LLPS-Mum-3165
Clcn7
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7 |
| Gene Name: | Clcn7, Clc7 |
| Ensembl Gene: | ENSMUSG00000036636.10 |
| Ensembl Protein: | ENSMUSP00000124527.2 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000162862.2 | ENSMUSP00000124527.2 |
| Ensembl | ENSMUST00000040729.8 | ENSMUSP00000035964.2 |
| Ensembl | ENSMUST00000160961.7 | ENSMUSP00000124194.1 |
| Ensembl | ENSMUST00000159773.1 | ENSMUSP00000125546.1 |
| Ensembl | ENSMUST00000233633.1 | ENSMUSP00000156968.1 |
| UniProt | O70496, CLCN7_MOUSE | |
| GeneBank | AF063100, AF063098, BC050907, AF063101, BC054799, AF063099, BC053049 | AAC18832.1, AAH50907.1, AAH53049.1, AAH54799.1 |
| RefSeq | NM_011930.4 | NP_036060.1 |
| Entrez | 26373 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA LFRIGQMNNV 60 61 ELDDELLDPE VDPPHTFPKE IPHNEKLLSL KYESLDYDNS ENQLFLEEER RINHTAFRTV 120 121 EIKRWVICAL IGILTGLVAC FIDIVVENLA GLKYRVIKDN IDKFTEKGGL SFSLLLWATL 180 181 NSAFVLVGSV IVAFIEPVAA GSGIPQIKCF LNGVKIPHVV RLKTLVIKVS GVILSVVGGL 240 241 AVGKEGPMIH SGSVIAAGIS QGRSTSLKRD FKIFEYFRRD TEKRDFVSAG AAAGVSAAFG 300 301 APVGGVLFSL EEGASFWNQF LTWRIFFASM ISTFTLNFVL SIYHGNMWDL SSPGLINFGR 360 361 FDSEKMAYTI HEIPVFIAMG VVGGILGAVF NALNYWLTMF RIRYIHRPCL QVIEAMLVAA 420 421 VTATVAFVLI YSSRDCQPLQ GSSMSYPLQR GGHASETLSE LHLGLYSEPR SCLVLSRLGV 480 481 HEQHSAAQHL PCGHLSLCVL PFSTLQLFCA DGEYNSMAAA FFNTPEKSVV SLFHDPPGSY 540 541 NPMTLGLFTL VYFFLACWTY GLTVSAGVFI PSLLIGAAWG RLFGISLSYL TGAAIWADPG 600 601 KYALMGAAAQ LGGIVRMTLS LTVIMMEATS NVTYGFPIML VLMTAKIVGD VFIEGLYDMH 660 661 IQLQSVPFLH WEAPVTSHSL TAREVMSTPV TCLRRREKVG IIVDVLSDTA SNHNGFPVVE 720 721 DVGDTQPARL QGLILRSQLI VLLKHKVFVE RSNMGLVQRR LRLKDFRDAY PRFPPIQSIH 780 781 VSQDERECTM DLSEFMNPSP YTVPQEASLP RVFKLFRALG LRHLVVVDNH NQVVGLVTRK 840 841 DLARYRLGKG GLEELSLAQT 860 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCAACG TCTCTAAGAA AGTGTCTTGG TCCGGCCGAG ATCGCGATGA TGAGGAGGGG 60 61 GCGCCACTGC TTCGAAGGAC AGGGCAGCCT GACGAGGAGA CGCCGCTGCT GAACGGAGCT 120 121 GGGCCGGGCG CGCGCCAGTC TCATTCTGCA CTGTTCCGAA TCGGACAGAT GAACAACGTG 180 181 GAGCTGGATG ACGAGCTCCT GGACCCGGAA GTCGATCCTC CTCACACCTT CCCCAAGGAG 240 241 ATTCCACACA ACGAGAAGCT CCTCTCCCTC AAGTATGAGA GCCTGGACTA TGACAACAGC 300 301 GAGAATCAGC TCTTCCTGGA GGAGGAAAGA CGAATCAACC ACACGGCTTT CCGGACAGTG 360 361 GAGATCAAGC GCTGGGTTAT CTGTGCCCTC ATTGGAATCC TCACAGGCCT AGTAGCCTGC 420 421 TTCATTGACA