LLPS-Ors-0923
BIP1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Heat shock 70 kDa protein BIP1; Luminal-binding protein 1; OsBiP1 |
| Gene Name: | BIP1, BIP, Os02g0115900, LOC_Os02g02410, OJ1442_E05.10, OsJ_05115, P0036E06.29 |
| Ensembl Gene: | Os02g0115900 |
| Ensembl Protein: | Os02t0115900-01 |
| Organism: | Oryza sativa |
| Taxa ID: | 39947 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Key chaperone involved in folding of secretory proteins in the endoplasmic reticulum (ER) lumen (Probable). Involved in ER quality control for seed storage proteins during seed maturation (PubMed:19567376, PubMed:21223397). Functions as a sensor of the ER stress response, and provides suitable conditions for the production of secretory proteins by alleviating ER stress (PubMed:19567376, PubMed:21223397). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Os02t0115900-01 | Os02t0115900-01 |
| Ensembl | Os02t0115900-02 | Os02t0115900-02 |
| Ensembl | Os02t0115900-03 | Os02t0115900-03 |
| UniProt | Q6Z7B0, BIP1_ORYSJ, O24182 | |
| GeneBank | CM000139, AP014958, AP004867, AP008208, AP004121, AF006825, EU267978 | AAB63469.1, BAS76651.1, EAZ21491.1, ACA50500.1, BAF07589.1, BAD07713.1, BAD07938.1 |
| RefSeq | XM_015770132.1 | XP_015625618.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDRVRGCAFL LGVLLAGSLF AFSVAKEETK KLGTVIGIDL GTTYSCVGVY KNGHVEIIAN 60 61 DQGNRITPSW VAFTDSERLI GEAAKNQAAV NPERTIFDVK RLIGRKFEDK EVQRDMKLVP 120 121 YKIVNKDGKP YIQVKIKDGE NKVFSPEEVS AMILGKMKET AEAYLGKKIN DAVVTVPAYF 180 181 NDAQRQATKD AGVIAGLNVA RIINEPTAAA IAYGLDKKGG EKNILVFDLG GGTFDVSILT 240 241 IDNGVFEVLA TNGDTHLGGE DFDQRIMEYF IKLIKKKYSK DISKDNRALG KLRREAERAK 300 301 RALSNQHQVR VEIESLFDGT DFSEPLTRAR FEELNNDLFR KTMGPVKKAM DDAGLEKSQI 360 361 HEIVLVGGST RIPKVQQLLR DYFEGKEPNK GVNPDEAVAY GAAVQGSILS GEGGDETKDI 420 421 LLLDVAPLTL GIETVGGVMT KLIPRNTVIP TKKSQVFTTY QDQQTTVSIQ VFEGERSMTK 480 481 DCRLLGKFDL SGIPAAPRGT PQIEVTFEVD ANGILNVKAE DKGTGKSEKI TITNEKGRLS 540 541 QEEIDRMVRE AEEFAEEDKK VKERIDARNQ LETYVYNMKN TVGDKDKLAD KLESEEKEKV 600 601 EEALKEALEW LDENQTAEKE EYEEKLKEVE AVCNPIISAV YQRTGGAPGG GADGEGGVDD 660 661 EHDEL 665 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATCGGG TTCGCGGATG CGCGTTCCTG CTCGGCGTCC TGCTCGCAGG ATCCCTGTTT 60 61 GCATTTTCTG TTGCGAAGGA GGAGACCAAG AAGCTCGGTA CCGTGATCGG TATTGATCTT 120 121 GGTACAACCT ACTCGTGTGT CGGTGTGTAC AAGAATGGTC ATGTCGAGAT