LLPS-Paa-0806
TOP1MT
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | DNA topoisomerase I; DNA topoisomerase 1 |
Gene Name: | TOP1MT |
Ensembl Gene: | ENSPANG00000009180.2 |
Ensembl Protein: | ENSPANP00000005905.1 |
Organism: | Papio anubis |
Taxa ID: | 9555 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSPANT00000026879.2 | ENSPANP00000005905.1 |
Ensembl | ENSPANT00000037287.1 | ENSPANP00000023943.1 |
UniProt | A0A096N0W5, A0A096N0W5_PAPAN | |
GeneBank | AHZZ02034579 | |
RefSeq | XM_003903238.3 | XP_003903287.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MRVVRLLRLR AALTLLGEVP RRPASRGVPG SRRTQKGSGT RWEEEKREDR VKWRQLEHKG 60 61 PYFAPPYEPL PNGVCFFYDG KPMRLSVKAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK 120 121 EMTVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLTREEK QKLKEEAEKL QQEFGYCILD 180 181 GHREKIGNFK TEPPGLFRGR GNHPKMGMLK RRVMPEDVVI NCSRDSIPKP PAGHQWKEVR 240 241 SDNTVMWLAA WTESIQNSIK YVMLNPCSKL KGEKAWQKFE TARRLRGFVD EIRSQYRADW 300 301 KSQEMKTRQR AVALYFIDKL ALRAGNEKED GEAADTVGCC SLRVEHVQLH PEADGCQHVV 360 361 EFDFLGKDSI RYNNRVPVEK PVYKNLELFM KNKDPQDDLF DRLTTTSLNK HLHELMDGLT 420 421 AKVFRTYNAS VTLQEQLRAL TRAEDSIAAK ILSYNRANRA VAILCNHQRA TSSTFEKSMQ 480 481 NLQTKIQVKK EQVAEARAEL RKARAEHKAQ GDDKSRSVLE KKRRLLEKLQ EQLAWLSVQA 540 541 TDKEENKQVA LSTSKLNYLD PRISIAWCKR FRVPVEKIYS KTQRERFAWA LAMAGEDFEF 600 |
Nucleotide CDS Sequence (FASTA) |
1 ATGCGCGTGG TGCGGCTGCT GCGGCTCCGG GCGGCTCTGA CGCTGCTCGG GGAGGTCCCC 60 61 CGCCGCCCGG CCTCCCGGGG CGTCCCGGGC TCGCGCAGGA CGCAGAAGGG CAGTGGAACC 120 121 AGGTGGGAGG AGGAGAAGCG CGAAGACAGG GTGAAGTGGA GACAGCTGGA GCACAAGGGC 180 181 CCGTACTTCG CACCCCCATA CGAGCCCCTT CCCAATGGAG TGTGTTTCTT CTATGACGGA 240 241 AAGCCCATGA GATTGAGCGT GAAAGCGGAG GAGGTGGCCA CTTTTTATGG GAGGATGTTG 300 301 GATCATGAAT ACACAACAAA GGAGGTTTTC CGGAAGAACT TCTTTAATGA CTGGCGAAAG 360 361 GAAATGACAG TGGAAGAGAG AGAAGTCATC AAGAGCCTGG ACAAGTGTGA CTTCACGGAG 420 421 ATCCACAGAT ACTTTGTGGA CAAGGCCGCA GCCCGGAAAG TGCTGACCAG GGAGGAGAAG 480 481 CAGAAGCTAA AAGAAGAGGC CGAAAAACTT CAGCAAGAGT TCGGCTACTG TATTTTAGAT 540 541 GGTCACCGAG AAAAAATAGG CAATTTCAAG ACTGAGCCGC CCGGCTTGTT CCGTGGCCGT 600 601 GGCAACCATC CCAAGATGGG GATGTTGAAG AGGAGGGTCA TGCCGGAGGA TGTGGTCATC 660 661 AACTGCAGCA GGGACTCGAT