• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Paa-0162
GTPBP4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nucleolar GTP-binding protein 1
Gene Name: GTPBP4
Ensembl Gene: ENSPANG00000023543.2
Ensembl Protein: ENSPANP00000041631.1
Organism: Papio anubis
Taxa ID: 9555
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, OthersPredicted from orthologs(View)

▼ FUNCTION

Involved in the biogenesis of the 60S ribosomal subunit.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAHYNFKKIT  VVPSAKDFID  LTLSKTQRKT  PTVIHKHYQI  HRIRHFYMRK  VKFTQQNYHD  60
61    RLSQILTDFP  KLDDIHPFYA  DLMNILYDKD  HYKLALGQIN  IAKNLVDNVA  KDYVRLMKYG  120
121   DSLYRCKQLK  RAALGRMCTV  IKRQKQSLEY  LEQVRQHLSR  LPTIDPNTRT  LILCGYPNVG  180
181   KSSFINKVTR  ADVDVQPYAF  TTKSLFVGHM  DYKYLRWQVV  DTPGILDHPL  EDRNTIEMQA  240
241   ITALAHLRAA  VLYVMDLSEQ  CGHGLREQLE  LFQNIRPLFI  NKPLIVVANK  CDVKRIAELS  300
301   EDDQKIFTDL  QTEGFPIIET  STLTEEGVIK  VKTEACDRLL  AHRVETKMKG  NKVNEVLNRL  360
361   HLAVPTRRDD  KERPPFIPDG  VVARRKRMEI  EEPKKKRERD  LELEMGDDYI  LDLQKYWDLM  420
421   NSSEKHDKIP  EIWEGHNIAD  YIDPAIMKKL  EELEKEEELR  TAAGEYDSES  ESEDEEMLEI  480
481   RQLANQIREK  KKLKILESKE  KNTQGPRMPR  TAKKVQRTVL  EKEMRSLGVD  MDDKDDAHYA  540
541   VQARRSRSVT  RKRKREDSAP  PSSVARSRSC  SRTPRDVSGL  RDVKMVKKAK  TMMKNAQKKM  600
601   NRLGKKGEAD  RHVFDMKPKH  LLSGKRKAGK  KDRR  634
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCACT  ACAACTTCAA  GAAAATTACG  GTGGTGCCGT  CCGCCAAGGA  CTTTATTGAC  60
61    CTGACATTGT  CGAAGACTCA  ACGAAAGACT  CCAACTGTTA  TTCATAAACA  TTACCAAATT  120
121   CATCGCATTA  GACATTTTTA  CATGAGAAAA  GTCAAATTTA  CTCAACAGAA  TTACCATGAT  180
181   AGACTTTCAC  AAATTCTAAC  AGATTTCCCT  AAATTGGATG  ATATTCATCC  GTTCTATGCT  240
241   GATTTGATGA  ATATTCTCTA  CGACAAGGAT  CATTACAAGT  TGGCTCTGGG  GCAAATAAAT  300
301   ATTGCCAAAA  ATTTAGTGGA  CAATGTTGCT  AAAGATTACG  TGCGACTGAT  GAAGTACGGC  360
361   GACTCTCTCT  ACCGCTGCAA  ACAGCTGAAG  CGCGCGGCCC  TGGGACGGAT  GTGCACGGTG  420
421   ATCAAGAGGC  AGAAGCAGAG  TTTGGAGTAT  TTGGAGCAAG  TGCGTCAGCA  TTTATCCCGT  480
481   TTGCCAACCA  TTGATCCAAA  TACCAGGACT  CTGATTTTGT  GTGGGTACCC  AAACGTTGGG  540
541   AAGTCCAGTT  TCATCAATAA  GGTGACGAGA  GCAGACGTGG  ATGTCCAGCC  CTACGCGTTC  600
601   ACTACCAAAT  CTCTGTTTGT  TGGGCACATG  GATTATAAGT  ATCTACGTTG  GCAGGTTGTA  660
661   GACACTCCTG  GGATCCTGGA  CCACCCTCTG  GAGGATAGGA  ACACCATCGA  GATGCAGGCC  720