TATCGCCAAT 180 181 GACCAGGGTA ACCGTATCAC ACCCTCATGG GTTGCATTCA CCGATAGCGA GAGGCTCATC 240 241 GGTGAGGCTG CCAAGAACCA GGCAGCTGTG AACCCAGAGA GGACCATCTT CGATGTCAAA 300 301 CGTCTCATTG GAAGAAAGTT TGAAGACAAG GAAGTTCAGA GGGACATGAA ACTTGTCCCC 360 361 TACAAGATTG TGAACAAGGA CGGTAAGCCC TACATTCAGG TCAAGATCAA GGATGGAGAG 420 421 AACAAGGTCT TCAGCCCTGA GGAGGTCAGT GCTATGATCC TTGGAAAGAT GAAGGAGACT 480 481 GCTGAGGCAT ACCTTGGCAA GAAGATCAAC GATGCTGTCG TGACTGTTCC TGCGTACTTC 540 541 AATGACGCGC AGAGGCAGGC AACCAAGGAT GCCGGTGTCA TTGCTGGCCT GAATGTTGCT 600 601 AGGATCATCA ATGAGCCAAC TGCTGCTGCT ATTGCGTACG GTTTGGACAA GAAGGGTGGT 660 661 GAGAAGAACA TCCTTGTCTT TGACCTTGGT GGTGGGACAT TCGATGTCAG TATCTTGACC 720 721 ATTGACAACG GTGTGTTTGA GGTGTTGGCC ACCAATGGTG ACACTCATCT TGGAGGTGAG 780 781 GACTTTGACC AGAGAATCAT GGAGTACTTC ATCAAGTTGA TCAAGAAGAA GTACAGCAAG 840 841 GACATCAGCA AGGACAACCG TGCTCTTGGA AAGCTGAGGA GGGAAGCTGA GCGTGCCAAG 900 901 AGGGCCCTCA GCAACCAGCA CCAGGTCCGT GTTGAGATTG AGTCCCTCTT TGACGGGACC 960 961 GATTTCTCGG AGCCGCTGAC CCGTGCCAGA TTTGAGGAGT TGAACAATGA TCTGTTCCGC 1020 1021 AAGACCATGG GACCTGTCAA GAAGGCTATG GACGATGCTG GCCTTGAGAA GAGCCAGATT 1080 1081 CATGAGATTG TTCTTGTCGG TGGTAGCACC AGGATTCCCA AGGTTCAGCA GCTCCTCAGA 1140 1141 GACTACTTCG AGGGCAAGGA GCCCAACAAG GGTGTCAACC CTGATGAGGC TGTTGCCTAT 1200 1201 GGTGCTGCGG TTCAGGGAAG CATTCTCAGC GGCGAGGGCG GTGACGAAAC CAAAGATATC 1260 1261 CTTCTCCTGG ATGTGGCACC CCTTACCCTC GGTATCGAGA CTGTCGGTGG AGTCATGACC 1320 1321 AAGTTGATCC CCAGGAACAC CGTCATCCCC ACCAAGAAGT CCCAGGTGTT CACCACCTAC 1380 1381 CAGGATCAGC AGACAACCGT CTCCATCCAG GTCTTTGAGG GTGAGCGCAG CATGACCAAG 1440 1441 GACTGCCGTC TTCTCGGCAA GTTCGACCTA TCTGGCATTC CAGCAGCACC AAGGGGCACC 1500 1501 CCCCAGATTG AGGTGACCTT CGAGGTGGAC GCCAACGGCA TCCTGAACGT GAAGGCTGAG 1560 1561 GACAAGGGCA CCGGCAAGTC GGAGAAGATC ACGATCACGA ACGAGAAGGG GCGCCTGAGC 1620 1621 CAGGAGGAGA TCGACCGGAT GGTGCGCGAG GCGGAGGAGT TTGCGGAGGA GGACAAGAAG 1680 1681 GTGAAGGAGC GGATCGACGC CCGCAACCAG CTCGAGACCT ACGTGTACAA CATGAAGAAC 1740 1741 ACCGTCGGCG ACAAGGACAA GCTGGCGGAC AAGCTGGAGA GCGAGGAGAA GGAGAAGGTG 1800 1801 GAGGAGGCCC TCAAGGAGGC CCTCGAGTGG CTGGACGAGA ACCAGACCGC CGAGAAGGAG 1860 1861 GAGTACGAGG AGAAGCTCAA GGAGGTCGAG GCCGTCTGCA ACCCCATCAT CTCCGCCGTC 1920 1921 TACCAGAGGA CCGGTGGCGC CCCGGGTGGC GGCGCCGACG GCGAGGGCGG CGTCGACGAC 1980 1981 GAGCATGACG AGCTGTAG 1998 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Endoplasmic reticulum chaperone complex | |
