• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Paa-0806
TOP1MT

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA topoisomerase I; DNA topoisomerase 1
Gene Name: TOP1MT
Ensembl Gene: ENSPANG00000009180.2
Ensembl Protein: ENSPANP00000005905.1
Organism: Papio anubis
Taxa ID: 9555
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MRVVRLLRLR  AALTLLGEVP  RRPASRGVPG  SRRTQKGSGT  RWEEEKREDR  VKWRQLEHKG  60
61    PYFAPPYEPL  PNGVCFFYDG  KPMRLSVKAE  EVATFYGRML  DHEYTTKEVF  RKNFFNDWRK  120
121   EMTVEEREVI  KSLDKCDFTE  IHRYFVDKAA  ARKVLTREEK  QKLKEEAEKL  QQEFGYCILD  180
181   GHREKIGNFK  TEPPGLFRGR  GNHPKMGMLK  RRVMPEDVVI  NCSRDSIPKP  PAGHQWKEVR  240
241   SDNTVMWLAA  WTESIQNSIK  YVMLNPCSKL  KGEKAWQKFE  TARRLRGFVD  EIRSQYRADW  300
301   KSQEMKTRQR  AVALYFIDKL  ALRAGNEKED  GEAADTVGCC  SLRVEHVQLH  PEADGCQHVV  360
361   EFDFLGKDSI  RYNNRVPVEK  PVYKNLELFM  KNKDPQDDLF  DRLTTTSLNK  HLHELMDGLT  420
421   AKVFRTYNAS  VTLQEQLRAL  TRAEDSIAAK  ILSYNRANRA  VAILCNHQRA  TSSTFEKSMQ  480
481   NLQTKIQVKK  EQVAEARAEL  RKARAEHKAQ  GDDKSRSVLE  KKRRLLEKLQ  EQLAWLSVQA  540
541   TDKEENKQVA  LSTSKLNYLD  PRISIAWCKR  FRVPVEKIYS  KTQRERFAWA  LAMAGEDFEF  600
Nucleotide CDS Sequence (FASTA)
1     ATGCGCGTGG  TGCGGCTGCT  GCGGCTCCGG  GCGGCTCTGA  CGCTGCTCGG  GGAGGTCCCC  60
61    CGCCGCCCGG  CCTCCCGGGG  CGTCCCGGGC  TCGCGCAGGA  CGCAGAAGGG  CAGTGGAACC  120
121   AGGTGGGAGG  AGGAGAAGCG  CGAAGACAGG  GTGAAGTGGA  GACAGCTGGA  GCACAAGGGC  180
181   CCGTACTTCG  CACCCCCATA  CGAGCCCCTT  CCCAATGGAG  TGTGTTTCTT  CTATGACGGA  240
241   AAGCCCATGA  GATTGAGCGT  GAAAGCGGAG  GAGGTGGCCA  CTTTTTATGG  GAGGATGTTG  300
301   GATCATGAAT  ACACAACAAA  GGAGGTTTTC  CGGAAGAACT  TCTTTAATGA  CTGGCGAAAG  360
361   GAAATGACAG  TGGAAGAGAG  AGAAGTCATC  AAGAGCCTGG  ACAAGTGTGA  CTTCACGGAG  420
421   ATCCACAGAT  ACTTTGTGGA  CAAGGCCGCA  GCCCGGAAAG  TGCTGACCAG  GGAGGAGAAG  480
481   CAGAAGCTAA  AAGAAGAGGC  CGAAAAACTT  CAGCAAGAGT  TCGGCTACTG  TATTTTAGAT  540
541   GGTCACCGAG  AAAAAATAGG  CAATTTCAAG  ACTGAGCCGC  CCGGCTTGTT  CCGTGGCCGT  600
601   GGCAACCATC  CCAAGATGGG  GATGTTGAAG  AGGAGGGTCA  TGCCGGAGGA  TGTGGTCATC  660
661   AACTGCAGCA  GGGACTCGAT  CCCCAAGCCA  CCGGCGGGGC  ACCAGTGGAA  GGAGGTGCGC  720
721   TCTGATAACA  CTGTCATGTG  GCTGGCAGCG  TGGACCGAGA  GCATTCAGAA  CTCCATCAAG  780
781   TACGTCATGC  TGAACCCTTG  CTCGAAGCTG  AAGGGGGAGA  AAGCTTGGCA  GAAGTTTGAA  840
841   ACAGCTCGAC  GCCTGCGGGG  ATTTGTGGAC  GAGATCCGCT  CCCAGTACCG  GGCTGATTGG  900
901   AAGTCTCAGG  AAATGAAGAC  GAGACAGCGG  GCGGTGGCCC  TGTATTTCAT  CGATAAGCTG  960
961   GCGCTGAGAG  CGGGAAATGA  GAAGGAGGAC  GGTGAGGCGG  CCGACACCGT  GGGCTGCTGT  1020
1021  TCTCTCCGCG  TGGAGCACGT  CCAGCTGCAC  CCGGAGGCCG  ACGGCTGCCA  GCACGTGGTG  1080
1081  GAATTTGACT  TCCTGGGGAA  GGACTCCATC  CGCTACAACA  ACAGAGTCCC  GGTGGAGAAG  1140
1141  CCTGTGTACA  AGAACTTAGA  GCTCTTTATG  AAGAACAAGG  ACCCCCAGGA  CGACCTCTTC  1200
