• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ova-3617
CLCN7

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Chloride channel protein
Gene Name: CLCN7
Ensembl Gene: ENSOARG00000015134.1
Ensembl Protein: ENSOARP00000016243.1
Organism: Ovis aries
Taxa ID: 9940
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     SLREAQPRLT  RHSGVTGPDH  LLPDMDPPHP  FPREIPHNEK  LLSLKYERHV  VTSEEAVLNG  60
61    GRSISIQAFR  TVEIKRWVIC  AMVGILTGLV  ACFIDIVVEK  LAGLKYRLVK  DTADIDRFTE  120
121   HGGLSFSLLL  WAALNADPLP  LGSSPVACVQ  TRPPQAPAGS  GIPQIKCFLN  GVKIPHVVRL  180
181   KTLVIKVSGR  AAQVSTGMQP  REEGPMIHSG  SVIAAGISQG  RSTSLKRDFK  IFEYFRRDTE  240
241   KRDFVSAGAA  AGVSAAFGAP  VGGVLFSLEE  GASFWNQFLT  WRIFFASMIS  TFTLNFVLSI  300
301   YHGNAWDLSS  PGLINFGRFD  TETMVYVIHE  IPIFIAMGVV  GGILGAVFNA  LNYWLTMFRI  360
361   RPRLLSEAAA  RHPTPPHPPA  FVLAPDAVWP  RTSASHWPVH  SHPLQLFCAD  GEYNSMAAAF  420
421   FNTPEKSVVS  LFHDPPGSYN  PVTLGLFTLV  YFFLACWTYG  LTVSAGVFIP  SLLIGAAWGR  480
481   LFGISLSYIT  GAAVSAAPPG  HSLPLPLPRA  GGIVRMTLSL  TVIMMEATSN  VTYGFPIMLV  540
541   LMTAKIVGDV  FIEVRQGMHL  QMETIAFMQW  FTEFMELFLS  VWEVMSTPVI  CLRRREKVGV  600
601   IVDVLSSTAS  NHNGFPVVED  ADGTQPARLQ  GLILRSQLIV  LLKHKVFVER  SSMGLLRRRL  660
661   RLKDFRDAYP  RFPPIQSIHV  SQDERECTMD  LSEFMNPSPY  TVPQEASLPR  VFKLFRALGL  720
721   RHLVVVDNCN  QVVGLVTRKD  LARYRLGKGG  LEELSLAQT  759
Nucleotide CDS Sequence (FASTA)
1     TCACTCAGAG  AAGCTCAGCC  CAGACTCACT  CGTCACTCAG  GTGTCACGGG  GCCTGACCAC  60
61    CTGCTTCCTG  ACATGGACCC  CCCTCACCCC  TTCCCCAGGG  AGATCCCACA  CAACGAGAAG  120
121   CTGCTGTCCC  TCAAGTACGA  GCGTCACGTT  GTCACCTCTG  AGGAGGCTGT  TCTCAATGGC  180
181   GGCCGCAGCA  TCAGCATCCA  GGCCTTCCGG  ACGGTGGAGA  TCAAGCGCTG  GGTCATCTGC  240
241   GCCATGGTGG  GCATCCTCAC  GGGTCTCGTG  GCCTGCTTCA  TTGACATCGT  GGTGGAGAAG  300
301   CTGGCCGGCC  TTAAGTACAG  GCTCGTCAAG  GACACCGCAG  ACATCGACAG  GTTCACAGAG  360
361   CACGGCGGGC  TGTCCTTCTC  CCTCCTGCTC  TGGGCCGCAC  TCAATGCCGA  CCCCTTGCCC  420
421   CTCGGCTCGT  CCCCCGTCGC  TTGTGTACAG  ACCAGGCCCC  CCCAGGCGCC  CGCTGGCAGC  480
481   GGGATCCCCC  AGATCAAGTG  CTTCCTCAAC  GGGGTGAAGA  TCCCCCACGT  GGTCAGGCTC  540
541   AAGACCCTGG  TGATCAAAGT  GTCCGGCAGG  GCCGCTCAAG  TGTCCACGGG  AATGCAGCCC  600
601   AGAGAGGAGG  GGCCGATGAT  CCACTCCGGC  TCGGTGATCG  CCGCGGGCAT  CTCCCAGGGC  660
661   CGGTCCACAT  CGCTGAAGCG  GGACTTCAAG  ATCTTCGAGT  ACTTTCGCAG  AGACACGGAG  720