CCCCAAGCCA CCGGCGGGGC ACCAGTGGAA GGAGGTGCGC 720 721 TCTGATAACA CTGTCATGTG GCTGGCAGCG TGGACCGAGA GCATTCAGAA CTCCATCAAG 780 781 TACGTCATGC TGAACCCTTG CTCGAAGCTG AAGGGGGAGA AAGCTTGGCA GAAGTTTGAA 840 841 ACAGCTCGAC GCCTGCGGGG ATTTGTGGAC GAGATCCGCT CCCAGTACCG GGCTGATTGG 900 901 AAGTCTCAGG AAATGAAGAC GAGACAGCGG GCGGTGGCCC TGTATTTCAT CGATAAGCTG 960 961 GCGCTGAGAG CGGGAAATGA GAAGGAGGAC GGTGAGGCGG CCGACACCGT GGGCTGCTGT 1020 1021 TCTCTCCGCG TGGAGCACGT CCAGCTGCAC CCGGAGGCCG ACGGCTGCCA GCACGTGGTG 1080 1081 GAATTTGACT TCCTGGGGAA GGACTCCATC CGCTACAACA ACAGAGTCCC GGTGGAGAAG 1140 1141 CCTGTGTACA AGAACTTAGA GCTCTTTATG AAGAACAAGG ACCCCCAGGA CGACCTCTTC 1200 1201 GACAGGCTCA CCACGACCAG CCTGAACAAA CACCTCCACG AGCTGATGGA CGGGCTGACG 1260 1261 GCCAAGGTGT TCCGGACCTA CAACGCCTCC GTCACTCTGC AGGAGCAGCT GCGGGCCCTG 1320 1321 ACACGTGCCG AGGACAGCAT AGCAGCCAAG ATCTTATCCT ACAACCGAGC CAACCGAGCC 1380 1381 GTGGCCATTC TCTGCAACCA TCAGCGAGCG ACCTCCAGCA CGTTTGAGAA GTCGATGCAG 1440 1441 AATCTCCAGA CCAAGATCCA GGTGAAGAAG GAGCAGGTGG CTGAGGCCAG GGCAGAGCTG 1500 1501 AGGAAGGCCA GGGCCGAGCA CAAAGCCCAA GGGGATGACA AGTCCAGGAG TGTCCTGGAG 1560 1561 AAGAAGAGGC GGCTCCTGGA GAAGCTGCAG GAGCAGCTGG CGTGGCTGAG TGTGCAGGCC 1620 1621 ACGGACAAGG AGGAGAACAA GCAGGTGGCT CTCAGCACGT CCAAGCTCAA CTACCTGGAC 1680 1681 CCCAGGATCA GCATTGCCTG GTGCAAGCGA TTCAGGGTGC CAGTGGAGAA GATCTACAGC 1740 1741 AAAACACAGC GGGAGAGGTT CGCCTGGGCT CTCGCCATGG CAGGAGAAGA CTTTGAATTC 1800 1801 TAA 1803 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome | |
Cellular Component | Mitochondrial nucleoid | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type I activity | |
Biological Process | DNA topological change |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Maf-0156 | Macaca fascicularis | 98.46 | 0.0 | 1094 |
LLPS-Mal-3903 | Mandrillus leucophaeus | 98.42 | 0.0 | 1060 |
LLPS-Cea-1596 | Cercocebus atys | 98.37 | 0.0 | 1020 |
LLPS-Chs-2502 | Chlorocebus sabaeus | 97.14 | 0.0 | 1025 |
LLPS-Rhb-3164 | Rhinopithecus bieti | 96.41 | 0.0 | 1075 |
LLPS-Man-1265 | Macaca nemestrina | 96.06 | 0.0 | 1055 |
LLPS-Nol-1574 | Nomascus leucogenys | 94.02 | 0.0 | 1044 |
LLPS-Hos-0767 | Homo sapiens | 93.5 | 0.0 | 1038 |
LLPS-Gog-1500 | Gorilla gorilla | 93.5 | 0.0 | 1038 |
