• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pap-3287
NCLN

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nicalin
Gene Name: NCLN
Ensembl Gene: ENSPPAG00000043465.1
Ensembl Protein: ENSPPAP00000041721.1
Organism: Pan paniscus
Taxa ID: 9597
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLEEAGEVLE  NMLKASCLPL  GFIVFLPAVL  LLVAPPLPAA  DAAHEFTVYR  MQQYDLQGQP  60
61    YGTRNAVLNT  EARTMAAEVL  SRRCVLMRLL  DFSYEQYQKA  LRQSAGAVVI  ILPRAMAAVP  120
121   QDVVRQFMEI  EPEMLAMETI  VPVYFAVEDE  ALLSIYEQTQ  AASASQGSAS  AAEVLLRTAT  180
181   ANGFQMVTSG  VQSKAVSDWL  IASVEGRLTG  LGGEDLPTIV  IVAHYDAFGV  APWLSLGADS  240
241   NGSGVSVLLE  LARLFSRLYT  YKRTHAAYNL  LFFASGGGKF  NYQGTKRWLE  DNLDHTDSSL  300
301   LQDNVAFVLC  LDTVGRGSSL  HLHVSKPPRE  GTLQHAFLRE  LETVAAHQFP  EVRFSMVHKR  360
361   INLAEDVLAW  EHERFAIRRL  PAFTLSHLES  HRDGQRSSIM  DVRSRVDSKT  LTRNTRIIAE  420
421   ALTRVIYNLT  EKVSPEPSVP  PAPAPQIQQE  QLDSVMDWLT  NQPRAAQLVD  KDSTFLSTLE  480
481   HHLSRYLKDV  KQHHVKADKR  DPEFVFYDQL  KQVMNAYRVK  PAIFDLLLAV  GIAAYLGMAY  540
541   VAVQHFSLLY  KTVQRLLVKA  KTQ  563
Nucleotide CDS Sequence (FASTA)
1     ATGCTGGAGG  AAGCGGGCGA  GGTGCTGGAG  AACATGCTGA  AGGCGTCTTG  TCTGCCGCTC  60
61    GGCTTCATCG  TCTTCCTGCC  CGCTGTGCTG  CTGCTGGTGG  CGCCGCCGCT  GCCCGCCGCC  120
121   GACGCCGCGC  ACGAGTTCAC  CGTGTACCGC  ATGCAGCAGT  ACGACCTGCA  GGGCCAGCCC  180
181   TACGGCACAC  GGAACGCAGT  GCTGAACACG  GAGGCGCGCA  CGATGGCGGC  AGAGGTGCTG  240
241   AGCCGCCGCT  GCGTGCTCAT  GCGGCTACTG  GACTTCTCCT  ACGAGCAGTA  CCAGAAGGCC  300
301   CTGCGGCAGT  CGGCGGGCGC  CGTGGTCATC  ATCCTGCCCA  GGGCCATGGC  CGCCGTGCCC  360
361   CAGGACGTCG  TCCGGCAATT  CATGGAGATC  GAGCCGGAGA  TGCTGGCCAT  GGAGACCATC  420
421   GTCCCCGTGT  ACTTTGCCGT  GGAGGACGAG  GCCCTGCTGT  CCATCTACGA  GCAGACCCAG  480
481   GCCGCCTCCG  CCTCCCAGGG  CTCCGCCTCT  GCTGCTGAAG  TACTGCTGCG  CACGGCCACT  540
541   GCCAACGGCT  TCCAGATGGT  CACCAGCGGG  GTACAGAGCA  AGGCCGTGAG  TGACTGGCTG  600
601   ATTGCCAGCG  TGGAGGGGCG  GCTGACGGGG  CTGGGCGGAG  AGGACCTTCC  CACCATCGTC  660
661   ATTGTGGCCC  ACTACGACGC  CTTTGGAGTG  GCCCCCTGGC  TGTCGCTGGG  CGCGGACTCC  720
721   AACGGGAGCG  GCGTCTCCGT  GCTGCTGGAG  CTGGCACGCC  TCTTCTCCCG  GCTCTACACC  780
781   TACAAGCGCA  CGCACGCCGC  GTACAATCTC  CTGTTCTTTG  CGTCTGGAGG  AGGCAAGTTT  840
841   AACTACCAGG  GAACCAAGCG  CTGGCTGGAA  GACAACCTGG  ACCACACAGA  CTCCAGCCTG  900
901   CTTCAGGACA  ATGTGGCCTT  CGTGCTGTGC  CTGGACACCG  TGGGCCGGGG  CAGCAGCCTG  960
961   CACCTGCACG  TGTCCAAGCC  GCCCCGGGAG  GGCACCCTGC  AGCACGCCTT  CCTGCGAGAG  1020
1021  CTGGAGACGG  TGGCCGCGCA  CCAGTTCCCC  GAGGTACGGT  TCTCCATGGT  GCACAAGCGG  1080
1081  ATCAACCTGG  CGGAGGACGT  GCTGGCCTGG  GAGCACGAGC  GCTTCGCCAT  CCGCCGACTG  1140
1141  CCCGCCTTCA  CGCTGTCCCA  CCTGGAGAGC  CACCGTGACG  GCCAGCGCAG  CAGCATCATG  1200
