LLPS-Gaga-0604
AGO3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein argonaute-3 |
| Gene Name: | AGO3, EIF2C3 |
| Ensembl Gene: | ENSGALG00000043711.3 |
| Ensembl Protein: | ENSGALP00000052719.2 |
| Organism: | Gallus gallus |
| Taxa ID: | 9031 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGALT00000050979.2 | ENSGALP00000052719.2 |
| Ensembl | ENSGALT00000084489.2 | ENSGALP00000062841.2 |
| Ensembl | ENSGALT00000065698.3 | ENSGALP00000049953.1 |
| UniProt | F1P3Z0, F1P3Z0_CHICK | |
| GeneBank | KX059705, AADN05000596 | , ANW82743.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEISSAGPVG AQPLLMVPRR PGYGTMGKPI KLLANCFQVE IPKIDVYLYE VDIKPDKCPR 60 61 RVNREVVDSM VQHFKVTIFG DRRPVYDGKR SLYTANPLPV ATTGVDLDVT LPGEGGKDRP 120 121 FKVSIKFVSR VSWHLLHEVL TGRTLPEPLE LDKPISTNPV HAVDVVLRHL PSMKYTPVGR 180 181 SFFSAPEGYD HPLGGGREVW FGFHQSVRPA MWKMMLNIDV SATAFYKAQP VIQFMCEVLD 240 241 IHNIDEQPRP LTDSHRVKFT KEIKGLKVEV THCGTMRRKY RVCNVTRRPA SHQTFPLQLE 300 301 NGQTVERTVA QYFREKYNLQ LKYPHLPCLQ VGQEQKHTYL PLEVCNIVAG QRCIKKLTDN 360 361 QTSTMIKATA RSAPDRQEEI SRLVRSANYD ADPFVQEFQF KVRDEMAHVT GRVLPAPMLQ 420 421 YGGRNRTVAT PSHGVWDMRG KQFHTGVEIK MWAIACFATQ RQCREEILKG FTDQLRKISK 480 481 DAGMPIQGQP CFCKYAQGAD SVEPMFRHLK NTYSGLQLII VILPGKTPVY AEVKRVGDTL 540 541 LGMATQCVQV KNVIKTSPQT LSNLCLKINV KLGGINNILV PHQRPSVFQQ PVIFLGADVT 600 601 HPPAGDGKKP SIAAVVGSMD AHPSRYCATV RVQRPRQEII QDLASMVREL LIQFYKSTRF 660 661 KPTRIIFYRD GVSEGQFRQV LYYELLAIRE ACISLEKDYQ PGITYIVVQK RHHTRLFCAD 720 721 RTERVGRSGN IPAGTTVDTD ITHPYEFDFY LCSHAGIQGT SRPSHYHVLW DDNCFTADEL 780 781 QLLTYQLCHT YVRCTRSVSI PAPAYYAHLV AFRARYHLVD KEHDSAEGSH VSGQSNGRDP 840 841 QALAKAVQIH QDTLRTMYFA 860 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTGCCCA GACGGCCTGG CTATGGCACC ATGGGCAAGC CCATTAAACT GCTGGCCAAC 60 61 TGCTTCCAAG TTGAAATCCC AAAGATTGAT GTCTACCTCT ATGAGGTGGA TATCAAACCA 120 121 GATAAGTGTC CTCGGAGGGT GAACAGGGAG GTGGTGGACT CAATGGTGCA GCATTTTAAA 180 181 GTGACGATAT TTGGGGACCG TCGACCAGTT TATGATGGGA AAAGAAGCCT TTATACAGCC 240 241 AACCCGCTTC CTGTGGCCAC TACTGGGGTG GATTTGGATG TGACATTGCC AGGAGAAGGT 300 301 GGAAAAGATC GTCCCTTCAA AGTGTCAATA AAGTTTGTTT CTCGGGTGAG CTGGCACTTG 360 361 CTGCATGAAG TTTTGACAGG AAGAACCTTG CCTGAGCCTC TGGAACTAGA CAAACCTATC 420 421 AGCACTAACC CTGTTCATGC TGTCGATGTG GTGCTACGAC ACCTGCCCTC CATGAAGTAT 480 481 ACCCCTGTGG GCCGCTCCTT CTTCTCAGCT CCAGAAGGCT ATGATCACCC CTTGGGGGGG 540 541 GGCAGGGAGG TCTGGTTTGG GTTCCATCAG TCTGTCCGGC CTGCCATGTG GAAGATGATG 600 601 CTCAACATTG ATGTTTCTGC CACTGCCTTC TACAAAGCAC AACCTGTGAT TCAGTTCATG 660 661 TGTGAAGTTC TTGACATTCA TAATATTGAT GAACAACCAA GACCTCTGAC TGATTCTCAT 720 721 CGGGTAAAAT TCACCAAAGA GATAAAGGGT CTGAAGGTAG AAGTGACTCA TTGTGGAACG 780 781 ATGAGGCGGA AATACCGTGT TTGTAACGTA ACCAGGAGGC