721   ATCACTGCCC  TGGCCCACCT  CCGTGCTGCG  GTCCTGTACG  TGATGGATTT  GTCTGAGCAG  780
781   TGTGGGCATG  GGCTGAGGGA  GCAGCTAGAG  CTCTTCCAGA  ACATCAGACC  TCTCTTCATC  840
841   AACAAGCCTC  TCATAGTTGT  AGCCAACAAA  TGTGATGTGA  AGAGAATAGC  TGAACTTTCT  900
901   GAAGATGATC  AGAAAATATT  TACAGATTTG  CAGACTGAAG  GATTCCCTAT  AATAGAGACC  960
961   AGCACCCTGA  CTGAGGAAGG  TGTTATTAAA  GTTAAAACAG  AGGCTTGCGA  CAGGCTTTTG  1020
1021  GCTCATCGAG  TGGAAACCAA  AATGAAGGGA  AATAAAGTGA  ATGAGGTGCT  GAATAGACTG  1080
1081  CACCTGGCTG  TCCCAACCAG  GAGGGACGAT  AAGGAGAGGC  CTCCTTTCAT  CCCTGATGGA  1140
1141  GTGGTGGCTC  GCAGGAAGAG  GATGGAAATT  GAGGAGCCCA  AGAAGAAGAG  GGAACGAGAT  1200
1201  CTTGAGCTGG  AAATGGGAGA  TGATTATATT  TTGGATCTTC  AGAAGTACTG  GGATTTAATG  1260
1261  AATTCGTCTG  AAAAGCATGA  TAAGATACCA  GAAATCTGGG  AAGGCCATAA  TATAGCTGAT  1320
1321  TATATTGATC  CAGCCATCAT  GAAGAAATTG  GAAGAATTAG  AAAAAGAAGA  AGAGCTGAGA  1380
1381  ACAGCTGCTG  GAGAGTATGA  CAGTGAATCT  GAGAGTGAAG  ATGAGGAGAT  GCTGGAAATC  1440
1441  CGACAGCTGG  CAAATCAGAT  TAGAGAGAAA  AAGAAGTTGA  AAATTCTGGA  GTCCAAAGAA  1500
1501  AAGAATACCC  AGGGACCCAG  GATGCCGCGA  ACAGCTAAGA  AGGTTCAGAG  GACAGTTTTG  1560
1561  GAGAAGGAGA  TGCGCAGTCT  TGGTGTTGAC  ATGGACGATA  AAGACGACGC  CCACTACGCA  1620
1621  GTCCAGGCAA  GAAGATCCCG  GAGCGTCACT  AGGAAAAGAA  AGCGGGAAGA  CTCCGCTCCC  1680
1681  CCGTCCTCTG  TGGCCCGGAG  TCGGAGCTGC  TCTCGAACTC  CACGTGACGT  TTCTGGTCTT  1740
1741  AGGGATGTCA  AGATGGTGAA  GAAAGCCAAG  ACTATGATGA  AGAATGCCCA  GAAGAAGATG  1800
1801  AATCGGTTGG  GGAAGAAAGG  GGAGGCAGAC  AGACACGTGT  TCGATATGAA  GCCTAAGCAC  1860
1861  TTGCTCTCTG  GGAAGAGGAA  AGCTGGCAAA  AAGGACAGGA  GATAG  1905

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Nucleus
Reference proteome
Ribosome biogenesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Nuclear membrane
Cellular Component
Nucleolus
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process
Negative regulation of cell migration
Biological Process
Negative regulation of cell population proliferation
Biological Process
Negative regulation of cell-cell adhesion
Biological Process
Negative regulation of collagen binding
Biological Process
Negative regulation of DNA replication
Biological Process
Negative regulation of protein ubiquitination
Biological Process
Protein stabilization
Biological Process
Regulation of cyclin-dependent protein serine/threonine kinase activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-0595Dipodomys ordii100.03e-63 224
