• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-1174
GNL2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nucleolar GTP-binding protein 2
Gene Name: GNL2
Ensembl Gene: ENSOCUG00000010877.3
Ensembl Protein: ENSOCUP00000009359.3
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Scaffold


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVKPKYKGRS  TINPSKASTN  PDRVQGPGGQ  NMRDRATIRR  LNMYRQKERR  NSRGKVIKPL  60
61    QYQSTVASGT  VARVEPNIKW  FGNTRVIKQS  SLQKFQEEME  AVMKDPYKVV  MKQSKLPMSL  120
121   LHDRIQPHNA  KVHILDTESF  ETTFGPKSQR  KRPNLAASDM  QSLVENAELS  TESYDQGKDR  180
181   DLVNEDTGVR  NEAQEEIYKK  GQSKRIWGEL  YKVIDSSDVV  VQVLDARDPM  GTRSPHIETY  240
241   LKKEKPWKHL  IFVLNKCDLV  PTWATKRWVA  VLSQDYPTLA  FHASLTNPFG  KGAFIQLLRQ  300
301   FGKLHTDKKQ  ISVGFIGYPN  VGKSSVINTL  RSKKVCNVAP  IAGETKVWQY  ITLMRRIFLI  360
361   DCPGVVYPSE  DSETDIVLKG  VVQVEKIKTP  EDHVGAVLER  AKPEYISKTY  KIDSWENAED  420
421   FLEKLAFRTG  KLLKGGEPDL  QTVGKMVLND  WQRGRIPFFV  KPPNAEPPAA  PQHRPSSPLD  480
481   AAVETPQNDP  EERTPEASSK  GLERVTENEK  EGAGHCTVSS  EMQEILARVR  QNFGKINVVP  540
541   QFSGDDLVPV  EMSELDEELE  SLSAGEEEEE  EELEQPGVDE  EEPCQEPQGE  PVGSNTKAVL  600
601   KALDEKIAKY  QKFLNKAKAK  KFSAVRISKG  LSEMVFAKSE  EQRKTSQEAE  DAGEAPTNKG  660
661   KKRKAQRDEE  CSDKTRRTLT  CRERRRAARQ  QQSKKVGVRY  YDTHNVKNRN  RNKKKTSDSE  720
721   GQGQRQRQRH  KAFRHKQ  737
Nucleotide CDS Sequence (FASTA)
1     ATGGTGAAGC  CCAAGTACAA  AGGACGGAGC  ACCATCAACC  CCTCTAAGGC  CAGCACGAAC  60
61    CCGGATCGAG  TGCAGGGACC  GGGAGGCCAA  AACATGAGGG  ACCGGGCCAC  CATCCGGCGC  120
121   CTGAATATGT  ACAGGCAGAA  GGAGCGCAGG  AATAGTCGTG  GTAAAGTGAT  CAAGCCCCTC  180
181   CAGTATCAAT  CGACGGTGGC  TTCTGGCACA  GTGGCAAGAG  TGGAGCCAAA  TATTAAGTGG  240
241   TTTGGAAACA  CACGTGTGAT  TAAGCAGTCG  TCATTGCAAA  AGTTTCAAGA  GGAAATGGAG  300
301   GCTGTCATGA  AGGATCCATA  CAAAGTCGTC  ATGAAGCAGA  GCAAGTTGCC  AATGTCTCTT  360
361   CTGCACGATC  GAATCCAGCC  TCATAACGCG  AAGGTGCACA  TTCTTGATAC  TGAAAGTTTC  420
421   GAAACGACTT  TTGGCCCCAA  GTCGCAGAGG  AAGCGACCCA  ACTTAGCGGC  GAGCGACATG  480
481   CAGTCCCTCG  TGGAGAATGC  TGAGCTGTCC  ACTGAGAGCT  ACGACCAGGG  CAAGGACCGC  540
541   GACCTGGTGA  ATGAGGACAC  TGGCGTGAGA  AATGAAGCCC  AAGAAGAGAT  ATATAAAAAG  600
601   GGACAATCCA  AAAGAATATG  GGGTGAGCTC  TACAAGGTGA  TCGACTCATC  AGATGTTGTT  660
661   GTTCAAGTTC  TTGATGCTAG  GGACCCCATG  GGGACCCGTT  CCCCTCACAT  CGAGACTTAC  720
