LLPS-Ors-1251
RRP46
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Exosome complex exonuclease RRP46 homolog; Exosome component 5; Ribosomal RNA-processing protein 46; oRrp46 |
| Gene Name: | RRP46, Os03g0854200, LOC_Os03g63720 |
| Ensembl Gene: | Os03g0854200 |
| Ensembl Protein: | Os03t0854200-01 |
| Organism: | Oryza sativa |
| Taxa ID: | 39947 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. May form a homodimer separately from exosome complexes and function in DNA cleavage process. Binds double-stranded DNA (dsDNA) and single-stranded RNA (ssRNA), and possesses hydrolytic DNase and phosphorolytic RNase activities in vitro. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Os03t0854200-01 | Os03t0854200-01 |
| UniProt | Q84T68, EXOS5_ORYSJ, A0A0P0W6B3 | |
| GeneBank | AP008209, AC120506, AK069107, AP014959, DP000009 | ABF99960.1, BAS87423.1, BAG91256.1, BAF13850.1, AAO66540.2 |
| RefSeq | XM_015774938.1 | XP_015630424.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEESRADGRN PNQLRPFSCT RNPLDRAHGS ARWAQGDTIV LAAVYGPKPG TRKGENPEKA 60 61 SIEVVWKPMT GQIGKQEKEY EMTLKRTLQS ICLLTVHPNT TTSVILQVVG NDGSLLPCAI 120 121 NACCAALVFA GIPLKHLAVA IGCGVLEDGE VILDTNKAEE QQLKSFAHLV FPNSRKSASS 180 181 KEPNQKEEDS ERGLITSITH GVMSEEDYFS CIERGLAASS RISDFMRTTL QKQAPGDV 238 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGAGA GCCGCGCGGA CGGGCGGAAC CCGAACCAGC TCCGCCCCTT CTCCTGCACA 60 61 CGCAACCCTC TCGACCGCGC CCATGGCTCC GCGCGGTGGG CTCAGGGGGA CACCATCGTG 120 121 CTCGCCGCCG TGTACGGGCC AAAGCCGGGA ACCAGGAAGG GGGAGAATCC CGAGAAGGCA 180 181 TCCATTGAGG TCGTCTGGAA GCCCATGACC GGCCAGATTG GGAAGCAAGA GAAGGAGTAT 240 241 GAGATGACGC TCAAGAGGAC ATTGCAGAGC ATTTGCCTGC TCACTGTTCA TCCAAACACC 300 301 ACCACCTCTG TCATTCTTCA GGTTGTGGGC AATGATGGTT CTCTTCTTCC ATGTGCAATT 360 361 AATGCTTGCT GCGCAGCCCT TGTTTTTGCT GGCATCCCCT TGAAACATCT TGCAGTTGCA 420 421 ATTGGTTGTG GAGTACTGGA GGATGGTGAA GTGATTTTGG ACACAAACAA AGCAGAAGAG 480 481 CAGCAATTGA AATCATTTGC TCATTTGGTG TTCCCCAATT CACGCAAGTC TGCTAGTTCA 540 541 AAAGAACCAA ACCAGAAAGA GGAGGATTCT GAGAGAGGAT TGATAACTTC CATTACCCAT 600 601 GGAGTGATGT CCGAGGAAGA TTATTTCAGC TGCATAGAGA GGGGCCTTGC TGCATCGTCA 660 661 CGGATCTCGG ATTTTATGAG GACAACATTG CAGAAGCAGG CACCTGGAGA TGTCTGA 717 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic exosome (RNase complex) | |
Cellular Component | Nuclear exosome (RNase complex) | |
Cellular Component | Nucleolus | |
Molecular Function | Deoxyribonuclease activity | |
Molecular Function | Double-stranded DNA binding | |
Molecular Function | Exonuclease activity | |
Molecular Function | Identical protein binding | |
Molecular Function | Ribonuclease activity | |
Molecular Function | Single-stranded RNA binding | |
Biological Process | Nuclear mRNA surveillance | |
Biological Process | Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' | |
Biological Process | Polyadenylation-dependent snoRNA 3'-end processing | |
