• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Php-0612
PHYPA_030512

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit A
Gene Name: PHYPA_030512
Ensembl Gene: Pp3c26_11290
Ensembl Protein: Pp3c26_11290V3.3
Organism: Physcomitrella patens
Taxa ID: 3218
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-body, OthersPredicted from orthologs(View)

▼ FUNCTION


RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MATFAKPENA  LKRAEELMNV  GQKQAALQAL  HDLITSKRYR  AWQKTLEKIM  FKYVELCVDM  60
61    KKGRFAKDGL  IQYRIVCQQV  NVSSLEEVIK  YFLQLSSERA  EAAQAQAAAA  EVTLDVEDLE  120
121   AEKRPEDLML  SYVSGERGKE  RSDRETVTPW  FKFLWETYRT  VLEILRNNSK  LESLYAMTAH  180
181   RAFQFCLQYK  RTTEFRRLCE  ILRNHLTNLN  KYRDQRDRPD  LSQPESLQLY  LETRFEQLKI  240
241   ATELELWQEA  FRSIEDIHGL  MSMVKRTPKP  QMMAVYYAKL  TLIYWVSDNH  LYHAYAWYKL  300
301   YNLQKSYNKN  LTAKDLQLMA  SAVVLATLAV  PPYDRKHGAH  HFELEMEKDR  NIRMANILGF  360
361   NIDAKKDSRE  VLSRAALLSE  LVAKGVMTYV  SPEVKDLYTL  LENEFHPLDL  AAKAQPFLSK  420
421   LPNLSDKLSS  ASPVPEVRLE  QYVPALERLT  TLRVLLQASQ  VYSTIRIADL  TRMVTFFDFS  480
481   VIEKLIVEAV  KYNFVQMKVD  HLKEVVNFGS  QDLESEKVKT  HLAILAKRLK  KACSMISPPT  540
541   VERSSKQILP  YAELQAIVEK  EHKKLLARKV  LIERRKEEQE  RQMLEMEREE  ESKRLKQQRL  600
601   TEEAEAKRLA  NESARREEAR  IRKEIEEKEL  EEARALLAEA  EKRKGKKGKK  GGVDGEVSKL  660
661   SKQLLMEEAL  SEQIRERQEM  ERKLQKLAKT  MDYLERAKRE  EERPLIEEAY  HKRLQDDERF  720
721   YQQQQEQAIE  QSKKQHETDV  VEKHRLERMG  EDKEIFQRQV  VSRRHGEFER  LKRLREERLA  780
781   EERAIRSHER  EIRRKKEYFK  RQEEQRLLKI  QEEEEARKRE  EEERKRREEA  ERLAKLEEIA  840
841   QKQREREAAA  EEREKREREE  ALQARLQEKP  GKFVPPSLRK  FRESGEELKR  PSMEDRRDVR  900
901   PPVEERRPLF  LSSRSAPPRD  ADRPIDRESA  NAPPSKAYQP  PRARQSDPEA  PPRAYEPPPV  960
961   RRTYDAPPAR  GDTNEPPRSG  VYAPPNRGGG  RSFGQRPVIG  GRPTEDRPER  TEDRPERRDR  1020
1021  W  1021
Nucleotide CDS Sequence (FASTA)
1     ATGGCGACCT  TTGCGAAACC  TGAAAATGCT  CTCAAGCGAG  CAGAAGAGTT  GATGAATGTT  60
61    GGGCAAAAGC  AGGCTGCACT  ACAAGCACTT  CACGATCTGA  TTACGTCGAA  AAGGTACCGA  120
121   GCATGGCAGA  AAACGCTAGA  GAAGATTATG  TTCAAGTATG  TCGAGCTCTG  TGTGGACATG  180
181   AAGAAGGGCA  GATTTGCCAA  GGATGGGTTA  ATCCAGTATC  GGATAGTCTG  CCAGCAAGTC  240