721   TTGAAGAAGG  AGAAGCCCTG  GAAACACCTC  ATTTTTGTAC  TTAACAAGTG  TGACCTTGTT  780
781   CCAACCTGGG  CAACAAAGCG  GTGGGTTGCC  GTGCTGTCCC  AGGATTATCC  GACCCTGGCT  840
841   TTCCATGCGA  GTCTCACCAA  CCCCTTCGGC  AAAGGGGCAT  TCATTCAGCT  CCTGCGGCAG  900
901   TTCGGAAAGT  TGCACACTGA  CAAGAAGCAG  ATCAGCGTTG  GCTTTATTGG  CTATCCAAAC  960
961   GTTGGCAAGA  GCTCTGTGAT  CAACACGCTG  CGTTCCAAGA  AAGTGTGCAA  CGTGGCCCCC  1020
1021  ATTGCAGGTG  AAACAAAGGT  CTGGCAGTAC  ATCACCTTGA  TGCGTCGGAT  TTTCCTGATC  1080
1081  GACTGTCCAG  GTGTGGTTTA  CCCGTCGGAG  GACTCGGAGA  CAGACATTGT  GCTGAAAGGA  1140
1141  GTTGTTCAAG  TCGAAAAAAT  TAAGACTCCT  GAAGACCATG  TTGGTGCCGT  ACTTGAACGA  1200
1201  GCCAAGCCAG  AGTATATCAG  CAAGACATAC  AAGATCGACT  CTTGGGAGAA  CGCTGAGGAC  1260
1261  TTCCTTGAGA  AGCTAGCTTT  CCGGACTGGG  AAGTTACTGA  AGGGTGGGGA  GCCCGACTTG  1320
1321  CAGACTGTGG  GTAAGATGGT  CCTCAATGAC  TGGCAGAGGG  GCCGGATTCC  TTTCTTTGTC  1380
1381  AAACCTCCCA  ACGCAGAGCC  TCCTGCAGCC  CCCCAGCATC  GCCCCTCCTC  ACCCCTGGAC  1440
1441  GCTGCCGTGG  AAACTCCCCA  GAACGACCCA  GAGGAGAGAA  CCCCAGAAGC  CAGCAGCAAA  1500
1501  GGGCTGGAGC  GAGTGACGGA  GAATGAGAAG  GAAGGGGCCG  GTCACTGCAC  TGTTAGCTCA  1560
1561  GAGATGCAGG  AGATCCTGGC  GCGGGTTCGG  CAGAACTTCG  GCAAGATCAA  CGTGGTGCCC  1620
1621  CAGTTCTCTG  GGGACGACCT  GGTGCCCGTG  GAGATGTCAG  AGCTTGACGA  AGAGCTTGAG  1680
1681  AGCTTGTCTG  CGGGGGAGGA  GGAGGAGGAG  GAGGAGCTGG  AGCAGCCCGG  AGTCGACGAG  1740
1741  GAAGAGCCTT  GCCAGGAGCC  CCAGGGAGAG  CCTGTCGGAA  GCAACACCAA  AGCAGTTCTT  1800
1801  AAAGCCCTGG  ATGAAAAGAT  CGCCAAGTAT  CAGAAGTTTT  TAAACAAAGC  CAAAGCCAAA  1860
1861  AAGTTTTCAG  CAGTCAGGAT  ATCCAAGGGG  CTAAGTGAAA  TGGTTTTTGC  GAAGTCTGAA  1920
1921  GAACAGAGAA  AAACATCTCA  AGAGGCAGAA  GATGCAGGTG  AAGCACCTAC  CAACAAAGGA  1980
1981  AAGAAGCGGA  AGGCACAGAG  GGACGAGGAG  TGCTCAGATA  AAACGCGCAG  GACGCTCACG  2040
2041  TGTAGAGAAC  GGAGGCGAGC  GGCACGGCAG  CAGCAGTCCA  AAAAAGTTGG  GGTCCGCTAC  2100
2101  TACGACACAC  ACAACGTGAA  GAACAGGAAC  AGGAACAAAA  AGAAGACCAG  TGATTCAGAG  2160
2161  GGACAGGGTC  AGCGACAGCG  ACAGCGACAC  AAAGCATTCA  GACATAAGCA  GTAA  2214

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
GTP-binding
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Molecular Function
GTP binding

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mup-0368Mustela putorius furo87.950.01175
LLPS-Eqc-2188Equus caballus87.40.01183
LLPS-Caf-0312Canis familiaris87.140.01153