TTGTAGTGGA GAACCTGGCA GGCCTCAAGT ACCGCGTCAT CAAGGACAAC 480 481 ATTGACAAGT TCACAGAGAA GGGCGGCCTG TCCTTCTCCC TCCTGCTGTG GGCCACGCTG 540 541 AACTCTGCCT TCGTACTCGT GGGGTCTGTG ATCGTGGCCT TCATAGAGCC TGTTGCTGCT 600 601 GGCAGCGGAA TCCCTCAGAT CAAGTGCTTC CTCAATGGGG TGAAGATCCC CCACGTGGTG 660 661 CGGCTCAAGA CGCTGGTGAT CAAGGTGTCC GGCGTGATTC TGTCTGTGGT AGGGGGACTG 720 721 GCTGTGGGAA AGGAAGGGCC AATGATCCAC TCAGGATCCG TGATAGCTGC AGGGATTTCA 780 781 CAGGGAAGGT CAACATCACT CAAGCGAGAT TTCAAGATCT TTGAATATTT CCGCAGAGAT 840 841 ACAGAGAAGC GGGATTTTGT CTCAGCTGGA GCTGCAGCTG GTGTATCTGC TGCATTTGGA 900 901 GCCCCTGTGG GTGGGGTCCT GTTTAGCTTG GAAGAGGGCG CCTCCTTCTG GAATCAGTTC 960 961 CTGACTTGGA GAATTTTCTT TGCTTCCATG ATTTCCACCT TTACATTGAA TTTTGTTCTG 1020 1021 AGCATCTACC ATGGAAATAT GTGGGACCTG TCCAGCCCTG GCCTCATAAA TTTTGGAAGA 1080 1081 TTTGACTCAG AGAAAATGGC CTACACCATC CATGAGATTC CAGTCTTCAT CGCCATGGGT 1140 1141 GTGGTGGGTG GCATTCTTGG AGCTGTGTTC AATGCCTTGA ATTACTGGCT AACCATGTTT 1200 1201 CGAATCAGGT ACATCCACCG GCCCTGCCTC CAAGTGATTG AGGCCATGCT GGTGGCTGCT 1260 1261 GTCACAGCAA CAGTTGCGTT TGTCTTGATT TACTCGTCTC GAGATTGCCA ACCCCTGCAG 1320 1321 GGGAGCTCCA TGTCCTACCC ACTCCAGCTC TTCTGTGCAG ATGGCGAATA CAACTCCATG 1380 1381 GCCGCAGCCT TCTTTAACAC CCCTGAGAAG AGCGTTGTCA GCCTGTTCCA TGACCCACCA 1440 1441 GGCTCCTATA ATCCCATGAC TCTCGGCCTG TTTACCCTGG TCTACTTCTT CCTGGCCTGC 1500 1501 TGGACCTATG GCCTCACAGT ATCTGCTGGT GTCTTCATCC CATCCCTGCT CATTGGGGCT 1560 1561 GCCTGGGGCC GACTCTTTGG CATCTCCCTG TCCTACCTCA CAGGGGCAGC GATCTGGGCA 1620 1621 GATCCGGGTA AATACGCCCT GATGGGAGCT GCTGCTCAGC TTGGTGGGAT CGTGAGAATG 1680 1681 ACCCTTAGCC TGACAGTCAT CATGATGGAG GCCACCAGCA ACGTGACCTA CGGTTTCCCC 1740 1741 ATCATGTTGG TGCTGATGAC TGCCAAGATT GTGGGTGATG TTTTCATTGA GGGCCTCTAT 1800 1801 GACATGCACA TCCAGCTGCA GAGTGTACCC TTCCTACACT GGGAAGCCCC GGTCACCTCA 1860 1861 CACTCGCTCA CGGCCAGGGA AGTAATGAGC ACACCTGTGA CCTGCCTGAG GAGGCGAGAG 1920 1921 AAGGTTGGCA TCATCGTGGA TGTCCTAAGC GACACAGCGT CTAATCACAA CGGATTCCCT 1980 1981 GTGGTGGAGG ATGTAGGAGA CACCCAGCCA GCCAGGCTCC AAGGCTTGAT CCTGCGTTCC 2040 2041 CAGCTTATCG TTCTCTTGAA GCATAAGGTG TTTGTGGAGA GGTCCAACAT GGGTTTGGTG 2100 2101 CAGCGGCGAC TGAGGCTGAA GGACTTCCGA GATGCCTATC CACGCTTCCC CCCAATCCAG 2160 2161 TCCATTCATG TATCCCAGGA TGAGCGTGAA TGCACCATGG ACCTTTCTGA ATTCATGAAC 2220 2221 CCTTCTCCCT ACACTGTGCC TCAGGAGGCA TCTCTTCCTC GAGTGTTCAA GCTCTTCCGG 2280 2281 GCTCTGGGCC TGAGGCACCT GGTAGTAGTA GACAACCACA ATCAGGTGGT CGGGCTGGTG 2340 2341 ACCAGGAAGG ACCTAGCAAG ATACCGCCTA GGAAAGGGAG GCCTAGAAGA GCTTTCGCTG 2400 2401 GCCCAGACGT GA 2412 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Integral component of membrane | |