241   AATGTCAGTT  CGCTGGAGGA  AGTCATCAAG  TACTTCCTTC  AGCTGTCCAG  CGAGCGTGCC  300
301   GAGGCTGCGC  AAGCCCAAGC  AGCAGCTGCT  GAGGTAACTT  TGGATGTTGA  GGATTTGGAG  360
361   GCTGAGAAAA  GGCCGGAGGA  TTTGATGTTG  AGTTACGTCA  GCGGCGAGAG  GGGGAAAGAA  420
421   CGCTCTGATC  GCGAAACCGT  GACTCCGTGG  TTTAAGTTTC  TATGGGAAAC  ATATCGAACA  480
481   GTACTGGAAA  TTCTGCGGAA  CAATTCAAAG  TTGGAGTCCT  TGTACGCCAT  GACAGCCCAT  540
541   CGGGCTTTTC  AGTTTTGCCT  CCAATATAAG  CGCACAACAG  AATTTCGACG  GCTCTGCGAA  600
601   ATTCTCCGCA  ATCATCTTAC  CAACCTGAAC  AAATACAGAG  ATCAGCGTGA  CAGGCCTGAT  660
661   CTCAGTCAGC  CAGAAAGTCT  GCAGTTGTAT  CTAGAGACTA  GGTTTGAACA  GCTCAAGATC  720
721   GCTACAGAGT  TAGAGTTATG  GCAGGAAGCG  TTCCGCTCGA  TTGAGGATAT  TCATGGACTG  780
781   ATGTCCATGG  TGAAGAGAAC  GCCGAAGCCC  CAAATGATGG  CCGTCTACTA  TGCCAAACTG  840
841   ACACTTATCT  ACTGGGTATC  TGACAATCAC  TTATATCATG  CCTACGCATG  GTACAAGTTA  900
901   TACAACCTGC  AAAAGAGCTA  TAACAAGAAT  CTCACAGCAA  AGGATTTGCA  ACTCATGGCG  960
961   TCAGCTGTAG  TGTTGGCAAC  TCTTGCTGTA  CCCCCCTATG  ACCGCAAGCA  TGGTGCTCAC  1020
1021  CACTTCGAGT  TAGAGATGGA  AAAGGACCGG  AACATTCGAA  TGGCCAACAT  TCTGGGATTC  1080
1081  AACATCGATG  CAAAGAAAGA  CTCTCGGGAA  GTCCTATCCA  GGGCAGCTCT  ACTTTCTGAA  1140
1141  CTTGTTGCGA  AAGGTGTGAT  GACGTATGTT  TCACCGGAGG  TCAAGGATCT  CTACACATTG  1200
1201  CTAGAGAATG  AATTCCACCC  GCTTGACCTT  GCTGCGAAAG  CTCAGCCTTT  TCTCTCGAAA  1260
1261  CTCCCAAATC  TAAGTGATAA  GCTGTCTTCA  GCATCACCGG  TTCCGGAAGT  GCGATTAGAG  1320
1321  CAGTATGTTC  CAGCTCTTGA  AAGGCTTACT  ACTCTCCGAG  TTCTTCTGCA  GGCATCTCAA  1380
1381  GTCTATTCGA  CCATTAGAAT  TGCAGACCTC  ACTCGAATGG  TCACATTTTT  TGATTTCTCG  1440
1441  GTCATCGAGA  AGTTGATTGT  GGAAGCAGTG  AAGTACAACT  TTGTGCAAAT  GAAGGTTGAT  1500
1501  CATCTGAAAG  AAGTTGTCAA  CTTCGGTAGT  CAGGACTTGG  AGTCTGAGAA  AGTAAAGACT  1560
1561  CACCTTGCTA  TTCTTGCGAA  GAGGTTGAAG  AAGGCCTGCA  GCATGATCTC  TCCACCCACT  1620
1621  GTCGAGAGGT  CTTCAAAGCA  GATTTTGCCA  TACGCTGAGC  TTCAAGCCAT  CGTAGAGAAA  1680
1681  GAGCACAAGA  AGTTGCTTGC  TCGCAAGGTT  TTGATCGAGC  GTCGGAAAGA  AGAACAGGAG  1740
1741  CGACAAATGC  TTGAAATGGA  GAGAGAAGAG  GAGTCGAAGA  GACTGAAACA  GCAACGCTTG  1800
1801  ACAGAAGAGG  CTGAGGCCAA  GAGACTCGCA  AACGAGTCAG  CCAGACGAGA  GGAAGCCAGG  1860