LLPS-Pap-2021 | Pan paniscus | 93.42 | 0.0 | 809 |
LLPS-Pat-1505 | Pan troglodytes | 92.82 | 0.0 | 1031 |
LLPS-Poa-2059 | Pongo abelii | 92.31 | 0.0 | 1012 |
LLPS-Mam-1378 | Macaca mulatta | 90.58 | 0.0 | 1005 |
LLPS-Cas-1396 | Carlito syrichta | 85.81 | 0.0 | 959 |
LLPS-Eqc-0339 | Equus caballus | 85.36 | 0.0 | 929 |
LLPS-Anp-1555 | Anas platyrhynchos | 82.09 | 2e-29 | 116 |
LLPS-Sus-4380 | Sus scrofa | 81.12 | 0.0 | 774 |
LLPS-Ora-1496 | Ornithorhynchus anatinus | 79.29 | 0.0 | 869 |
LLPS-Otg-1544 | Otolemur garnettii | 78.46 | 0.0 | 880 |
LLPS-Sah-1212 | Sarcophilus harrisii | 78.39 | 0.0 | 869 |
LLPS-Cap-3508 | Cavia porcellus | 78.05 | 0.0 | 785 |
LLPS-Pes-2524 | Pelodiscus sinensis | 77.32 | 0.0 | 860 |
LLPS-Gaga-3373 | Gallus gallus | 75.93 | 0.0 | 704 |
LLPS-Meg-2329 | Meleagris gallopavo | 75.71 | 0.0 | 844 |
LLPS-Mum-4954 | Mus musculus | 75.4 | 0.0 | 822 |
LLPS-Ran-2961 | Rattus norvegicus | 74.83 | 0.0 | 832 |
LLPS-Tag-2007 | Taeniopygia guttata | 74.38 | 0.0 | 833 |
LLPS-Fia-2799 | Ficedula albicollis | 74.32 | 0.0 | 819 |
LLPS-Dio-0534 | Dipodomys ordii | 73.79 | 0.0 | 786 |
LLPS-Anc-0367 | Anolis carolinensis | 73.6 | 0.0 | 729 |
LLPS-Xet-1271 | Xenopus tropicalis | 73.39 | 0.0 | 816 |
LLPS-Ova-1652 | Ovis aries | 72.45 | 0.0 | 600 |
LLPS-Mea-3576 | Mesocricetus auratus | 72.38 | 0.0 | 804 |
LLPS-Lac-2401 | Latimeria chalumnae | 71.14 | 0.0 | 792 |
LLPS-Tut-0222 | Tursiops truncatus | 71.14 | 0.0 | 789 |
LLPS-Loa-2967 | Loxodonta africana | 70.96 | 0.0 | 789 |
LLPS-Aim-0343 | Ailuropoda melanoleuca | 70.9 | 0.0 | 764 |
LLPS-Fec-2542 | Felis catus | 70.78 | 0.0 | 790 |
LLPS-Urm-0041 | Ursus maritimus | 70.78 | 0.0 | 788 |
LLPS-Myl-1935 | Myotis lucifugus | 70.78 | 0.0 | 792 |
LLPS-Mup-0709 | Mustela putorius furo | 70.78 | 0.0 | 790 |
LLPS-Caf-0801 | Canis familiaris | 70.6 | 0.0 | 790 |
LLPS-Aon-1989 | Aotus nancymaae | 70.6 | 0.0 | 788 |
LLPS-Bot-0142 | Bos taurus | 70.6 | 0.0 | 787 |
LLPS-Orc-3131 | Oryctolagus cuniculus | 70.42 | 0.0 | 783 |
LLPS-Caj-0741 | Callithrix jacchus | 70.42 | 0.0 | 788 |
LLPS-Pof-2889 | Poecilia formosa | 70.34 | 0.0 | 792 |
LLPS-Dar-0038 | Danio rerio | 70.34 | 0.0 | 780 |
LLPS-Ten-0234 | Tetraodon nigroviridis | 70.34 | 0.0 | 778 |