721   AAGCGGGACT  TCGTCTCGGC  AGGAGCTGCA  GCTGGAGTGT  CCGCAGCCTT  CGGGGCCCCC  780
781   GTGGGTGGGG  TGCTGTTCAG  CTTGGAGGAG  GGTGCGTCCT  TCTGGAACCA  GTTCCTGACG  840
841   TGGAGAATCT  TCTTTGCTTC  CATGATCTCC  ACTTTCACCT  TGAACTTTGT  CCTGAGTATT  900
901   TATCATGGGA  ATGCGTGGGA  CCTGTCCAGC  CCTGGGCTCA  TCAACTTCGG  AAGATTCGAT  960
961   ACTGAGACCA  TGGTGTACGT  GATCCATGAG  ATCCCCATCT  TCATCGCCAT  GGGCGTGGTG  1020
1021  GGGGGCATTC  TCGGAGCTGT  GTTCAACGCC  TTGAATTACT  GGCTGACGAT  GTTTCGAATC  1080
1081  AGGCCCCGCC  TCCTTTCTGA  GGCCGCAGCC  AGACACCCCA  CCCCACCCCA  CCCCCCCGCA  1140
1141  TTCGTGCTTG  CGCCTGATGC  CGTCTGGCCC  AGGACCAGCG  CATCCCACTG  GCCCGTCCAC  1200
1201  TCTCACCCCT  TGCAGCTCTT  CTGCGCTGAT  GGTGAGTACA  ACTCGATGGC  TGCGGCCTTC  1260
1261  TTCAACACCC  CGGAGAAAAG  TGTGGTCAGC  CTTTTCCACG  ACCCCCCAGG  CTCCTACAAC  1320
1321  CCCGTGACGC  TTGGCCTGTT  TACCCTGGTC  TACTTCTTCC  TGGCCTGCTG  GACCTACGGG  1380
1381  CTCACGGTGT  CGGCTGGTGT  CTTCATTCCG  TCCCTGCTCA  TTGGCGCTGC  CTGGGGCCGG  1440
1441  CTGTTCGGCA  TCTCCCTGTC  CTACATCACG  GGGGCCGCGG  TGAGTGCAGC  TCCGCCGGGC  1500
1501  CACAGTCTCC  CTCTTCCCCT  CCCCCGGGCA  GGTGGGATCG  TGAGGATGAC  GCTGAGCCTA  1560
1561  ACGGTCATCA  TGATGGAGGC  CACCAGCAAC  GTGACCTACG  GCTTCCCCAT  CATGCTGGTG  1620
1621  CTCATGACCG  CCAAGATCGT  GGGGGACGTC  TTCATCGAGG  TGCGGCAGGG  AATGCATCTG  1680
1681  CAAATGGAAA  CTATAGCATT  TATGCAATGG  TTTACAGAAT  TCATGGAATT  ATTTTTATCA  1740
1741  GTATGGGAGG  TGATGAGCAC  GCCGGTCATC  TGCCTGCGGA  GGAGGGAGAA  GGTGGGCGTC  1800
1801  ATCGTGGACG  TGCTGAGCAG  CACGGCATCC  AACCACAACG  GTTTCCCTGT  GGTGGAGGAT  1860
1861  GCTGACGGCA  CGCAGCCAGC  TCGGCTCCAG  GGCTTGATCC  TGCGCTCGCA  GCTCATCGTC  1920
1921  CTGCTCAAGC  ACAAGGTGTT  CGTGGAGCGC  TCCAGCATGG  GCCTGCTGCG  ACGCCGGCTG  1980
1981  CGGCTAAAGG  ACTTCCGCGA  CGCCTACCCA  CGCTTCCCCC  CAATCCAGTC  CATCCACGTG  2040
2041  TCGCAGGACG  AGCGGGAGTG  CACCATGGAC  CTGTCCGAGT  TCATGAACCC  CTCGCCCTAC  2100
2101  ACGGTGCCCC  AGGAGGCGTC  GCTCCCACGG  GTGTTCAAGC  TGTTCCGGGC  CCTGGGCCTC  2160
2161  CGGCATCTGG  TGGTGGTGGA  CAATTGCAAT  CAGGTGGTCG  GGCTGGTGAC  CAGGAAGGAC  2220
2221  CTGGCCAGGT  ACCGGCTTGG  AAAGGGGGGC  CTGGAGGAGC  TCTCTCTGGC  CCAGACGTGA  2280

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-1037Mesocricetus auratus95.623e-72 254
LLPS-Urm-2588Ursus maritimus93.14e-0654.7
LLPS-Mum-3165Mus musculus86.240.0 605
