• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fia-1648
ARPC2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Arp2/3 complex 34 kDa subunit
Gene Name: ARPC2
Ensembl Gene: ENSFALG00000003999.1
Ensembl Protein: ENSFALP00000004175.1
Organism: Ficedula albicollis
Taxa ID: 59894
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSFALT00000004196.1ENSFALP00000004175.1
UniProtU3JN21, U3JN21_FICAL
GeneBankAGTO01001151

▼ SEQUENCE

Protein Sequence (FASTA)
1     ADMILLEVNN  RIIEETLTLK  FEGAAAGNKP  EAVEVTFADF  DGVLYHISNP  NGDKTKVMVS  60
61    ISLKFYKELQ  EHGADEVLKK  VYGSYLVNPE  SGYNVSLLYD  LENLPADKDA  IVHQAGMLKR  120
121   NCFASVFEKY  FKFQEEGKEG  EKRAVIHYRD  DETMYVEAKK  DRVTVVFSTV  FKDDDDVVIG  180
181   KVFMQEFKEG  RRASHTAPQV  LFSHREPPLE  LKDTDAAVGD  NIGYITFVLF  PRHTNAAARD  240
241   NTINLIHTFR  DYLHYHIKCS  KAYIHTRMRA  KTSDFLKVLN  RARPDAEKKE  MKTITGKTFT  300
301   TR  302
Nucleotide CDS Sequence (FASTA)
1     GCCGACATGA  TCCTGCTCGA  GGTCAACAAC  CGCATCATCG  AGGAGACCCT  CACGCTCAAG  60
61    TTCGAGGGCG  CGGCCGCCGG  AAATAAACCA  GAGGCAGTAG  AAGTAACATT  TGCAGACTTT  120
121   GATGGAGTCC  TTTACCATAT  TTCAAACCCC  AATGGAGACA  AGACAAAAGT  GATGGTCAGT  180
181   ATTTCTCTGA  AATTCTACAA  GGAACTCCAG  GAACACGGTG  CTGATGAGGT  ATTGAAGAAA  240
241   GTCTATGGAA  GCTACTTGGT  AAATCCTGAA  TCAGGTTACA  ATGTCTCTTT  GCTCTACGAC  300
301   CTGGAGAACC  TCCCTGCAGA  CAAGGATGCC  ATTGTGCACC  AAGCTGGCAT  GTTGAAGCGC  360
361   AACTGCTTTG  CTTCAGTCTT  TGAGAAGTAT  TTCAAATTCC  AGGAGGAGGG  CAAAGAAGGA  420
421   GAAAAAAGAG  CAGTCATCCA  CTACAGGGAT  GATGAGACAA  TGTATGTTGA  GGCAAAGAAG  480
481   GACCGTGTCA  CAGTTGTGTT  CAGCACAGTA  TTTAAGGACG  ACGATGACGT  GGTGATCGGA  540
541   AAGGTGTTTA  TGCAGGAGTT  CAAGGAGGGT  CGCCGGGCCA  GTCACACAGC  CCCACAGGTA  600
601   CTGTTCAGCC  ACAGGGAGCC  ACCCTTGGAG  CTGAAAGACA  CGGACGCAGC  CGTTGGCGAC  660
661   AATATTGGCT  ACATCACTTT  CGTGTTGTTC  CCCCGTCACA  CCAATGCTGC  AGCCAGAGAC  720
721   AACACCATAA  ACCTGATCCA  CACATTCCGG  GACTACCTGC  ACTACCACAT  CAAGTGCTCA  780
781   AAGGCCTATA  TTCATACACG  TATGAGGGCG  AAAACGTCAG  ATTTCCTCAA  GGTGCTCAAC  840
841   CGTGCCCGTC  CAGACGCAGA  GAAGAAAGAA  ATGAAAACAA  TCACGGGGAA  GACGTTCACA  900
901   ACCCGTTAA  909

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Endosome
Cellular Component
Focal adhesion
Cellular Component
Glutamatergic synapse
Cellular Component
Lamellipodium
Cellular Component
Muscle cell projection membrane
Molecular Function
Actin filament binding
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Actin filament polymerization
Biological Process
Arp2/3 complex-mediated actin nucleation
Biological Process
Positive regulation of lamellipodium assembly
Biological Process
Positive regulation of substrate adhesion-dependent cell spreading

