• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Otg-1474
DDOST

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Gene Name: DDOST
Ensembl Gene: ENSOGAG00000013135.2
Ensembl Protein: ENSOGAP00000011767.2
Organism: Otolemur garnettii
Taxa ID: 30611
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGHFRCPGAG  FFGKMRKMES  GGGARGWALF  WLLLLLLGSV  LASGPRTLVL  LDNLNVRETH  60
61    SLFFRSLKDR  GFELTFKTAD  DPSLSLIKYG  EFLYDNLIIF  SPSVEDFGGN  INVETISAFI  120
121   DGGGSVLVAA  SSDIGDPLRE  LGSECGIEFD  EEKTAVIDHH  NYDISDLGQH  TLIVADAENL  180
181   LKAPTIVGKS  ALNPILFRGV  GMVADPDNPL  VLDILTGSST  SYSFFPDKPI  TQYPHAVGKN  240
241   TLLIAGLQAR  NNARVIFSGS  LDFFSDAFFN  SAVQKATPGS  QRYSQTGNFE  LAVALSRWVF  300
301   KEEGVLRVGP  VSHHRVGETA  PPNAYTVTDL  VEYSIVIEQL  SNGRWVPFDG  DDIQLEFVRI  360
361   DPFVRTFLKK  KGGKYSVQFK  LPDVYGVFQF  KVDYNRLGYT  HLYSSTQVSV  RPLQHTQYER  420
421   FIPSAYPYYA  SAFSMMLGLL  IFSVVFLHMK  EKEKSD  456
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCACT  TCCGGTGTCC  AGGTGCTGGG  TTCTTTGGCA  AAATGAGGAA  GATGGAGTCC  60
61    GGCGGCGGTG  CCCGTGGTTG  GGCCCTTTTC  TGGCTGCTGT  TGCTCTTGCT  TGGCTCGGTC  120
121   TTGGCCAGCG  GTCCCCGCAC  CTTAGTGCTG  CTGGACAACC  TCAACGTGCG  GGAGACGCAC  180
181   TCGCTTTTCT  TCCGGAGCTT  GAAGGATCGG  GGCTTTGAAC  TCACCTTCAA  GACTGCTGAT  240
241   GACCCCAGCC  TGTCCCTCAT  TAAGTATGGA  GAGTTCCTGT  ATGACAATCT  CATCATCTTC  300
301   TCTCCCTCAG  TAGAAGATTT  TGGAGGCAAC  ATAAACGTGG  AGACCATCAG  CGCCTTTATT  360
361   GACGGTGGAG  GCAGTGTTCT  GGTAGCTGCC  AGCTCAGACA  TCGGTGACCC  TCTGCGAGAG  420
421   CTGGGCAGTG  AGTGTGGGAT  CGAGTTTGAT  GAGGAGAAAA  CGGCTGTCAT  TGACCATCAC  480
481   AACTATGATA  TCTCAGACCT  TGGCCAGCAT  ACGCTCATCG  TGGCTGATGC  CGAGAACTTG  540
541   CTGAAGGCCC  CAACCATCGT  TGGGAAATCA  GCTCTAAATC  CTATCCTCTT  TCGAGGTGTT  600
601   GGGATGGTGG  CTGATCCTGA  CAATCCTTTG  GTATTGGACA  TCCTGACGGG  CTCTTCTACC  660
661   TCCTACTCCT  TCTTCCCGGA  CAAACCCATC  ACCCAGTACC  CCCATGCCGT  GGGAAAGAAC  720
721   ACCCTCCTAA  TTGCTGGGCT  CCAGGCCAGA  AACAATGCCC  GCGTCATCTT  CAGTGGCTCC  780
781   CTCGACTTCT  TCAGCGACGC  CTTCTTCAAC  TCAGCAGTGC  AGAAGGCCAC  GCCGGGCTCC  840
841   CAGAGGTATT  CCCAGACAGG  CAACTTCGAG  CTAGCTGTGG  CCCTCTCCCG  CTGGGTGTTC  900
901   AAGGAGGAGG  GTGTCCTCCG  TGTGGGGCCT  GTGTCCCATC  ATCGGGTGGG  CGAGACAGCC  960
961   CCTCCCAATG  CCTACACTGT  CACTGACCTA  GTGGAGTATA  GCATCGTGAT  TGAGCAGCTC  1020
1021  TCAAATGGCA  GATGGGTCCC  CTTTGATGGT  GATGACATCC  AGCTGGAGTT  TGTGCGCATC  1080
1081  GATCCTTTTG  TGAGGACCTT  CTTGAAGAAG  AAAGGCGGCA  AGTACAGTGT  TCAGTTCAAG  1140
1141  TTGCCCGACG  TGTATGGTGT  GTTCCAGTTT  AAGGTGGATT  ACAACCGGCT  AGGCTACACA  1200