LLPS-Bot-4176Bos taurus82.670.01078
LLPS-Fec-3822Felis catus80.080.01079
LLPS-Sus-3559Sus scrofa79.950.01068
LLPS-Aim-0412Ailuropoda melanoleuca79.810.01074
LLPS-Caf-0544Canis familiaris79.670.01072
LLPS-Eqc-3815Equus caballus79.540.01039
LLPS-Loa-0987Loxodonta africana79.540.01047
LLPS-Cap-1765Cavia porcellus79.40.01074
LLPS-Mup-1658Mustela putorius furo79.40.01070
LLPS-Fud-3796Fukomys damarensis79.40.01071
LLPS-Pat-3624Pan troglodytes79.260.01043
LLPS-Chs-3452Chlorocebus sabaeus79.260.01043
LLPS-Aon-1846Aotus nancymaae79.130.01038
LLPS-Dio-3140Dipodomys ordii78.990.01065
LLPS-Ran-2951Rattus norvegicus78.990.01065
LLPS-Caj-4342Callithrix jacchus78.990.01039
LLPS-Ict-3430Ictidomys tridecemlineatus78.690.01060
LLPS-Otg-0099Otolemur garnettii78.170.01060
LLPS-Myl-3987Myotis lucifugus78.170.01026
LLPS-Cas-3643Carlito syrichta77.880.0 959
LLPS-Mod-3838Monodelphis domestica77.760.01050
LLPS-Ora-2760Ornithorhynchus anatinus77.760.01027
LLPS-Paa-3578Papio anubis77.730.0 910
LLPS-Maf-2865Macaca fascicularis77.730.0 932
LLPS-Poa-1472Pongo abelii77.680.0 981
LLPS-Sah-0121Sarcophilus harrisii77.520.01044
LLPS-Pap-0464Pan paniscus77.310.0 932
LLPS-Hos-1915Homo sapiens77.160.0 931
LLPS-Mam-3357Macaca mulatta76.480.0 907
LLPS-Cea-1707Cercocebus atys75.440.0 892
LLPS-Gog-0522Gorilla gorilla75.110.0 886
LLPS-Fia-1161Ficedula albicollis74.80.01007
LLPS-Tag-1800Taeniopygia guttata74.670.0 702
LLPS-Gaga-2788Gallus gallus74.520.0 985
LLPS-Meg-3263Meleagris gallopavo74.520.0 988
LLPS-Nol-1088Nomascus leucogenys73.930.0 883
LLPS-Mal-3897Mandrillus leucophaeus73.080.0 848
LLPS-Anp-2173Anas platyrhynchos72.750.0 999
LLPS-Anc-3819Anolis carolinensis72.620.0 963
LLPS-Man-0258Macaca nemestrina72.390.0 861
LLPS-Rhb-1427Rhinopithecus bieti71.780.0 851
LLPS-Scf-3420Scleropages formosus67.160.0 890
LLPS-Tar-2406Takifugu rubripes67.030.0 900
LLPS-Xim-1538Xiphophorus maculatus66.980.0 866
LLPS-Scm-0859Scophthalmus maximus66.580.0 882
LLPS-Orl-1917Oryzias latipes66.490.0 891
LLPS-Asm-0427Astyanax mexicanus66.490.0 900
LLPS-Dar-4268Danio rerio66.350.0 876
LLPS-Xet-2542Xenopus tropicalis66.170.0 879
LLPS-Orn-3154Oreochromis niloticus66.040.0 889
LLPS-Gaa-0952Gasterosteus aculeatus65.680.0 885
LLPS-Leo-0489Lepisosteus oculatus65.490.0 857
LLPS-Icp-1534Ictalurus punctatus65.310.0 866
LLPS-Pof-1707Poecilia formosa63.650.0 675