Cellular Component | Endoplasmic reticulum lumen | |
Cellular Component | Membrane | |
Cellular Component | Nucleus | |
Cellular Component | Plant-type vacuole membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity | |
Molecular Function | ATPase activity, coupled | |
Molecular Function | Heat shock protein binding | |
Molecular Function | Misfolded protein binding | |
Molecular Function | Protein folding chaperone | |
Molecular Function | Unfolded protein binding | |
Biological Process | Cellular response to heat | |
Biological Process | Cellular response to unfolded protein | |
Biological Process | Chaperone cofactor-dependent protein refolding | |
Biological Process | Endoplasmic reticulum unfolded protein response | |
Biological Process | Protein folding in endoplasmic reticulum | |
Biological Process | Protein refolding | |
Biological Process | Response to unfolded protein | |
Biological Process | Ubiquitin-dependent ERAD pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Org-0958 | Oryza glaberrima | 100.0 | 0.0 | 1156 |
| LLPS-Orm-1109 | Oryza meridionalis | 100.0 | 0.0 | 1156 |
| LLPS-Orr-1968 | Oryza rufipogon | 100.0 | 0.0 | 1156 |
| LLPS-Orgl-0486 | Oryza glumaepatula | 100.0 | 0.0 | 1156 |
| LLPS-Orni-0512 | Oryza nivara | 100.0 | 0.0 | 1156 |
| LLPS-Orb-0598 | Oryza barthii | 100.0 | 0.0 | 1156 |
| LLPS-Ori-0672 | Oryza indica | 100.0 | 0.0 | 1156 |
| LLPS-Orp-1090 | Oryza punctata | 99.84 | 0.0 | 1153 |
| LLPS-Lep-0278 | Leersia perrieri | 98.76 | 0.0 | 1143 |
| LLPS-Sob-2131 | Sorghum bicolor | 98.31 | 0.0 | 1118 |
| LLPS-Orbr-0819 | Oryza brachyantha | 98.14 | 0.0 | 1141 |
| LLPS-Brd-0012 | Brachypodium distachyon | 97.52 | 0.0 | 1103 |
| LLPS-Sei-0902 | Setaria italica | 97.36 | 0.0 | 1130 |
| LLPS-Zem-0077 | Zea mays | 97.2 | 0.0 | 1136 |
| LLPS-Tra-0654 | Triticum aestivum | 96.12 | 0.0 | 1088 |
| LLPS-Tru-1026 | Triticum urartu | 95.96 | 0.0 | 1086 |
| LLPS-Phv-1238 | Phaseolus vulgaris | 93.24 | 0.0 | 1075 |
| LLPS-Mua-0203 | Musa acuminata | 93.14 | 0.0 | 1084 |
| LLPS-Via-1059 | Vigna angularis | 93.08 | 0.0 | 1075 |
| LLPS-Glm-2508 | Glycine max | 92.97 | 0.0 | 1081 |
| LLPS-Mae-0910 | Manihot esculenta | 92.21 | 0.0 | 1070 |
| LLPS-Arl-2678 | Arabidopsis lyrata | 92.13 | 0.0 | 1065 |
| LLPS-Hea-1266 | Helianthus annuus | 92.03 | 0.0 | 1049 |
| LLPS-Bro-1604 | Brassica oleracea | 91.97 | 0.0 | 1065 |
