• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pes-1782
DDOST

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Gene Name: DDOST
Ensembl Gene: ENSPSIG00000011114.1
Ensembl Protein: ENSPSIP00000012405.1
Organism: Pelodiscus sinensis
Taxa ID: 13735
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGSLIRDRGF  DLTFRTADDP  GLSLIKYGEF  LYDNLIIFSP  SVEDFGGNIN  VETITAFIDG  60
61    GGSVLVAASS  DIGDPLRELG  SECGIEFDED  RTAVIDHHNY  DVSDPGQHTL  IVADSENLLK  120
121   APTIVGRTPV  NPVLFCGVGM  VADPDNPLVL  DILTGSSTSY  SFFPDKPISQ  YPHAVGKNTL  180
181   LIAGLQARNN  ARVVFSGSLD  FFSDAFFNSA  VQKATPGSQR  YSQTGNYELA  VALSRWVFKE  240
241   EGVLRVGEVS  HHRVGETSPP  NAYTVTDLVE  YSIVIEKLSD  GKWIPFDGDD  IQLEFVRIDP  300
301   FVRTFLKKNG  GRYSVQFKLP  DVYGVFQFKV  DYNRLGYTHL  YSSTQVSVRP  LQHTQYERFI  360
361   PSAYPYYASA  FSMMIGLFMF  SIVFLHMKEK  EIPITC  396
Nucleotide CDS Sequence (FASTA)
1     ATGGGCTCTT  TGATCCGGGA  TAGAGGCTTT  GACCTCACCT  TCAGGACTGC  TGATGACCCT  60
61    GGCTTGTCTC  TCATAAAATA  TGGAGAATTT  CTGTATGACA  ACTTGATCAT  TTTCTCCCCT  120
121   TCTGTAGAAG  ATTTTGGCGG  AAACATCAAT  GTGGAGACAA  TTACTGCTTT  CATCGATGGA  180
181   GGTGGAAGTG  TCCTTGTGGC  TGCCAGTTCT  GACATTGGTG  ATCCTCTGCG  AGAGCTGGGC  240
241   AGTGAGTGTG  GGATAGAGTT  TGATGAAGAC  CGAACAGCAG  TCATTGACCA  TCACAACTAT  300
301   GACGTCTCAG  ACCCAGGCCA  GCACACGCTC  ATTGTTGCAG  ACTCTGAAAA  TCTGTTGAAG  360
361   GCTCCCACCA  TTGTTGGGAG  AACTCCGGTA  AACCCTGTTC  TCTTCTGCGG  AGTCGGGATG  420
421   GTAGCTGATC  CTGATAACCC  TCTGGTACTA  GATATCTTGA  CTGGCTCCTC  TACATCTTAT  480
481   TCCTTCTTCC  CAGATAAACC  CATTTCGCAG  TACCCTCATG  CTGTTGGGAA  GAATACCCTT  540
541   TTGATTGCTG  GTCTCCAGGC  CAGAAACAAT  GCCCGTGTCG  TTTTCAGCGG  CTCTTTGGAT  600
601   TTCTTCAGTG  ATGCTTTCTT  CAACTCTGCT  GTGCAGAAAG  CTACACCTGG  CTCTCAAAGG  660
661   TACTCTCAGA  CTGGTAACTA  TGAGCTTGCT  GTTGCCTTGT  CCCGCTGGGT  ATTCAAAGAA  720
721   GAGGGTGTAC  TGCGGGTTGG  AGAGGTATCT  CACCATCGTG  TTGGGGAGAC  GTCCCCACCT  780
781   AATGCCTACA  CTGTCACCGA  CCTGGTCGAG  TACAGCATTG  TGATTGAAAA  GCTCTCTGAT  840
841   GGGAAGTGGA  TCCCCTTTGA  TGGAGATGAT  ATTCAGCTGG  AATTTGTCCG  CATTGATCCA  900
901   TTTGTAAGGA  CTTTTCTGAA  AAAAAATGGT  GGCAGATATA  GTGTGCAGTT  CAAACTGCCG  960
961   GATGTATATG  GAGTGTTTCA  GTTTAAAGTG  GATTACAACA  GGCTGGGATA  CACTCATCTG  1020
1021  TACTCCTCTA  CCCAGGTGTC  TGTACGTCCC  CTCCAACACA  CACAGTATGA  GCGTTTTATC  1080
1081  CCCTCAGCAT  ATCCATATTA  TGCCAGTGCC  TTCTCCATGA  TGATAGGCCT  CTTCATGTTC  1140
1141  AGCATAGTCT  TCTTGCACAT  GAAAGAGAAG  GAGATCCCCA  TCACATGTTG  A  1191