Biological Process | RRNA catabolic process | |
Biological Process | RRNA processing | |
Biological Process | U4 snRNA 3'-end processing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orr-0754 | Oryza rufipogon | 100.0 | 4e-178 | 496 |
| LLPS-Orni-1712 | Oryza nivara | 100.0 | 4e-178 | 496 |
| LLPS-Orb-0413 | Oryza barthii | 100.0 | 4e-178 | 496 |
| LLPS-Org-0282 | Oryza glaberrima | 99.58 | 1e-177 | 495 |
| LLPS-Ori-0316 | Oryza indica | 99.58 | 5e-177 | 493 |
| LLPS-Orp-1253 | Oryza punctata | 98.73 | 5e-175 | 489 |
| LLPS-Orgl-0960 | Oryza glumaepatula | 97.54 | 3e-175 | 489 |
| LLPS-Lep-0517 | Leersia perrieri | 97.06 | 9e-173 | 483 |
| LLPS-Orbr-1272 | Oryza brachyantha | 96.22 | 4e-171 | 478 |
| LLPS-Brd-0904 | Brachypodium distachyon | 87.66 | 3e-153 | 433 |
| LLPS-Tra-1655 | Triticum aestivum | 84.68 | 7e-149 | 422 |
| LLPS-Sob-0166 | Sorghum bicolor | 84.62 | 2e-149 | 423 |
| LLPS-Sei-1104 | Setaria italica | 84.26 | 1e-148 | 421 |
| LLPS-Tru-1956 | Triticum urartu | 82.35 | 3e-54 | 176 |
| LLPS-Viv-0530 | Vitis vinifera | 67.23 | 2e-105 | 312 |
| LLPS-Pot-0766 | Populus trichocarpa | 66.81 | 2e-111 | 327 |
| LLPS-Sol-1134 | Solanum lycopersicum | 66.81 | 1e-108 | 320 |
| LLPS-Thc-0867 | Theobroma cacao | 66.67 | 8e-111 | 325 |
| LLPS-Mae-0140 | Manihot esculenta | 66.39 | 2e-108 | 320 |
| LLPS-Gor-0278 | Gossypium raimondii | 66.1 | 8e-108 | 318 |
| LLPS-Nia-0132 | Nicotiana attenuata | 65.97 | 5e-112 | 328 |
| LLPS-Prp-0806 | Prunus persica | 65.55 | 5e-109 | 321 |
| LLPS-Sot-0380 | Solanum tuberosum | 65.55 | 3e-110 | 324 |
| LLPS-Bro-0929 | Brassica oleracea | 65.09 | 2e-107 | 317 |
| LLPS-Coc-0186 | Corchorus capsularis | 64.66 | 5e-100 | 298 |
| LLPS-Cus-0445 | Cucumis sativus | 64.41 | 3e-105 | 311 |
| LLPS-Amt-0689 | Amborella trichopoda | 64.36 | 1e-86 | 263 |
| LLPS-Art-0491 | Arabidopsis thaliana | 64.26 | 1e-105 | 312 |
| LLPS-Brn-0644 | Brassica napus | 64.22 | 7e-106 | 313 |
| LLPS-Arl-0653 | Arabidopsis lyrata | 63.95 | 6e-105 | 310 |
| LLPS-Glm-1801 | Glycine max | 63.79 | 4e-102 | 303 |
| LLPS-Hea-0555 | Helianthus annuus | 63.75 | 2e-107 | 317 |
| LLPS-Via-0541 | Vigna angularis | 62.98 | 2e-85 | 260 |
| LLPS-Dac-1833 | Daucus carota | 62.7 | 8e-101 | 301 |
| LLPS-Phv-0158 | Phaseolus vulgaris | 62.44 | 2e-86 | 262 |
| LLPS-Met-0040 | Medicago truncatula | 61.04 | 5e-102 | 303 |
| LLPS-Mua-0497 | Musa acuminata | 59.52 | 3e-44 | 151 |
| LLPS-Vir-1751 | Vigna radiata | 58.23 | 4e-88 | 268 |
| LLPS-Zem-0313 | Zea mays | 57.23 | 3e-111 | 328 |
| LLPS-Brr-1517 | Brassica rapa | 56.25 | 4e-95 | 286 |
| LLPS-Php-0973 | Physcomitrella patens | 51.71 | 9e-73 | 229 |
| LLPS-Aon-1148 | Aotus nancymaae | 43.93 | 2e-19 | 87.4 |
| LLPS-Gaga-3012 | Gallus gallus | 41.07 | 4e-32 | 127 |
| LLPS-Chr-0159 | Chlamydomonas reinhardtii | 40.0 | 8e-29 | 114 |
| LLPS-Gog-1515 | Gorilla gorilla | 36.36 | 1e-36 | 134 |
