• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ova-3872
KPNA7

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit alpha
Gene Name: KPNA7
Ensembl Gene: ENSOARG00000018824.1
Ensembl Protein: ENSOARP00000020222.1
Organism: Ovis aries
Taxa ID: 9940
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOART00000020502.1ENSOARP00000020222.1
UniProtW5QBX5, W5QBX5_SHEEP
GeneBankAMGL01069518

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPTSDAPEER  LRKFKYRGKD  ASARRQQRIA  VSLELRKAKK  DEQALKRRNI  TDVSLDPSDQ  60
61    QTKGVSLTMQ  EIISGVNASD  PELCFQATQA  ARLQRKMLSR  EKNPPLKLIV  DAGLIPRLVE  120
121   LLKSSFHPRL  QFEAAWALTN  IASGASELTR  AVVDGGAIQP  LVELLSSPHM  TVCEQAVWAL  180
181   GNIAGDGPEF  RDNVIASDAI  PHLLTLVSSN  IPERQVPFLR  NIAWTLSNLC  RNKNPYPSDH  240
241   AVKQMLPVLF  YLLGHPDREV  LSDTCWALSY  LTDGCDVRIG  QVVDTGVLPR  LVELMCSSEL  300
301   NILTPSLRTV  GNIVTGTDHQ  TQLALDAGIL  GVLPQLLTHP  RSSIQKEAAW  ALSNVAAGPR  360
361   QHIQQLIACG  ALPPLVAVLK  NGEFKVQKEA  VWTVANFTTG  GSVDQLIQLV  QAGVLEPLIN  420
421   LLTIPDNKMV  IIILDILFFI  LQAAEKISQK  ENMCLLIEGL  GGLDRIEALQ  LHENHQVALT  480
481   ALNIIERHFS  EEEETVTALP  ARDQDHKFLK  DLTNTYHCCT  TPKLGPRP  528
Nucleotide CDS Sequence (FASTA)
1     ATGCCAACTT  CGGATGCTCC  GGAAGAGAGG  CTGAGAAAAT  TTAAGTATCG  GGGCAAGGAT  60
61    GCATCTGCGA  GGCGGCAGCA  GAGGATAGCA  GTCAGCCTGG  AGCTCCGGAA  AGCCAAGAAG  120
121   GATGAGCAGG  CCTTGAAGAG  GAGAAACATC  ACCGATGTCT  CACTTGACCC  TTCTGATCAG  180
181   CAGACCAAAG  GGGTCAGCCT  CACCATGCAA  GAAATAATCA  GTGGTGTCAA  TGCCTCAGAT  240
241   CCAGAACTAT  GTTTCCAGGC  CACCCAAGCA  GCCAGACTGC  AAAGGAAAAT  GCTGTCCCGG  300
301   GAGAAGAACC  CTCCTCTGAA  GCTGATTGTG  GACGCGGGAC  TCATTCCCAG  GCTGGTGGAG  360
