• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cea-0155
GTPBP4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nucleolar GTP-binding protein 1
Gene Name: GTPBP4
Ensembl Gene: ENSCATG00000004303.1
Ensembl Protein: ENSCATP00000000909.1
Organism: Cercocebus atys
Taxa ID: 9531
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, OthersPredicted from orthologs(View)

▼ FUNCTION

Involved in the biogenesis of the 60S ribosomal subunit.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAHYNFKKIT  VVPSAKDFID  LTLSKTQRKT  PTVIHKHYQI  HRIRHFYMRK  VKFTQQNYHD  60
61    RLSQILTDFP  KLDDIHPFYA  DLMNILYDKD  HYKLALGQIN  IAKNLVDNVA  KDYVRLMKYG  120
121   DSLYRCKQLK  RAALGRMCTV  IKRQKQSLEY  LEQVRQHLSR  LPTIDPNTRT  LLLCGYPNVG  180
181   KSSFINKVTR  ADVDVQPYAF  TTKSLFVGHM  DYKYLRWQVV  DTPGILDHPL  EDRNTIEMQA  240
241   ITALAHLRAA  VLYVMDLSEQ  CGHGLREQLE  LFQNIRPLFI  NKPLIVVANK  CDVKRIAELS  300
301   EDDQKIFTDL  QTEGFPVIET  STLTEEGVIK  VKTEACDRLL  AHRVETKMKG  NKVNEVLNRL  360
361   HLAVPTRRDD  KERPPFIPDG  VVARRKRMEI  EEPKKKRERD  LELEMGDDYI  LDLQKYWDLM  420
421   NSSEKHDKIP  EIWEGHNIAD  YIDPAIMKKL  EELEKEEELR  TAAGEYDSES  ESEDEEMLEI  480
481   RQLANQIRET  KKLKILESKE  KNTQGPRMPR  TAKKVQRTVL  EKEMRSLGVD  MDDKDDAHYA  540
541   VQARRSRSVT  RKRKREDSAP  PSSVARSRSC  SRTPRDVSGL  RDVKMVKKAK  TMMKNAQKKM  600
601   NRLGKKGEAD  RHVFDMKPKH  LLSGKRKAGK  KDRR  634
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCACT  ACAACTTCAA  GAAAATTACG  GTGGTGCCGT  CCGCCAAGGA  CTTTATTGAC  60
61    CTGACATTGT  CGAAGACTCA  ACGAAAGACT  CCAACTGTTA  TTCATAAACA  TTACCAAATT  120
121   CATCGCATTA  GACATTTTTA  CATGAGAAAA  GTCAAATTTA  CTCAACAGAA  TTACCATGAT  180
181   AGACTTTCAC  AAATTCTAAC  AGATTTCCCT  AAATTGGATG  ATATTCATCC  GTTCTATGCT  240
241   GATTTGATGA  ATATTCTCTA  CGACAAGGAT  CATTACAAGT  TGGCTCTGGG  GCAAATAAAT  300
301   ATTGCCAAAA  ATTTAGTGGA  CAATGTTGCT  AAAGATTACG  TGCGACTGAT  GAAGTACGGC  360
361   GACTCTCTCT  ACCGCTGCAA  ACAGCTGAAG  CGCGCGGCCC  TGGGACGGAT  GTGCACGGTG  420
421   ATCAAGAGGC  AGAAGCAGAG  TTTGGAGTAT  TTGGAGCAAG  TGCGTCAGCA  TTTATCCCGT  480
481   TTGCCAACCA  TTGATCCAAA  TACCAGGACT  CTGCTTTTGT  GTGGGTACCC  AAATGTTGGG  540
541   AAGTCCAGTT  TCATCAATAA  GGTGACGAGA  GCAGACGTGG  ATGTCCAGCC  CTACGCGTTC  600
601   ACTACCAAAT  CTCTGTTTGT  TGGGCACATG  GATTATAAGT  ATCTACGTTG  GCAGGTTGTA  660
661   GACACTCCTG  GGATCCTGGA  CCACCCTCTG  GAGGATAGGA  ACACCATCGA  GATGCAGGCC  720
721   ATCACTGCCC  TGGCCCACCT  CCGTGCTGCG  GTCCTGTACG  TGATGGATTT  GTCTGAGCAG  780
781   TGTGGGCATG  GGCTGAGGGA  GCAGCTAGAG  CTCTTCCAGA  ACATCAGACC  TCTCTTCATC  840
841   AACAAGCCTC  TCATAGTTGT  AGCCAACAAA  TGTGATGTGA  AGAGAATAGC  GGAACTTTCT  900
901   GAAGATGATC  AGGCTTGCGA  TAGGCTTTTG  GCTCATCGAG  TGGAAACCAA  AATGAAGGGA  960
961   AATAAAGTGA  ATGAGGTGCT  GAATAGACTG  CACCTGGCTG  TCCCAACCAG  GAGGGACGAT  1020
1021  AAGGAGAGGC  CTCCTTTCAT  CCCTGACGGA  GTGGTGGCTC  GCAGGAAGAG  GATGGAAATT  1080
1081  GAGGAGCCCA  AGAAGAAGAG  GGAACGAGAT  CTTGAGCTGG  AAATGGGAGA  TGATTATATT  1140
