LLPS-Fec-4789
HAX1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | HCLS1-associated protein X-1; HS1-associating protein X-1 |
| Gene Name: | HAX1 |
| Ensembl Gene: | ENSFCAG00000031262.3 |
| Ensembl Protein: | ENSFCAP00000038969.2 |
| Organism: | Felis catus |
| Taxa ID: | 9685 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFCAT00000043410.2 | ENSFCAP00000038969.2 |
| UniProt | A0A2I2V2F4, A0A2I2V2F4_FELCA | |
| GeneBank | AANG04002876 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSLFDLFRGF FGLSPPRSHR DPFFGGMTRD EDEDDEEEEE EGATWGRGSS RFEGPQPPEE 60 61 FGFGFSFSPG GGMRFHENFG FDYLIQDFNN IFSEMGAWTL PSRPPELPGP GPESEIPGER 120 121 RQEGQTLRDS MLKYPDSHQP RIFGGGLESD ARSESPKPAP DWGSQRPFGL FDDLWPMPPH 180 181 SRAREDNDLD SQVSQEGLGP VLQPQPKSYF KSVSVTKITK PDGTVEERRT VVDSEGRTET 240 241 TVTHQEADGG PRDDPESPAP PALDDTYSIL DLFLGRWFRP R 281 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCCTCT TTGATCTCTT TCGGGGCTTT TTCGGCCTTT CTCCACCTCG GAGCCACAGA 60 61 GACCCCTTTT TTGGAGGGAT GACACGAGAT GAAGATGAGG ATGATGAAGA AGAGGAAGAA 120 121 GAAGGAGCCA CGTGGGGCCG TGGGAGCTCG AGGTTTGAGG GTCCGCAGCC CCCGGAGGAA 180 181 TTTGGCTTCG GCTTCAGCTT CAGCCCGGGA GGAGGGATGC GTTTCCATGA GAACTTCGGC 240 241 TTTGATTACC TAATACAGGA TTTTAACAAC ATCTTCAGCG AGATGGGGGC CTGGACCTTG 300 301 CCTTCCCGCC CTCCTGAACT TCCTGGTCCT GGTCCTGAGT CAGAGATACC TGGTGAGAGA 360 361 CGGCAGGAGG GACAGACTCT CCGGGACTCA ATGCTTAAGT ATCCAGATAG TCACCAGCCC 420 421 AGGATCTTTG GGGGGGGCTT GGAGAGTGAT GCAAGAAGTG AATCCCCCAA ACCAGCGCCG 480 481 GACTGGGGCT CCCAGAGGCC ATTTGGTCTG TTTGATGATT TGTGGCCTAT GCCCCCCCAT 540 541 TCTAGAGCCA GAGAAGACAA CGATCTTGAT TCCCAGGTTT CCCAGGAGGG CCTCGGTCCA 600 601 GTTCTGCAGC CCCAGCCCAA ATCCTATTTC AAGAGCGTCT CTGTGACCAA GATCACTAAG 660 661 CCAGATGGGA CAGTAGAGGA GCGCCGAACT GTGGTGGACA GCGAGGGCCG GACAGAGACC 720 721 ACAGTAACCC ATCAAGAAGC AGACGGCGGC CCTAGAGATG ATCCAGAATC ACCAGCACCT 780 781 CCAGCCCTGG ATGACACCTA TTCCATCCTG GATTTGTTCT TAGGACGCTG GTTCCGGCCC 840 841 CGGTAG 846 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Actin cytoskeleton | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Lamellipodium | |
Cellular Component | Mitochondrial intermembrane space | |
Cellular Component | Mitochondrial outer membrane | |
Cellular Component | Nuclear membrane | |
Cellular Component | Sarcoplasmic reticulum | |
Cellular Component | Transcription factor complex | |
Molecular Function | Interleukin-1 binding | |
Molecular Function | Protein N-terminus binding | |
Biological Process | Cellular response to cytokine stimulus | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Positive regulation of actin cytoskeleton reorganization | |
Biological Process | Positive regulation of granulocyte differentiation | |
Biological Process | Positive regulation of peptidyl-serine phosphorylation | |
Biological Process | Positive regulation of peptidyl-tyrosine phosphorylation | |
Biological Process | Positive regulation of phosphatidylinositol 3-kinase signaling | |
Biological Process | Positive regulation of protein kinase B signaling | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Regulation of actin filament polymerization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-3170 | Ailuropoda melanoleuca | 90.39 | 4e-130 | 378 |
| LLPS-Caf-3359 | Canis familiaris | 89.32 | 1e-130 | 379 |
