LLPS-Ova-1760
HAX1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | HCLS1-associated protein X-1; HS1-associating protein X-1 |
| Gene Name: | HAX1 |
| Ensembl Gene: | ENSOARG00000002271.1 |
| Ensembl Protein: | ENSOARP00000002405.1 |
| Organism: | Ovis aries |
| Taxa ID: | 9940 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOART00000002457.1 | ENSOARP00000002405.1 |
| UniProt | W5NW58, W5NW58_SHEEP | |
| GeneBank | AMGL01004792 | |
| RefSeq | XM_004002555.3 | XP_004002604.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSLFDLFRGF FGFSGPRSHR DPFFGGMTRD EDEDDEEEEE EGVTWGRGNS RFEGPQPPEE 60 61 FSFGFSFSPG GGMRFHDNFG FDDLVRDFNN IFSEMGAWTL PSRPPELPGP ESETPGERRQ 120 121 EGQTLRDSML KYPDSHQPKI FGGGLESDAR SESPKPAPDW GPQRPFHRFD DTWPVTPHSR 180 181 AREDNDLDSQ VSQEGLGPVL QPQPKTYFKS VSVTKITKPD GTIEERRTVV DSEGRKETTV 240 241 THQEAGGSPR DGPESPTPPS LDDSSSILDL FLGRWFRSR 279 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCCTTT TTGACCTCTT TCGGGGCTTT TTCGGCTTTT CTGGACCTCG GAGCCACAGA 60 61 GATCCCTTTT TTGGAGGAAT GACTCGCGAT GAAGACGAAG ATGATGAGGA AGAGGAAGAA 120 121 GAAGGAGTCA CGTGGGGCCG TGGGAACTCG AGGTTTGAGG GTCCCCAGCC CCCTGAGGAA 180 181 TTTAGCTTTG GCTTCAGCTT CAGCCCGGGA GGAGGAATGC GTTTCCACGA TAACTTCGGC 240 241 TTTGATGACC TAGTACGGGA TTTCAACAAC ATCTTCAGCG AGATGGGGGC CTGGACCTTG 300 301 CCTTCCCGCC CTCCTGAACT TCCAGGTCCT GAGTCAGAGA CACCTGGTGA GAGACGGCAG 360 361 GAAGGACAGA CGCTTCGGGA CTCAATGCTT AAGTATCCAG ATAGTCACCA GCCCAAGATC 420 421 TTTGGTGGGG GCTTGGAGAG TGATGCAAGA TCTGAATCCC CCAAACCAGC ACCAGACTGG 480 481 GGCCCCCAGA GACCTTTTCA TAGGTTCGAT GATACGTGGC CTGTGACCCC CCACTCTAGA 540 541 GCCAGAGAAG ACAATGATCT TGATTCCCAG GTTTCTCAGG AGGGTCTTGG CCCAGTTCTG 600 601 CAGCCCCAAC CCAAAACCTA TTTCAAGAGT GTCTCTGTGA CCAAGATCAC TAAGCCAGAT 660 661 GGGACTATAG AGGAGCGCCG GACTGTGGTG GACAGCGAGG GCCGGAAAGA GACCACAGTA 720 721 ACCCATCAAG AGGCAGGCGG CAGTCCTAGA GATGGTCCAG AATCACCAAC ACCTCCATCC 780 781 TTGGATGATT CCTCTTCCAT CCTGGATTTG TTCCTAGGAC GTTGGTTCCG GTCCCGG 837 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Actin cytoskeleton | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Lamellipodium | |
Cellular Component | Mitochondrial intermembrane space | |
Cellular Component | Mitochondrial outer membrane | |
Cellular Component | Nuclear membrane | |
Cellular Component | Sarcoplasmic reticulum | |
Cellular Component | Transcription factor complex | |
Molecular Function | Interleukin-1 binding | |
Molecular Function | Protein N-terminus binding | |
Biological Process | Cellular response to cytokine stimulus | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Positive regulation of actin cytoskeleton reorganization | |
Biological Process | Positive regulation of granulocyte differentiation | |
Biological Process | Positive regulation of peptidyl-serine phosphorylation | |
Biological Process | Positive regulation of peptidyl-tyrosine phosphorylation | |
Biological Process | Positive regulation of phosphatidylinositol 3-kinase signaling | |
Biological Process | Positive regulation of protein kinase B signaling | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Regulation of actin filament polymerization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bot-2349 | Bos taurus | 97.85 | 6e-141 | 405 |
| LLPS-Tut-1296 | Tursiops truncatus | 93.19 | 4e-133 | 385 |
| LLPS-Sus-0254 | Sus scrofa | 90.32 | 2e-128 | 374 |
