LLPS-Orc-0262
AGO3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein argonaute-3 |
| Gene Name: | AGO3, EIF2C3 |
| Ensembl Gene: | ENSOCUG00000006255.2 |
| Ensembl Protein: | ENSOCUP00000005411.2 |
| Organism: | Oryctolagus cuniculus |
| Taxa ID: | 9986 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOCUT00000006255.2 | ENSOCUP00000005411.2 |
| UniProt | G1SQM3, G1SQM3_RABIT | |
| RefSeq | XM_008273686.2 | XP_008271908.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEIGSAGPVG AQPLLMVPRR PGYGTMGKPI KLLANCFQVE IPKIDVYLYE VDIKPDKCPR 60 61 RVNREVVDSM VQHFKVTIFG DRRPVYDGKR SLYTANPLPV ATTGVDLDVT LPGEGGKDRP 120 121 FKVSIKFVSR VSWHLLHEVL TGRTLPEPLE LDKPISTNPV HAVDVVLRHL PSMKYTPVGR 180 181 SFFSAPEGYD HPLGGGREVW FGFHQSVRPA MWKMMLNIDV SATAFYKAQP VIQFMCEVLD 240 241 IHNIDEQPRP LTDSHRVKFT KEIKGLKVEV THCGTMRRKY RVCNVTRRPA SHQTFPLQLE 300 301 NGQTVERTVA QYFREKYTLQ LKYPHLPCLQ VGQEQKHTYL PLEVCNIVAG QRCIKKLTDN 360 361 QTSTMIKATA RSAPDRQEEI SRLVRSANYE TDPFVQEFQF KVRDEMAHVT GRVLPAPMLQ 420 421 YGGRNRTVAT PSHGVWDMRG KQFHTGVEIK MWAIACFATQ RQCREEILKG FTDQLRKISK 480 481 DAGMPIQGQP CFCKYAQGAD SVEPMFRHLK NTYSGLQLII VILPGKTPVY AEVKRVGDTL 540 541 LGMATQCVQV KNVIKTSPQT LSNLCLKINV KLGGINNILV PHQRPSVFQQ PVIFLGADVT 600 601 HPPAGDGKKP SIAAVVGSMD AHPSRYCATV RVQRPRQEII QDLASMVREL LIQFYKSTRF 660 661 KPTRIIFYRD GVSEGQFRQV LYYELLAIRE ACISLEKDYQ PGITYIVVQK RHHTRLFCAD 720 721 RTERVGRSGN IPAGTTVDTD ITHPYEFDFY LCSHAGIQGT SRPSHYHVLW DDNCFTADEL 780 781 QLLTYQLCHT YVRCTRSVSI PAPAYYAHLV AFRARYHLVD KEHDSAEGSH VSGQSNGRDP 840 841 QALAKAVQIH QDTLRTMYFA 860 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAATCG GCTCCGCAGG ACCCGTTGGG GCCCAGCCCC TACTCATGGT GCCCAGAAGA 60 61 CCTGGCTATG GCACCATGGG CAAACCCATT AAATTGCTGG CTAACTGTTT TCAAGTTGAA 120 121 ATCCCAAAGA TTGATGTCTA CCTCTATGAG GTAGATATTA AACCAGACAA GTGTCCTAGG 180 181 AGAGTGAACA GGGAGGTGGT TGACTCAATG GTTCAGCATT TTAAAGTAAC TATATTTGGA 240 241 GACCGTAGAC CAGTTTATGA TGGAAAAAGA AGCCTTTATA CAGCCAATCC ACTTCCTGTG 300 301 GCAACCACTG GGGTAGATTT AGATGTCACA TTACCTGGGG AAGGTGGAAA AGATCGACCT 360 361 TTCAAAGTGT CAATCAAATT TGTTTCTCGG GTGAGTTGGC ACCTACTGCA TGAAGTACTG 420 421 ACAGGACGGA CCTTGCCTGA GCCACTGGAA TTAGACAAGC CAATCAGCAC TAACCCTGTC 480 481 CATGCCGTTG ATGTGGTGCT ACGTCATCTG CCCTCCATGA AATATACACC TGTGGGACGC 540 541 TCCTTTTTCT CAGCTCCAGA AGGATATGAC CACCCTCTAG GAGGGGGCAG GGAAGTATGG 600 601 TTTGGATTCC ATCAGTCTGT TCGGCCTGCC ATGTGGAAAA TGATGCTGAA TATCGATGTT 660 661 TCTGCCACTG CCTTCTACAA AGCACAACCT GTAATTCAGT TCATGTGTGA AGTTCTTGAC 720 721 ATTCATAATA TTGATGAACA ACCAAGACCT CTGACTGATT CTCATCGGGT AAAATTCACC 780 781 AAAGAGATAA AAGGTCTGAA GGTTGAAGTG ACTCATTGTG GAACAATGAG GCGGAAATAC 840 841 CGTGTTTGTA ATGTAACAAG AAGGCCTGCC AGTCATCAAA CCTTTCCTTT ACAGTTAGAA 900 901 AATGGCCAAA CTGTGGAAAG AACTGTAGCG