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Membrane
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Protein-containing complex
Molecular Function
Dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Biological Process
Protein N-linked glycosylation via asparagine
Biological Process
Response to cytokine
Biological Process
T cell activation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-2930Mandrillus leucophaeus94.055e-176 498
LLPS-Tag-3188Taeniopygia guttata93.80.0 759
LLPS-Gaga-3485Gallus gallus93.80.0 756
LLPS-Meg-2875Meleagris gallopavo93.770.0 754
LLPS-Fia-1381Ficedula albicollis93.280.0 755
LLPS-Ora-0008Ornithorhynchus anatinus93.140.0 685
LLPS-Sah-1121Sarcophilus harrisii92.530.0 678
LLPS-Dio-1208Dipodomys ordii92.510.0 748
LLPS-Bot-0934Bos taurus92.510.0 746
LLPS-Ict-0301Ictidomys tridecemlineatus92.510.0 748
LLPS-Mea-2400Mesocricetus auratus92.250.0 748
LLPS-Ova-0917Ovis aries92.250.0 748
LLPS-Cas-2195Carlito syrichta92.250.0 744
LLPS-Eqc-2207Equus caballus92.250.0 749
LLPS-Fud-0938Fukomys damarensis91.990.0 746
LLPS-Hos-0394Homo sapiens91.990.0 748
LLPS-Pat-0401Pan troglodytes91.990.0 747
LLPS-Pap-0190Pan paniscus91.990.0 748
LLPS-Anc-1695Anolis carolinensis91.990.0 745
LLPS-Nol-1149Nomascus leucogenys91.990.0 746
LLPS-Caf-4018Canis familiaris91.990.0 741
LLPS-Cap-0158Cavia porcellus91.990.0 748
LLPS-Gog-0584Gorilla gorilla91.730.0 748
LLPS-Cea-2426Cercocebus atys91.730.0 745
LLPS-Maf-0956Macaca fascicularis91.730.0 745
LLPS-Mum-2275Mus musculus91.730.0 744
LLPS-Chs-0175Chlorocebus sabaeus91.730.0 746
LLPS-Paa-2886Papio anubis91.730.0 745
LLPS-Myl-2929Myotis lucifugus91.730.0 745
LLPS-Ran-0125Rattus norvegicus91.730.0 745
LLPS-Rhb-2744Rhinopithecus bieti91.730.0 747
LLPS-Otg-1474Otolemur garnettii91.730.0 745
LLPS-Man-1229Macaca nemestrina91.730.0 745
LLPS-Loa-1939Loxodonta africana91.730.0 743
LLPS-Fec-4109Felis catus91.730.0 739
LLPS-Mam-1207Macaca mulatta91.730.0 745
LLPS-Mup-1566Mustela putorius furo91.470.0 740
LLPS-Orc-0499Oryctolagus cuniculus91.470.0 744
LLPS-Sus-2114Sus scrofa91.210.0 741
LLPS-Aim-0470Ailuropoda melanoleuca91.210.0 735
LLPS-Urm-0254Ursus maritimus91.210.0 738
LLPS-Leo-0633Lepisosteus oculatus90.180.0 731
LLPS-Tut-0832Tursiops truncatus90.180.0 727
LLPS-Orn-2448Oreochromis niloticus89.660.0 726
LLPS-Scf-1667Scleropages formosus88.630.0 719
LLPS-Icp-3517Ictalurus punctatus88.110.0 716
LLPS-Mod-1111Monodelphis domestica88.042e-179 508
LLPS-Xim-1383Xiphophorus maculatus87.860.0 715