LLPS-Chs-0144Chlorocebus sabaeus99.680.01134
LLPS-Cea-0155Cercocebus atys99.530.01135
LLPS-Man-0467Macaca nemestrina99.370.01132
LLPS-Maf-0592Macaca fascicularis99.210.01129
LLPS-Mal-0256Mandrillus leucophaeus99.210.01128
LLPS-Rhb-0699Rhinopithecus bieti98.90.01130
LLPS-Poa-1930Pongo abelii98.580.01130
LLPS-Nol-1757Nomascus leucogenys98.260.01123
LLPS-Pat-0268Pan troglodytes98.210.0 916
LLPS-Pap-0888Pan paniscus98.110.01123
LLPS-Gog-0559Gorilla gorilla98.110.01124
LLPS-Hos-0965Homo sapiens97.950.01122
LLPS-Caj-1798Callithrix jacchus97.010.01106
LLPS-Otg-1957Otolemur garnettii96.370.01092
LLPS-Mam-1614Macaca mulatta96.210.01070
LLPS-Cas-1557Carlito syrichta95.580.01090
LLPS-Ict-0290Ictidomys tridecemlineatus95.580.01092
LLPS-Fud-0439Fukomys damarensis95.430.01096
LLPS-Mea-0721Mesocricetus auratus95.270.01082
LLPS-Mum-1228Mus musculus95.270.01084
LLPS-Fec-2338Felis catus95.110.01096
LLPS-Cap-1172Cavia porcellus95.110.01096
LLPS-Loa-1701Loxodonta africana94.480.01085
LLPS-Caf-1786Canis familiaris94.210.0 989
LLPS-Ran-0154Rattus norvegicus94.030.01077
LLPS-Bot-0216Bos taurus93.850.01086
LLPS-Myl-1655Myotis lucifugus93.690.01085
LLPS-Ova-0398Ovis aries93.410.01080
LLPS-Aim-1680Ailuropoda melanoleuca93.380.01069
LLPS-Urm-0280Ursus maritimus93.020.0 977
LLPS-Mup-0028Mustela putorius furo93.020.0 976
LLPS-Sus-1620Sus scrofa91.960.01058
LLPS-Mod-1453Monodelphis domestica90.380.01042
LLPS-Sah-0979Sarcophilus harrisii89.970.01022
LLPS-Tut-0070Tursiops truncatus88.280.01055
LLPS-Orc-2468Oryctolagus cuniculus86.810.0 662
LLPS-Eqc-0609Equus caballus86.640.0 999
LLPS-Meg-0035Meleagris gallopavo85.872e-113 345
LLPS-Anc-0629Anolis carolinensis84.860.0 988
LLPS-Gaga-2597Gallus gallus84.70.0 989
LLPS-Tag-0790Taeniopygia guttata84.390.0 971
LLPS-Fia-0080Ficedula albicollis83.990.0 985
LLPS-Orn-0640Oreochromis niloticus83.440.0 967
LLPS-Lac-0438Latimeria chalumnae83.440.0 980
LLPS-Ora-0708Ornithorhynchus anatinus83.331e-51 182
LLPS-Icp-1722Ictalurus punctatus83.280.0 979
LLPS-Scf-0696Scleropages formosus83.280.0 984
LLPS-Pof-0469Poecilia formosa82.810.0 954
LLPS-Ten-1165Tetraodon nigroviridis82.810.0 971
LLPS-Asm-0451Astyanax mexicanus82.810.0 965
LLPS-Scm-0941Scophthalmus maximus82.180.0 962
LLPS-Orl-0556Oryzias latipes82.180.0 973
LLPS-Aon-0057Aotus nancymaae82.160.0 893
LLPS-Xim-1915Xiphophorus maculatus81.950.0 949