1861  ATTCGAAAGG  AAATTGAAGA  AAAGGAACTG  GAAGAAGCGA  GGGCTTTGCT  TGCTGAAGCT  1920
1921  GAAAAACGAA  AGGGCAAGAA  GGGCAAGAAA  GGAGGTGTTG  ATGGAGAAGT  CAGTAAACTC  1980
1981  TCGAAGCAGC  TTCTGATGGA  AGAAGCTCTG  AGTGAGCAAA  TTAGAGAACG  GCAAGAGATG  2040
2041  GAGCGGAAGC  TTCAAAAGCT  TGCCAAGACA  ATGGACTATC  TGGAACGCGC  GAAGCGAGAG  2100
2101  GAGGAGAGAC  CACTGATTGA  GGAGGCTTAC  CATAAGCGGC  TTCAAGATGA  TGAGAGGTTC  2160
2161  TATCAGCAGC  AGCAGGAGCA  AGCTATTGAG  CAGAGCAAGA  AGCAGCATGA  GACTGACGTT  2220
2221  GTCGAGAAGC  ATCGGTTGGA  GCGGATGGGA  GAAGACAAGG  AAATTTTCCA  ACGACAAGTT  2280
2281  GTCAGCCGTC  GTCATGGAGA  GTTCGAGAGG  TTGAAGCGCT  TGCGGGAGGA  AAGACTTGCT  2340
2341  GAGGAGCGTG  CTATTAGATC  TCATGAACGT  GAAATCAGAC  GCAAAAAAGA  ATACTTCAAG  2400
2401  AGACAAGAGG  AGCAGCGCCT  TCTCAAGATC  CAGGAAGAAG  AGGAGGCTAG  GAAGAGAGAA  2460
2461  GAGGAAGAGC  GCAAACGCAG  AGAAGAAGCT  GAACGCCTTG  CGAAGTTGGA  GGAAATTGCC  2520
2521  CAAAAGCAAC  GTGAGAGGGA  AGCTGCCGCC  GAAGAGAGAG  AGAAGCGTGA  GAGAGAGGAA  2580
2581  GCTTTACAAG  CTAGGCTTCA  AGAGAAACCA  GGAAAGTTTG  TTCCTCCTTC  GCTTCGAAAG  2640
2641  TTTAGGGAGA  GCGGCGAGGA  ATTGAAGCGT  CCTAGCATGG  AAGACCGTCG  AGATGTGCGT  2700
2701  CCACCAGTGG  AGGAACGTCG  GCCTCTTTTC  CTGTCGTCGC  GATCAGCTCC  TCCTCGTGAT  2760
2761  GCTGATAGGC  CGATCGATAG  AGAGTCTGCC  AATGCTCCTC  CCTCCAAAGC  TTATCAACCG  2820
2821  CCTCGAGCCC  GTCAGTCCGA  CCCTGAAGCT  CCTCCACGAG  CGTATGAGCC  TCCTCCAGTG  2880
2881  CGACGGACTT  ATGATGCACC  ACCTGCACGT  GGGGACACCA  ATGAGCCTCC  TCGGTCTGGT  2940
2941  GTATACGCTC  CTCCCAATCG  TGGAGGAGGC  AGGTCCTTTG  GGCAGCGTCC  TGTCATCGGT  3000
3001  GGCAGACCAA  CAGAAGATCG  TCCAGAGCGC  ACTGAAGATC  GTCCAGAGCG  TCGAGATCGT  3060
3061  TGGTAA  3066

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sem-0336Selaginella moellendorffii79.90.0 950
LLPS-Amt-0137Amborella trichopoda74.810.01025
LLPS-Pot-0396Populus trichocarpa74.380.0 852
LLPS-Ori-1613Oryza indica73.080.0 860
LLPS-Orb-0329Oryza barthii73.080.0 859
LLPS-Orni-0562Oryza nivara73.080.0 861
LLPS-Lep-1793Leersia perrieri73.080.0 859
LLPS-Ors-0761Oryza sativa73.080.0 858
LLPS-Orm-0829Oryza meridionalis73.080.0 860
LLPS-Orr-0489Oryza rufipogon73.080.0 859
LLPS-Org-0875Oryza glaberrima73.080.0 858
LLPS-Orgl-0581Oryza glumaepatula72.90.0 860
LLPS-Orp-0081Oryza punctata72.90.0 858