CAGTACTTCA GAGAAAAGTA TACTCTTCAG 960 961 CTGAAGTACC CACACCTTCC CTGTCTGCAA GTGGGGCAGG AGCAGAAGCA TACTTACCTG 1020 1021 CCCCTAGAAG TCTGTAATAT TGTGGCAGGG CAACGATGTA TCAAAAAGCT AACAGACAAT 1080 1081 CAGACTTCCA CTATGATCAA GGCTACAGCA AGATCTGCAC CAGATAGACA AGAGGAAATT 1140 1141 AGCCGATTGG TAAGAAGTGC AAATTATGAA ACAGATCCAT TTGTTCAGGA GTTTCAGTTT 1200 1201 AAAGTTCGGG ATGAGATGGC ACATGTAACT GGACGTGTAC TGCCAGCACC TATGCTCCAG 1260 1261 TATGGAGGAC GGAATCGAAC AGTAGCAACA CCAAGCCATG GAGTATGGGA CATGCGAGGA 1320 1321 AAACAGTTCC ACACAGGAGT TGAAATAAAA ATGTGGGCAA TTGCCTGTTT TGCCACACAG 1380 1381 AGGCAGTGCA GAGAAGAAAT ACTGAAGGGG TTCACAGACC AGCTGCGGAA GATTTCCAAG 1440 1441 GATGCAGGGA TGCCTATCCA GGGTCAGCCT TGCTTCTGCA AATACGCACA GGGGGCAGAC 1500 1501 AGCGTGGAGC CCATGTTCCG GCATCTCAAG AACACCTACT CAGGGCTGCA GCTCATTATC 1560 1561 GTCATCCTGC CAGGGAAGAC GCCGGTGTAT GCGGAGGTGA AACGTGTGGG AGACACCCTT 1620 1621 TTGGGTATGG CTACACAGTG TGTTCAAGTC AAGAATGTAA TAAAAACATC TCCTCAAACT 1680 1681 CTCTCAAACT TGTGCCTGAA GATAAATGTT AAACTTGGAG GGATCAATAA TATTCTTGTA 1740 1741 CCTCATCAAA GACCTTCTGT GTTCCAGCAA CCAGTGATCT TTTTGGGAGC AGATGTCACG 1800 1801 CATCCACCTG CTGGTGATGG AAAGAAGCCT TCAATTGCTG CTGTTGTAGG TAGTATGGAC 1860 1861 GCCCACCCAA GCAGATACTG TGCCACAGTT CGAGTTCAGA GACCCCGACA GGAGATTATT 1920 1921 CAGGATTTAG CTTCCATGGT CCGGGAACTT CTCATTCAGT TTTATAAGTC AACTCGATTC 1980 1981 AAACCTACTC GTATCATCTT TTATCGGGAT GGTGTTTCAG AGGGACAATT TAGACAGGTT 2040 2041 TTATATTATG AATTATTAGC AATTCGAGAA GCCTGCATCA GTTTGGAGAA AGACTATCAA 2100 2101 CCTGGAATAA CCTACATTGT AGTTCAGAAG AGACATCACA CTCGATTATT TTGTGCTGAT 2160 2161 AGGACGGAAA GGGTTGGCAG AAGTGGCAAT ATCCCAGCTG GAACAACAGT TGATACAGAC 2220 2221 ATCACACACC CATATGAGTT TGATTTTTAC CTCTGTAGCC ATGCTGGAAT ACAGGGTACC 2280 2281 AGCCGTCCTT CCCACTATCA TGTTTTATGG GATGATAACT GCTTTACTGC AGATGAACTT 2340 2341 CAGCTGCTAA CTTACCAACT CTGCCACACG TATGTGCGCT GTACACGGTC TGTTTCTATA 2400 2401 CCTGCACCAG CGTATTATGC TCACCTGGTG GCATTCCGAG CCAGATATCA TCTCGTGGAC 2460 2461 AAAGAACATG ACAGTGCTGA AGGAAGTCAT GTTTCAGGAC AGAGCAATGG GCGAGATCCT 2520 2521 CAAGCTCTTG CCAAGGCTGT ACAGATTCAC CAAGATACCT TACGCACAAT GTACTTTGCT 2580 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed nuclear chromosome | |
Cellular Component | Micro-ribonucleoprotein complex | |
Cellular Component | Nucleoplasm | |
Cellular Component | P-body | |
Cellular Component | RISC complex | |
Cellular Component | RISC-loading complex | |
Molecular Function | Double-stranded RNA binding | |
Molecular Function | Endoribonuclease activity, cleaving miRNA-paired mRNA | |
Molecular Function | MiRNA binding | |
Molecular Function | Single-stranded RNA binding | |
Biological Process | MiRNA loading onto RISC involved in gene silencing by miRNA | |
Biological Process | MiRNA mediated inhibition of translation | |