LLPS-Leo-1256 | Lepisosteus oculatus | 70.34 | 0.0 | 795 |
LLPS-Mod-0876 | Monodelphis domestica | 70.24 | 0.0 | 780 |
LLPS-Fud-1048 | Fukomys damarensis | 70.24 | 0.0 | 785 |
LLPS-Orl-0201 | Oryzias latipes | 70.16 | 0.0 | 786 |
LLPS-Xim-1834 | Xiphophorus maculatus | 70.16 | 0.0 | 776 |
LLPS-Ict-2300 | Ictidomys tridecemlineatus | 70.05 | 0.0 | 780 |
LLPS-Tar-1671 | Takifugu rubripes | 69.98 | 0.0 | 659 |
LLPS-Scf-2030 | Scleropages formosus | 69.82 | 0.0 | 782 |
LLPS-Scm-3092 | Scophthalmus maximus | 69.8 | 0.0 | 773 |
LLPS-Orn-0149 | Oreochromis niloticus | 69.62 | 0.0 | 781 |
LLPS-Icp-0822 | Ictalurus punctatus | 69.62 | 0.0 | 780 |
LLPS-Asm-1515 | Astyanax mexicanus | 66.84 | 0.0 | 743 |
LLPS-Cis-0286 | Ciona savignyi | 64.24 | 0.0 | 602 |
LLPS-Gaa-1900 | Gasterosteus aculeatus | 61.46 | 0.0 | 675 |
LLPS-Drm-0041 | Drosophila melanogaster | 60.79 | 0.0 | 662 |
LLPS-Gas-0014 | Galdieria sulphuraria | 60.34 | 4e-13 | 76.6 |
LLPS-Cii-0007 | Ciona intestinalis | 60.0 | 0.0 | 581 |
LLPS-Abg-1221 | Absidia glauca | 59.9 | 1e-68 | 240 |
LLPS-Cae-0577 | Caenorhabditis elegans | 59.89 | 0.0 | 645 |
LLPS-Chc-0687 | Chondrus crispus | 58.62 | 5e-13 | 76.3 |
LLPS-Miv-0739 | Microbotryum violaceum | 57.69 | 2e-12 | 74.3 |
LLPS-Kop-0227 | Komagataella pastoris | 57.63 | 3e-14 | 80.1 |
LLPS-Asni-0175 | Aspergillus niger | 55.38 | 2e-16 | 87.0 |
LLPS-Crn-0655 | Cryptococcus neoformans | 55.22 | 6e-15 | 82.8 |
LLPS-Asg-0037 | Ashbya gossypii | 54.69 | 1e-15 | 85.1 |
LLPS-Sac-0024 | Saccharomyces cerevisiae | 54.69 | 4e-16 | 86.3 |
LLPS-Cog-0169 | Colletotrichum gloeosporioides | 54.55 | 3e-15 | 83.6 |
LLPS-Ast-0483 | Aspergillus terreus | 53.85 | 6e-16 | 85.9 |
LLPS-Nef-0103 | Neosartorya fischeri | 53.85 | 7e-16 | 85.5 |
LLPS-Phn-0072 | Phaeosphaeria nodorum | 53.85 | 3e-15 | 83.6 |
LLPS-Lem-1229 | Leptosphaeria maculans | 53.85 | 2e-15 | 84.3 |
LLPS-Zem-1771 | Zea mays | 53.7 | 2e-12 | 68.2 |
LLPS-Fus-0334 | Fusarium solani | 53.57 | 2e-12 | 74.7 |
LLPS-Fuo-0214 | Fusarium oxysporum | 53.57 | 2e-12 | 74.7 |
LLPS-Fuv-0179 | Fusarium verticillioides | 53.57 | 2e-12 | 74.7 |
LLPS-Dac-1194 | Daucus carota | 53.45 | 6e-10 | 66.6 |
LLPS-Mel-0956 | Melampsora laricipopulina | 52.73 | 2e-12 | 74.7 |