361   CTCCTGAAGT  CGTCCTTTCA  CCCCCGCTTG  CAGTTCGAGG  CAGCCTGGGC  TCTGACCAAC  420
421   ATTGCTTCAG  GGGCCTCGGA  GCTGACTCGC  GCCGTCGTGG  ACGGGGGTGC  CATCCAGCCC  480
481   CTGGTTGAGC  TCCTGTCTTC  CCCTCACATG  ACTGTGTGTG  AACAGGCCGT  GTGGGCCCTC  540
541   GGGAACATAG  CAGGTGATGG  ACCAGAATTC  AGAGACAATG  TTATCGCAAG  TGATGCCATT  600
601   CCACATCTGC  TGACCCTGGT  TTCGTCAAAC  ATACCAGAGA  GACAGGTCCC  GTTCCTGCGC  660
661   AACATCGCCT  GGACCCTGTC  CAACCTGTGC  CGGAACAAGA  ACCCGTACCC  CTCTGACCAC  720
721   GCGGTGAAGC  AGATGCTGCC  CGTCCTCTTC  TACCTCCTGG  GGCACCCAGA  CAGAGAGGTC  780
781   CTCTCGGACA  CCTGCTGGGC  CCTGTCCTAC  CTCACTGATG  GCTGCGATGT  GCGCATTGGC  840
841   CAGGTGGTGG  ACACCGGGGT  CCTGCCCAGG  CTGGTTGAGC  TTATGTGCAG  CTCAGAACTC  900
901   AACATCTTGA  CCCCCTCTCT  CCGCACCGTG  GGCAACATTG  TCACAGGAAC  GGACCACCAG  960
961   ACCCAGCTGG  CCCTGGATGC  GGGCATATTG  GGAGTGCTGC  CCCAGCTCCT  GACGCATCCC  1020
1021  CGCTCCTCCA  TCCAGAAGGA  GGCAGCCTGG  GCCCTGAGCA  ACGTGGCTGC  TGGGCCCCGC  1080
1081  CAACACATCC  AGCAGCTAAT  CGCCTGTGGC  GCCCTGCCTC  CTTTGGTGGC  CGTGTTAAAA  1140
1141  AACGGAGAGT  TTAAAGTCCA  GAAAGAGGCT  GTCTGGACGG  TGGCTAACTT  CACAACCGGG  1200
1201  GGCTCCGTGG  ACCAGTTGAT  CCAGCTTGTC  CAGGCTGGAG  TCTTGGAGCC  ACTCATAAAT  1260
1261  CTCCTCACCA  TCCCAGACAA  CAAAATGGTT  ATCATCATAC  TCGACATTCT  CTTTTTCATC  1320
1321  CTCCAGGCAG  CGGAGAAGAT  TTCTCAGAAG  GAAAACATGT  GTCTGCTGAT  AGAAGGACTC  1380
1381  GGTGGGCTTG  ATAGAATCGA  GGCTCTGCAG  CTTCACGAGA  ACCATCAGGT  CGCCCTGACT  1440
1441  GCGCTGAACA  TTATCGAGAG  ACACTTCTCC  GAGGAAGAAG  AAACTGTCAC  AGCCTTACCA  1500
1501  GCCCGGGACC  AAGACCACAA  ATTCTTAAAG  GACTTAACAA  ACACATACCA  CTGCTGCACA  1560
1561  ACTCCTAAAC  TGGGACCCAG  ACCCTAA  1587