| LLPS-Eqc-4179 | Equus caballus | 89.25 | 4e-123 | 364 |
| LLPS-Fec-4789 | Felis catus | 88.97 | 4e-118 | 347 |
| LLPS-Aim-3170 | Ailuropoda melanoleuca | 88.26 | 3e-121 | 355 |
| LLPS-Myl-2411 | Myotis lucifugus | 87.1 | 9e-121 | 354 |
| LLPS-Caf-3359 | Canis familiaris | 86.48 | 9e-120 | 352 |
| LLPS-Ict-3761 | Ictidomys tridecemlineatus | 85.38 | 4e-116 | 341 |
| LLPS-Cas-1394 | Carlito syrichta | 85.3 | 1e-119 | 351 |
| LLPS-Mup-0035 | Mustela putorius furo | 85.09 | 1e-51 | 171 |
| LLPS-Ere-0891 | Erinaceus europaeus | 84.24 | 2e-91 | 276 |
| LLPS-Cap-3665 | Cavia porcellus | 83.51 | 3e-110 | 327 |
| LLPS-Cea-1011 | Cercocebus atys | 82.14 | 2e-118 | 348 |
| LLPS-Dio-2629 | Dipodomys ordii | 81.9 | 5e-93 | 281 |
| LLPS-Pap-4628 | Pan paniscus | 81.79 | 3e-118 | 348 |
| LLPS-Man-4052 | Macaca nemestrina | 81.79 | 1e-117 | 346 |
| LLPS-Chs-3164 | Chlorocebus sabaeus | 81.79 | 2e-117 | 345 |
| LLPS-Pat-2748 | Pan troglodytes | 81.43 | 1e-117 | 346 |
| LLPS-Maf-3222 | Macaca fascicularis | 81.43 | 3e-117 | 345 |
| LLPS-Gog-4705 | Gorilla gorilla | 81.43 | 2e-117 | 345 |
| LLPS-Orc-1502 | Oryctolagus cuniculus | 81.32 | 1e-07 | 55.1 |
| LLPS-Poa-0361 | Pongo abelii | 81.07 | 2e-116 | 343 |
| LLPS-Rhb-1512 | Rhinopithecus bieti | 80.71 | 2e-118 | 348 |
| LLPS-Mal-0806 | Mandrillus leucophaeus | 79.86 | 1e-115 | 341 |
| LLPS-Paa-2299 | Papio anubis | 79.86 | 1e-115 | 341 |
| LLPS-Hos-0987 | Homo sapiens | 79.51 | 1e-115 | 341 |
| LLPS-Mam-1994 | Macaca mulatta | 79.51 | 6e-115 | 339 |
| LLPS-Caj-2905 | Callithrix jacchus | 78.75 | 2e-111 | 330 |
| LLPS-Fud-3397 | Fukomys damarensis | 77.78 | 9e-97 | 291 |
| LLPS-Aon-0858 | Aotus nancymaae | 77.7 | 1e-107 | 321 |
| LLPS-Loa-4556 | Loxodonta africana | 77.42 | 1e-111 | 330 |
| LLPS-Mea-4219 | Mesocricetus auratus | 76.43 | 2e-108 | 322 |
| LLPS-Otg-3063 | Otolemur garnettii | 76.34 | 3e-103 | 309 |
| LLPS-Mum-3694 | Mus musculus | 75.89 | 3e-111 | 330 |
| LLPS-Nol-1613 | Nomascus leucogenys | 75.27 | 1e-99 | 300 |
| LLPS-Ran-4547 | Rattus norvegicus | 75.27 | 3e-62 | 201 |
| LLPS-Urm-1277 | Ursus maritimus | 74.73 | 1e-94 | 286 |
| LLPS-Mod-3445 | Monodelphis domestica | 71.22 | 1e-84 | 262 |
| LLPS-Sah-0803 | Sarcophilus harrisii | 69.53 | 1e-79 | 249 |
| LLPS-Tar-0789 | Takifugu rubripes | 63.41 | 3e-09 | 58.5 |
| LLPS-Ten-3353 | Tetraodon nigroviridis | 58.82 | 4e-15 | 75.9 |
| LLPS-Ora-2963 | Ornithorhynchus anatinus | 55.05 | 2e-51 | 175 |
| LLPS-Lac-3920 | Latimeria chalumnae | 46.22 | 1e-41 | 150 |
| LLPS-Xet-0510 | Xenopus tropicalis | 44.44 | 2e-14 | 73.6 |
| LLPS-Leo-0530 | Lepisosteus oculatus | 40.54 | 2e-24 | 104 |
| LLPS-Dar-2674 | Danio rerio | 39.38 | 4e-22 | 97.4 |
| LLPS-Pof-4063 | Poecilia formosa | 38.5 | 5e-21 | 94.4 |
| LLPS-Icp-3819 | Ictalurus punctatus | 38.2 | 6e-21 | 94.0 |
| LLPS-Scm-3107 | Scophthalmus maximus | 37.5 | 5e-17 | 82.8 |
| LLPS-Xim-2747 | Xiphophorus maculatus | 36.45 | 8e-23 | 100 |
| LLPS-Asm-2722 | Astyanax mexicanus | 36.41 | 9e-19 | 87.8 |
| LLPS-Orn-0817 | Oreochromis niloticus | 36.32 | 4e-25 | 106 |
| LLPS-Scf-4183 | Scleropages formosus | 35.14 | 7e-18 | 85.1 |
| LLPS-Gaa-3817 | Gasterosteus aculeatus | 34.63 | 1e-17 | 84.7 |
| LLPS-Orl-1646 | Oryzias latipes | 34.59 | 2e-16 | 80.9 |
| LLPS-Gaga-3049 | Gallus gallus | 30.2 | 8e-09 | 59.7 |