• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nol-1582
ARPC2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Arp2/3 complex 34 kDa subunit
Gene Name: ARPC2
Ensembl Gene: ENSNLEG00000033566.1
Ensembl Protein: ENSNLEP00000045030.1
Organism: Nomascus leucogenys
Taxa ID: 61853
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

▼ SEQUENCE

Protein Sequence (FASTA)
1     NKPEAVEVTF  ADFDGVLYHI  SNPNGDKTKV  MVSISLKFYK  ELQAHGADEL  LKRVYGSFLV  60
61    NPESGYNVSL  LYDLENLPAS  KDSIVHQAGM  LKRNCFASVF  EKYFQFQEEG  KEGENRAVIH  120
121   YRDDETMYVE  SKKDRVTVVF  STVFKDDDDV  VIGKVFMQEF  KEGRRASHTA  PQVLFSHREP  180
181   PLELKDTDAA  VGDNIGYITF  VLFPRHTNAS  ARDNTINLIH  TFRDYLHYHI  KCSKAYIHTR  240
241   MRAKTSDFLK  VLNRARPDAE  KKEMKTITGK  TFSSR  275
Nucleotide CDS Sequence (FASTA)
1     AACAAACCGG  AAGCAGTAGA  AGTAACATTT  GCAGATTTCG  ATGGGGTCCT  CTATCATATT  60
61    TCAAATCCTA  ATGGAGACAA  AACAAAAGTG  ATGGTCAGTA  TTTCTTTGAA  ATTCTACAAG  120
121   GAACTTCAGG  CACATGGTGC  TGATGAGTTA  TTAAAGAGGG  TGTACGGGAG  TTTCTTGGTA  180
181   AATCCAGAAT  CAGGATACAA  TGTCTCTTTG  CTATACGACC  TTGAAAATCT  TCCGGCATCC  240
241   AAGGATTCCA  TTGTGCATCA  AGCTGGCATG  TTGAAGCGAA  ATTGTTTTGC  CTCTGTCTTT  300
301   GAAAAATACT  TCCAATTCCA  AGAAGAGGGC  AAGGAAGGAG  AGAACAGGGC  AGTTATCCAT  360
361   TATAGGGATG  ATGAGACCAT  GTATGTTGAG  TCTAAAAAGG  ACAGAGTCAC  AGTAGTCTTC  420
421   AGCACAGTGT  TTAAGGATGA  CGACGATGTG  GTCATTGGAA  AGGTGTTCAT  GCAGGAGTTC  480
481   AAAGAAGGAC  GCAGAGCCAG  CCACACAGCC  CCACAGGTCC  TCTTTAGCCA  CAGGGAACCT  540
541   CCTCTGGAGC  TGAAAGACAC  GGACGCCGCT  GTGGGTGACA  ACATTGGCTA  CATTACCTTT  600
601   GTGCTGTTCC  CTCGTCACAC  CAATGCCAGT  GCTCGAGACA  ACACCATCAA  CCTGATCCAC  660
661   ACGTTCCGGG  ACTACCTGCA  CTACCACATC  AAGTGCTCTA  AGGCCTATAT  TCACACACGT  720
721   ATGCGGGCGA  AAACGTCTGA  CTTCCTCAAG  GTGCTCAACC  GCGCACGCCC  AGATGCCGAG  780
781   AAAAAAGAAA  TGAAAACAAT  CACGGGGAAG  ACGTTTTCAT  CCCGCTAA  828

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Endosome
Cellular Component
Focal adhesion
Cellular Component
Glutamatergic synapse
Cellular Component
Lamellipodium
Cellular Component
Muscle cell projection membrane
Molecular Function
Actin filament binding
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Actin filament polymerization
Biological Process
Arp2/3 complex-mediated actin nucleation
Biological Process
Positive regulation of lamellipodium assembly
Biological Process
Positive regulation of substrate adhesion-dependent cell spreading

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caj-3949Callithrix jacchus100.00.0 572
LLPS-Chs-2285Chlorocebus sabaeus100.00.0 572
LLPS-Myl-0050Myotis lucifugus100.00.0 570
LLPS-Mup-0645Mustela putorius furo100.00.0 572
LLPS-Orc-0162Oryctolagus cuniculus100.00.0 572
LLPS-Hos-1108Homo sapiens100.00.0 572
LLPS-Cas-1972Carlito syrichta100.00.0 572
LLPS-Ict-0972Ictidomys tridecemlineatus100.00.0 572
LLPS-Poa-0510Pongo abelii100.00.0 572
LLPS-Mam-1528Macaca mulatta100.00.0 572
LLPS-Sus-3254Sus scrofa99.640.0 570
LLPS-Ran-2318Rattus norvegicus99.640.0 571
LLPS-Ova-2591Ovis aries99.640.0 571
LLPS-Tut-1030Tursiops truncatus99.640.0 566
LLPS-Bot-0224Bos taurus99.640.0 571
LLPS-Fec-0257Felis catus99.640.0 571
LLPS-Loa-2923Loxodonta africana99.640.0 570