Biological Process | MRNA catabolic process | |
Biological Process | Positive regulation of gene expression | |
Biological Process | Positive regulation of NIK/NF-kappaB signaling | |
Biological Process | Pre-miRNA processing | |
Biological Process | Regulation of stem cell proliferation | |
Biological Process | RNA secondary structure unwinding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-3202 | Ursus maritimus | 100.0 | 0.0 | 786 |
| LLPS-Otg-2252 | Otolemur garnettii | 100.0 | 0.0 | 1794 |
| LLPS-Eqc-2279 | Equus caballus | 100.0 | 0.0 | 1794 |
| LLPS-Cas-3321 | Carlito syrichta | 100.0 | 0.0 | 1505 |
| LLPS-Sus-3271 | Sus scrofa | 100.0 | 0.0 | 1781 |
| LLPS-Fud-0551 | Fukomys damarensis | 100.0 | 0.0 | 1781 |
| LLPS-Bot-0584 | Bos taurus | 100.0 | 0.0 | 1794 |
| LLPS-Ova-2383 | Ovis aries | 100.0 | 0.0 | 1794 |
| LLPS-Aim-1561 | Ailuropoda melanoleuca | 100.0 | 0.0 | 1794 |
| LLPS-Man-0707 | Macaca nemestrina | 99.88 | 0.0 | 1792 |
| LLPS-Pap-2185 | Pan paniscus | 99.88 | 0.0 | 1792 |
| LLPS-Pat-0335 | Pan troglodytes | 99.88 | 0.0 | 1792 |
| LLPS-Hos-0290 | Homo sapiens | 99.88 | 0.0 | 1792 |
| LLPS-Rhb-1788 | Rhinopithecus bieti | 99.88 | 0.0 | 1792 |
| LLPS-Mam-0012 | Macaca mulatta | 99.88 | 0.0 | 1792 |
| LLPS-Caf-0783 | Canis familiaris | 99.88 | 0.0 | 1791 |
| LLPS-Poa-0903 | Pongo abelii | 99.88 | 0.0 | 1792 |
| LLPS-Aon-3211 | Aotus nancymaae | 99.88 | 0.0 | 1792 |
| LLPS-Cea-0805 | Cercocebus atys | 99.88 | 0.0 | 1792 |
| LLPS-Chs-0989 | Chlorocebus sabaeus | 99.88 | 0.0 | 1792 |
| LLPS-Maf-2390 | Macaca fascicularis | 99.88 | 0.0 | 1792 |
| LLPS-Gog-1315 | Gorilla gorilla | 99.88 | 0.0 | 1792 |
| LLPS-Mal-1965 | Mandrillus leucophaeus | 99.88 | 0.0 | 1792 |
| LLPS-Paa-2010 | Papio anubis | 99.88 | 0.0 | 1792 |
| LLPS-Loa-1007 | Loxodonta africana | 99.77 | 0.0 | 1778 |
| LLPS-Dio-2699 | Dipodomys ordii | 99.65 | 0.0 | 1791 |
| LLPS-Ran-1380 | Rattus norvegicus | 99.65 | 0.0 | 1791 |
| LLPS-Anp-1024 | Anas platyrhynchos | 99.53 | 0.0 | 1773 |
| LLPS-Meg-1658 | Meleagris gallopavo | 99.53 | 0.0 | 1772 |
| LLPS-Tag-2430 | Taeniopygia guttata | 99.53 | 0.0 | 1332 |
| LLPS-Gaga-0604 | Gallus gallus | 99.53 | 0.0 | 1787 |
| LLPS-Ora-0880 | Ornithorhynchus anatinus | 99.53 | 0.0 | 1754 |
| LLPS-Fia-0927 | Ficedula albicollis | 99.42 | 0.0 | 1771 |
| LLPS-Mod-2573 | Monodelphis domestica | 99.3 | 0.0 | 1784 |
| LLPS-Anc-1176 | Anolis carolinensis | 99.3 | 0.0 | 1785 |
| LLPS-Pes-2874 | Pelodiscus sinensis | 99.15 | 0.0 | 1703 |
| LLPS-Xet-0329 | Xenopus tropicalis | 98.95 | 0.0 | 1766 |
| LLPS-Mum-3143 | Mus musculus | 98.95 | 0.0 | 1779 |
| LLPS-Scm-0410 | Scophthalmus maximus | 97.21 | 0.0 | 1756 |
| LLPS-Orn-0762 | Oreochromis niloticus | 96.63 | 0.0 | 1741 |