LLPS-Dar-1521Danio rerio81.860.0 962
LLPS-Tar-0044Takifugu rubripes81.390.0 962
LLPS-Leo-1169Lepisosteus oculatus81.080.0 966
LLPS-Gaa-1499Gasterosteus aculeatus79.780.0 954
LLPS-Anp-1378Anas platyrhynchos77.341e-127 387
LLPS-Xet-0490Xenopus tropicalis72.870.0 805
LLPS-Ori-0067Oryza indica68.388e-60 209
LLPS-Php-2184Physcomitrella patens62.230.0 608
LLPS-Cii-0218Ciona intestinalis61.960.0 752
LLPS-Viv-0608Vitis vinifera61.940.0 606
LLPS-Sot-0771Solanum tuberosum61.880.0 610
LLPS-Mae-0200Manihot esculenta61.80.0 597
LLPS-Glm-2557Glycine max61.640.0 608
LLPS-Hea-1833Helianthus annuus61.560.0 589
LLPS-Sol-0902Solanum lycopersicum61.460.0 607
LLPS-Phv-0263Phaseolus vulgaris61.420.0 586
LLPS-Prp-0994Prunus persica61.420.0 610
LLPS-Vir-0923Vigna radiata61.420.0 599
LLPS-Via-0264Vigna angularis61.420.0 600
LLPS-Gor-0621Gossypium raimondii61.340.0 587
LLPS-Thc-0391Theobroma cacao61.340.0 607
LLPS-Chr-0440Chlamydomonas reinhardtii61.290.0 590
LLPS-Nia-0433Nicotiana attenuata61.240.0 602
LLPS-Amt-1995Amborella trichopoda61.210.0 607
LLPS-Coc-1073Corchorus capsularis61.120.0 606
LLPS-Cis-0258Ciona savignyi61.080.0 743
LLPS-Brd-1168Brachypodium distachyon60.950.0 585
LLPS-Pug-0064Puccinia graminis60.890.0 584
LLPS-Sei-0267Setaria italica60.740.0 577
LLPS-Met-1522Medicago truncatula60.690.0 593
LLPS-Cus-0441Cucumis sativus60.560.0 597
LLPS-Spr-0113Sporisorium reilianum60.540.0 573
LLPS-Orm-0510Oryza meridionalis60.520.0 591
LLPS-Brr-1161Brassica rapa60.50.0 591
LLPS-Mel-0773Melampsora laricipopulina60.430.0 578
LLPS-Sem-1694Selaginella moellendorffii60.430.0 592
LLPS-Pot-0107Populus trichocarpa60.340.0 593
LLPS-Usm-0191Ustilago maydis60.310.0 573
LLPS-Orbr-1065Oryza brachyantha60.30.0 585
LLPS-Tru-0715Triticum urartu60.30.0 578
LLPS-Hov-1093Hordeum vulgare60.30.0 578
LLPS-Bro-0792Brassica oleracea60.290.0 588
LLPS-Sob-0237Sorghum bicolor60.170.0 578
LLPS-Osl-1086Ostreococcus lucimarinus60.130.0 597
LLPS-Tra-1134Triticum aestivum60.090.0 577
LLPS-Put-0387Puccinia triticina60.00.0 583
LLPS-Zem-0503Zea mays59.960.0 588
LLPS-Orp-1291Oryza punctata59.870.0 583
LLPS-Org-1012Oryza glaberrima59.870.0 587
LLPS-Orni-0191Oryza nivara59.870.0 585
LLPS-Lep-0447Leersia perrieri59.870.0 582
LLPS-Dac-0198Daucus carota59.70.0 583
LLPS-Orr-0730Oryza rufipogon59.660.0 583
LLPS-Orb-0199Oryza barthii59.660.0 583
LLPS-Orgl-0557Oryza glumaepatula59.660.0 583
LLPS-Mua-1396Musa acuminata59.520.0 560
