LLPS-Brr-2998
TOP6B
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA topoisomerase 6 subunit B |
| Gene Name: | TOP6B |
| Ensembl Gene: | Bra035745 |
| Ensembl Protein: | Bra035745.1-P |
| Organism: | Brassica rapa |
| Taxa ID: | 51351 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Bra035745.1 | Bra035745.1-P |
| UniProt | M4F3U5, M4F3U5_BRARP |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGGDSPAET KKGSSKTSKN SKDSSKESTL KQKSPAEFFA ENKNIAGFDN PGKSLYTTVR 60 61 ELVENALDSS ESISELPEVE VTIEEIGKSK FNSMIGLIDR ERVDTKLYDD YETDKAREKR 120 121 LVKEARASEI QAKNLASGKK NKEPGVSKVL KARGEASYYK VTCKDNGKGM PHDDIPNMFG 180 181 RDLRIVLLTV LSGTKYGLKQ TRGKFGLGAK MALIWSKMST GLPIEISSSM KSQNYVTFCR 240 241 LDIDIHRNIP HIHLHEKKAN KEKWHGAEIQ VVIEGNWTTY RSKILHYMRQ MAVITPYAQF 300 301 LFRFISETPE KNVTVKFTRR TDVMPPIPIE TKHHPSSVDL LLIKRLVTDT SKKTLLQFLQ 360 361 NEFVNINKNL AARLIGEMGP DFSPGMAVKS VTSQQMVRIH QLFRQAKFDD PSGDCLSPAG 420 421 EYNLRLGIIK ELHPDMVATH SGSAQVFEGH PFIVEAGVSV GGRDVKQASH ILLLFIHGIN 480 481 IFRFANRIPL LFEQGGDVVT RTALKRINWN SYKINQTQDK IGVFVSIVST KIPFKGTGKE 540 541 YIGDDISEIA TAVKSAIQQC CIQLKSKIVK RLQAREQQER KRSLSRYIPD ATGAVYEVLK 600 601 QMTEEHTKKR KRYKEEETAM LEKVSKLIIT KETLKEKLAE HVEQVDYEMA LEYATQSGVS 660 661 EEPKENIYLQ QLNPNHSNFI DLHSPTFVFR LIL 693 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGGAG GTGATAGTCC AGCTGAAACG AAGAAGGGAA GCTCTAAGAC CTCTAAGAAC 60 61 AGTAAAGACA GCAGCAAAGA GAGCACTCTC AAGCAGAAAT CTCCAGCTGA GTTTTTCGCC 120 121 GAGAACAAGA ACATTGCTGG ATTCGATAAT CCAGGGAAGT CACTGTACAC TACAGTGAGA 180 181 GAGCTTGTTG AAAACGCTCT TGATTCTTCT GAGTCCATCT CTGAGCTCCC TGAGGTTGAA 240 241 GTTACTATCG AAGAGATTGG AAAATCTAAG TTCAATTCCA TGATTGGTCT TATTGATCGG 300 301 GAACGTGTTG ACACCAAGCT CTATGATGAC TACGAGACTG ACAAGGCCCG TGAGAAAAGG 360 361 TTAGTAAAGG AAGCTCGTGC CAGTGAGATA CAAGCCAAAA ATTTGGCTTC AGGAAAGAAA 420 421 AACAAAGAGC CTGGAGTCTC TAAGGTTTTA AAGGCTCGTG GGGAAGCATC CTATTACAAG 480 481 GTTACATGTA AGGATAATGG TAAGGGGATG CCACACGATG ACATCCCAAA TATGTTTGGC 540 541 AGAGATTTAA GAATTGTTCT TCTTACAGTT CTGTCTGGGA CGAAGTATGG ACTGAAGCAA 600 601 ACTCGTGGAA AGTTTGGTTT AGGGGCAAAG ATGGCTTTAA TTTGGTCCAA AATGAGTACA 660 661 GGCCTCCCCA TAGAGATCTC TTCATCTATG AAGAGCCAAA ACTATGTTAC GTTCTGCAGA 720 721 TTGGATATTG ATATTCACAG GAACATTCCT CACATTCATC TACACGAGAA GAAGGCCAAC 780 781 AAAGAGAAAT GGCATGGAGC