1141  TTGGATCTTC  AGAAGTACTG  GGATTTAATG  AATTCGTCTG  AAAAGCATGA  TAAGATACCA  1200
1201  GAAATCTGGG  AAGGCCATAA  TATAGCTGAT  TATATTGATC  CAGCCATCAT  GAAGAAATTG  1260
1261  GAAGAATTAG  AAAAAGAAGA  AGAGCTGAGA  ACAGCTGCTG  GAGAGTATGA  CAGTGAATCT  1320
1321  GAGAGTGAAG  ATGAGGAGAT  GCTGGAAATC  CGACAGCTGG  CAAATCAGAT  TAGAGAGACA  1380
1381  AAGAAGTTGA  AAATTCTGGA  GTCCAAAGAA  AAGAATACAC  AGGGACCCAG  GATGCCACGA  1440
1441  ACTGCTAAGA  AGGTTCAGAG  GACAGTTTTG  GAGAAGGAGA  TGCGCAGTCT  TGGTGTTGAC  1500
1501  ATGGACGATA  AAGACGACGC  CCACTACGCA  GTCCAGGCAA  GAAGATCCCG  GAGCGTCACT  1560
1561  AGGAAAAGAA  AGCGGGAAGA  CTCCGCTCCC  CCGTCCTCTG  TGGCCCGGAG  TCGGAGCTGC  1620
1621  TCTCGAACTC  CACGTGACGT  TTCTGGTCTT  AGGGATGTCA  AGATGGTGAA  GAAAGCCAAG  1680
1681  ACTATGATGA  AGAACGCCCA  GAAGAAGATG  AACCGGTTGG  GGAAGAAAGG  GGAGGCAGAC  1740
1741  AGACACGTGT  TCGACATGAA  GCCTAAGCAC  TTGCTCTCTG  GGAAGAGGAA  AGCTGGCAAA  1800
1801  AAGGACAGGA  GATAG  1815

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Nucleus
Reference proteome
Ribosome biogenesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Nuclear membrane
Cellular Component
Nucleolus
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process
Negative regulation of cell migration
Biological Process
Negative regulation of cell population proliferation
Biological Process
Negative regulation of cell-cell adhesion
Biological Process
Negative regulation of collagen binding
Biological Process
Negative regulation of DNA replication
Biological Process
Negative regulation of protein ubiquitination
Biological Process
Protein stabilization
Biological Process
Regulation of cyclin-dependent protein serine/threonine kinase activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-0595Dipodomys ordii100.01e-63 225
LLPS-Chs-0144Chlorocebus sabaeus99.840.01161
LLPS-Man-0467Macaca nemestrina99.530.01160
LLPS-Paa-0162Papio anubis99.530.01160
LLPS-Maf-0592Macaca fascicularis99.370.01156
LLPS-Mal-0256Mandrillus leucophaeus99.370.01156
LLPS-Rhb-0699Rhinopithecus bieti99.050.01156
LLPS-Poa-1930Pongo abelii98.740.01157
LLPS-Pat-0268Pan troglodytes98.660.0 919
LLPS-Nol-1757Nomascus leucogenys98.420.01151
LLPS-Pap-0888Pan paniscus98.260.01150
LLPS-Gog-0559Gorilla gorilla98.260.01151
LLPS-Hos-0965Homo sapiens98.110.01149
LLPS-Caj-1798Callithrix jacchus97.170.01132
LLPS-Otg-1957Otolemur garnettii96.530.01119
LLPS-Mam-1614Macaca mulatta96.370.01098
LLPS-Cas-1557Carlito syrichta95.740.01118
LLPS-Ict-0290Ictidomys tridecemlineatus95.740.01117
LLPS-Fud-0439Fukomys damarensis95.580.01121
LLPS-Mum-1228Mus musculus95.430.01110
LLPS-Mea-0721Mesocricetus auratus95.430.01108
LLPS-Fec-2338Felis catus95.270.01122
LLPS-Cap-1172Cavia porcellus95.270.01121
LLPS-Loa-1701Loxodonta africana94.640.01111
LLPS-Caf-1786Canis familiaris94.380.01014
LLPS-Ran-0154Rattus norvegicus94.180.01103
LLPS-Bot-0216Bos taurus94.010.01111
LLPS-Myl-1655Myotis lucifugus93.850.01109
LLPS-Ova-0398Ovis aries93.560.01105
LLPS-Aim-1680Ailuropoda melanoleuca93.220.01093