| LLPS-Mup-0311 | Mustela putorius furo | 36.28 | 2e-37 | 137 |
| LLPS-Caj-2896 | Callithrix jacchus | 36.28 | 7e-37 | 135 |
| LLPS-Urm-0110 | Ursus maritimus | 36.08 | 1e-34 | 129 |
| LLPS-Loa-1158 | Loxodonta africana | 35.91 | 6e-34 | 127 |
| LLPS-Aim-0148 | Ailuropoda melanoleuca | 35.91 | 1e-36 | 135 |
| LLPS-Dio-1375 | Dipodomys ordii | 35.91 | 2e-34 | 129 |
| LLPS-Cae-1763 | Caenorhabditis elegans | 35.88 | 7e-17 | 80.9 |
| LLPS-Mam-0457 | Macaca mulatta | 35.84 | 2e-36 | 134 |
| LLPS-Caf-0346 | Canis familiaris | 35.84 | 3e-36 | 134 |
| LLPS-Rhb-0079 | Rhinopithecus bieti | 35.84 | 3e-36 | 134 |
| LLPS-Man-0710 | Macaca nemestrina | 35.84 | 2e-36 | 135 |
| LLPS-Hos-1431 | Homo sapiens | 35.84 | 9e-37 | 135 |
| LLPS-Pat-1231 | Pan troglodytes | 35.84 | 2e-36 | 134 |
| LLPS-Pap-0509 | Pan paniscus | 35.84 | 2e-36 | 134 |
| LLPS-Mal-0943 | Mandrillus leucophaeus | 35.84 | 2e-36 | 134 |
| LLPS-Paa-1638 | Papio anubis | 35.84 | 2e-36 | 134 |
| LLPS-Cea-1033 | Cercocebus atys | 35.84 | 2e-36 | 134 |
| LLPS-Chs-1652 | Chlorocebus sabaeus | 35.84 | 5e-37 | 136 |
| LLPS-Maf-1135 | Macaca fascicularis | 35.84 | 2e-36 | 135 |
| LLPS-Sus-0300 | Sus scrofa | 35.5 | 4e-34 | 128 |
| LLPS-Cap-0210 | Cavia porcellus | 35.45 | 7e-38 | 138 |
| LLPS-Mod-1551 | Monodelphis domestica | 35.45 | 2e-38 | 139 |
| LLPS-Ran-0713 | Rattus norvegicus | 35.45 | 7e-36 | 132 |
| LLPS-Bot-0220 | Bos taurus | 35.45 | 8e-40 | 143 |
| LLPS-Mum-0444 | Mus musculus | 35.45 | 6e-36 | 133 |
| LLPS-Zyt-0004 | Zymoseptoria tritici | 35.44 | 4e-19 | 87.0 |
| LLPS-Nol-0860 | Nomascus leucogenys | 35.4 | 3e-35 | 131 |
| LLPS-Eqc-0049 | Equus caballus | 35.4 | 2e-36 | 134 |
| LLPS-Otg-1986 | Otolemur garnettii | 35.4 | 4e-36 | 133 |
| LLPS-Ova-1886 | Ovis aries | 35.4 | 5e-40 | 144 |
| LLPS-Tut-0256 | Tursiops truncatus | 35.4 | 2e-35 | 131 |
| LLPS-Fud-0031 | Fukomys damarensis | 35.4 | 7e-39 | 140 |
| LLPS-Gas-0267 | Galdieria sulphuraria | 35.19 | 2e-24 | 102 |
| LLPS-Ict-0544 | Ictidomys tridecemlineatus | 35.0 | 3e-35 | 131 |
| LLPS-Fec-1502 | Felis catus | 34.96 | 2e-35 | 132 |
| LLPS-Cas-0418 | Carlito syrichta | 34.51 | 2e-34 | 129 |
| LLPS-Poa-0563 | Pongo abelii | 34.34 | 2e-28 | 112 |
| LLPS-Anc-0657 | Anolis carolinensis | 34.29 | 5e-30 | 117 |
| LLPS-Asf-0314 | Aspergillus flavus | 34.23 | 5e-13 | 70.1 |
| LLPS-Aso-0462 | Aspergillus oryzae | 34.23 | 5e-13 | 70.1 |
| LLPS-Xet-2091 | Xenopus tropicalis | 34.09 | 8e-35 | 130 |
| LLPS-Tar-0941 | Takifugu rubripes | 34.09 | 2e-35 | 131 |
| LLPS-Orc-0341 | Oryctolagus cuniculus | 34.05 | 9e-38 | 138 |
| LLPS-Dos-0154 | Dothistroma septosporum | 34.04 | 4e-16 | 78.6 |
| LLPS-Asm-1358 | Astyanax mexicanus | 33.64 | 4e-34 | 127 |
| LLPS-Orl-0967 | Oryzias latipes | 33.64 | 1e-34 | 129 |
| LLPS-Ast-0192 | Aspergillus terreus | 33.56 | 1e-13 | 72.0 |
| LLPS-Mea-0616 | Mesocricetus auratus | 33.33 | 1e-27 | 111 |