LLPS-Fec-0552Felis catus86.570.01162
LLPS-Ict-0699Ictidomys tridecemlineatus86.430.01186
LLPS-Aim-1907Ailuropoda melanoleuca86.430.01171
LLPS-Tut-0680Tursiops truncatus86.360.01147
LLPS-Myl-0861Myotis lucifugus86.010.01168
LLPS-Ova-0847Ovis aries85.950.01093
LLPS-Sus-0968Sus scrofa85.210.01175
LLPS-Rhb-0439Rhinopithecus bieti85.20.01162
LLPS-Cas-0584Carlito syrichta85.070.01165
LLPS-Bot-0331Bos taurus84.90.01133
LLPS-Pap-2078Pan paniscus84.710.01180
LLPS-Loa-0484Loxodonta africana84.650.01155
LLPS-Fud-0438Fukomys damarensis84.640.01155
LLPS-Hos-1141Homo sapiens84.570.01177
LLPS-Cap-0872Cavia porcellus84.480.01117
LLPS-Pat-0878Pan troglodytes84.440.01175
LLPS-Nol-1783Nomascus leucogenys84.440.01179
LLPS-Poa-2528Pongo abelii84.30.01172
LLPS-Gog-1822Gorilla gorilla84.30.01170
LLPS-Aon-2255Aotus nancymaae84.280.01168
LLPS-Paa-2218Papio anubis84.170.01167
LLPS-Mam-0393Macaca mulatta84.030.01167
LLPS-Chs-0983Chlorocebus sabaeus84.030.01168
LLPS-Maf-2069Macaca fascicularis83.90.01163
LLPS-Caj-0994Callithrix jacchus83.830.01164
LLPS-Man-1314Macaca nemestrina83.760.01163
LLPS-Cea-0142Cercocebus atys83.630.01161
LLPS-Mea-1203Mesocricetus auratus83.580.01136
LLPS-Mum-2196Mus musculus83.580.01137
LLPS-Ran-1705Rattus norvegicus81.760.01127
LLPS-Otg-3266Otolemur garnettii81.710.01045
LLPS-Xim-2654Xiphophorus maculatus81.290.0 806
LLPS-Mal-0971Mandrillus leucophaeus80.410.01102
LLPS-Dio-0672Dipodomys ordii78.980.01071
LLPS-Mod-1414Monodelphis domestica77.270.01073
LLPS-Sah-1602Sarcophilus harrisii76.220.01050
LLPS-Ora-0986Ornithorhynchus anatinus74.70.01022
LLPS-Gaa-0068Gasterosteus aculeatus74.640.0 841
LLPS-Pes-0129Pelodiscus sinensis74.480.01006
LLPS-Anp-0777Anas platyrhynchos74.150.01019
LLPS-Fia-0876Ficedula albicollis72.980.01011
LLPS-Tag-0405Taeniopygia guttata72.870.01006
LLPS-Gaga-0032Gallus gallus72.470.01013
LLPS-Lac-1254Latimeria chalumnae71.760.0 969
LLPS-Anc-1804Anolis carolinensis70.960.0 962
LLPS-Tar-1144Takifugu rubripes69.50.0 873
LLPS-Xet-0831Xenopus tropicalis69.370.0 969
LLPS-Leo-1070Lepisosteus oculatus68.940.0 955
LLPS-Orbr-0826Oryza brachyantha68.912e-133 405
LLPS-Scf-0608Scleropages formosus67.890.0 912
LLPS-Meg-2374Meleagris gallopavo67.120.0 917
LLPS-Dar-0211Danio rerio66.850.0 896
LLPS-Icp-0237Ictalurus punctatus66.250.0 882
LLPS-Ten-0003Tetraodon nigroviridis65.740.0 869
LLPS-Asm-0462Astyanax mexicanus65.410.0 849
LLPS-Orn-2587Oreochromis niloticus65.160.0 879