Cellular Component | Lysosomal membrane | |
Cellular Component | Nucleoplasm | |
Molecular Function | Antiporter activity | |
Molecular Function | ATP binding | |
Molecular Function | Voltage-gated chloride channel activity | |
Biological Process | Chloride transmembrane transport | |
Biological Process | Response to pH |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-1037 | Mesocricetus auratus | 100.0 | 2e-79 | 276 |
| LLPS-Urm-2588 | Ursus maritimus | 93.1 | 4e-06 | 54.7 |
| LLPS-Ran-2951 | Rattus norvegicus | 90.0 | 0.0 | 1390 |
| LLPS-Eqc-3815 | Equus caballus | 87.3 | 0.0 | 1331 |
| LLPS-Loa-0987 | Loxodonta africana | 87.2 | 0.0 | 1337 |
| LLPS-Dio-3140 | Dipodomys ordii | 87.08 | 0.0 | 1255 |
| LLPS-Cap-1765 | Cavia porcellus | 86.88 | 0.0 | 1339 |
| LLPS-Caj-4342 | Callithrix jacchus | 86.77 | 0.0 | 1307 |
| LLPS-Pat-3624 | Pan troglodytes | 86.66 | 0.0 | 1306 |
| LLPS-Chs-3452 | Chlorocebus sabaeus | 86.66 | 0.0 | 1306 |
| LLPS-Ova-3617 | Ovis aries | 86.24 | 0.0 | 605 |
| LLPS-Fud-3796 | Fukomys damarensis | 86.16 | 0.0 | 1335 |
| LLPS-Otg-0099 | Otolemur garnettii | 86.08 | 0.0 | 1324 |
| LLPS-Pap-0464 | Pan paniscus | 86.01 | 0.0 | 1113 |
| LLPS-Caf-0544 | Canis familiaris | 85.88 | 0.0 | 1236 |
| LLPS-Aon-1846 | Aotus nancymaae | 85.8 | 0.0 | 1269 |
| LLPS-Poa-1472 | Pongo abelii | 85.78 | 0.0 | 1245 |
| LLPS-Aim-0412 | Ailuropoda melanoleuca | 85.49 | 0.0 | 1259 |
| LLPS-Ict-3430 | Ictidomys tridecemlineatus | 85.37 | 0.0 | 1305 |
| LLPS-Myl-3987 | Myotis lucifugus | 84.8 | 0.0 | 1212 |
| LLPS-Sah-0121 | Sarcophilus harrisii | 84.56 | 0.0 | 1228 |
| LLPS-Ora-2760 | Ornithorhynchus anatinus | 84.28 | 0.0 | 1215 |
| LLPS-Fec-3822 | Felis catus | 84.18 | 0.0 | 1303 |
| LLPS-Sus-3559 | Sus scrofa | 84.06 | 0.0 | 1279 |
| LLPS-Cas-3643 | Carlito syrichta | 83.48 | 0.0 | 1200 |
| LLPS-Mal-3897 | Mandrillus leucophaeus | 83.45 | 0.0 | 1056 |
| LLPS-Maf-2865 | Macaca fascicularis | 83.37 | 0.0 | 1174 |
| LLPS-Lac-0250 | Latimeria chalumnae | 83.29 | 0.0 | 622 |
| LLPS-Bot-4176 | Bos taurus | 83.26 | 0.0 | 1253 |
| LLPS-Mod-3838 | Monodelphis domestica | 82.91 | 0.0 | 1282 |
| LLPS-Hos-1915 | Homo sapiens | 82.86 | 0.0 | 1172 |