| LLPS-Prp-0027 | Prunus persica | 91.9 | 0.0 | 1073 |
| LLPS-Art-1405 | Arabidopsis thaliana | 91.9 | 0.0 | 1055 |
| LLPS-Cus-0312 | Cucumis sativus | 91.9 | 0.0 | 1079 |
| LLPS-Nia-0007 | Nicotiana attenuata | 91.89 | 0.0 | 1065 |
| LLPS-Gor-1333 | Gossypium raimondii | 91.74 | 0.0 | 1073 |
| LLPS-Thc-0198 | Theobroma cacao | 91.74 | 0.0 | 1072 |
| LLPS-Met-0071 | Medicago truncatula | 91.71 | 0.0 | 1054 |
| LLPS-Pot-0915 | Populus trichocarpa | 91.43 | 0.0 | 1065 |
| LLPS-Brr-0942 | Brassica rapa | 91.34 | 0.0 | 1056 |
| LLPS-Coc-0528 | Corchorus capsularis | 91.28 | 0.0 | 1068 |
| LLPS-Viv-1412 | Vitis vinifera | 91.28 | 0.0 | 1061 |
| LLPS-Sot-1340 | Solanum tuberosum | 90.47 | 0.0 | 1057 |
| LLPS-Sol-0215 | Solanum lycopersicum | 90.31 | 0.0 | 1058 |
| LLPS-Brn-1201 | Brassica napus | 90.11 | 0.0 | 1040 |
| LLPS-Dac-0841 | Daucus carota | 87.56 | 0.0 | 996 |
| LLPS-Amt-1551 | Amborella trichopoda | 87.32 | 0.0 | 1006 |
| LLPS-Php-1011 | Physcomitrella patens | 87.3 | 0.0 | 1024 |
| LLPS-Sem-2037 | Selaginella moellendorffii | 86.56 | 0.0 | 998 |
| LLPS-Chr-0978 | Chlamydomonas reinhardtii | 82.08 | 0.0 | 900 |
| LLPS-Hov-1127 | Hordeum vulgare | 80.59 | 0.0 | 910 |
| LLPS-Osl-0295 | Ostreococcus lucimarinus | 80.35 | 0.0 | 899 |
| LLPS-Tag-2254 | Taeniopygia guttata | 73.54 | 0.0 | 810 |
| LLPS-Tut-1066 | Tursiops truncatus | 73.5 | 0.0 | 808 |
| LLPS-Fia-1571 | Ficedula albicollis | 73.4 | 0.0 | 810 |
| LLPS-Xet-2451 | Xenopus tropicalis | 72.56 | 0.0 | 811 |
| LLPS-Drm-0842 | Drosophila melanogaster | 72.22 | 0.0 | 816 |
| LLPS-Lac-3426 | Latimeria chalumnae | 71.61 | 0.0 | 813 |
| LLPS-Otg-3831 | Otolemur garnettii | 71.52 | 0.0 | 810 |
| LLPS-Mod-1244 | Monodelphis domestica | 71.52 | 0.0 | 806 |
| LLPS-Myl-3612 | Myotis lucifugus | 71.52 | 0.0 | 813 |
| LLPS-Ora-0768 | Ornithorhynchus anatinus | 71.52 | 0.0 | 812 |
| LLPS-Mum-0261 | Mus musculus | 71.45 | 0.0 | 815 |
| LLPS-Loa-0752 | Loxodonta africana | 71.41 | 0.0 | 813 |
| LLPS-Trv-1559 | Trichoderma virens | 71.4 | 0.0 | 781 |
| LLPS-Caf-1606 | Canis familiaris | 71.29 | 0.0 | 813 |
| LLPS-Ran-3206 | Rattus norvegicus | 71.29 | 0.0 | 813 |
| LLPS-Mea-0724 | Mesocricetus auratus | 71.29 | 0.0 | 813 |
| LLPS-Mam-0397 | Macaca mulatta | 71.24 | 0.0 | 811 |
| LLPS-Poa-1791 | Pongo abelii | 71.24 | 0.0 | 811 |
| LLPS-Man-0532 | Macaca nemestrina | 71.24 | 0.0 | 811 |