LLPS-Pof-0707Poecilia formosa87.860.0 714
LLPS-Tar-1805Takifugu rubripes87.60.0 712
LLPS-Dar-0987Danio rerio87.60.0 710
LLPS-Asm-1419Astyanax mexicanus87.340.0 706
LLPS-Ten-1505Tetraodon nigroviridis86.960.0 708
LLPS-Orl-0962Oryzias latipes86.820.0 711
LLPS-Scm-1534Scophthalmus maximus86.560.0 702
LLPS-Gaa-1679Gasterosteus aculeatus85.790.0 696
LLPS-Xet-2049Xenopus tropicalis81.650.0 641
LLPS-Lac-1319Latimeria chalumnae74.550.0 577
LLPS-Cii-1083Ciona intestinalis64.940.0 528
LLPS-Cis-1621Ciona savignyi64.360.0 520
LLPS-Drm-0577Drosophila melanogaster61.178e-173 498
LLPS-Cae-0562Caenorhabditis elegans54.221e-147 433
LLPS-Dac-1597Daucus carota48.333e-117 355
LLPS-Sob-0156Sorghum bicolor48.334e-122 368
LLPS-Met-1013Medicago truncatula47.811e-124 374
LLPS-Gor-0564Gossypium raimondii47.812e-121 366
LLPS-Brn-0577Brassica napus47.691e-122 369
LLPS-Brr-1928Brassica rapa47.699e-123 369
LLPS-Bro-0355Brassica oleracea47.695e-122 367
LLPS-Thc-0944Theobroma cacao47.565e-123 370
LLPS-Amt-0602Amborella trichopoda47.422e-119 361
LLPS-Orni-1441Oryza nivara47.31e-118 359
LLPS-Orb-2107Oryza barthii47.35e-118 357
LLPS-Ori-0114Oryza indica47.32e-118 358
LLPS-Cus-0364Cucumis sativus47.31e-120 364
LLPS-Orgl-1482Oryza glumaepatula47.35e-118 357
LLPS-Ors-1549Oryza sativa47.31e-118 359
LLPS-Org-1084Oryza glaberrima47.35e-118 357
LLPS-Coc-1855Corchorus capsularis47.31e-122 369
LLPS-Sei-0018Setaria italica47.164e-120 363
LLPS-Via-0651Vigna angularis47.163e-118 357
LLPS-Viv-0553Vitis vinifera47.164e-121 365
LLPS-Orp-0304Oryza punctata47.043e-117 356
LLPS-Orm-0658Oryza meridionalis47.044e-117 355
LLPS-Hea-0753Helianthus annuus46.919e-123 369
LLPS-Nia-1265Nicotiana attenuata46.915e-122 367
LLPS-Orbr-1861Oryza brachyantha46.799e-118 357
LLPS-Glm-2128Glycine max46.531e-120 364
LLPS-Prp-2257Prunus persica46.533e-118 358
LLPS-Arl-0074Arabidopsis lyrata46.396e-119 360
LLPS-Art-0347Arabidopsis thaliana46.392e-119 361
LLPS-Phv-1158Phaseolus vulgaris46.272e-118 358
LLPS-Tru-1013Triticum urartu46.113e-116 352
LLPS-Sem-0782Selaginella moellendorffii45.882e-120 363
LLPS-Orr-1533Oryza rufipogon45.846e-116 352
LLPS-Tra-0611Triticum aestivum45.766e-116 352
LLPS-Brd-0464Brachypodium distachyon45.764e-116 352
LLPS-Mae-1507Manihot esculenta45.362e-117 356
LLPS-Hov-1038Hordeum vulgare45.245e-114 347
LLPS-Vir-0538Vigna radiata44.951e-112 345
LLPS-Mua-0021Musa acuminata44.91e-115 352
LLPS-Lep-1349Leersia perrieri44.851e-108 332
LLPS-Zem-0392Zea mays44.691e-112 344
LLPS-Pot-1477Populus trichocarpa43.967e-110 337