1201  CACCTGTACT  CTTCCACTCA  GGTGTCAGTG  AGGCCACTCC  AGCACACGCA  GTATGAGCGC  1260
1261  TTCATTCCCT  CGGCCTACCC  CTACTACGCC  AGTGCCTTCT  CCATGATGTT  GGGGCTTCTC  1320
1321  ATCTTCAGTG  TCGTCTTCTT  ACACATGAAG  GAGAAGGAGA  AATCTGACTG  A  1371

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Membrane
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Protein-containing complex
Molecular Function
Dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Biological Process
Protein N-linked glycosylation via asparagine
Biological Process
Response to cytokine
Biological Process
T cell activation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Eqc-2207Equus caballus98.30.0 829
LLPS-Mam-1207Macaca mulatta97.570.0 827
LLPS-Rhb-2744Rhinopithecus bieti97.570.0 828
LLPS-Chs-0175Chlorocebus sabaeus97.570.0 828
LLPS-Ict-0301Ictidomys tridecemlineatus97.330.0 829
LLPS-Ova-0917Ovis aries97.090.0 824
LLPS-Mal-2930Mandrillus leucophaeus96.860.0 516
LLPS-Urm-0254Ursus maritimus96.840.0 820
LLPS-Dio-1208Dipodomys ordii96.840.0 824
LLPS-Mup-1566Mustela putorius furo96.840.0 818
LLPS-Ran-0125Rattus norvegicus96.840.0 823
LLPS-Mea-2400Mesocricetus auratus96.840.0 826
LLPS-Cap-0158Cavia porcellus96.60.0 820
LLPS-Orc-0499Oryctolagus cuniculus96.60.0 823
LLPS-Sus-2114Sus scrofa96.60.0 819
LLPS-Mum-2275Mus musculus96.60.0 823
LLPS-Fud-0938Fukomys damarensis96.60.0 822
LLPS-Gog-0584Gorilla gorilla95.490.0 830
LLPS-Nol-1149Nomascus leucogenys95.390.0 856
LLPS-Man-1229Macaca nemestrina95.380.0 854
LLPS-Paa-2886Papio anubis95.380.0 850
LLPS-Cea-2426Cercocebus atys95.380.0 854
LLPS-Maf-0956Macaca fascicularis95.380.0 854
LLPS-Pap-0190Pan paniscus95.180.0 853
LLPS-Hos-0394Homo sapiens94.960.0 850
LLPS-Pat-0401Pan troglodytes94.960.0 850
LLPS-Myl-2929Myotis lucifugus94.830.0 828
LLPS-Sah-1121Sarcophilus harrisii94.30.0 687
LLPS-Caf-4018Canis familiaris94.290.0 847
LLPS-Cas-2195Carlito syrichta94.290.0 841
LLPS-Fec-4109Felis catus94.290.0 843
LLPS-Loa-1939Loxodonta africana94.070.0 833
LLPS-Ora-0008Ornithorhynchus anatinus94.050.0 690
LLPS-Bot-0934Bos taurus92.530.0 836
LLPS-Gaga-3485Gallus gallus92.480.0 791
LLPS-Tag-3188Taeniopygia guttata92.230.0 791
LLPS-Aim-0470Ailuropoda melanoleuca92.040.0 817
LLPS-Tut-0832Tursiops truncatus91.850.0 815
LLPS-Fia-1381Ficedula albicollis91.730.0 785
LLPS-Pes-1782Pelodiscus sinensis91.730.0 746
LLPS-Meg-2875Meleagris gallopavo91.160.0 753
LLPS-Anc-1695Anolis carolinensis91.00.0 781
LLPS-Orn-2448Oreochromis niloticus89.540.0 771
LLPS-Mod-1111Monodelphis domestica89.250.0 514
LLPS-Leo-0633Lepisosteus oculatus88.810.0 764