LLPS-Orbr-1098Oryza brachyantha72.550.0 855
LLPS-Hov-0369Hordeum vulgare72.380.0 858
LLPS-Tra-0743Triticum aestivum72.030.0 859
LLPS-Tru-0894Triticum urartu72.030.0 860
LLPS-Sob-1639Sorghum bicolor71.850.0 853
LLPS-Brd-1665Brachypodium distachyon71.150.0 842
LLPS-Zem-1185Zea mays71.150.0 839
LLPS-Viv-0885Vitis vinifera69.640.0 966
LLPS-Sei-0630Setaria italica69.60.0 758
LLPS-Mua-1391Musa acuminata68.770.0 957
LLPS-Mae-0510Manihot esculenta68.510.0 963
LLPS-Phv-0370Phaseolus vulgaris68.310.0 946
LLPS-Vir-0284Vigna radiata68.280.0 946
LLPS-Glm-1144Glycine max67.90.0 940
LLPS-Cus-0757Cucumis sativus67.70.0 944
LLPS-Coc-1440Corchorus capsularis67.650.0 927
LLPS-Thc-0247Theobroma cacao66.630.0 942
LLPS-Gor-0600Gossypium raimondii66.630.0 946
LLPS-Brn-2096Brassica napus66.380.0 939
LLPS-Arl-0341Arabidopsis lyrata66.260.0 939
LLPS-Brr-1395Brassica rapa66.260.0 939
LLPS-Bro-0581Brassica oleracea66.260.0 940
LLPS-Dac-0439Daucus carota66.010.0 915
LLPS-Met-0081Medicago truncatula65.970.0 924
LLPS-Art-2707Arabidopsis thaliana65.970.0 933
LLPS-Via-0841Vigna angularis65.720.0 878
LLPS-Prp-1021Prunus persica65.270.0 906
LLPS-Sol-0993Solanum lycopersicum64.270.0 915
LLPS-Hea-1664Helianthus annuus64.210.0 915
LLPS-Sot-0022Solanum tuberosum64.120.0 918
LLPS-Nia-0434Nicotiana attenuata64.120.0 943
LLPS-Chr-0851Chlamydomonas reinhardtii52.670.0 576
LLPS-Osl-0946Ostreococcus lucimarinus49.880.0 648
LLPS-Asn-0846Aspergillus nidulans43.998e-130 426
LLPS-Nef-1170Neosartorya fischeri42.317e-133 435
LLPS-Asfu-0717Aspergillus fumigatus42.315e-133 435
LLPS-Asc-0268Aspergillus clavatus41.996e-133 435
LLPS-Ved-0012Verticillium dahliae41.831e-129 427
LLPS-Scj-0577Schizosaccharomyces japonicus41.679e-119 394
LLPS-Aso-0629Aspergillus oryzae41.511e-132 434
LLPS-Ast-0339Aspergillus terreus41.512e-133 436
LLPS-Xet-1944Xenopus tropicalis41.484e-141 464
LLPS-Scs-0678Sclerotinia sclerotiorum41.198e-132 431
LLPS-Coo-1154Colletotrichum orbiculare41.183e-127 420
LLPS-Asm-2057Astyanax mexicanus41.156e-141 462
LLPS-Mod-0435Monodelphis domestica41.159e-141 457
LLPS-Asni-0491Aspergillus niger41.038e-131 429
LLPS-Cea-0090Cercocebus atys40.983e-139 459
LLPS-Sus-0395Sus scrofa40.983e-139 459
LLPS-Chs-2477Chlorocebus sabaeus40.983e-140 459