| LLPS-Cap-3529 | Cavia porcellus | 96.37 | 0.0 | 1697 |
| LLPS-Dar-0582 | Danio rerio | 96.31 | 0.0 | 1748 |
| LLPS-Xim-3267 | Xiphophorus maculatus | 96.31 | 0.0 | 1748 |
| LLPS-Asm-0104 | Astyanax mexicanus | 95.7 | 0.0 | 1580 |
| LLPS-Caj-4093 | Callithrix jacchus | 95.67 | 0.0 | 1690 |
| LLPS-Gaa-3433 | Gasterosteus aculeatus | 95.57 | 0.0 | 1676 |
| LLPS-Nol-2169 | Nomascus leucogenys | 95.55 | 0.0 | 1681 |
| LLPS-Scf-4191 | Scleropages formosus | 95.32 | 0.0 | 1566 |
| LLPS-Ict-2929 | Ictidomys tridecemlineatus | 95.23 | 0.0 | 1689 |
| LLPS-Pof-0305 | Poecilia formosa | 94.26 | 0.0 | 1694 |
| LLPS-Tar-1591 | Takifugu rubripes | 93.66 | 0.0 | 1700 |
| LLPS-Icp-3354 | Ictalurus punctatus | 93.08 | 0.0 | 1688 |
| LLPS-Orl-2266 | Oryzias latipes | 92.67 | 0.0 | 1687 |
| LLPS-Ten-3426 | Tetraodon nigroviridis | 91.91 | 0.0 | 1640 |
| LLPS-Mea-2976 | Mesocricetus auratus | 91.91 | 1e-76 | 271 |
| LLPS-Mup-0618 | Mustela putorius furo | 87.47 | 0.0 | 1350 |
| LLPS-Leo-0053 | Lepisosteus oculatus | 85.7 | 0.0 | 1551 |
| LLPS-Fec-0286 | Felis catus | 84.92 | 0.0 | 1523 |
| LLPS-Sah-2657 | Sarcophilus harrisii | 84.15 | 0.0 | 1509 |
| LLPS-Myl-0397 | Myotis lucifugus | 82.0 | 0.0 | 1444 |
| LLPS-Lac-3215 | Latimeria chalumnae | 81.34 | 0.0 | 1464 |
| LLPS-Tut-0067 | Tursiops truncatus | 81.14 | 0.0 | 1442 |
| LLPS-Drm-0106 | Drosophila melanogaster | 72.11 | 0.0 | 1283 |
| LLPS-Cis-1295 | Ciona savignyi | 69.98 | 0.0 | 1243 |
| LLPS-Cii-0529 | Ciona intestinalis | 69.23 | 0.0 | 1220 |
| LLPS-Cae-0166 | Caenorhabditis elegans | 65.9 | 0.0 | 1199 |
| LLPS-Tra-2271 | Triticum aestivum | 45.98 | 0.0 | 704 |
| LLPS-Met-2300 | Medicago truncatula | 45.79 | 0.0 | 701 |
| LLPS-Orbr-1022 | Oryza brachyantha | 45.55 | 0.0 | 694 |
| LLPS-Ors-0559 | Oryza sativa | 45.51 | 0.0 | 695 |
| LLPS-Org-0505 | Oryza glaberrima | 45.51 | 0.0 | 694 |
| LLPS-Ori-0525 | Oryza indica | 45.51 | 0.0 | 694 |
| LLPS-Orb-1037 | Oryza barthii | 45.51 | 0.0 | 695 |
| LLPS-Arl-0946 | Arabidopsis lyrata | 45.36 | 0.0 | 698 |
| LLPS-Art-0603 | Arabidopsis thaliana | 45.24 | 0.0 | 692 |
| LLPS-Via-0388 | Vigna angularis | 45.23 | 0.0 | 693 |
| LLPS-Sot-1268 | Solanum tuberosum | 45.1 | 0.0 | 693 |
| LLPS-Sem-1697 | Selaginella moellendorffii | 44.82 | 0.0 | 699 |
| LLPS-Viv-1186 | Vitis vinifera | 44.73 | 0.0 | 693 |
| LLPS-Nia-1214 | Nicotiana attenuata | 44.7 | 0.0 | 693 |
| LLPS-Prp-0710 | Prunus persica | 44.69 | 0.0 | 692 |
| LLPS-Mua-2179 | Musa acuminata | 44.69 | 0.0 | 693 |
| LLPS-Glm-1852 | Glycine max | 44.11 | 0.0 | 692 |
| LLPS-Mae-2036 | Manihot esculenta | 43.82 | 0.0 | 690 |
| LLPS-Phv-2057 | Phaseolus vulgaris | 43.29 | 0.0 | 691 |
| LLPS-Orr-2268 | Oryza rufipogon | 42.37 | 0.0 | 691 |