| LLPS-Mup-1658 | Mustela putorius furo | 82.18 | 0.0 | 1284 |
| LLPS-Tar-2406 | Takifugu rubripes | 82.12 | 0.0 | 597 |
| LLPS-Asm-0427 | Astyanax mexicanus | 81.84 | 0.0 | 607 |
| LLPS-Paa-3578 | Papio anubis | 81.02 | 0.0 | 1114 |
| LLPS-Mam-3357 | Macaca mulatta | 80.96 | 0.0 | 1113 |
| LLPS-Man-0258 | Macaca nemestrina | 80.96 | 0.0 | 1119 |
| LLPS-Cea-1707 | Cercocebus atys | 79.4 | 0.0 | 1095 |
| LLPS-Gog-0522 | Gorilla gorilla | 79.28 | 0.0 | 1093 |
| LLPS-Meg-3263 | Meleagris gallopavo | 78.87 | 0.0 | 1159 |
| LLPS-Nol-1088 | Nomascus leucogenys | 78.61 | 0.0 | 1102 |
| LLPS-Gaga-2788 | Gallus gallus | 78.55 | 0.0 | 1196 |
| LLPS-Rhb-1427 | Rhinopithecus bieti | 78.18 | 0.0 | 1080 |
| LLPS-Fia-1161 | Ficedula albicollis | 77.94 | 0.0 | 1199 |
| LLPS-Anc-3819 | Anolis carolinensis | 77.43 | 0.0 | 1187 |
| LLPS-Tag-1800 | Taeniopygia guttata | 76.94 | 0.0 | 795 |
| LLPS-Anp-2173 | Anas platyrhynchos | 75.67 | 0.0 | 1162 |
| LLPS-Orl-1917 | Oryzias latipes | 70.93 | 0.0 | 1097 |
| LLPS-Xim-1538 | Xiphophorus maculatus | 69.67 | 0.0 | 1023 |
| LLPS-Scf-3420 | Scleropages formosus | 69.59 | 0.0 | 1054 |
| LLPS-Ten-3570 | Tetraodon nigroviridis | 68.61 | 0.0 | 1029 |
| LLPS-Scm-0859 | Scophthalmus maximus | 68.39 | 0.0 | 1021 |
| LLPS-Orn-3154 | Oreochromis niloticus | 68.32 | 0.0 | 1033 |
| LLPS-Dar-4268 | Danio rerio | 68.24 | 0.0 | 1010 |
| LLPS-Leo-0489 | Lepisosteus oculatus | 68.17 | 0.0 | 1050 |
| LLPS-Gaa-0952 | Gasterosteus aculeatus | 67.47 | 0.0 | 1007 |
| LLPS-Pof-1707 | Poecilia formosa | 66.58 | 0.0 | 808 |
| LLPS-Xet-2542 | Xenopus tropicalis | 66.06 | 0.0 | 962 |
| LLPS-Pes-2687 | Pelodiscus sinensis | 65.11 | 0.0 | 850 |
| LLPS-Icp-1534 | Ictalurus punctatus | 62.5 | 0.0 | 906 |
| LLPS-Cii-2007 | Ciona intestinalis | 57.93 | 5e-92 | 311 |
| LLPS-Cis-1384 | Ciona savignyi | 50.13 | 0.0 | 590 |
| LLPS-Cae-1136 | Caenorhabditis elegans | 46.05 | 0.0 | 550 |
| LLPS-Drm-1871 | Drosophila melanogaster | 43.79 | 5e-156 | 484 |
| LLPS-Orm-1686 | Oryza meridionalis | 39.94 | 5e-52 | 199 |
| LLPS-Ors-2117 | Oryza sativa | 39.94 | 7e-52 | 199 |
| LLPS-Orgl-1780 | Oryza glumaepatula | 39.94 | 4e-52 | 199 |
| LLPS-Orb-0534 | Oryza barthii | 39.94 | 3e-52 | 199 |
| LLPS-Ori-1093 | Oryza indica | 39.94 | 4e-52 | 199 |
| LLPS-Tru-1932 | Triticum urartu | 39.87 | 1e-34 | 146 |