LLPS-Urm-0280Ursus maritimus93.190.01002
LLPS-Mup-0028Mustela putorius furo93.190.01001
LLPS-Sus-1620Sus scrofa92.110.01083
LLPS-Mod-1453Monodelphis domestica90.540.01068
LLPS-Sah-0979Sarcophilus harrisii90.130.01049
LLPS-Tut-0070Tursiops truncatus88.440.01080
LLPS-Orc-2468Oryctolagus cuniculus87.340.0 665
LLPS-Meg-0035Meleagris gallopavo86.963e-114 346
LLPS-Eqc-0609Equus caballus86.490.01023
LLPS-Anc-0629Anolis carolinensis85.020.01015
LLPS-Gaga-2597Gallus gallus84.860.01014
LLPS-Tag-0790Taeniopygia guttata84.550.0 996
LLPS-Fia-0080Ficedula albicollis84.150.01010
LLPS-Orn-0640Oreochromis niloticus83.60.0 992
LLPS-Lac-0438Latimeria chalumnae83.60.01003
LLPS-Icp-1722Ictalurus punctatus83.440.01006
LLPS-Scf-0696Scleropages formosus83.440.01007
LLPS-Pof-0469Poecilia formosa82.970.0 977
LLPS-Ten-1165Tetraodon nigroviridis82.970.0 993
LLPS-Asm-0451Astyanax mexicanus82.970.0 991
LLPS-Ora-0708Ornithorhynchus anatinus82.845e-60 205
LLPS-Scm-0941Scophthalmus maximus82.330.0 982
LLPS-Orl-0556Oryzias latipes82.330.0 994
LLPS-Xim-1915Xiphophorus maculatus82.10.0 972
LLPS-Dar-1521Danio rerio82.020.0 983
LLPS-Aon-0057Aotus nancymaae82.00.0 919
LLPS-Tar-0044Takifugu rubripes81.550.0 981
LLPS-Leo-1169Lepisosteus oculatus81.230.0 976
LLPS-Gaa-1499Gasterosteus aculeatus79.940.0 969
LLPS-Anp-1378Anas platyrhynchos77.341e-136 410
LLPS-Xet-0490Xenopus tropicalis73.030.0 831
LLPS-Ori-0067Oryza indica68.386e-60 210
LLPS-Cii-0218Ciona intestinalis62.440.0 761
LLPS-Sot-0771Solanum tuberosum62.10.0 611
LLPS-Hea-1833Helianthus annuus61.770.0 591
LLPS-Sol-0902Solanum lycopersicum61.670.0 608
LLPS-Nia-0433Nicotiana attenuata61.460.0 603
LLPS-Amt-1995Amborella trichopoda61.420.0 609
LLPS-Chr-0440Chlamydomonas reinhardtii61.290.0 592
LLPS-Pug-0064Puccinia graminis61.110.0 585
LLPS-Cis-0258Ciona savignyi60.920.0 755
LLPS-Cus-0441Cucumis sativus60.780.0 599
LLPS-Spr-0113Sporisorium reilianum60.760.0 575
LLPS-Mel-0773Melampsora laricipopulina60.650.0 579
LLPS-Usm-0191Ustilago maydis60.540.0 575
LLPS-Put-0387Puccinia triticina60.220.0 583
LLPS-Osl-1086Ostreococcus lucimarinus60.130.0 599
LLPS-Arl-0606Arabidopsis lyrata59.650.0 582
LLPS-Chc-0112Chondrus crispus59.010.0 556
LLPS-Crn-0106Cryptococcus neoformans58.80.0 608
LLPS-Drm-1124Drosophila melanogaster57.430.0 696
LLPS-Viv-0608Vitis vinifera57.220.0 610
LLPS-Prp-2241Prunus persica57.20.0 567
LLPS-Gor-0621Gossypium raimondii56.780.0 593
LLPS-Thc-0391Theobroma cacao56.780.0 610
LLPS-Mae-0200Manihot esculenta56.650.0 602
LLPS-Phv-0263Phaseolus vulgaris56.60.0 593
LLPS-Vir-0923Vigna radiata56.60.0 608
LLPS-Via-0264Vigna angularis56.60.0 607
LLPS-Met-1522Medicago truncatula55.620.0 596
LLPS-Pot-0107Populus trichocarpa55.330.0 601
LLPS-Orgl-0557Oryza glumaepatula55.120.0 586
LLPS-Miv-0060Microbotryum violaceum54.910.0 560
LLPS-Cym-0236Cyanidioschyzon merolae53.196e-169 504
LLPS-Php-2184Physcomitrella patens53.040.0 634
LLPS-Abg-1595Absidia glauca52.890.0 630