1201  GACAGGCTCA  CCACGACCAG  CCTGAACAAA  CACCTCCACG  AGCTGATGGA  CGGGCTGACG  1260
1261  GCCAAGGTGT  TCCGGACCTA  CAACGCCTCC  GTCACTCTGC  AGGAGCAGCT  GCGGGCCCTG  1320
1321  ACACGTGCCG  AGGACAGCAT  AGCAGCCAAG  ATCTTATCCT  ACAACCGAGC  CAACCGAGCC  1380
1381  GTGGCCATTC  TCTGCAACCA  TCAGCGAGCG  ACCTCCAGCA  CGTTTGAGAA  GTCGATGCAG  1440
1441  AATCTCCAGA  CCAAGATCCA  GGTGAAGAAG  GAGCAGGTGG  CTGAGGCCAG  GGCAGAGCTG  1500
1501  AGGAAGGCCA  GGGCCGAGCA  CAAAGCCCAA  GGGGATGACA  AGTCCAGGAG  TGTCCTGGAG  1560
1561  AAGAAGAGGC  GGCTCCTGGA  GAAGCTGCAG  GAGCAGCTGG  CGTGGCTGAG  TGTGCAGGCC  1620
1621  ACGGACAAGG  AGGAGAACAA  GCAGGTGGCT  CTCAGCACGT  CCAAGCTCAA  CTACCTGGAC  1680
1681  CCCAGGATCA  GCATTGCCTG  GTGCAAGCGA  TTCAGGGTGC  CAGTGGAGAA  GATCTACAGC  1740
1741  AAAACACAGC  GGGAGAGGTT  CGCCTGGGCT  CTCGCCATGG  CAGGAGAAGA  CTTTGAATTC  1800
1801  TAA  1803

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
DNA-binding
Isomerase
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Mitochondrial nucleoid
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type I activity
Biological Process
DNA topological change

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-0156Macaca fascicularis98.460.01094
LLPS-Mal-3903Mandrillus leucophaeus98.420.01060
LLPS-Cea-1596Cercocebus atys98.370.01020
LLPS-Chs-2502Chlorocebus sabaeus97.140.01025
LLPS-Rhb-3164Rhinopithecus bieti96.410.01075
LLPS-Man-1265Macaca nemestrina96.060.01055
LLPS-Nol-1574Nomascus leucogenys94.020.01044
LLPS-Hos-0767Homo sapiens93.50.01038
LLPS-Gog-1500Gorilla gorilla93.50.01038
LLPS-Pap-2021Pan paniscus93.420.0 809
LLPS-Pat-1505Pan troglodytes92.820.01031
LLPS-Poa-2059Pongo abelii92.310.01012
LLPS-Mam-1378Macaca mulatta90.580.01005
LLPS-Cas-1396Carlito syrichta85.810.0 959
LLPS-Eqc-0339Equus caballus85.360.0 929
LLPS-Anp-1555Anas platyrhynchos82.092e-29 116
LLPS-Sus-4380Sus scrofa81.120.0 774
LLPS-Ora-1496Ornithorhynchus anatinus79.290.0 869
LLPS-Otg-1544Otolemur garnettii78.460.0 880
LLPS-Sah-1212Sarcophilus harrisii78.390.0 869
LLPS-Cap-3508Cavia porcellus78.050.0 785
LLPS-Pes-2524Pelodiscus sinensis77.320.0 860
LLPS-Gaga-3373Gallus gallus75.930.0 704
LLPS-Meg-2329Meleagris gallopavo75.710.0 844
LLPS-Mum-4954Mus musculus75.40.0 822
LLPS-Ran-2961Rattus norvegicus74.830.0 832
LLPS-Tag-2007Taeniopygia guttata74.380.0 833
LLPS-Fia-2799Ficedula albicollis74.320.0 819
LLPS-Dio-0534Dipodomys ordii73.790.0 786
LLPS-Anc-0367Anolis carolinensis73.60.0 729
LLPS-Xet-1271Xenopus tropicalis73.390.0 816
LLPS-Ova-1652Ovis aries72.450.0 600
LLPS-Mea-3576Mesocricetus auratus72.380.0 804
LLPS-Lac-2401Latimeria chalumnae71.140.0 792
LLPS-Tut-0222Tursiops truncatus71.140.0 789
LLPS-Loa-2967Loxodonta africana70.960.0 789
LLPS-Aim-0343Ailuropoda melanoleuca70.90.0 764
LLPS-Fec-2542Felis catus70.780.0 790
LLPS-Urm-0041Ursus maritimus70.780.0 788