1201  GACGTGCGGT  CCCGGGTGGA  TTCTAAGACC  CTGACCCGTA  ACACGAGGAT  CATCGCAGAG  1260
1261  GCCCTGACTC  GAGTCATCTA  CAACCTGACG  GAGAAGGGGA  CACCCCCAGA  CATGCCAGTG  1320
1321  TTCACGGAGC  AGATGCAGAT  CCAGCAGGAG  CAGCTGGACT  CGGTGATGGA  CTGGCTCACC  1380
1381  AACCAGCCCC  GGGCCGCGCA  GCTGGTGGAC  AAGGACAGCA  CCTTCCTCAG  CACGCTGGAG  1440
1441  CACCACCTGA  GCCGCTACCT  GAAGGACGTG  AAGCAGCACC  ACGTCAAGGC  CGACAAGCGG  1500
1501  GACCCAGAGT  TTGTCTTCTA  CGACCAGCTG  AAGCAAGTGA  TGAATGCGTA  CAGAGTCAAG  1560
1561  CCAGCCATCT  TTGACCTGCT  CCTGGCCGTT  GGCATTGCTG  CCTACCTTGG  CATGGCCTAC  1620
1621  GTGGCTGTCC  AGCACTTCAG  CCTCCTCTAC  AAGACCGTCC  AGAGGCTGCT  CGTGAAGGCC  1680
1681  AAGACACAGT  GA  1692

▼ KEYWORD

ID
Family
Complete proteome
Membrane
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Biological Process
Regulation of signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-2136Mandrillus leucophaeus98.444e-32 132
LLPS-Gog-1765Gorilla gorilla97.870.01035
LLPS-Chs-3971Chlorocebus sabaeus97.690.01038
LLPS-Paa-1013Papio anubis97.690.01038
LLPS-Pat-1812Pan troglodytes97.690.01038
LLPS-Maf-0425Macaca fascicularis97.510.01036
LLPS-Hos-2968Homo sapiens97.340.01035
LLPS-Mam-2515Macaca mulatta97.340.0 927
LLPS-Aon-0908Aotus nancymaae97.160.01031
LLPS-Ict-4568Ictidomys tridecemlineatus94.840.01006
LLPS-Otg-3983Otolemur garnettii94.320.01003
LLPS-Rhb-3872Rhinopithecus bieti94.170.0 981
LLPS-Fec-2863Felis catus93.610.01002
LLPS-Sus-1526Sus scrofa93.430.0 991
LLPS-Myl-3038Myotis lucifugus93.430.0 998
LLPS-Caf-1594Canis familiaris93.430.0 999
LLPS-Dio-0955Dipodomys ordii92.90.0 988
LLPS-Bot-2713Bos taurus92.720.0 983
LLPS-Cas-1419Carlito syrichta92.191e-29 124
LLPS-Man-3938Macaca nemestrina92.180.0 967
LLPS-Mup-4566Mustela putorius furo91.870.0 905
LLPS-Ova-2712Ovis aries91.70.0 968
LLPS-Mum-3059Mus musculus91.650.0 977
LLPS-Mea-3841Mesocricetus auratus91.470.0 968
LLPS-Ran-2864Rattus norvegicus91.30.0 966
LLPS-Nol-4044Nomascus leucogenys90.230.0 932
LLPS-Caj-4096Callithrix jacchus90.080.01009
LLPS-Mod-0312Monodelphis domestica89.520.0 957
LLPS-Cap-0509Cavia porcellus89.320.0 947
LLPS-Poa-4079Pongo abelii87.570.0 896
LLPS-Pes-2575Pelodiscus sinensis86.650.0 872
LLPS-Ora-3381Ornithorhynchus anatinus86.030.0 881
LLPS-Aim-3694Ailuropoda melanoleuca85.640.0 932
LLPS-Eqc-2270Equus caballus85.30.0 923
LLPS-Fia-3336Ficedula albicollis85.060.0 852
LLPS-Anc-3549Anolis carolinensis85.020.0 708
LLPS-Tag-2666Taeniopygia guttata84.550.0 926
LLPS-Anp-2059Anas platyrhynchos84.380.0 853
LLPS-Gaga-0798Gallus gallus84.370.0 923
LLPS-Fud-2935Fukomys damarensis83.630.0 779
LLPS-Sah-2870Sarcophilus harrisii83.150.0 880
LLPS-Meg-1584Meleagris gallopavo82.950.0 840