LLPS-Cap-1209Cavia porcellus99.640.0 571
LLPS-Eqc-2509Equus caballus99.630.0 558
LLPS-Urm-3193Ursus maritimus99.579e-174 490
LLPS-Fud-1960Fukomys damarensis99.270.0 569
LLPS-Mea-3060Mesocricetus auratus99.270.0 570
LLPS-Mum-3688Mus musculus99.270.0 569
LLPS-Sah-1935Sarcophilus harrisii99.270.0 567
LLPS-Otg-1704Otolemur garnettii99.270.0 569
LLPS-Aon-2478Aotus nancymaae99.250.0 549
LLPS-Aim-0204Ailuropoda melanoleuca98.920.0 566
LLPS-Mod-0448Monodelphis domestica97.80.0 556
LLPS-Gog-1361Gorilla gorilla96.740.0 550
LLPS-Maf-1074Macaca fascicularis96.740.0 550
LLPS-Cea-1408Cercocebus atys96.740.0 550
LLPS-Paa-1045Papio anubis96.740.0 550
LLPS-Mal-0816Mandrillus leucophaeus96.740.0 550
LLPS-Rhb-3004Rhinopithecus bieti96.740.0 550
LLPS-Pap-3737Pan paniscus96.740.0 550
LLPS-Pat-3271Pan troglodytes96.740.0 550
LLPS-Man-2531Macaca nemestrina96.740.0 550
LLPS-Anc-1096Anolis carolinensis96.360.0 556
LLPS-Pes-2668Pelodiscus sinensis95.70.0 510
LLPS-Fia-1648Ficedula albicollis95.640.0 554
LLPS-Tag-0544Taeniopygia guttata95.640.0 553
LLPS-Anp-1121Anas platyrhynchos95.270.0 553
LLPS-Gaga-2314Gallus gallus94.910.0 552
LLPS-Caf-2462Canis familiaris94.481e-122 355
LLPS-Meg-1778Meleagris gallopavo93.140.0 540
LLPS-Xim-0781Xiphophorus maculatus93.010.0 535
LLPS-Tar-0717Takifugu rubripes93.010.0 533
LLPS-Pof-2163Poecilia formosa93.010.0 537
LLPS-Orn-1093Oreochromis niloticus92.650.0 536
LLPS-Scf-1716Scleropages formosus92.310.0 538
LLPS-Scm-0185Scophthalmus maximus92.280.0 534
LLPS-Ten-1369Tetraodon nigroviridis91.970.0 527
LLPS-Gaa-1085Gasterosteus aculeatus91.760.0 521
LLPS-Orl-1339Oryzias latipes91.70.0 518
LLPS-Asm-0752Astyanax mexicanus91.210.0 533
LLPS-Dar-0123Danio rerio89.740.0 526
LLPS-Lac-2313Latimeria chalumnae89.420.0 512
LLPS-Xet-1101Xenopus tropicalis89.010.0 510
LLPS-Leo-2281Lepisosteus oculatus88.130.0 512
LLPS-Icp-2425Ictalurus punctatus87.183e-179 503
LLPS-Dio-0819Dipodomys ordii86.917e-171 482
LLPS-Ora-0135Ornithorhynchus anatinus76.323e-67 212
LLPS-Drm-1114Drosophila melanogaster76.011e-157 448
LLPS-Cae-1414Caenorhabditis elegans70.762e-144 414
LLPS-Cis-0054Ciona savignyi70.184e-142 409
LLPS-Cii-0994Ciona intestinalis69.29e-141 405
LLPS-Scs-0702Sclerotinia sclerotiorum51.366e-93 284
LLPS-Pyt-0900Pyrenophora teres50.341e-90 278
LLPS-Pytr-0528Pyrenophora triticirepentis50.341e-90 278
LLPS-Lem-0991Leptosphaeria maculans50.171e-92 283
LLPS-Abg-0998Absidia glauca49.471e-87 270
LLPS-Yal-0109Yarrowia lipolytica48.981e-90 278
LLPS-Ved-0638Verticillium dahliae48.983e-91 280
LLPS-Dos-1086Dothistroma septosporum48.647e-89 274
LLPS-Cogr-1019Colletotrichum graminicola48.453e-90 277
LLPS-Mao-0220Magnaporthe oryzae48.35e-90 277
LLPS-Zyt-1138Zymoseptoria tritici48.32e-89 275
LLPS-Cog-0098Colletotrichum gloeosporioides48.32e-90 278
LLPS-Asfu-0928Aspergillus fumigatus48.143e-88 272
LLPS-Tum-0625Tuber melanosporum47.992e-78 249
LLPS-Asn-0530Aspergillus nidulans47.978e-88 271
LLPS-Coo-0727Colletotrichum orbiculare47.963e-88 272
LLPS-Trr-0831Trichoderma reesei47.623e-84 262
LLPS-Trv-0289Trichoderma virens47.623e-84 262
LLPS-Blg-0488Blumeria graminis47.61e-84 263
LLPS-Asc-1206Aspergillus clavatus47.474e-89 275
LLPS-Nef-1544Neosartorya fischeri47.474e-88 272