LLPS-Ten-3570Tetraodon nigroviridis63.590.0 841
LLPS-Lac-0250Latimeria chalumnae60.540.0 817
LLPS-Pes-2687Pelodiscus sinensis60.120.0 678
LLPS-Cis-1384Ciona savignyi50.740.0 580
LLPS-Cii-2007Ciona intestinalis48.990.0 569
LLPS-Drm-1871Drosophila melanogaster44.165e-160 491
LLPS-Cae-1136Caenorhabditis elegans43.62e-154 476
LLPS-Php-1712Physcomitrella patens34.884e-92 311
LLPS-Prp-1590Prunus persica34.542e-84 291
LLPS-Sei-1837Setaria italica34.352e-77 269
LLPS-Met-0863Medicago truncatula34.291e-82 286
LLPS-Glm-1472Glycine max34.291e-86 297
LLPS-Sob-1719Sorghum bicolor34.241e-82 286
LLPS-Amt-1891Amborella trichopoda34.24e-83 287
LLPS-Via-1934Vigna angularis34.052e-83 288
LLPS-Zem-1515Zea mays34.05e-81 281
LLPS-Pot-1213Populus trichocarpa33.956e-86 295
LLPS-Hea-2502Helianthus annuus33.863e-76 268
LLPS-Brd-0168Brachypodium distachyon33.852e-80 280
LLPS-Cus-0612Cucumis sativus33.772e-82 285
LLPS-Hov-1965Hordeum vulgare33.769e-69 247
LLPS-Tra-0254Triticum aestivum33.755e-81 282
LLPS-Tru-1932Triticum urartu33.733e-74 263
LLPS-Orm-1686Oryza meridionalis33.672e-75 266
LLPS-Ors-2117Oryza sativa33.673e-75 267
LLPS-Orgl-1780Oryza glumaepatula33.672e-75 266
LLPS-Ori-1093Oryza indica33.672e-75 266
LLPS-Orb-0534Oryza barthii33.671e-75 267
LLPS-Orni-2359Oryza nivara33.622e-76 270
LLPS-Coc-0911Corchorus capsularis33.571e-81 283
LLPS-Orr-2454Oryza rufipogon33.533e-74 263
LLPS-Mae-1159Manihot esculenta33.536e-83 286
LLPS-Lep-2015Leersia perrieri33.481e-78 275
LLPS-Nia-0681Nicotiana attenuata33.384e-78 273
LLPS-Sem-0562Selaginella moellendorffii33.384e-86 295
LLPS-Dac-0270Daucus carota33.386e-79 276
LLPS-Thc-1396Theobroma cacao33.381e-81 283
LLPS-Orbr-2014Oryza brachyantha33.197e-77 268
LLPS-Gor-0360Gossypium raimondii33.054e-80 280
LLPS-Mua-1945Musa acuminata33.03e-76 268
LLPS-Org-2086Oryza glaberrima32.494e-66 238
LLPS-Phv-1045Phaseolus vulgaris32.059e-75 264
LLPS-Sot-0331Solanum tuberosum32.015e-78 273
LLPS-Viv-1930Vitis vinifera31.951e-79 277
LLPS-Arl-0746Arabidopsis lyrata31.821e-74 263
LLPS-Art-2524Arabidopsis thaliana31.689e-75 264
LLPS-Sol-1161Solanum lycopersicum31.461e-75 267
LLPS-Orp-1699Oryza punctata31.421e-76 270
LLPS-Chr-1259Chlamydomonas reinhardtii31.425e-57 214
LLPS-Vir-0553Vigna radiata31.348e-69 247
LLPS-Bro-1642Brassica oleracea31.088e-73 258
LLPS-Brr-1692Brassica rapa31.081e-72 258
LLPS-Brn-0292Brassica napus31.081e-72 258