCCAATCGT 1380 1381 ATCCCTCTAC TATTTGAGCA AGGGGGAGAT GTTGTCACAC GTACCGCCAT GAAACGCATC 1440 1441 AACTGGGGCT CGTATAAAAT CAATCAACAA CAAGACAAGA TTGGTGTATT TGTGAGCATT 1500 1501 GTGAGCACCA AAATTCCGTT CAAGGGCACT GGCAAAGAGT ACATTGGTGA TGATATATCT 1560 1561 GAAATTGCAG CAGCGGTTAA GTCATCACTT CAAAATTGCT GCATTCAGCT GAAAGCCAAA 1620 1621 ATAGTTCGAC AGCAGCAAGC TAAAGAAAGG CAGCAACGGA AGCGGAATCT CTCAAAGTAC 1680 1681 ATTCCAGATG TTTCGCGCGC AATTTATGAT GTATTGCAAC TTATGGCGGG ACCAGCGGCC 1740 1741 AAGAGGCAGA AGTTTGGTTT TGAATATCAA GATATGCTTG AGAAAGTTGC TAAGCGTGAA 1800 1801 ATCACAGAAG CCACATTGAA GCAAAAGCTT ACACAGCATG TTCAACAGGT TGACTCGGAG 1860 1861 ATGGCTCTAG AATTTGCTAC CCAGAGTGGC ATGGTTGATA CTGCTCGAGA GAATGTCTAT 1920 1921 CTGACGGCTT TAGATGCCAA GAGGGAATTT GCAGTAGAAT TTCACAATTC AGTTGGCGTA 1980 1981 TTTAAACTAT TTACAGGATT ATAA 2004 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | DNA topoisomerase complex (ATP-hydrolyzing) | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (ATP-hydrolyzing) activity | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Cell morphogenesis | |
Biological Process | DNA endoreduplication | |
Biological Process | DNA topological change | |
Biological Process | Pattern specification process | |
Biological Process | Response to brassinosteroid | |
Biological Process | Trichome differentiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Coc-1218 | Corchorus capsularis | 78.56 | 0.0 | 845 |
| LLPS-Dac-0500 | Daucus carota | 75.2 | 1e-109 | 350 |
| LLPS-Gor-1606 | Gossypium raimondii | 74.07 | 0.0 | 944 |
| LLPS-Viv-1747 | Vitis vinifera | 73.95 | 0.0 | 941 |
| LLPS-Thc-2188 | Theobroma cacao | 73.72 | 0.0 | 940 |
| LLPS-Sem-0287 | Selaginella moellendorffii | 73.38 | 0.0 | 918 |
| LLPS-Mae-2138 | Manihot esculenta | 73.3 | 0.0 | 935 |
| LLPS-Hea-1247 | Helianthus annuus | 73.23 | 0.0 | 923 |
| LLPS-Cus-2215 | Cucumis sativus | 73.05 | 0.0 | 924 |
| LLPS-Phv-1860 | Phaseolus vulgaris | 72.8 | 0.0 | 932 |
| LLPS-Met-0946 | Medicago truncatula | 72.64 | 0.0 | 933 |
| LLPS-Via-2251 | Vigna angularis | 72.64 | 0.0 | 929 |
| LLPS-Tra-2337 | Triticum aestivum | 72.56 | 0.0 | 914 |
| LLPS-Art-0920 | Arabidopsis thaliana | 72.49 | 0.0 | 926 |
| LLPS-Nia-1820 | Nicotiana attenuata | 72.33 | 0.0 | 918 |
| LLPS-Sei-1526 | Setaria italica | 72.25 | 0.0 | 918 |
| LLPS-Mua-2510 | Musa acuminata | 72.16 | 0.0 | 913 |
| LLPS-Amt-0076 | Amborella trichopoda | 72.14 | 0.0 | 914 |
| LLPS-Pot-1412 | Populus trichocarpa | 72.14 | 0.0 | 930 |
| LLPS-Ors-0260 | Oryza sativa | 72.09 | 0.0 | 899 |
| LLPS-Orp-1186 | Oryza punctata | 72.09 | 0.0 | 899 |
| LLPS-Ori-0704 | Oryza indica | 72.09 | 0.0 | 900 |
| LLPS-Orbr-0299 | Oryza brachyantha | 72.05 | 0.0 | 912 |
| LLPS-Glm-1566 | Glycine max | 72.02 | 0.0 | 927 |
| LLPS-Brd-0485 | Brachypodium distachyon | 71.36 | 0.0 | 898 |
| LLPS-Brn-0484 | Brassica napus | 70.94 | 0.0 | 910 |
| LLPS-Sob-0712 | Sorghum bicolor | 70.7 | 0.0 | 897 |
| LLPS-Arl-2383 | Arabidopsis lyrata | 69.75 | 0.0 | 903 |
| LLPS-Brr-2998 | Brassica rapa | 69.47 | 0.0 | 904 |
| LLPS-Hov-2033 | Hordeum vulgare | 69.35 | 0.0 | 896 |
| LLPS-Sot-1438 | Solanum tuberosum | 68.98 | 5e-160 | 474 |
| LLPS-Prp-1879 | Prunus persica | 68.27 | 0.0 | 893 |
| LLPS-Bro-0054 | Brassica oleracea | 68.09 | 0.0 | 901 |
| LLPS-Orb-0322 | Oryza barthii | 68.01 | 0.0 | 826 |
| LLPS-Orm-0660 | Oryza meridionalis | 67.75 | 0.0 | 821 |
| LLPS-Orni-1483 | Oryza nivara | 67.75 | 0.0 | 820 |
| LLPS-Sol-2074 | Solanum lycopersicum | 66.4 | 6e-167 | 492 |
| LLPS-Orr-1855 | Oryza rufipogon | 64.84 | 0.0 | 805 |
| LLPS-Vir-0101 | Vigna radiata | 64.45 | 0.0 | 781 |
| LLPS-Orgl-2143 | Oryza glumaepatula | 62.24 | 0.0 | 723 |
| LLPS-Zem-1027 | Zea mays | 61.23 | 0.0 | 699 |
| LLPS-Lep-1044 | Leersia perrieri | 58.45 | 0.0 | 665 |
| LLPS-Chr-0328 | Chlamydomonas reinhardtii | 55.39 | 0.0 | 710 |
| LLPS-Osl-1328 | Ostreococcus lucimarinus | 54.38 | 0.0 | 648 |
| LLPS-Chc-0738 | Chondrus crispus | 50.54 | 0.0 | 601 |
| LLPS-Cym-1061 | Cyanidioschyzon merolae | 48.34 | 0.0 | 558 |