LLPS-Scm-0603Scophthalmus maximus64.930.0 876
LLPS-Pof-0573Poecilia formosa64.650.0 856
LLPS-Orl-3646Oryzias latipes64.550.0 878
LLPS-Sem-0907Selaginella moellendorffii59.030.0 540
LLPS-Orp-0328Oryza punctata58.62e-177 526
LLPS-Cii-0270Ciona intestinalis58.420.0 645
LLPS-Lep-0868Leersia perrieri58.372e-176 523
LLPS-Orni-0017Oryza nivara58.299e-178 526
LLPS-Abg-1947Absidia glauca58.110.0 542
LLPS-Kop-1419Komagataella pastoris57.682e-175 520
LLPS-Sei-0184Setaria italica57.64e-177 525
LLPS-Zem-0288Zea mays57.442e-175 521
LLPS-Gor-0332Gossypium raimondii57.242e-180 535
LLPS-Php-0091Physcomitrella patens57.240.0 538
LLPS-Sob-1592Sorghum bicolor57.219e-175 519
LLPS-Drm-0356Drosophila melanogaster56.50.0 597
LLPS-Yal-0593Yarrowia lipolytica56.429e-176 520
LLPS-Hov-1604Hordeum vulgare56.295e-174 518
LLPS-Mae-1295Manihot esculenta56.222e-171 511
LLPS-Met-1508Medicago truncatula56.221e-172 515
LLPS-Cis-1071Ciona savignyi56.091e-178 535
LLPS-Sac-0032Saccharomyces cerevisiae56.088e-171 507
LLPS-Sol-0207Solanum lycopersicum55.942e-173 515
LLPS-Thc-0103Theobroma cacao55.93e-178 529
LLPS-Viv-1215Vitis vinifera55.793e-178 531
LLPS-Asni-0728Aspergillus niger55.684e-165 495
LLPS-Amt-0505Amborella trichopoda55.515e-168 506
LLPS-Brn-1164Brassica napus55.274e-175 521
LLPS-Dac-0707Daucus carota55.193e-174 518
LLPS-Brd-0103Brachypodium distachyon55.161e-175 521
LLPS-Pot-0161Populus trichocarpa55.114e-180 533
LLPS-Cae-1382Caenorhabditis elegans55.113e-176 527
LLPS-Phv-0519Phaseolus vulgaris55.063e-127 390
LLPS-Glm-2599Glycine max54.953e-176 523
LLPS-Scs-0585Sclerotinia sclerotiorum54.862e-164 495
LLPS-Fus-0771Fusarium solani54.598e-166 499
LLPS-Chr-0271Chlamydomonas reinhardtii54.57e-166 505
LLPS-Cus-1048Cucumis sativus54.377e-177 525
LLPS-Osl-0014Ostreococcus lucimarinus54.27e-169 500
LLPS-Trr-1371Trichoderma reesei54.192e-165 497
LLPS-Tum-1027Tuber melanosporum54.147e-153 463
LLPS-Nia-0965Nicotiana attenuata54.017e-177 524
LLPS-Asn-0277Aspergillus nidulans54.04e-157 474
LLPS-Arl-0670Arabidopsis lyrata53.892e-172 514
LLPS-Brr-0740Brassica rapa53.838e-175 521
LLPS-Bro-1640Brassica oleracea53.832e-174 520
LLPS-Asg-0638Ashbya gossypii53.73e-173 514
LLPS-Put-0302Puccinia triticina53.691e-155 473
LLPS-Art-0423Arabidopsis thaliana53.681e-172 515
LLPS-Hea-0375Helianthus annuus53.574e-173 514
LLPS-Zyt-0139Zymoseptoria tritici53.452e-161 486
LLPS-Cogr-1417Colletotrichum graminicola53.426e-161 486