CTGCAAGTCA TCAAACCTTT 840 841 CCTTTACAGT TAGAAAATGG CCAGACTGTG GAGAGAACAG TAGCACAGTA CTTCAGAGAG 900 901 AAATACAACC TCCAGCTGAA GTATCCTCAT CTGCCTTGCC TGCAAGTGGG ACAGGAACAG 960 961 AAACACACCT ACCTGCCTTT AGAAGTTTGT AACATTGTGG CTGGCCAACG GTGTATCAAG 1020 1021 AAGCTAACAG ACAATCAGAC ATCAACTATG ATAAAGGCCA CAGCAAGGTC TGCTCCAGAT 1080 1081 AGGCAAGAGG AAATAAGCAG ATTGGTGAGA AGTGCAAACT ATGATGCGGA TCCATTTGTT 1140 1141 CAAGAGTTCC AATTCAAGGT CCGGGATGAG ATGGCCCACG TGACGGGGCG CGTGCTCCCT 1200 1201 GCACCCATGC TGCAGTATGG AGGACGGAAC CGAACGGTGG CAACCCCCAG CCATGGAGTT 1260 1261 TGGGACATGC GAGGGAAGCA ATTCCACACT GGTGTTGAGA TCAAAATGTG GGCTATAGCT 1320 1321 TGTTTTGCAA CGCAGAGGCA ATGCAGAGAA GAAATACTGA AGGGTTTTAC AGACCAGCTG 1380 1381 CGCAAGATCT CCAAGGACGC AGGGATGCCG ATCCAAGGCC AGCCCTGTTT CTGTAAATAC 1440 1441 GCCCAGGGTG CAGACAGTGT GGAGCCCATG TTTCGGCACC TCAAGAACAC CTATTCAGGG 1500 1501 CTTCAGCTCA TCATTGTCAT CCTGCCAGGA AAAACACCGG TGTACGCGGA GGTGAAGCGT 1560 1561 GTGGGAGATA CGCTATTGGG AATGGCCACG CAGTGTGTTC AAGTCAAAAA TGTCATTAAA 1620 1621 ACATCTCCAC AGACCCTTTC AAACCTGTGC CTGAAGATTA ACGTTAAATT AGGAGGAATC 1680 1681 AATAACATCC TTGTACCTCA TCAACGCCCT TCTGTGTTCC AGCAGCCAGT GATCTTTCTG 1740 1741 GGAGCTGATG TCACTCACCC TCCTGCTGGA GATGGAAAGA AACCTTCCAT AGCTGCTGTT 1800 1801 GTAGGTAGTA TGGATGCTCA TCCAAGCCGA TACTGTGCCA CGGTGAGAGT TCAGCGGCCC 1860 1861 CGGCAGGAGA TTATCCAAGA CCTGGCCTCC ATGGTGAGGG AGCTTCTCAT CCAGTTCTAC 1920 1921 AAGTCAACGC GCTTCAAGCC CACACGTATC ATCTTCTATA GGGATGGGGT CTCTGAAGGA 1980 1981 CAGTTCCGAC AGGTTTTGTA CTACGAACTG CTAGCCATTA GAGAAGCCTG CATCAGTTTG 2040 2041 GAGAAGGATT ACCAGCCTGG AATAACCTAT ATTGTGGTGC AGAAACGACA TCATACACGG 2100 2101 TTGTTCTGTG CTGACAGAAC AGAGAGGGTT GGACGAAGTG GCAATATCCC AGCTGGAACA 2160 2161 ACTGTAGATA CAGACATTAC ACATCCATAT GAGTTCGATT TTTACCTCTG CAGTCATGCT 2220 2221 GGAATACAGG GTACCAGCCG TCCCTCACAC TATCATGTTT TGTGGGATGA TAACTGTTTT 2280 2281 ACTGCAGATG AACTTCAGCT GCTGACTTAC CAGCTCTGCC ACACATACGT GCGCTGCACA 2340 2341 CGATCAGTTT CTATACCTGC ACCAGCGTAT TATGCTCACC TGGTAGCATT CAGAGCACGA 2400 2401 TACCATCTTG TGGACAAAGA ACACGACAGT GCTGAAGGAA GCCACGTTTC AGGACAGAGC 2460 2461 AATGGCAGAG ATCCACAGGC CCTGGCGAAG GCTGTACAGA TTCACCAAGA CACCTTACGC 2520 2521 ACGATGTACT TCGCTTAA 2538 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Condensed nuclear chromosome | |
Cellular Component | Micro-ribonucleoprotein complex | |
Cellular Component | Nucleoplasm | |
Cellular Component | P-body | |
Cellular Component | RISC complex | |
Cellular Component | RISC-loading complex | |
Molecular Function | Double-stranded RNA binding | |
Molecular Function | Endoribonuclease activity, cleaving miRNA-paired mRNA | |
Molecular Function | MiRNA binding | |
Molecular Function | Single-stranded RNA binding | |