LLPS-Scp-0401 | Schizosaccharomyces pombe | 52.73 | 1e-10 | 68.6 |
LLPS-Scj-1143 | Schizosaccharomyces japonicus | 52.73 | 2e-11 | 71.2 |
LLPS-Pytr-0692 | Pyrenophora triticirepentis | 52.31 | 9e-15 | 82.0 |
LLPS-Asfu-0136 | Aspergillus fumigatus | 52.31 | 2e-15 | 84.0 |
LLPS-Asc-0022 | Aspergillus clavatus | 52.31 | 2e-15 | 84.3 |
LLPS-Asn-0001 | Aspergillus nidulans | 52.31 | 8e-16 | 85.5 |
LLPS-Aso-0623 | Aspergillus oryzae | 52.31 | 1e-15 | 84.7 |
LLPS-Pyt-0166 | Pyrenophora teres | 52.31 | 9e-15 | 82.0 |
LLPS-Asf-0388 | Aspergillus flavus | 52.31 | 1e-15 | 84.7 |
LLPS-Ved-0262 | Verticillium dahliae | 51.61 | 1e-13 | 78.6 |
LLPS-Nec-0941 | Neurospora crassa | 51.61 | 6e-14 | 79.3 |
LLPS-Blg-0112 | Blumeria graminis | 51.56 | 2e-13 | 78.2 |
LLPS-Cogr-0227 | Colletotrichum graminicola | 51.52 | 1e-14 | 81.6 |
LLPS-Coo-0704 | Colletotrichum orbiculare | 51.52 | 3e-14 | 80.5 |
LLPS-Tum-0273 | Tuber melanosporum | 51.22 | 4e-138 | 432 |
LLPS-Scc-0569 | Schizosaccharomyces cryophilus | 50.91 | 1e-10 | 68.9 |
LLPS-Mao-0644 | Magnaporthe oryzae | 50.77 | 6e-15 | 82.4 |
LLPS-Trr-0678 | Trichoderma reesei | 50.75 | 2e-13 | 77.8 |
LLPS-Trv-0179 | Trichoderma virens | 50.75 | 2e-13 | 77.4 |
LLPS-Dos-0835 | Dothistroma septosporum | 50.75 | 4e-15 | 83.2 |
LLPS-Yal-0350 | Yarrowia lipolytica | 50.55 | 3e-143 | 441 |
LLPS-Pug-0198 | Puccinia graminis | 49.56 | 9e-140 | 437 |
LLPS-Beb-1429 | Beauveria bassiana | 49.25 | 7e-13 | 75.9 |
LLPS-Put-0273 | Puccinia triticina | 49.22 | 4e-132 | 416 |
LLPS-Map-0654 | Magnaporthe poae | 48.71 | 1e-132 | 418 |
LLPS-Zyt-0133 | Zymoseptoria tritici | 48.48 | 7e-133 | 417 |
LLPS-Nia-0032 | Nicotiana attenuata | 48.45 | 3e-155 | 475 |
LLPS-Gag-0312 | Gaeumannomyces graminis | 48.28 | 8e-129 | 408 |
LLPS-Viv-0932 | Vitis vinifera | 48.11 | 3e-152 | 467 |
LLPS-Sol-0382 | Solanum lycopersicum | 48.0 | 4e-156 | 478 |
LLPS-Tra-1007 | Triticum aestivum | 47.66 | 3e-146 | 450 |
LLPS-Sot-0087 | Solanum tuberosum | 47.64 | 3e-154 | 473 |
LLPS-Prp-1027 | Prunus persica | 47.58 | 1e-152 | 466 |
LLPS-Mua-0764 | Musa acuminata | 47.4 | 8e-146 | 450 |
LLPS-Coc-1255 | Corchorus capsularis | 46.98 | 3e-146 | 452 |
LLPS-Tru-0513 | Triticum urartu | 46.94 | 2e-145 | 448 |