| LLPS-Mup-0035 | Mustela putorius furo | 88.6 | 2e-63 | 202 |
| LLPS-Ova-1760 | Ovis aries | 86.83 | 8e-130 | 377 |
| LLPS-Bot-2349 | Bos taurus | 86.12 | 8e-128 | 372 |
| LLPS-Eqc-4179 | Equus caballus | 86.12 | 2e-124 | 368 |
| LLPS-Tut-1296 | Tursiops truncatus | 85.77 | 7e-126 | 367 |
| LLPS-Sus-0254 | Sus scrofa | 84.7 | 2e-123 | 361 |
| LLPS-Myl-2411 | Myotis lucifugus | 82.92 | 3e-119 | 350 |
| LLPS-Orc-1502 | Oryctolagus cuniculus | 82.56 | 3e-14 | 73.2 |
| LLPS-Ict-3761 | Ictidomys tridecemlineatus | 81.57 | 9e-106 | 315 |
| LLPS-Cas-1394 | Carlito syrichta | 81.49 | 4e-118 | 347 |
| LLPS-Ere-0891 | Erinaceus europaeus | 80.49 | 4e-74 | 232 |
| LLPS-Cap-3665 | Cavia porcellus | 80.43 | 2e-111 | 330 |
| LLPS-Pap-4628 | Pan paniscus | 78.72 | 2e-119 | 350 |
| LLPS-Hos-0987 | Homo sapiens | 78.47 | 2e-119 | 351 |
| LLPS-Pat-2748 | Pan troglodytes | 78.37 | 1e-118 | 348 |
| LLPS-Cea-1011 | Cercocebus atys | 78.01 | 3e-118 | 348 |
| LLPS-Gog-4705 | Gorilla gorilla | 78.01 | 5e-118 | 347 |
| LLPS-Man-4052 | Macaca nemestrina | 78.01 | 3e-118 | 348 |
| LLPS-Poa-0361 | Pongo abelii | 78.01 | 5e-118 | 347 |
| LLPS-Paa-2299 | Papio anubis | 77.78 | 3e-118 | 348 |
| LLPS-Mal-0806 | Mandrillus leucophaeus | 77.78 | 3e-118 | 348 |
| LLPS-Mam-1994 | Macaca mulatta | 77.78 | 3e-118 | 348 |
| LLPS-Maf-3222 | Macaca fascicularis | 77.66 | 8e-118 | 347 |
| LLPS-Chs-3164 | Chlorocebus sabaeus | 77.66 | 2e-117 | 345 |
| LLPS-Rhb-1512 | Rhinopithecus bieti | 77.66 | 8e-119 | 349 |
| LLPS-Urm-1277 | Ursus maritimus | 77.22 | 1e-113 | 334 |
| LLPS-Caj-2905 | Callithrix jacchus | 75.26 | 1e-113 | 336 |
| LLPS-Loa-4556 | Loxodonta africana | 75.09 | 1e-112 | 333 |
| LLPS-Otg-3063 | Otolemur garnettii | 74.91 | 7e-110 | 326 |
| LLPS-Dio-2629 | Dipodomys ordii | 74.89 | 2e-77 | 241 |
| LLPS-Mea-4219 | Mesocricetus auratus | 74.06 | 1e-97 | 295 |
| LLPS-Aon-0858 | Aotus nancymaae | 73.52 | 8e-113 | 334 |
| LLPS-Fud-3397 | Fukomys damarensis | 72.73 | 1e-92 | 280 |
| LLPS-Nol-1613 | Nomascus leucogenys | 71.93 | 1e-101 | 305 |
| LLPS-Mum-3694 | Mus musculus | 71.48 | 8e-107 | 318 |
| LLPS-Mod-3445 | Monodelphis domestica | 68.46 | 1e-91 | 280 |
| LLPS-Ran-4547 | Rattus norvegicus | 68.09 | 6e-50 | 169 |
| LLPS-Sah-0803 | Sarcophilus harrisii | 67.14 | 2e-90 | 276 |
| LLPS-Tar-0789 | Takifugu rubripes | 62.5 | 2e-10 | 61.6 |
| LLPS-Gaga-3049 | Gallus gallus | 58.0 | 4e-08 | 57.4 |
| LLPS-Ora-2963 | Ornithorhynchus anatinus | 56.34 | 2e-50 | 173 |
| LLPS-Ten-3353 | Tetraodon nigroviridis | 54.67 | 8e-16 | 78.2 |
| LLPS-Lac-3920 | Latimeria chalumnae | 46.48 | 1e-41 | 150 |
| LLPS-Pof-4063 | Poecilia formosa | 38.81 | 6e-23 | 100 |
| LLPS-Scm-3107 | Scophthalmus maximus | 38.34 | 3e-21 | 95.1 |
| LLPS-Xet-0510 | Xenopus tropicalis | 37.78 | 1e-17 | 82.8 |
| LLPS-Xim-2747 | Xiphophorus maculatus | 37.28 | 8e-25 | 106 |
| LLPS-Orl-1646 | Oryzias latipes | 35.98 | 3e-18 | 85.9 |
| LLPS-Leo-0530 | Lepisosteus oculatus | 35.83 | 4e-26 | 108 |
| LLPS-Asm-2722 | Astyanax mexicanus | 34.64 | 1e-19 | 90.5 |
| LLPS-Dar-2674 | Danio rerio | 34.58 | 3e-26 | 109 |
| LLPS-Scf-4183 | Scleropages formosus | 34.28 | 3e-21 | 95.1 |
| LLPS-Icp-3819 | Ictalurus punctatus | 34.22 | 2e-23 | 101 |
| LLPS-Gaa-3817 | Gasterosteus aculeatus | 34.22 | 1e-20 | 93.6 |
| LLPS-Orn-0817 | Oreochromis niloticus | 33.23 | 2e-24 | 104 |