| LLPS-Pat-3099 | Pan troglodytes | 71.24 | 0.0 | 811 |
| LLPS-Urm-0428 | Ursus maritimus | 71.24 | 0.0 | 811 |
| LLPS-Pap-1942 | Pan paniscus | 71.24 | 0.0 | 811 |
| LLPS-Hos-0375 | Homo sapiens | 71.24 | 0.0 | 811 |
| LLPS-Fec-0789 | Felis catus | 71.24 | 0.0 | 811 |
| LLPS-Mal-1104 | Mandrillus leucophaeus | 71.24 | 0.0 | 811 |
| LLPS-Mup-2741 | Mustela putorius furo | 71.24 | 0.0 | 811 |
| LLPS-Aim-3020 | Ailuropoda melanoleuca | 71.24 | 0.0 | 811 |
| LLPS-Gog-2076 | Gorilla gorilla | 71.24 | 0.0 | 811 |
| LLPS-Cea-0975 | Cercocebus atys | 71.24 | 0.0 | 811 |
| LLPS-Aon-2439 | Aotus nancymaae | 71.24 | 0.0 | 811 |
| LLPS-Sus-0432 | Sus scrofa | 71.24 | 0.0 | 811 |
| LLPS-Maf-0390 | Macaca fascicularis | 71.24 | 0.0 | 811 |
| LLPS-Chs-0675 | Chlorocebus sabaeus | 71.24 | 0.0 | 811 |
| LLPS-Cas-0070 | Carlito syrichta | 71.2 | 0.0 | 810 |
| LLPS-Cae-1273 | Caenorhabditis elegans | 71.16 | 0.0 | 795 |
| LLPS-Gaga-1387 | Gallus gallus | 71.13 | 0.0 | 812 |
| LLPS-Ova-0891 | Ovis aries | 71.13 | 0.0 | 812 |
| LLPS-Bot-3329 | Bos taurus | 71.13 | 0.0 | 813 |
| LLPS-Sah-3126 | Sarcophilus harrisii | 71.13 | 0.0 | 808 |
| LLPS-Anp-1043 | Anas platyrhynchos | 71.09 | 0.0 | 780 |
| LLPS-Leo-1488 | Lepisosteus oculatus | 71.09 | 0.0 | 815 |
| LLPS-Ict-1593 | Ictidomys tridecemlineatus | 71.08 | 0.0 | 810 |
| LLPS-Cap-1431 | Cavia porcellus | 71.08 | 0.0 | 810 |
| LLPS-Fud-1862 | Fukomys damarensis | 71.08 | 0.0 | 811 |
| LLPS-Cym-0933 | Cyanidioschyzon merolae | 70.82 | 0.0 | 800 |
| LLPS-Pof-2009 | Poecilia formosa | 70.78 | 0.0 | 807 |
| LLPS-Orl-0864 | Oryzias latipes | 70.69 | 0.0 | 812 |
| LLPS-Xim-1086 | Xiphophorus maculatus | 70.62 | 0.0 | 804 |
| LLPS-Nol-2775 | Nomascus leucogenys | 70.6 | 0.0 | 802 |
| LLPS-Dar-1271 | Danio rerio | 70.6 | 0.0 | 819 |
| LLPS-Blg-0194 | Blumeria graminis | 70.56 | 0.0 | 764 |
| LLPS-Chc-0171 | Chondrus crispus | 70.52 | 0.0 | 800 |
| LLPS-Orc-0520 | Oryctolagus cuniculus | 70.44 | 0.0 | 803 |
| LLPS-Cii-0730 | Ciona intestinalis | 70.34 | 0.0 | 784 |
| LLPS-Pes-1097 | Pelodiscus sinensis | 70.18 | 0.0 | 772 |
| LLPS-Scm-1039 | Scophthalmus maximus | 70.16 | 0.0 | 809 |
| LLPS-Gaa-0292 | Gasterosteus aculeatus | 70.08 | 0.0 | 814 |
| LLPS-Tar-1694 | Takifugu rubripes | 70.0 | 0.0 | 808 |
| LLPS-Gas-0365 | Galdieria sulphuraria | 69.97 | 0.0 | 820 |
| LLPS-Asm-1719 | Astyanax mexicanus | 69.97 | 0.0 | 813 |