LLPS-Sol-1617Solanum lycopersicum43.542e-107 339
LLPS-Php-0225Physcomitrella patens42.272e-111 340
LLPS-Abg-0408Absidia glauca42.013e-41 150
LLPS-Chr-0812Chlamydomonas reinhardtii40.581e-94 296
LLPS-Put-0143Puccinia triticina36.781e-77 255
LLPS-Pug-0954Puccinia graminis35.868e-77 251
LLPS-Gas-0363Galdieria sulphuraria34.242e-73 242
LLPS-Mel-0885Melampsora laricipopulina32.921e-70 235
LLPS-Gag-0921Gaeumannomyces graminis32.866e-53 189
LLPS-Blg-0324Blumeria graminis32.292e-52 187
LLPS-Spr-0898Sporisorium reilianum32.113e-30 126
LLPS-Scp-0367Schizosaccharomyces pombe32.081e-58 203
LLPS-Mao-0312Magnaporthe oryzae32.05e-52 186
LLPS-Miv-0412Microbotryum violaceum31.912e-59 205
LLPS-Trr-0383Trichoderma reesei31.844e-49 178
LLPS-Trv-1191Trichoderma virens31.842e-48 176
LLPS-Scj-0551Schizosaccharomyces japonicus31.652e-58 202
LLPS-Cogr-0284Colletotrichum graminicola31.634e-54 192
LLPS-Asf-0416Aspergillus flavus31.621e-53 190
LLPS-Aso-1229Aspergillus oryzae31.621e-53 190
LLPS-Beb-0021Beauveria bassiana31.625e-49 178
LLPS-Fus-0129Fusarium solani31.511e-52 187
LLPS-Usm-0120Ustilago maydis31.454e-27 117
LLPS-Tum-0540Tuber melanosporum31.341e-52 188
LLPS-Coo-0506Colletotrichum orbiculare31.312e-53 190
LLPS-Ast-1129Aspergillus terreus31.237e-52 188
LLPS-Asni-0954Aspergillus niger31.221e-51 185
LLPS-Cog-0800Colletotrichum gloeosporioides31.187e-55 194
LLPS-Scs-0642Sclerotinia sclerotiorum31.067e-52 186
LLPS-Nec-0151Neurospora crassa30.991e-49 179
LLPS-Map-1201Magnaporthe poae30.667e-48 175
LLPS-Fuv-0198Fusarium verticillioides30.535e-47 172
LLPS-Asc-0391Aspergillus clavatus30.515e-52 186
LLPS-Nef-0288Neosartorya fischeri30.514e-53 189
LLPS-Asfu-1000Aspergillus fumigatus30.515e-52 186
LLPS-Chc-0374Chondrus crispus30.463e-51 184
LLPS-Scc-0275Schizosaccharomyces cryophilus30.23e-52 186
LLPS-Asn-1060Aspergillus nidulans30.171e-52 188
LLPS-Fuo-0860Fusarium oxysporum30.055e-47 172
LLPS-Dos-0651Dothistroma septosporum29.882e-48 176
LLPS-Crn-0040Cryptococcus neoformans29.784e-55 194
LLPS-Phn-0727Phaeosphaeria nodorum29.558e-44 164
LLPS-Pytr-0799Pyrenophora triticirepentis29.438e-46 169
LLPS-Zyt-0222Zymoseptoria tritici29.44e-45 167
LLPS-Cym-0402Cyanidioschyzon merolae29.275e-50 182
LLPS-Pyt-0905Pyrenophora teres29.195e-45 167
LLPS-Ved-0296Verticillium dahliae28.851e-40 155
LLPS-Lem-1213Leptosphaeria maculans28.572e-38 148
LLPS-Sac-1137Saccharomyces cerevisiae26.74e-25 109
LLPS-Kop-0261Komagataella pastoris26.261e-28 120
LLPS-Asg-0124Ashbya gossypii25.759e-23 102
LLPS-Yal-0087Yarrowia lipolytica24.553e-31 128