LLPS-Asni-0566Aspergillus niger47.466e-87 269
LLPS-Scj-1309Schizosaccharomyces japonicus47.462e-82 257
LLPS-Nec-1429Neurospora crassa47.32e-88 273
LLPS-Map-0629Magnaporthe poae47.285e-89 274
LLPS-Scp-1144Schizosaccharomyces pombe47.13e-84 262
LLPS-Asf-0850Aspergillus flavus46.983e-87 270
LLPS-Aso-0438Aspergillus oryzae46.984e-87 270
LLPS-Phn-0679Phaeosphaeria nodorum46.982e-77 244
LLPS-Fus-0189Fusarium solani46.965e-84 261
LLPS-Fuv-0977Fusarium verticillioides46.944e-84 261
LLPS-Fuo-0378Fusarium oxysporum46.944e-84 261
LLPS-Ast-0723Aspergillus terreus46.784e-88 272
LLPS-Usm-1436Ustilago maydis46.746e-84 261
LLPS-Miv-1174Microbotryum violaceum46.084e-87 269
LLPS-Mel-0182Melampsora laricipopulina45.881e-76 242
LLPS-Spr-0295Sporisorium reilianum45.243e-82 257
LLPS-Beb-0942Beauveria bassiana44.711e-82 258
LLPS-Osl-0802Ostreococcus lucimarinus44.292e-30 117
LLPS-Pug-0201Puccinia graminis44.184e-81 254
LLPS-Put-0573Puccinia triticina43.718e-77 243
LLPS-Scc-1064Schizosaccharomyces cryophilus43.12e-76 241
LLPS-Crn-0753Cryptococcus neoformans42.727e-72 230
LLPS-Gag-0896Gaeumannomyces graminis42.573e-61 201
LLPS-Kop-0825Komagataella pastoris40.987e-68 220
LLPS-Asg-0352Ashbya gossypii39.663e-52 179
LLPS-Sac-0964Saccharomyces cerevisiae37.541e-46 165
LLPS-Prp-1482Prunus persica34.556e-41 149
LLPS-Gor-1439Gossypium raimondii33.893e-37 140
LLPS-Mua-0746Musa acuminata33.571e-40 149
LLPS-Pot-1490Populus trichocarpa33.564e-39 145
LLPS-Sem-1646Selaginella moellendorffii33.221e-42 154
LLPS-Glm-2364Glycine max33.194e-37 138
LLPS-Lep-1647Leersia perrieri32.986e-39 144
LLPS-Php-0148Physcomitrella patens32.412e-43 156
LLPS-Met-1458Medicago truncatula32.41e-38 143
LLPS-Vir-1107Vigna radiata32.47e-39 144
LLPS-Viv-2187Vitis vinifera32.381e-41 152
LLPS-Orr-0439Oryza rufipogon32.383e-34 132
LLPS-Hea-1903Helianthus annuus32.357e-34 130
LLPS-Ori-1098Oryza indica31.791e-39 146
LLPS-Org-0867Oryza glaberrima31.791e-39 146
LLPS-Amt-0253Amborella trichopoda31.452e-39 145
LLPS-Cus-0332Cucumis sativus31.362e-35 135
LLPS-Orbr-1360Oryza brachyantha31.073e-39 145
LLPS-Orm-1028Oryza meridionalis31.072e-34 132
LLPS-Sei-1186Setaria italica30.961e-38 143
LLPS-Tra-0577Triticum aestivum30.961e-36 138
LLPS-Phv-0825Phaseolus vulgaris30.852e-37 140
LLPS-Orb-0188Oryza barthii30.716e-34 130
LLPS-Hov-0465Hordeum vulgare30.715e-37 140
LLPS-Orgl-0994Oryza glumaepatula30.716e-34 130
LLPS-Orp-0811Oryza punctata30.718e-34 130
LLPS-Thc-0433Theobroma cacao30.672e-36 138
LLPS-Sol-0544Solanum lycopersicum30.636e-37 139
LLPS-Mae-2170Manihot esculenta30.613e-38 142
LLPS-Brd-0151Brachypodium distachyon30.427e-38 141
LLPS-Orni-1177Oryza nivara30.362e-33 129
LLPS-Sob-1825Sorghum bicolor30.363e-37 140
LLPS-Sot-0879Solanum tuberosum30.187e-37 139
LLPS-Via-1398Vigna angularis29.976e-28 115
LLPS-Nia-0658Nicotiana attenuata29.214e-32 125
LLPS-Dac-1420Daucus carota28.997e-36 137
LLPS-Zem-0200Zea mays28.434e-33 129
LLPS-Arl-0295Arabidopsis lyrata27.961e-29 119
LLPS-Art-2949Arabidopsis thaliana27.965e-30 120
LLPS-Brn-0324Brassica napus26.865e-31 122
LLPS-Brr-0816Brassica rapa26.866e-31 122
LLPS-Bro-0697Brassica oleracea26.865e-31 122
LLPS-Tru-0244Triticum urartu26.323e-23 101
LLPS-Coc-1093Corchorus capsularis25.76e-2091.7
LLPS-Ors-1374Oryza sativa24.631e-1990.9