▼ KEYWORD

ID
Family
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Protein transporter activity
Biological Process
Protein import into nucleus

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-4100Bos taurus96.020.0 999
LLPS-Sus-4246Sus scrofa83.30.0 809
LLPS-Fec-2329Felis catus81.630.0 839
LLPS-Eqc-2506Equus caballus81.390.0 779
LLPS-Aim-3687Ailuropoda melanoleuca80.720.0 832
LLPS-Caf-3994Canis familiaris79.40.0 812
LLPS-Mup-4384Mustela putorius furo78.260.0 801
LLPS-Ere-0808Erinaceus europaeus77.010.0 543
LLPS-Loa-1233Loxodonta africana76.880.0 714
LLPS-Poa-4407Pongo abelii76.40.0 743
LLPS-Otg-3447Otolemur garnettii76.220.0 743
LLPS-Orc-0773Oryctolagus cuniculus75.250.0 740
LLPS-Gog-3228Gorilla gorilla74.710.0 748
LLPS-Paa-2594Papio anubis74.660.0 731
LLPS-Aon-3740Aotus nancymaae74.510.0 749
LLPS-Cea-4244Cercocebus atys74.460.0 728
LLPS-Caj-3833Callithrix jacchus74.270.0 746
LLPS-Mal-0629Mandrillus leucophaeus74.270.0 726
LLPS-Pap-4025Pan paniscus74.190.0 753
LLPS-Pat-4163Pan troglodytes74.00.0 749
LLPS-Hos-2361Homo sapiens73.80.0 750
LLPS-Nol-0568Nomascus leucogenys73.80.0 747
LLPS-Rhb-2481Rhinopithecus bieti73.750.0 729
LLPS-Maf-0665Macaca fascicularis73.560.0 728
LLPS-Myl-1791Myotis lucifugus73.430.0 704
LLPS-Man-1010Macaca nemestrina73.370.0 726
LLPS-Mam-1702Macaca mulatta73.370.0 728
LLPS-Chs-1470Chlorocebus sabaeus72.950.0 691
LLPS-Dio-2669Dipodomys ordii70.330.0 663
LLPS-Fud-2280Fukomys damarensis69.760.0 691
LLPS-Ict-1397Ictidomys tridecemlineatus69.720.0 664
LLPS-Cap-3774Cavia porcellus68.810.0 677
LLPS-Urm-2440Ursus maritimus64.930.0 610
LLPS-Ora-1990Ornithorhynchus anatinus63.040.0 625
LLPS-Ran-2474Rattus norvegicus63.030.0 601
LLPS-Mod-3035Monodelphis domestica61.520.0 616
LLPS-Mum-3125Mus musculus57.590.0 555
LLPS-Asm-1298Astyanax mexicanus55.871e-180 526
LLPS-Scf-1898Scleropages formosus55.561e-178 523
LLPS-Gaga-1383Gallus gallus55.490.0 533
LLPS-Cas-0743Carlito syrichta55.457e-160 470
LLPS-Meg-2119Meleagris gallopavo55.280.0 533
LLPS-Lac-0280Latimeria chalumnae55.230.0 546
LLPS-Tag-1745Taeniopygia guttata55.220.0 538
LLPS-Anp-0346Anas platyrhynchos55.080.0 529
LLPS-Leo-1361Lepisosteus oculatus55.072e-179 522
LLPS-Icp-0460Ictalurus punctatus55.05e-162 478
LLPS-Pes-0806Pelodiscus sinensis54.960.0 530
LLPS-Fia-1452Ficedula albicollis54.820.0 534
LLPS-Dar-0438Danio rerio54.530.0 536
LLPS-Ten-0697Tetraodon nigroviridis54.223e-178 520
LLPS-Orn-3891Oreochromis niloticus53.613e-169 497
LLPS-Xet-1957Xenopus tropicalis53.052e-173 507
LLPS-Sah-0458Sarcophilus harrisii52.982e-178 520
LLPS-Orl-2043Oryzias latipes52.852e-171 502
LLPS-Scm-1340Scophthalmus maximus52.41e-172 505
LLPS-Anc-1579Anolis carolinensis52.324e-172 504
LLPS-Pof-0231Poecilia formosa52.252e-170 501
LLPS-Gaa-0738Gasterosteus aculeatus52.161e-175 513
LLPS-Xim-1865Xiphophorus maculatus52.057e-168 493
LLPS-Tar-0586Takifugu rubripes51.194e-172 504
LLPS-Drm-0244Drosophila melanogaster45.43e-130 397
LLPS-Tut-0366Tursiops truncatus45.344e-131 398
LLPS-Cii-1885Ciona intestinalis44.931e-137 416
LLPS-Abg-1931Absidia glauca44.562e-121 374
LLPS-Mea-2049Mesocricetus auratus43.824e-122 375
LLPS-Brr-0552Brassica rapa43.52e-119 369
LLPS-Scc-1122Schizosaccharomyces cryophilus43.052e-121 374
LLPS-Yal-0529Yarrowia lipolytica42.912e-121 374
LLPS-Scp-0605Schizosaccharomyces pombe42.468e-122 375
LLPS-Scj-0981Schizosaccharomyces japonicus42.038e-121 373
LLPS-Chc-0767Chondrus crispus41.82e-120 373
LLPS-Gas-0099Galdieria sulphuraria41.441e-119 369