LLPS-Scf-1667Scleropages formosus88.560.0 760
LLPS-Pof-0707Poecilia formosa88.080.0 758
LLPS-Xim-1383Xiphophorus maculatus87.830.0 759
LLPS-Asm-1419Astyanax mexicanus87.830.0 749
LLPS-Icp-3517Ictalurus punctatus87.590.0 754
LLPS-Dar-0987Danio rerio87.350.0 747
LLPS-Tar-1805Takifugu rubripes87.350.0 755
LLPS-Orl-0962Oryzias latipes86.860.0 758
LLPS-Ten-1505Tetraodon nigroviridis86.750.0 750
LLPS-Gaa-1679Gasterosteus aculeatus86.370.0 746
LLPS-Scm-1534Scophthalmus maximus86.130.0 745
LLPS-Xet-2049Xenopus tropicalis83.250.0 692
LLPS-Lac-1319Latimeria chalumnae76.270.0 622
LLPS-Cis-1621Ciona savignyi64.810.0 556
LLPS-Cii-1083Ciona intestinalis64.320.0 558
LLPS-Drm-0577Drosophila melanogaster62.620.0 536
LLPS-Cae-0562Caenorhabditis elegans54.772e-156 458
LLPS-Gor-0564Gossypium raimondii48.548e-131 392
LLPS-Dac-1597Daucus carota48.299e-125 377
LLPS-Org-1084Oryza glaberrima47.81e-126 382
LLPS-Ors-1549Oryza sativa47.84e-127 383
LLPS-Orgl-1482Oryza glumaepatula47.82e-126 381
LLPS-Ori-0114Oryza indica47.81e-126 382
LLPS-Orb-2107Oryza barthii47.81e-126 382
LLPS-Orni-1441Oryza nivara47.84e-127 383
LLPS-Viv-0553Vitis vinifera47.688e-132 395
LLPS-Thc-0944Theobroma cacao47.564e-131 393
LLPS-Sob-0156Sorghum bicolor47.371e-123 374
LLPS-Prp-2257Prunus persica47.324e-128 385
LLPS-Coc-1855Corchorus capsularis47.324e-131 393
LLPS-Orm-0658Oryza meridionalis47.322e-125 379
LLPS-Orp-0304Oryza punctata47.322e-125 379
LLPS-Orbr-1861Oryza brachyantha47.323e-126 381
LLPS-Bro-0355Brassica oleracea47.241e-125 379
LLPS-Brr-1928Brassica rapa47.195e-131 393
LLPS-Sem-0782Selaginella moellendorffii47.192e-130 391
LLPS-Met-1013Medicago truncatula47.071e-131 394
LLPS-Sei-0018Setaria italica46.981e-123 374
LLPS-Brn-0577Brassica napus46.985e-126 380
LLPS-Via-0651Vigna angularis46.947e-125 377
LLPS-Hea-0753Helianthus annuus46.943e-131 394
LLPS-Nia-1265Nicotiana attenuata46.71e-130 392
LLPS-Amt-0602Amborella trichopoda46.71e-126 382
LLPS-Phv-1158Phaseolus vulgaris46.595e-126 380
LLPS-Glm-2128Glycine max46.595e-128 385
LLPS-Orr-1533Oryza rufipogon46.411e-124 377
LLPS-Tra-0611Triticum aestivum46.344e-124 375
LLPS-Cus-0364Cucumis sativus46.344e-127 383
LLPS-Mae-1507Manihot esculenta45.977e-127 382
LLPS-Tru-1013Triticum urartu45.856e-115 350
LLPS-Brd-0464Brachypodium distachyon45.853e-124 375
LLPS-Hov-1038Hordeum vulgare45.856e-122 370
LLPS-Art-0347Arabidopsis thaliana45.732e-123 374
LLPS-Arl-0074Arabidopsis lyrata45.735e-123 372
LLPS-Lep-1349Leersia perrieri45.232e-115 352
LLPS-Pot-1477Populus trichocarpa44.611e-114 351
LLPS-Mua-0021Musa acuminata44.313e-115 353