LLPS-Prp-0044Prunus persica53.283e-172 512
LLPS-Nef-0387Neosartorya fischeri53.264e-161 485
LLPS-Usm-0411Ustilago maydis53.166e-166 503
LLPS-Scj-1251Schizosaccharomyces japonicus53.126e-162 485
LLPS-Asfu-0366Aspergillus fumigatus53.061e-160 484
LLPS-Crn-0200Cryptococcus neoformans53.064e-158 483
LLPS-Sot-0124Solanum tuberosum52.974e-175 519
LLPS-Asc-1483Aspergillus clavatus52.947e-158 476
LLPS-Fuo-0498Fusarium oxysporum52.937e-162 489
LLPS-Fuv-0130Fusarium verticillioides52.935e-162 489
LLPS-Blg-0360Blumeria graminis52.924e-162 490
LLPS-Pug-0585Puccinia graminis52.711e-155 477
LLPS-Org-1454Oryza glaberrima52.561e-178 529
LLPS-Ors-0688Oryza sativa52.366e-178 527
LLPS-Orr-0283Oryza rufipogon52.366e-178 527
LLPS-Orb-0159Oryza barthii52.366e-178 527
LLPS-Ori-1076Oryza indica52.365e-178 527
LLPS-Orgl-0018Oryza glumaepatula52.366e-178 527
LLPS-Spr-1403Sporisorium reilianum52.328e-166 503
LLPS-Aso-1183Aspergillus oryzae52.293e-158 477
LLPS-Phn-0558Phaeosphaeria nodorum52.152e-148 454
LLPS-Ved-0689Verticillium dahliae51.762e-155 472
LLPS-Coo-1203Colletotrichum orbiculare51.663e-153 466
LLPS-Scp-1435Schizosaccharomyces pombe51.527e-162 486
LLPS-Mel-1343Melampsora laricipopulina51.261e-155 478
LLPS-Nec-0138Neurospora crassa51.194e-152 464
LLPS-Cog-1329Colletotrichum gloeosporioides51.12e-153 469
LLPS-Asf-0673Aspergillus flavus51.074e-154 467
LLPS-Chc-1064Chondrus crispus50.981e-144 442
LLPS-Miv-0401Microbotryum violaceum50.941e-155 477
LLPS-Dos-1321Dothistroma septosporum50.91e-158 479
LLPS-Tru-0148Triticum urartu50.654e-129 399
LLPS-Beb-0562Beauveria bassiana50.597e-160 483
LLPS-Orm-0538Oryza meridionalis50.566e-145 441
LLPS-Pytr-0354Pyrenophora triticirepentis50.566e-146 446
LLPS-Pyt-1092Pyrenophora teres50.566e-146 447
LLPS-Mua-0541Musa acuminata50.462e-170 508
LLPS-Coc-0475Corchorus capsularis50.239e-148 449
LLPS-Ast-0378Aspergillus terreus50.212e-148 453
LLPS-Trv-1340Trichoderma virens50.192e-166 500
LLPS-Mao-1320Magnaporthe oryzae49.781e-146 449
LLPS-Scc-0315Schizosaccharomyces cryophilus48.881e-162 488
LLPS-Gag-1065Gaeumannomyces graminis48.812e-144 444
LLPS-Map-0488Magnaporthe poae48.85e-144 443
LLPS-Lem-1228Leptosphaeria maculans47.792e-147 451
LLPS-Gas-0925Galdieria sulphuraria43.81e-141 434
LLPS-Via-0876Vigna angularis38.412e-58 214
LLPS-Cym-0415Cyanidioschyzon merolae36.592e-108 354
LLPS-Tra-1893Triticum aestivum35.692e-54 202