| LLPS-Orr-2454 | Oryza rufipogon | 39.82 | 1e-50 | 195 |
| LLPS-Mae-1159 | Manihot esculenta | 39.63 | 1e-37 | 155 |
| LLPS-Cus-0612 | Cucumis sativus | 39.19 | 4e-60 | 223 |
| LLPS-Orp-1699 | Oryza punctata | 38.0 | 1e-35 | 149 |
| LLPS-Glm-1472 | Glycine max | 36.91 | 6e-109 | 360 |
| LLPS-Brd-0168 | Brachypodium distachyon | 36.78 | 1e-102 | 343 |
| LLPS-Gor-0360 | Gossypium raimondii | 36.77 | 7e-104 | 348 |
| LLPS-Met-0863 | Medicago truncatula | 36.77 | 4e-102 | 341 |
| LLPS-Sei-1837 | Setaria italica | 36.75 | 5e-93 | 314 |
| LLPS-Thc-1396 | Theobroma cacao | 36.73 | 3e-103 | 345 |
| LLPS-Via-1934 | Vigna angularis | 36.7 | 5e-104 | 346 |
| LLPS-Zem-1515 | Zea mays | 36.65 | 3e-102 | 341 |
| LLPS-Orbr-2014 | Oryza brachyantha | 36.65 | 1e-95 | 322 |
| LLPS-Tra-0254 | Triticum aestivum | 36.6 | 4e-103 | 344 |
| LLPS-Hea-2502 | Helianthus annuus | 36.47 | 4e-103 | 344 |
| LLPS-Sob-1719 | Sorghum bicolor | 36.45 | 1e-103 | 345 |
| LLPS-Sem-0562 | Selaginella moellendorffii | 36.41 | 9e-108 | 356 |
| LLPS-Php-1712 | Physcomitrella patens | 36.39 | 8e-109 | 359 |
| LLPS-Chr-1259 | Chlamydomonas reinhardtii | 36.33 | 2e-23 | 110 |
| LLPS-Prp-1590 | Prunus persica | 36.27 | 1e-103 | 345 |
| LLPS-Amt-1891 | Amborella trichopoda | 35.83 | 1e-100 | 337 |
| LLPS-Org-2086 | Oryza glaberrima | 35.28 | 2e-87 | 299 |
| LLPS-Coc-0911 | Corchorus capsularis | 35.2 | 8e-88 | 302 |
| LLPS-Lep-2015 | Leersia perrieri | 34.73 | 4e-90 | 309 |
| LLPS-Mua-1945 | Musa acuminata | 34.61 | 7e-85 | 294 |
| LLPS-Dac-0270 | Daucus carota | 34.55 | 4e-83 | 289 |
| LLPS-Viv-1930 | Vitis vinifera | 34.52 | 6e-102 | 340 |
| LLPS-Pot-1213 | Populus trichocarpa | 34.34 | 9e-98 | 329 |
| LLPS-Hov-1965 | Hordeum vulgare | 34.03 | 3e-84 | 293 |
| LLPS-Nia-0681 | Nicotiana attenuata | 34.02 | 2e-77 | 274 |
| LLPS-Orni-2359 | Oryza nivara | 33.94 | 5e-94 | 320 |
| LLPS-Sot-0331 | Solanum tuberosum | 33.6 | 8e-94 | 318 |
| LLPS-Sol-1161 | Solanum lycopersicum | 33.07 | 7e-91 | 312 |
| LLPS-Brr-1692 | Brassica rapa | 32.98 | 3e-94 | 319 |
| LLPS-Brn-0292 | Brassica napus | 32.98 | 4e-94 | 319 |
| LLPS-Art-2524 | Arabidopsis thaliana | 32.86 | 7e-85 | 294 |
| LLPS-Bro-1642 | Brassica oleracea | 32.85 | 4e-94 | 319 |
| LLPS-Arl-0746 | Arabidopsis lyrata | 32.73 | 3e-84 | 292 |
| LLPS-Phv-1045 | Phaseolus vulgaris | 31.79 | 5e-84 | 292 |
| LLPS-Vir-0553 | Vigna radiata | 31.4 | 4e-81 | 284 |