LLPS-Php-0225Physcomitrella patens44.252e-123 374
LLPS-Vir-0538Vigna radiata44.232e-119 364
LLPS-Zem-0392Zea mays44.15e-115 352
LLPS-Sol-1617Solanum lycopersicum43.841e-116 366
LLPS-Abg-0408Absidia glauca42.944e-41 151
LLPS-Chr-0812Chlamydomonas reinhardtii40.252e-98 308
LLPS-Put-0143Puccinia triticina36.83e-82 269
LLPS-Pug-0954Puccinia graminis36.567e-83 269
LLPS-Gas-0363Galdieria sulphuraria36.087e-83 269
LLPS-Gag-0921Gaeumannomyces graminis33.497e-57 201
LLPS-Fus-0129Fusarium solani33.253e-58 204
LLPS-Cogr-0284Colletotrichum graminicola32.482e-57 202
LLPS-Mel-0885Melampsora laricipopulina32.451e-74 247
LLPS-Scp-0367Schizosaccharomyces pombe32.434e-61 212
LLPS-Mao-0312Magnaporthe oryzae32.42e-54 194
LLPS-Nec-0151Neurospora crassa32.336e-55 196
LLPS-Spr-0898Sporisorium reilianum32.113e-30 127
LLPS-Crn-0040Cryptococcus neoformans31.962e-62 216
LLPS-Tum-0540Tuber melanosporum31.913e-57 202
LLPS-Trr-0383Trichoderma reesei31.871e-52 189
LLPS-Usm-0120Ustilago maydis31.842e-26 116
LLPS-Cog-0800Colletotrichum gloeosporioides31.766e-58 203
LLPS-Asc-0391Aspergillus clavatus31.582e-54 194
LLPS-Coo-0506Colletotrichum orbiculare31.413e-58 204
LLPS-Pytr-0799Pyrenophora triticirepentis31.321e-50 184
LLPS-Beb-0021Beauveria bassiana31.251e-50 184
LLPS-Scj-0551Schizosaccharomyces japonicus31.252e-57 201
LLPS-Pyt-0905Pyrenophora teres31.142e-50 184
LLPS-Fuv-0198Fusarium verticillioides31.123e-51 186
LLPS-Ast-1129Aspergillus terreus31.111e-54 197
LLPS-Blg-0324Blumeria graminis31.062e-52 189
LLPS-Ved-0296Verticillium dahliae31.034e-47 174
LLPS-Scs-0642Sclerotinia sclerotiorum30.988e-55 196
LLPS-Trv-1191Trichoderma virens30.955e-51 185
LLPS-Miv-0412Microbotryum violaceum30.947e-62 214
LLPS-Fuo-0860Fusarium oxysporum30.892e-51 186
LLPS-Nef-0288Neosartorya fischeri30.883e-55 196
LLPS-Map-1201Magnaporthe poae30.864e-51 186
LLPS-Asfu-1000Aspergillus fumigatus30.655e-54 193
LLPS-Asn-1060Aspergillus nidulans30.652e-53 192
LLPS-Aso-1229Aspergillus oryzae30.541e-54 195
LLPS-Asf-0416Aspergillus flavus30.541e-54 195
LLPS-Scc-0275Schizosaccharomyces cryophilus30.528e-54 192
LLPS-Phn-0727Phaeosphaeria nodorum30.497e-50 182
LLPS-Chc-0374Chondrus crispus30.293e-53 191
LLPS-Asni-0954Aspergillus niger29.861e-52 189
LLPS-Dos-0651Dothistroma septosporum29.661e-50 184
LLPS-Zyt-0222Zymoseptoria tritici29.324e-49 180
LLPS-Cym-0402Cyanidioschyzon merolae29.269e-50 182
LLPS-Lem-1213Leptosphaeria maculans28.681e-35 142
LLPS-Kop-0261Komagataella pastoris27.081e-29 124
LLPS-Asg-0124Ashbya gossypii25.443e-23 105
LLPS-Yal-0087Yarrowia lipolytica24.882e-33 135
LLPS-Sac-1137Saccharomyces cerevisiae24.285e-27 115