Biological Process | MiRNA loading onto RISC involved in gene silencing by miRNA | |
Biological Process | MiRNA mediated inhibition of translation | |
Biological Process | MRNA catabolic process | |
Biological Process | Positive regulation of gene expression | |
Biological Process | Positive regulation of NIK/NF-kappaB signaling | |
Biological Process | Pre-miRNA processing | |
Biological Process | Regulation of stem cell proliferation | |
Biological Process | RNA secondary structure unwinding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tag-2430 | Taeniopygia guttata | 100.0 | 0.0 | 1338 |
| LLPS-Urm-3202 | Ursus maritimus | 100.0 | 0.0 | 786 |
| LLPS-Ora-0880 | Ornithorhynchus anatinus | 99.88 | 0.0 | 1761 |
| LLPS-Anp-1024 | Anas platyrhynchos | 99.65 | 0.0 | 1780 |
| LLPS-Meg-1658 | Meleagris gallopavo | 99.65 | 0.0 | 1779 |
| LLPS-Sus-3271 | Sus scrofa | 99.65 | 0.0 | 1775 |
| LLPS-Fud-0551 | Fukomys damarensis | 99.65 | 0.0 | 1775 |
| LLPS-Pes-2874 | Pelodiscus sinensis | 99.64 | 0.0 | 1712 |
| LLPS-Eqc-2279 | Equus caballus | 99.53 | 0.0 | 1787 |
| LLPS-Anc-1176 | Anolis carolinensis | 99.53 | 0.0 | 1790 |
| LLPS-Mod-2573 | Monodelphis domestica | 99.53 | 0.0 | 1788 |
| LLPS-Orc-0262 | Oryctolagus cuniculus | 99.53 | 0.0 | 1787 |
| LLPS-Fia-0927 | Ficedula albicollis | 99.53 | 0.0 | 1779 |
| LLPS-Otg-2252 | Otolemur garnettii | 99.53 | 0.0 | 1787 |
| LLPS-Bot-0584 | Bos taurus | 99.53 | 0.0 | 1787 |
| LLPS-Ova-2383 | Ovis aries | 99.53 | 0.0 | 1787 |
| LLPS-Aim-1561 | Ailuropoda melanoleuca | 99.53 | 0.0 | 1787 |
| LLPS-Cas-3321 | Carlito syrichta | 99.45 | 0.0 | 1499 |
| LLPS-Mam-0012 | Macaca mulatta | 99.42 | 0.0 | 1786 |
| LLPS-Caf-0783 | Canis familiaris | 99.42 | 0.0 | 1785 |
| LLPS-Poa-0903 | Pongo abelii | 99.42 | 0.0 | 1786 |
| LLPS-Man-0707 | Macaca nemestrina | 99.42 | 0.0 | 1786 |
| LLPS-Hos-0290 | Homo sapiens | 99.42 | 0.0 | 1786 |
| LLPS-Pap-2185 | Pan paniscus | 99.42 | 0.0 | 1786 |
| LLPS-Pat-0335 | Pan troglodytes | 99.42 | 0.0 | 1786 |
| LLPS-Rhb-1788 | Rhinopithecus bieti | 99.42 | 0.0 | 1786 |
| LLPS-Mal-1965 | Mandrillus leucophaeus | 99.42 | 0.0 | 1786 |
| LLPS-Paa-2010 | Papio anubis | 99.42 | 0.0 | 1786 |
| LLPS-Aon-3211 | Aotus nancymaae | 99.42 | 0.0 | 1786 |
| LLPS-Cea-0805 | Cercocebus atys | 99.42 | 0.0 | 1786 |
| LLPS-Maf-2390 | Macaca fascicularis | 99.42 | 0.0 | 1786 |
| LLPS-Chs-0989 | Chlorocebus sabaeus | 99.42 | 0.0 | 1786 |
| LLPS-Gog-1315 | Gorilla gorilla | 99.42 | 0.0 | 1786 |
| LLPS-Loa-1007 | Loxodonta africana | 99.3 | 0.0 | 1774 |
| LLPS-Dio-2699 | Dipodomys ordii | 99.19 | 0.0 | 1785 |
| LLPS-Ran-1380 | Rattus norvegicus | 99.19 | 0.0 | 1785 |
| LLPS-Xet-0329 | Xenopus tropicalis | 99.07 | 0.0 | 1774 |