LLPS-Brn-0493Brassica napus59.450.0 572
LLPS-Arl-0606Arabidopsis lyrata59.430.0 580
LLPS-Scj-0393Schizosaccharomyces japonicus59.020.0 573
LLPS-Art-0317Arabidopsis thaliana58.820.0 582
LLPS-Chc-0112Chondrus crispus58.80.0 554
LLPS-Miv-0060Microbotryum violaceum58.650.0 556
LLPS-Crn-0106Cryptococcus neoformans58.610.0 601
LLPS-Drm-1124Drosophila melanogaster57.520.0 692
LLPS-Nef-0279Neosartorya fischeri54.73e-172 513
LLPS-Trr-0310Trichoderma reesei54.293e-170 508
LLPS-Trv-0423Trichoderma virens54.196e-170 507
LLPS-Gas-0245Galdieria sulphuraria54.190.0 541
LLPS-Fus-0718Fusarium solani53.961e-170 509
LLPS-Beb-0332Beauveria bassiana53.964e-168 503
LLPS-Fuo-0648Fusarium oxysporum53.961e-169 506
LLPS-Fuv-0732Fusarium verticillioides53.962e-169 506
LLPS-Cym-0236Cyanidioschyzon merolae52.982e-168 503
LLPS-Cogr-0328Colletotrichum graminicola52.862e-166 498
LLPS-Map-0919Magnaporthe poae52.643e-167 497
LLPS-Abg-1595Absidia glauca52.570.0 618
LLPS-Dos-0242Dothistroma septosporum52.534e-164 492
LLPS-Cae-0850Caenorhabditis elegans52.050.0 651
LLPS-Ved-0315Verticillium dahliae51.917e-133 409
LLPS-Zyt-0628Zymoseptoria tritici51.881e-162 488
LLPS-Scp-0290Schizosaccharomyces pombe51.630.0 588
LLPS-Cog-0165Colletotrichum gloeosporioides51.241e-155 469
LLPS-Scc-0297Schizosaccharomyces cryophilus50.230.0 582
LLPS-Aso-0089Aspergillus oryzae49.240.0 549
LLPS-Asn-0485Aspergillus nidulans49.160.0 542
LLPS-Scs-0005Sclerotinia sclerotiorum48.930.0 544
LLPS-Asf-0701Aspergillus flavus48.766e-178 533
LLPS-Asc-0125Aspergillus clavatus48.630.0 539
LLPS-Asni-0039Aspergillus niger48.620.0 543
LLPS-Ast-0810Aspergillus terreus48.480.0 544
LLPS-Blg-0106Blumeria graminis48.469e-178 527
LLPS-Tum-0344Tuber melanosporum48.170.0 546
LLPS-Asfu-0020Aspergillus fumigatus47.781e-170 509
LLPS-Gag-1008Gaeumannomyces graminis46.961e-177 527
LLPS-Asg-0202Ashbya gossypii46.261e-172 514
LLPS-Yal-0464Yarrowia lipolytica46.134e-175 520
LLPS-Sac-0650Saccharomyces cerevisiae46.051e-169 506
LLPS-Kop-0289Komagataella pastoris46.01e-168 503
LLPS-Ors-0316Oryza sativa45.991e-25 113
LLPS-Mao-0422Magnaporthe oryzae45.991e-172 514
LLPS-Phn-0275Phaeosphaeria nodorum45.962e-164 492
LLPS-Pytr-0163Pyrenophora triticirepentis45.797e-168 502
LLPS-Pyt-0281Pyrenophora teres45.794e-168 503
LLPS-Nec-0295Neurospora crassa45.731e-169 507
LLPS-Coo-0190Colletotrichum orbiculare45.431e-172 514
LLPS-Lem-0545Leptosphaeria maculans45.211e-164 494