LLPS-Brd-1783 | Brachypodium distachyon | 46.94 | 6e-151 | 464 |
LLPS-Hov-1353 | Hordeum vulgare | 46.94 | 1e-146 | 455 |
LLPS-Met-0016 | Medicago truncatula | 46.78 | 1e-153 | 472 |
LLPS-Art-1206 | Arabidopsis thaliana | 46.76 | 6e-146 | 452 |
LLPS-Gor-0232 | Gossypium raimondii | 46.76 | 7e-149 | 459 |
LLPS-Brr-2053 | Brassica rapa | 46.76 | 7e-147 | 454 |
LLPS-Brn-2913 | Brassica napus | 46.76 | 9e-148 | 454 |
LLPS-Bro-0855 | Brassica oleracea | 46.58 | 4e-148 | 457 |
LLPS-Cus-0295 | Cucumis sativus | 46.58 | 3e-149 | 460 |
LLPS-Sem-1223 | Selaginella moellendorffii | 46.53 | 1e-149 | 451 |
LLPS-Pot-0105 | Populus trichocarpa | 46.44 | 4e-148 | 456 |
LLPS-Hea-0802 | Helianthus annuus | 46.44 | 9e-148 | 455 |
LLPS-Php-1960 | Physcomitrella patens | 46.43 | 2e-146 | 451 |
LLPS-Orbr-0790 | Oryza brachyantha | 46.4 | 2e-147 | 456 |
LLPS-Sob-0391 | Sorghum bicolor | 46.4 | 2e-147 | 457 |
LLPS-Thc-1572 | Theobroma cacao | 46.4 | 1e-149 | 461 |
LLPS-Sei-0917 | Setaria italica | 46.4 | 5e-149 | 460 |
LLPS-Amt-0088 | Amborella trichopoda | 46.27 | 2e-141 | 440 |
LLPS-Orm-1714 | Oryza meridionalis | 46.27 | 9e-140 | 438 |
LLPS-Arl-1327 | Arabidopsis lyrata | 46.04 | 5e-145 | 450 |
LLPS-Ors-0740 | Oryza sativa | 45.96 | 2e-144 | 448 |
LLPS-Orr-0809 | Oryza rufipogon | 45.96 | 2e-144 | 448 |
LLPS-Ori-1250 | Oryza indica | 45.96 | 1e-144 | 449 |
LLPS-Orb-0471 | Oryza barthii | 45.96 | 2e-144 | 448 |
LLPS-Orni-1203 | Oryza nivara | 45.96 | 1e-144 | 449 |
LLPS-Orgl-0085 | Oryza glumaepatula | 45.96 | 2e-144 | 448 |
LLPS-Mae-1784 | Manihot esculenta | 45.89 | 9e-150 | 461 |
LLPS-Orp-0149 | Oryza punctata | 45.78 | 3e-145 | 450 |
LLPS-Lep-0068 | Leersia perrieri | 45.6 | 6e-146 | 452 |
LLPS-Glm-0422 | Glycine max | 45.58 | 4e-150 | 462 |
LLPS-Phv-0993 | Phaseolus vulgaris | 45.5 | 4e-146 | 453 |
LLPS-Via-0266 | Vigna angularis | 44.09 | 5e-134 | 420 |
LLPS-Vir-0484 | Vigna radiata | 43.88 | 4e-141 | 435 |
LLPS-Cym-0044 | Cyanidioschyzon merolae | 43.79 | 2e-119 | 377 |
LLPS-Osl-0705 | Ostreococcus lucimarinus | 42.22 | 6e-121 | 374 |
LLPS-Chr-0521 | Chlamydomonas reinhardtii | 40.67 | 7e-132 | 409 |
LLPS-Spr-0617 | Sporisorium reilianum | 38.28 | 1e-88 | 302 |
LLPS-Usm-0494 | Ustilago maydis | 36.8 | 1e-88 | 302 |