CGAAATACAG GTGGTAATTG AGGGAAACTG GACAACATAC 840 841 AGATCAAAGA TCTTGCACTA CATGCGCCAA ATGGCTGTTA TTACTCCTTA TGCGCAGTTT 900 901 CTATTTAGAT TTATTTCAGA AACACCCGAG AAAAATGTCA CTGTAAAATT TACTCGAAGA 960 961 ACGGATGTGA TGCCCCCAAT TCCTATCGAG ACAAAGCACC ATCCTTCGTC AGTTGACTTG 1020 1021 CTGCTTATCA AGCGCCTTGT TACAGACACT TCCAAAAAGA CCCTTCTGCA GTTTCTTCAG 1080 1081 AATGAATTTG TGAATATTAA CAAAAACCTT GCAGCGCGAT TAATTGGGGA AATGGGACCC 1140 1141 GATTTCAGCC CTGGCATGGC TGTCAAGTCT GTGACATCTC AGCAAATGGT GCGCATACAT 1200 1201 CAGTTATTCC GCCAAGCTAA ATTCGATGAC CCTAGTGGTG ATTGTCTTAG CCCGGCAGGA 1260 1261 GAATACAATC TTCGTCTAGG GATTATCAAG GAGCTGCATC CAGATATGGT GGCAACGCAT 1320 1321 TCAGGCAGTG CTCAGGTATT TGAAGGTCAT CCTTTCATTG TTGAAGCTGG TGTTAGTGTG 1380 1381 GGTGGAAGAG ATGTGAAACA GGCAAGTCAT ATCCTCCTTT TGTTTATTCA TGGGATCAAC 1440 1441 ATATTCCGTT TTGCAAACCG GATTCCTCTC CTTTTTGAAC AAGGAGGTGA TGTTGTGACC 1500 1501 AGGACAGCCT TAAAGAGAAT CAATTGGAAT AGCTATAAGA TTAACCAGAC GCAAGATAAA 1560 1561 ATAGGAGTAT TTGTGAGCAT AGTGAGTACA AAAATTCCTT TCAAAGGGAC AGGGAAAGAA 1620 1621 TACATAGGAG ATGACATCAG TGAAATAGCT ACTGCAGTCA AGTCTGCAAT TCAACAATGC 1680 1681 TGCATTCAAC TGAAATCAAA AATAGTCAAG AGGCTTCAAG CACGCGAACA ACAAGAGAGA 1740 1741 AAACGCAGTT TGAGCAGGTA CATCCCGGAT GCAACTGGAG CGGTGTACGA GGTTCTAAAA 1800 1801 CAAATGACAG AAGAACATAC AAAAAAGAGA AAGCGCTACA AAGAGGAAGA AACAGCTATG 1860 1861 CTTGAGAAAG TGTCTAAACT TATAATCACC AAAGAAACAT TGAAAGAAAA GCTTGCTGAG 1920 1921 CATGTGGAAC AGGTGGATTA CGAGATGGCA TTAGAGTATG CAACACAGAG TGGAGTGAGT 1980 1981 GAAGAACCCA AAGAAAATAT ATATCTCCAA CAATTGAATC CCAACCATTC CAACTTCATT 2040 2041 GATCTTCACA GTCCGACCTT TGTCTTCAGG CTCATCTTGT AA 2082 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | DNA topoisomerase complex (ATP-hydrolyzing) | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (ATP-hydrolyzing) activity | |
Biological Process | DNA topological change |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Brn-0484 | Brassica napus | 95.67 | 0.0 | 1290 |
| LLPS-Art-0920 | Arabidopsis thaliana | 93.07 | 0.0 | 1246 |
| LLPS-Bro-0054 | Brassica oleracea | 91.85 | 0.0 | 1276 |
| LLPS-Arl-2383 | Arabidopsis lyrata | 89.53 | 0.0 | 1224 |
| LLPS-Coc-1218 | Corchorus capsularis | 84.38 | 0.0 | 997 |
| LLPS-Gor-1606 | Gossypium raimondii | 81.33 | 0.0 | 1115 |
| LLPS-Viv-1747 | Vitis vinifera | 81.27 | 0.0 | 1115 |