| LLPS-Dar-0568 | Danio rerio | 33.18 | 5e-34 | 127 |
| LLPS-Myl-1118 | Myotis lucifugus | 33.18 | 2e-33 | 126 |
| LLPS-Pof-1664 | Poecilia formosa | 33.03 | 8e-31 | 119 |
| LLPS-Kop-0954 | Komagataella pastoris | 32.79 | 1e-18 | 85.9 |
| LLPS-Xim-0182 | Xiphophorus maculatus | 32.73 | 5e-33 | 127 |
| LLPS-Lac-0671 | Latimeria chalumnae | 32.68 | 4e-21 | 92.4 |
| LLPS-Orn-1709 | Oreochromis niloticus | 32.27 | 7e-35 | 130 |
| LLPS-Scm-0693 | Scophthalmus maximus | 32.27 | 8e-35 | 130 |
| LLPS-Gaa-1432 | Gasterosteus aculeatus | 32.27 | 5e-33 | 124 |
| LLPS-Icp-1450 | Ictalurus punctatus | 32.27 | 6e-31 | 119 |
| LLPS-Ten-1864 | Tetraodon nigroviridis | 32.0 | 8e-27 | 108 |
| LLPS-Coo-0601 | Colletotrichum orbiculare | 31.93 | 1e-16 | 80.1 |
| LLPS-Tag-1038 | Taeniopygia guttata | 31.82 | 6e-28 | 110 |
| LLPS-Cii-0140 | Ciona intestinalis | 31.47 | 2e-27 | 110 |
| LLPS-Yal-0069 | Yarrowia lipolytica | 31.36 | 5e-15 | 75.9 |
| LLPS-Fia-0123 | Ficedula albicollis | 31.31 | 1e-29 | 115 |
| LLPS-Pytr-0102 | Pyrenophora triticirepentis | 31.29 | 4e-15 | 75.9 |
| LLPS-Scf-1513 | Scleropages formosus | 30.91 | 2e-34 | 129 |
| LLPS-Abg-0484 | Absidia glauca | 30.87 | 2e-30 | 118 |
| LLPS-Beb-0441 | Beauveria bassiana | 30.77 | 4e-12 | 67.8 |
| LLPS-Scj-0332 | Schizosaccharomyces japonicus | 30.77 | 7e-14 | 72.4 |
| LLPS-Pyt-0663 | Pyrenophora teres | 30.61 | 2e-14 | 73.9 |
| LLPS-Cis-0862 | Ciona savignyi | 30.51 | 2e-27 | 110 |
| LLPS-Cogr-0923 | Colletotrichum graminicola | 30.49 | 2e-13 | 71.2 |
| LLPS-Drm-1760 | Drosophila melanogaster | 30.41 | 2e-18 | 85.5 |
| LLPS-Chc-0001 | Chondrus crispus | 30.39 | 7e-20 | 90.1 |
| LLPS-Ved-0434 | Verticillium dahliae | 30.37 | 1e-12 | 69.3 |
| LLPS-Lem-0560 | Leptosphaeria maculans | 29.93 | 3e-12 | 68.6 |
| LLPS-Spr-0143 | Sporisorium reilianum | 29.73 | 3e-15 | 76.6 |
| LLPS-Usm-0370 | Ustilago maydis | 29.73 | 7e-15 | 75.5 |
| LLPS-Scc-0927 | Schizosaccharomyces cryophilus | 29.73 | 3e-17 | 82.0 |
| LLPS-Asg-0221 | Ashbya gossypii | 29.48 | 7e-18 | 84.0 |
| LLPS-Orm-1353 | Oryza meridionalis | 29.25 | 2e-14 | 73.9 |
| LLPS-Ora-0879 | Ornithorhynchus anatinus | 29.11 | 4e-14 | 73.2 |
| LLPS-Phn-0545 | Phaeosphaeria nodorum | 28.89 | 1e-14 | 74.7 |
| LLPS-Sah-1855 | Sarcophilus harrisii | 28.74 | 3e-15 | 76.3 |
| LLPS-Leo-1252 | Lepisosteus oculatus | 28.39 | 1e-13 | 71.6 |
| LLPS-Fus-0124 | Fusarium solani | 28.33 | 4e-12 | 67.8 |
| LLPS-Asn-1124 | Aspergillus nidulans | 28.33 | 8e-14 | 72.4 |
| LLPS-Scp-0896 | Schizosaccharomyces pombe | 28.3 | 9e-14 | 71.6 |
| LLPS-Hov-0514 | Hordeum vulgare | 28.14 | 2e-14 | 73.9 |
| LLPS-Crn-0907 | Cryptococcus neoformans | 26.33 | 1e-15 | 77.8 |
| LLPS-Osl-0641 | Ostreococcus lucimarinus | 26.32 | 5e-20 | 90.5 |
| LLPS-Mel-0374 | Melampsora laricipopulina | 25.77 | 4e-13 | 70.5 |
| LLPS-Nec-0437 | Neurospora crassa | 24.37 | 1e-13 | 71.6 |