LLPS-Mea-1773Mesocricetus auratus40.982e-140 458
LLPS-Mum-0015Mus musculus40.985e-139 458
LLPS-Gog-0965Gorilla gorilla40.989e-141 459
LLPS-Bot-2842Bos taurus40.986e-139 458
LLPS-Dio-0869Dipodomys ordii40.982e-139 459
LLPS-Myl-2518Myotis lucifugus40.981e-136 452
LLPS-Paa-0066Papio anubis40.983e-139 459
LLPS-Ran-0623Rattus norvegicus40.986e-139 458
LLPS-Hos-1018Homo sapiens40.983e-139 459
LLPS-Orc-2967Oryctolagus cuniculus40.984e-139 459
LLPS-Otg-1062Otolemur garnettii40.986e-139 458
LLPS-Mam-0588Macaca mulatta40.984e-139 459
LLPS-Eqc-1710Equus caballus40.983e-139 459
LLPS-Cap-0952Cavia porcellus40.984e-139 458
LLPS-Poa-3313Pongo abelii40.983e-139 459
LLPS-Cas-1796Carlito syrichta40.981e-138 457
LLPS-Loa-0625Loxodonta africana40.921e-137 454
LLPS-Gaa-2181Gasterosteus aculeatus40.916e-141 461
LLPS-Blg-0618Blumeria graminis40.861e-128 423
LLPS-Aon-2312Aotus nancymaae40.816e-139 458
LLPS-Tar-3448Takifugu rubripes40.814e-139 457
LLPS-Aim-0186Ailuropoda melanoleuca40.818e-139 457
LLPS-Fec-0067Felis catus40.815e-139 458
LLPS-Caf-1416Canis familiaris40.815e-139 458
LLPS-Nol-2298Nomascus leucogenys40.85e-130 432
LLPS-Lem-0000Leptosphaeria maculans40.713e-134 439
LLPS-Pyt-0036Pyrenophora teres40.718e-134 439
LLPS-Pytr-0849Pyrenophora triticirepentis40.715e-134 439
LLPS-Cog-0227Colletotrichum gloeosporioides40.73e-128 421
LLPS-Cogr-0497Colletotrichum graminicola40.71e-125 416
LLPS-Ora-0586Ornithorhynchus anatinus40.596e-133 440
LLPS-Scm-1761Scophthalmus maximus40.472e-139 457
LLPS-Dar-0159Danio rerio40.443e-139 457
LLPS-Gaga-1420Gallus gallus40.442e-137 454
LLPS-Sah-1478Sarcophilus harrisii40.412e-132 440
LLPS-Pes-0891Pelodiscus sinensis40.411e-132 439
LLPS-Pap-0435Pan paniscus40.352e-131 436
LLPS-Fud-0634Fukomys damarensis40.35e-134 444
LLPS-Ova-0256Ovis aries40.245e-132 439
LLPS-Anc-0781Anolis carolinensis40.244e-136 452
LLPS-Leo-0013Lepisosteus oculatus40.26e-141 461
LLPS-Caj-2102Callithrix jacchus40.171e-130 436
LLPS-Tag-0426Taeniopygia guttata40.072e-132 440
LLPS-Rhb-2196Rhinopithecus bieti40.036e-129 430
LLPS-Spr-0531Sporisorium reilianum39.95e-130 427
LLPS-Tum-1297Tuber melanosporum39.842e-126 417
LLPS-Gag-0109Gaeumannomyces graminis39.811e-123 410
LLPS-Map-0507Magnaporthe poae39.819e-124 411