LLPS-Myl-1935Myotis lucifugus70.780.0 792
LLPS-Mup-0709Mustela putorius furo70.780.0 790
LLPS-Caf-0801Canis familiaris70.60.0 790
LLPS-Aon-1989Aotus nancymaae70.60.0 788
LLPS-Bot-0142Bos taurus70.60.0 787
LLPS-Orc-3131Oryctolagus cuniculus70.420.0 783
LLPS-Caj-0741Callithrix jacchus70.420.0 788
LLPS-Pof-2889Poecilia formosa70.340.0 792
LLPS-Dar-0038Danio rerio70.340.0 780
LLPS-Ten-0234Tetraodon nigroviridis70.340.0 778
LLPS-Leo-1256Lepisosteus oculatus70.340.0 795
LLPS-Mod-0876Monodelphis domestica70.240.0 780
LLPS-Fud-1048Fukomys damarensis70.240.0 785
LLPS-Orl-0201Oryzias latipes70.160.0 786
LLPS-Xim-1834Xiphophorus maculatus70.160.0 776
LLPS-Ict-2300Ictidomys tridecemlineatus70.050.0 780
LLPS-Tar-1671Takifugu rubripes69.980.0 659
LLPS-Scf-2030Scleropages formosus69.820.0 782
LLPS-Scm-3092Scophthalmus maximus69.80.0 773
LLPS-Orn-0149Oreochromis niloticus69.620.0 781
LLPS-Icp-0822Ictalurus punctatus69.620.0 780
LLPS-Asm-1515Astyanax mexicanus66.840.0 743
LLPS-Cis-0286Ciona savignyi64.240.0 602
LLPS-Gaa-1900Gasterosteus aculeatus61.460.0 675
LLPS-Drm-0041Drosophila melanogaster60.790.0 662
LLPS-Gas-0014Galdieria sulphuraria60.344e-1376.6
LLPS-Cii-0007Ciona intestinalis60.00.0 581
LLPS-Abg-1221Absidia glauca59.91e-68 240
LLPS-Cae-0577Caenorhabditis elegans59.890.0 645
LLPS-Chc-0687Chondrus crispus58.625e-1376.3
LLPS-Miv-0739Microbotryum violaceum57.692e-1274.3
LLPS-Kop-0227Komagataella pastoris57.633e-1480.1
LLPS-Asni-0175Aspergillus niger55.382e-1687.0
LLPS-Crn-0655Cryptococcus neoformans55.226e-1582.8
LLPS-Asg-0037Ashbya gossypii54.691e-1585.1
LLPS-Sac-0024Saccharomyces cerevisiae54.694e-1686.3
LLPS-Cog-0169Colletotrichum gloeosporioides54.553e-1583.6
LLPS-Ast-0483Aspergillus terreus53.856e-1685.9
LLPS-Nef-0103Neosartorya fischeri53.857e-1685.5
LLPS-Phn-0072Phaeosphaeria nodorum53.853e-1583.6
LLPS-Lem-1229Leptosphaeria maculans53.852e-1584.3
LLPS-Zem-1771Zea mays53.72e-1268.2
LLPS-Fus-0334Fusarium solani53.572e-1274.7
LLPS-Fuo-0214Fusarium oxysporum53.572e-1274.7
LLPS-Fuv-0179Fusarium verticillioides53.572e-1274.7
LLPS-Dac-1194Daucus carota53.456e-1066.6
LLPS-Mel-0956Melampsora laricipopulina52.732e-1274.7
LLPS-Scp-0401Schizosaccharomyces pombe52.731e-1068.6
LLPS-Scj-1143Schizosaccharomyces japonicus52.732e-1171.2
LLPS-Pytr-0692Pyrenophora triticirepentis52.319e-1582.0
LLPS-Asfu-0136Aspergillus fumigatus52.312e-1584.0
LLPS-Asc-0022Aspergillus clavatus52.312e-1584.3
LLPS-Asn-0001Aspergillus nidulans52.318e-1685.5
LLPS-Aso-0623Aspergillus oryzae52.311e-1584.7
LLPS-Pyt-0166Pyrenophora teres52.319e-1582.0
LLPS-Asf-0388Aspergillus flavus52.311e-1584.7
LLPS-Ved-0262Verticillium dahliae51.611e-1378.6
LLPS-Nec-0941Neurospora crassa51.616e-1479.3
LLPS-Blg-0112Blumeria graminis51.562e-1378.2
LLPS-Cogr-0227Colletotrichum graminicola51.521e-1481.6