LLPS-Cea-4007Cercocebus atys82.690.0 826
LLPS-Xet-2331Xenopus tropicalis80.990.0 883
LLPS-Leo-2225Lepisosteus oculatus78.60.0 855
LLPS-Lac-3572Latimeria chalumnae77.20.0 759
LLPS-Scf-3603Scleropages formosus77.160.0 842
LLPS-Tar-2963Takifugu rubripes76.620.0 842
LLPS-Ten-2646Tetraodon nigroviridis76.340.0 832
LLPS-Orn-2784Oreochromis niloticus76.050.0 843
LLPS-Pof-3123Poecilia formosa75.520.0 842
LLPS-Xim-1892Xiphophorus maculatus75.350.0 840
LLPS-Icp-4008Ictalurus punctatus75.180.0 827
LLPS-Gaa-1598Gasterosteus aculeatus74.830.0 830
LLPS-Orl-2820Oryzias latipes74.780.0 829
LLPS-Asm-1257Astyanax mexicanus73.950.0 811
LLPS-Scm-1461Scophthalmus maximus73.950.0 823
LLPS-Dar-2965Danio rerio72.850.0 805
LLPS-Loa-2224Loxodonta africana72.170.0 691
LLPS-Cii-2309Ciona intestinalis41.568e-136 413
LLPS-Tru-1153Triticum urartu35.353e-47 179
LLPS-Vir-0634Vigna radiata35.254e-39 153
LLPS-Orb-1277Oryza barthii35.186e-79 266
LLPS-Orgl-1342Oryza glumaepatula35.181e-79 267
LLPS-Sob-0099Sorghum bicolor35.111e-81 272
LLPS-Orni-0798Oryza nivara34.984e-79 266
LLPS-Ors-2359Oryza sativa34.983e-79 266
LLPS-Orr-1905Oryza rufipogon34.983e-79 266
LLPS-Zem-0901Zea mays34.919e-82 273
LLPS-Sei-1096Setaria italica34.93e-76 258
LLPS-Lep-1143Leersia perrieri34.779e-76 256
LLPS-Orbr-1355Oryza brachyantha34.581e-73 251
LLPS-Ori-2248Oryza indica34.273e-74 250
LLPS-Hov-0790Hordeum vulgare34.183e-76 259
LLPS-Drm-2324Drosophila melanogaster33.823e-78 263
LLPS-Tra-1084Triticum aestivum33.592e-74 253
LLPS-Pot-1772Populus trichocarpa33.43e-65 229
LLPS-Glm-1182Glycine max33.333e-70 242
LLPS-Php-1503Physcomitrella patens33.338e-76 259
LLPS-Brd-1990Brachypodium distachyon33.24e-75 255
LLPS-Via-0082Vigna angularis33.141e-70 243
LLPS-Mua-2547Musa acuminata32.951e-65 229
LLPS-Phv-2394Phaseolus vulgaris32.943e-71 245
LLPS-Brn-3372Brassica napus32.887e-69 238
LLPS-Arl-2744Arabidopsis lyrata32.889e-71 243
LLPS-Brr-0414Brassica rapa32.883e-69 239
LLPS-Art-0511Arabidopsis thaliana32.889e-71 243
LLPS-Bro-2415Brassica oleracea32.887e-69 238
LLPS-Amt-2180Amborella trichopoda32.814e-68 236
LLPS-Nia-1618Nicotiana attenuata32.347e-70 241
LLPS-Cus-2004Cucumis sativus31.874e-67 236
LLPS-Met-0924Medicago truncatula31.832e-66 232
LLPS-Viv-1971Vitis vinifera31.795e-62 220
LLPS-Mae-1300Manihot esculenta31.717e-65 228
LLPS-Thc-2357Theobroma cacao31.572e-63 223
LLPS-Prp-2095Prunus persica31.524e-63 223
LLPS-Dac-1899Daucus carota31.454e-64 225
LLPS-Gor-2181Gossypium raimondii31.372e-62 221
LLPS-Coc-2280Corchorus capsularis31.322e-61 218
LLPS-Sol-2476Solanum lycopersicum30.96e-64 225
LLPS-Hea-1072Helianthus annuus30.93e-64 226
LLPS-Cae-1852Caenorhabditis elegans30.443e-58 209
LLPS-Sem-1745Selaginella moellendorffii30.377e-66 230