| LLPS-Abg-0084 | Absidia glauca | 69.88 | 0.0 | 792 |
| LLPS-Ten-1400 | Tetraodon nigroviridis | 69.81 | 0.0 | 808 |
| LLPS-Trr-0657 | Trichoderma reesei | 69.79 | 0.0 | 775 |
| LLPS-Icp-2123 | Ictalurus punctatus | 69.78 | 0.0 | 811 |
| LLPS-Dio-2385 | Dipodomys ordii | 69.63 | 0.0 | 816 |
| LLPS-Scs-0152 | Sclerotinia sclerotiorum | 69.6 | 0.0 | 759 |
| LLPS-Scf-0530 | Scleropages formosus | 69.5 | 0.0 | 815 |
| LLPS-Mao-0061 | Magnaporthe oryzae | 69.47 | 0.0 | 786 |
| LLPS-Anc-1615 | Anolis carolinensis | 69.4 | 0.0 | 812 |
| LLPS-Asc-0134 | Aspergillus clavatus | 69.35 | 0.0 | 763 |
| LLPS-Asfu-0766 | Aspergillus fumigatus | 69.3 | 0.0 | 769 |
| LLPS-Nef-1194 | Neosartorya fischeri | 69.13 | 0.0 | 766 |
| LLPS-Ast-1487 | Aspergillus terreus | 69.13 | 0.0 | 786 |
| LLPS-Map-0493 | Magnaporthe poae | 69.06 | 0.0 | 781 |
| LLPS-Asni-1193 | Aspergillus niger | 68.84 | 0.0 | 765 |
| LLPS-Kop-0588 | Komagataella pastoris | 68.67 | 0.0 | 763 |
| LLPS-Nec-0630 | Neurospora crassa | 68.53 | 0.0 | 786 |
| LLPS-Gag-1465 | Gaeumannomyces graminis | 68.38 | 0.0 | 778 |
| LLPS-Cis-0701 | Ciona savignyi | 68.25 | 0.0 | 791 |
| LLPS-Asg-0498 | Ashbya gossypii | 68.21 | 0.0 | 760 |
| LLPS-Asf-0636 | Aspergillus flavus | 68.1 | 0.0 | 758 |
| LLPS-Aso-0276 | Aspergillus oryzae | 68.1 | 0.0 | 758 |
| LLPS-Ved-1322 | Verticillium dahliae | 67.98 | 0.0 | 760 |
| LLPS-Mel-0277 | Melampsora laricipopulina | 67.87 | 0.0 | 775 |
| LLPS-Beb-0588 | Beauveria bassiana | 67.86 | 0.0 | 766 |
| LLPS-Tum-1076 | Tuber melanosporum | 67.7 | 0.0 | 766 |
| LLPS-Crn-1338 | Cryptococcus neoformans | 67.46 | 0.0 | 766 |
| LLPS-Cogr-0841 | Colletotrichum graminicola | 67.39 | 0.0 | 763 |
| LLPS-Scj-1500 | Schizosaccharomyces japonicus | 67.16 | 0.0 | 760 |
| LLPS-Pug-0721 | Puccinia graminis | 67.13 | 0.0 | 771 |
| LLPS-Fus-1024 | Fusarium solani | 67.01 | 0.0 | 773 |
| LLPS-Eqc-1314 | Equus caballus | 66.61 | 0.0 | 756 |
| LLPS-Cog-0961 | Colletotrichum gloeosporioides | 66.61 | 0.0 | 762 |
| LLPS-Meg-2738 | Meleagris gallopavo | 66.56 | 0.0 | 759 |
| LLPS-Scp-1400 | Schizosaccharomyces pombe | 66.45 | 0.0 | 756 |
| LLPS-Fuo-1509 | Fusarium oxysporum | 66.32 | 0.0 | 755 |
| LLPS-Fuv-0938 | Fusarium verticillioides | 66.32 | 0.0 | 754 |
| LLPS-Zyt-0747 | Zymoseptoria tritici | 66.1 | 0.0 | 758 |
| LLPS-Orn-3737 | Oreochromis niloticus | 65.79 | 0.0 | 753 |