| LLPS-Thc-2188 | Theobroma cacao | 81.15 | 0.0 | 1116 |
| LLPS-Pot-1412 | Populus trichocarpa | 80.84 | 0.0 | 1109 |
| LLPS-Phv-1860 | Phaseolus vulgaris | 80.69 | 0.0 | 1099 |
| LLPS-Met-0946 | Medicago truncatula | 80.54 | 0.0 | 1103 |
| LLPS-Cus-2215 | Cucumis sativus | 80.48 | 0.0 | 1105 |
| LLPS-Mae-2138 | Manihot esculenta | 80.39 | 0.0 | 1102 |
| LLPS-Via-2251 | Vigna angularis | 80.24 | 0.0 | 1102 |
| LLPS-Dac-0500 | Daucus carota | 80.16 | 2e-137 | 423 |
| LLPS-Glm-1566 | Glycine max | 79.79 | 0.0 | 1092 |
| LLPS-Nia-1820 | Nicotiana attenuata | 79.15 | 0.0 | 1078 |
| LLPS-Hea-1247 | Helianthus annuus | 77.23 | 0.0 | 1092 |
| LLPS-Prp-1879 | Prunus persica | 76.8 | 0.0 | 1081 |
| LLPS-Sot-1438 | Solanum tuberosum | 76.02 | 0.0 | 582 |
| LLPS-Amt-0076 | Amborella trichopoda | 75.9 | 0.0 | 1037 |
| LLPS-Mua-2510 | Musa acuminata | 74.85 | 0.0 | 1033 |
| LLPS-Sei-1526 | Setaria italica | 74.81 | 0.0 | 1036 |
| LLPS-Sol-2074 | Solanum lycopersicum | 74.54 | 0.0 | 574 |
| LLPS-Tra-2337 | Triticum aestivum | 74.36 | 0.0 | 1026 |
| LLPS-Orp-1186 | Oryza punctata | 74.06 | 0.0 | 1019 |
| LLPS-Sob-0712 | Sorghum bicolor | 73.8 | 0.0 | 1018 |
| LLPS-Ori-0704 | Oryza indica | 73.76 | 0.0 | 1016 |
| LLPS-Brd-0485 | Brachypodium distachyon | 73.6 | 0.0 | 1013 |
| LLPS-Ors-0260 | Oryza sativa | 73.6 | 0.0 | 1013 |
| LLPS-Orbr-0299 | Oryza brachyantha | 73.3 | 0.0 | 1023 |
| LLPS-Zem-1027 | Zea mays | 71.29 | 0.0 | 594 |
| LLPS-Hov-2033 | Hordeum vulgare | 71.16 | 0.0 | 1007 |
| LLPS-Vir-0101 | Vigna radiata | 71.02 | 0.0 | 940 |
| LLPS-Orb-0322 | Oryza barthii | 69.68 | 0.0 | 937 |
| LLPS-Php-1050 | Physcomitrella patens | 69.53 | 0.0 | 956 |
| LLPS-Orm-0660 | Oryza meridionalis | 69.23 | 0.0 | 929 |
| LLPS-Orni-1483 | Oryza nivara | 69.08 | 0.0 | 929 |
| LLPS-Sem-0287 | Selaginella moellendorffii | 68.56 | 0.0 | 939 |
| LLPS-Orr-1855 | Oryza rufipogon | 66.33 | 0.0 | 913 |
| LLPS-Orgl-2143 | Oryza glumaepatula | 62.94 | 0.0 | 811 |
| LLPS-Lep-1044 | Leersia perrieri | 59.28 | 0.0 | 752 |
| LLPS-Chr-0328 | Chlamydomonas reinhardtii | 53.37 | 0.0 | 739 |
| LLPS-Osl-1328 | Ostreococcus lucimarinus | 49.85 | 0.0 | 649 |
| LLPS-Chc-0738 | Chondrus crispus | 49.11 | 0.0 | 623 |
| LLPS-Cym-1061 | Cyanidioschyzon merolae | 44.74 | 0.0 | 568 |