LLPS-Fia-0193Ficedula albicollis39.751e-126 421
LLPS-Abg-0914Absidia glauca39.739e-130 425
LLPS-Meg-1968Meleagris gallopavo39.721e-130 436
LLPS-Usm-0700Ustilago maydis39.716e-131 429
LLPS-Mao-1429Magnaporthe oryzae39.655e-122 406
LLPS-Mup-2552Mustela putorius furo39.596e-128 427
LLPS-Yal-0777Yarrowia lipolytica39.562e-110 372
LLPS-Zyt-0164Zymoseptoria tritici39.371e-129 427
LLPS-Lac-0085Latimeria chalumnae39.231e-129 432
LLPS-Dos-0694Dothistroma septosporum39.173e-130 429
LLPS-Mal-2977Mandrillus leucophaeus38.863e-122 412
LLPS-Maf-0125Macaca fascicularis38.831e-121 411
LLPS-Man-0022Macaca nemestrina38.838e-122 411
LLPS-Drm-0296Drosophila melanogaster38.445e-112 380
LLPS-Scf-0964Scleropages formosus38.427e-147 477
LLPS-Pof-1144Poecilia formosa38.422e-145 474
LLPS-Xim-0895Xiphophorus maculatus38.39e-146 474
LLPS-Orn-0451Oreochromis niloticus38.176e-145 472
LLPS-Asf-0691Aspergillus flavus38.163e-100 346
LLPS-Scc-0341Schizosaccharomyces cryophilus37.928e-118 391
LLPS-Orl-1930Oryzias latipes37.911e-144 471
LLPS-Chc-0832Chondrus crispus37.592e-112 377
LLPS-Miv-0040Microbotryum violaceum37.591e-95 332
LLPS-Scp-0823Schizosaccharomyces pombe37.542e-115 385
LLPS-Nec-1029Neurospora crassa37.472e-129 426
LLPS-Beb-1221Beauveria bassiana37.045e-137 446
LLPS-Put-0093Puccinia triticina36.862e-104 359
LLPS-Ict-0861Ictidomys tridecemlineatus36.761e-109 375
LLPS-Cae-0073Caenorhabditis elegans36.735e-105 359
LLPS-Asg-0027Ashbya gossypii36.75e-83 295
LLPS-Gas-0051Galdieria sulphuraria36.527e-107 360
LLPS-Trr-0690Trichoderma reesei36.477e-132 432
LLPS-Pug-0601Puccinia graminis36.312e-101 350
LLPS-Trv-0529Trichoderma virens36.288e-129 425
LLPS-Fus-1159Fusarium solani36.118e-129 424
LLPS-Fuv-0009Fusarium verticillioides35.996e-128 421
LLPS-Fuo-0554Fusarium oxysporum35.862e-128 423
LLPS-Cii-0363Ciona intestinalis35.471e-129 426
LLPS-Kop-0603Komagataella pastoris35.452e-84 297
LLPS-Mel-0352Melampsora laricipopulina35.273e-94 329
LLPS-Sac-0156Saccharomyces cerevisiae35.213e-81 290
LLPS-Ten-1186Tetraodon nigroviridis34.465e-71 260
LLPS-Crn-0205Cryptococcus neoformans33.898e-71 259
LLPS-Phn-1167Phaeosphaeria nodorum33.632e-98 340
LLPS-Pat-0419Pan troglodytes29.128e-53 206
LLPS-Cym-0030Cyanidioschyzon merolae24.884e-44 178