| LLPS-Mum-3143 | Mus musculus | 98.49 | 0.0 | 1773 |
| LLPS-Scm-0410 | Scophthalmus maximus | 97.21 | 0.0 | 1756 |
| LLPS-Orn-0762 | Oreochromis niloticus | 96.75 | 0.0 | 1744 |
| LLPS-Dar-0582 | Danio rerio | 96.31 | 0.0 | 1748 |
| LLPS-Xim-3267 | Xiphophorus maculatus | 96.31 | 0.0 | 1748 |
| LLPS-Cap-3529 | Cavia porcellus | 96.02 | 0.0 | 1692 |
| LLPS-Asm-0104 | Astyanax mexicanus | 95.83 | 0.0 | 1584 |
| LLPS-Gaa-3433 | Gasterosteus aculeatus | 95.57 | 0.0 | 1678 |
| LLPS-Scf-4191 | Scleropages formosus | 95.45 | 0.0 | 1570 |
| LLPS-Caj-4093 | Callithrix jacchus | 95.32 | 0.0 | 1686 |
| LLPS-Nol-2169 | Nomascus leucogenys | 95.19 | 0.0 | 1676 |
| LLPS-Ict-2929 | Ictidomys tridecemlineatus | 94.77 | 0.0 | 1683 |
| LLPS-Pof-0305 | Poecilia formosa | 94.15 | 0.0 | 1693 |
| LLPS-Tar-1591 | Takifugu rubripes | 93.66 | 0.0 | 1701 |
| LLPS-Icp-3354 | Ictalurus punctatus | 93.19 | 0.0 | 1691 |
| LLPS-Orl-2266 | Oryzias latipes | 92.79 | 0.0 | 1690 |
| LLPS-Ten-3426 | Tetraodon nigroviridis | 92.03 | 0.0 | 1641 |
| LLPS-Mea-2976 | Mesocricetus auratus | 91.91 | 1e-76 | 271 |
| LLPS-Mup-0618 | Mustela putorius furo | 87.6 | 0.0 | 1352 |
| LLPS-Leo-0053 | Lepisosteus oculatus | 85.58 | 0.0 | 1548 |
| LLPS-Fec-0286 | Felis catus | 85.04 | 0.0 | 1527 |
| LLPS-Sah-2657 | Sarcophilus harrisii | 84.27 | 0.0 | 1511 |
| LLPS-Myl-0397 | Myotis lucifugus | 82.0 | 0.0 | 1445 |
| LLPS-Lac-3215 | Latimeria chalumnae | 81.26 | 0.0 | 1467 |
| LLPS-Tut-0067 | Tursiops truncatus | 81.02 | 0.0 | 1443 |
| LLPS-Drm-0106 | Drosophila melanogaster | 71.46 | 0.0 | 1284 |
| LLPS-Cis-1295 | Ciona savignyi | 69.98 | 0.0 | 1244 |
| LLPS-Cii-0529 | Ciona intestinalis | 69.23 | 0.0 | 1220 |
| LLPS-Cae-0166 | Caenorhabditis elegans | 66.02 | 0.0 | 1201 |
| LLPS-Tra-2271 | Triticum aestivum | 45.98 | 0.0 | 702 |
| LLPS-Met-2300 | Medicago truncatula | 45.79 | 0.0 | 702 |
| LLPS-Orbr-1022 | Oryza brachyantha | 45.73 | 0.0 | 694 |
| LLPS-Org-0505 | Oryza glaberrima | 45.51 | 0.0 | 694 |
| LLPS-Ors-0559 | Oryza sativa | 45.51 | 0.0 | 694 |
| LLPS-Orb-1037 | Oryza barthii | 45.51 | 0.0 | 694 |
| LLPS-Ori-0525 | Oryza indica | 45.51 | 0.0 | 695 |
| LLPS-Arl-0946 | Arabidopsis lyrata | 45.36 | 0.0 | 697 |
| LLPS-Via-0388 | Vigna angularis | 45.17 | 0.0 | 695 |
| LLPS-Sot-1268 | Solanum tuberosum | 45.1 | 0.0 | 693 |
| LLPS-Sem-1697 | Selaginella moellendorffii | 44.78 | 0.0 | 701 |
| LLPS-Nia-1214 | Nicotiana attenuata | 44.7 | 0.0 | 693 |
| LLPS-Prp-0710 | Prunus persica | 44.69 | 0.0 | 693 |
| LLPS-Mua-2179 | Musa acuminata | 44.69 | 0.0 | 693 |
| LLPS-Viv-1186 | Vitis vinifera | 44.62 | 0.0 | 692 |
| LLPS-Glm-1852 | Glycine max | 44.05 | 0.0 | 693 |
| LLPS-Phv-2057 | Phaseolus vulgaris | 43.04 | 0.0 | 693 |