LLPS-Nef-0279Neosartorya fischeri52.158e-173 514
LLPS-Sem-2017Selaginella moellendorffii52.010.0 627
LLPS-Orbr-1065Oryza brachyantha51.990.0 608
LLPS-Glm-1513Glycine max51.930.0 631
LLPS-Ved-0315Verticillium dahliae51.918e-133 409
LLPS-Cae-0850Caenorhabditis elegans51.90.0 659
LLPS-Scp-0290Schizosaccharomyces pombe51.790.0 605
LLPS-Mua-1396Musa acuminata51.680.0 581
LLPS-Coc-1073Corchorus capsularis51.610.0 628
LLPS-Lep-0447Leersia perrieri51.260.0 606
LLPS-Sei-0267Setaria italica51.20.0 598
LLPS-Dac-0198Daucus carota51.10.0 605
LLPS-Orp-1291Oryza punctata50.660.0 602
LLPS-Orm-0510Oryza meridionalis50.660.0 609
LLPS-Sob-0237Sorghum bicolor50.60.0 598
LLPS-Brr-1161Brassica rapa50.370.0 617
LLPS-Orni-0191Oryza nivara50.370.0 605
LLPS-Map-0919Magnaporthe poae50.377e-168 499
LLPS-Brd-1168Brachypodium distachyon50.370.0 610
LLPS-Scj-0393Schizosaccharomyces japonicus50.310.0 606
LLPS-Zem-0503Zea mays50.30.0 604
LLPS-Scc-0297Schizosaccharomyces cryophilus50.230.0 595
LLPS-Bro-0792Brassica oleracea50.220.0 615
LLPS-Org-1012Oryza glaberrima50.220.0 605
LLPS-Orr-0730Oryza rufipogon50.220.0 601
LLPS-Orb-0199Oryza barthii50.220.0 602
LLPS-Gas-0245Galdieria sulphuraria50.090.0 543
LLPS-Brn-0493Brassica napus49.630.0 598
LLPS-Tru-0715Triticum urartu49.40.0 598
LLPS-Hov-1093Hordeum vulgare49.250.0 597
LLPS-Tra-1134Triticum aestivum49.250.0 597
LLPS-Aso-0089Aspergillus oryzae49.240.0 558
LLPS-Asn-0485Aspergillus nidulans49.160.0 551
LLPS-Scs-0005Sclerotinia sclerotiorum48.930.0 555
LLPS-Asf-0701Aspergillus flavus48.760.0 543
LLPS-Asc-0125Aspergillus clavatus48.630.0 548
LLPS-Asni-0039Aspergillus niger48.620.0 551
LLPS-Ast-0810Aspergillus terreus48.480.0 553
LLPS-Blg-0106Blumeria graminis48.460.0 537
LLPS-Tum-0344Tuber melanosporum48.320.0 554
LLPS-Art-0317Arabidopsis thaliana48.290.0 601
LLPS-Asfu-0020Aspergillus fumigatus47.782e-174 519
LLPS-Trv-0423Trichoderma virens47.494e-180 533
LLPS-Trr-0310Trichoderma reesei47.263e-180 534
LLPS-Fus-0718Fusarium solani47.062e-180 534
LLPS-Fuo-0648Fusarium oxysporum46.963e-177 526
LLPS-Gag-1008Gaeumannomyces graminis46.960.0 537
LLPS-Fuv-0732Fusarium verticillioides46.964e-177 526
LLPS-Beb-0332Beauveria bassiana46.41e-174 519
LLPS-Yal-0464Yarrowia lipolytica46.274e-177 525
LLPS-Asg-0202Ashbya gossypii46.112e-175 521
LLPS-Cogr-0328Colletotrichum graminicola46.052e-174 518
LLPS-Sac-0650Saccharomyces cerevisiae46.051e-173 516
LLPS-Kop-0289Komagataella pastoris46.08e-173 514
LLPS-Mao-0422Magnaporthe oryzae45.991e-176 524
LLPS-Zyt-0628Zymoseptoria tritici45.954e-174 518
LLPS-Nec-0295Neurospora crassa45.734e-174 518
LLPS-Phn-0275Phaeosphaeria nodorum45.652e-167 500
LLPS-Pytr-0163Pyrenophora triticirepentis45.642e-171 511
LLPS-Pyt-0281Pyrenophora teres45.643e-171 511
LLPS-Dos-0242Dothistroma septosporum45.592e-172 514
LLPS-Cog-0165Colletotrichum gloeosporioides45.518e-165 493
LLPS-Coo-0190Colletotrichum orbiculare45.432e-176 524
LLPS-Lem-0545Leptosphaeria maculans45.066e-168 503
LLPS-Ors-0316Oryza sativa35.632e-29 124