LLPS-Coo-0704Colletotrichum orbiculare51.523e-1480.5
LLPS-Tum-0273Tuber melanosporum51.224e-138 432
LLPS-Scc-0569Schizosaccharomyces cryophilus50.911e-1068.9
LLPS-Mao-0644Magnaporthe oryzae50.776e-1582.4
LLPS-Trr-0678Trichoderma reesei50.752e-1377.8
LLPS-Trv-0179Trichoderma virens50.752e-1377.4
LLPS-Dos-0835Dothistroma septosporum50.754e-1583.2
LLPS-Yal-0350Yarrowia lipolytica50.553e-143 441
LLPS-Pug-0198Puccinia graminis49.569e-140 437
LLPS-Beb-1429Beauveria bassiana49.257e-1375.9
LLPS-Put-0273Puccinia triticina49.224e-132 416
LLPS-Map-0654Magnaporthe poae48.711e-132 418
LLPS-Zyt-0133Zymoseptoria tritici48.487e-133 417
LLPS-Nia-0032Nicotiana attenuata48.453e-155 475
LLPS-Gag-0312Gaeumannomyces graminis48.288e-129 408
LLPS-Viv-0932Vitis vinifera48.113e-152 467
LLPS-Sol-0382Solanum lycopersicum48.04e-156 478
LLPS-Tra-1007Triticum aestivum47.663e-146 450
LLPS-Sot-0087Solanum tuberosum47.643e-154 473
LLPS-Prp-1027Prunus persica47.581e-152 466
LLPS-Mua-0764Musa acuminata47.48e-146 450
LLPS-Coc-1255Corchorus capsularis46.983e-146 452
LLPS-Tru-0513Triticum urartu46.942e-145 448
LLPS-Brd-1783Brachypodium distachyon46.946e-151 464
LLPS-Hov-1353Hordeum vulgare46.941e-146 455
LLPS-Met-0016Medicago truncatula46.781e-153 472
LLPS-Art-1206Arabidopsis thaliana46.766e-146 452
LLPS-Gor-0232Gossypium raimondii46.767e-149 459
LLPS-Brr-2053Brassica rapa46.767e-147 454
LLPS-Brn-2913Brassica napus46.769e-148 454
LLPS-Bro-0855Brassica oleracea46.584e-148 457
LLPS-Cus-0295Cucumis sativus46.583e-149 460
LLPS-Sem-1223Selaginella moellendorffii46.531e-149 451
LLPS-Pot-0105Populus trichocarpa46.444e-148 456
LLPS-Hea-0802Helianthus annuus46.449e-148 455
LLPS-Php-1960Physcomitrella patens46.432e-146 451
LLPS-Orbr-0790Oryza brachyantha46.42e-147 456
LLPS-Sob-0391Sorghum bicolor46.42e-147 457
LLPS-Thc-1572Theobroma cacao46.41e-149 461
LLPS-Sei-0917Setaria italica46.45e-149 460
LLPS-Amt-0088Amborella trichopoda46.272e-141 440
LLPS-Orm-1714Oryza meridionalis46.279e-140 438
LLPS-Arl-1327Arabidopsis lyrata46.045e-145 450
LLPS-Ors-0740Oryza sativa45.962e-144 448
LLPS-Orr-0809Oryza rufipogon45.962e-144 448
LLPS-Ori-1250Oryza indica45.961e-144 449
LLPS-Orb-0471Oryza barthii45.962e-144 448
LLPS-Orni-1203Oryza nivara45.961e-144 449
LLPS-Orgl-0085Oryza glumaepatula45.962e-144 448
LLPS-Mae-1784Manihot esculenta45.899e-150 461
LLPS-Orp-0149Oryza punctata45.783e-145 450
LLPS-Lep-0068Leersia perrieri45.66e-146 452
LLPS-Glm-0422Glycine max45.584e-150 462
LLPS-Phv-0993Phaseolus vulgaris45.54e-146 453
LLPS-Via-0266Vigna angularis44.095e-134 420
LLPS-Vir-0484Vigna radiata43.884e-141 435
LLPS-Cym-0044Cyanidioschyzon merolae43.792e-119 377
LLPS-Osl-0705Ostreococcus lucimarinus42.226e-121 374
LLPS-Chr-0521Chlamydomonas reinhardtii40.677e-132 409
LLPS-Spr-0617Sporisorium reilianum38.281e-88 302
LLPS-Usm-0494Ustilago maydis36.81e-88 302