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-2314Gallus gallus99.330.0 578
LLPS-Tag-0544Taeniopygia guttata98.670.0 573
LLPS-Anc-1096Anolis carolinensis96.330.0 563
LLPS-Sah-1935Sarcophilus harrisii96.00.0 516
LLPS-Bot-0224Bos taurus95.670.0 565
LLPS-Nol-1582Nomascus leucogenys95.640.0 518
LLPS-Eqc-2509Equus caballus95.560.0 551
LLPS-Cas-1972Carlito syrichta95.330.0 563
LLPS-Ict-0972Ictidomys tridecemlineatus95.330.0 563
LLPS-Poa-0510Pongo abelii95.330.0 563
LLPS-Cap-1209Cavia porcellus95.330.0 562
LLPS-Mam-1528Macaca mulatta95.330.0 563
LLPS-Orc-0162Oryctolagus cuniculus95.330.0 563
LLPS-Hos-1108Homo sapiens95.330.0 563
LLPS-Fec-0257Felis catus95.330.0 561
LLPS-Ran-2318Rattus norvegicus95.330.0 562
LLPS-Mup-0645Mustela putorius furo95.330.0 563
LLPS-Caj-3949Callithrix jacchus95.330.0 563
LLPS-Chs-2285Chlorocebus sabaeus95.330.0 563
LLPS-Pes-2668Pelodiscus sinensis95.311e-167 474
LLPS-Mod-0448Monodelphis domestica95.30.0 553
LLPS-Myl-0050Myotis lucifugus95.030.0 563
LLPS-Otg-1704Otolemur garnettii95.00.0 560
LLPS-Urm-3193Ursus maritimus95.03e-170 483
LLPS-Fud-1960Fukomys damarensis95.00.0 560
LLPS-Mea-3060Mesocricetus auratus95.00.0 561
LLPS-Mum-3688Mus musculus95.00.0 560
LLPS-Sus-3254Sus scrofa95.00.0 561
LLPS-Ova-2591Ovis aries94.850.0 543
LLPS-Loa-2923Loxodonta africana94.70.0 561
LLPS-Anp-1121Anas platyrhynchos94.20.0 532
LLPS-Aim-0204Ailuropoda melanoleuca93.440.0 554
LLPS-Tut-1030Tursiops truncatus92.670.0 559
LLPS-Pof-2163Poecilia formosa91.950.0 543
LLPS-Xim-0781Xiphophorus maculatus91.950.0 540
LLPS-Aon-2478Aotus nancymaae91.720.0 533
LLPS-Orn-1093Oreochromis niloticus91.610.0 540
LLPS-Tar-0717Takifugu rubripes91.280.0 536
LLPS-Scf-1716Scleropages formosus91.280.0 542
LLPS-Meg-1778Meleagris gallopavo91.060.0 517
LLPS-Scm-0185Scophthalmus maximus90.940.0 539
LLPS-Rhb-3004Rhinopithecus bieti90.850.0 536
LLPS-Pap-3737Pan paniscus90.850.0 535
LLPS-Pat-3271Pan troglodytes90.850.0 535
LLPS-Man-2531Macaca nemestrina90.850.0 536
LLPS-Paa-1045Papio anubis90.850.0 536
LLPS-Mal-0816Mandrillus leucophaeus90.850.0 536
LLPS-Gog-1361Gorilla gorilla90.850.0 535
LLPS-Maf-1074Macaca fascicularis90.850.0 536
LLPS-Cea-1408Cercocebus atys90.850.0 536
LLPS-Xet-1101Xenopus tropicalis90.841e-170 481
LLPS-Ten-1369Tetraodon nigroviridis90.070.0 530
LLPS-Asm-0752Astyanax mexicanus89.930.0 536
LLPS-Gaa-1085Gasterosteus aculeatus89.560.0 524
LLPS-Caf-2462Canis familiaris89.58e-103 305
LLPS-Dar-0123Danio rerio88.590.0 529
LLPS-Lac-2313Latimeria chalumnae88.040.0 516
LLPS-Icp-2425Ictalurus punctatus87.920.0 512
LLPS-Orl-1339Oryzias latipes87.460.0 516
LLPS-Leo-2281Lepisosteus oculatus87.130.0 511
LLPS-Dio-0819Dipodomys ordii83.02e-165 469
LLPS-Drm-1114Drosophila melanogaster76.096e-160 455
LLPS-Ora-0135Ornithorhynchus anatinus74.342e-65 209
LLPS-Cae-1414Caenorhabditis elegans70.534e-143 412
LLPS-Cis-0054Ciona savignyi70.433e-147 423
LLPS-Cii-0994Ciona intestinalis68.113e-143 413
LLPS-Scs-0702Sclerotinia sclerotiorum49.537e-93 285
LLPS-Pytr-0528Pyrenophora triticirepentis48.63e-90 278
LLPS-Pyt-0900Pyrenophora teres48.63e-90 278
LLPS-Lem-0991Leptosphaeria maculans48.442e-92 284
LLPS-Cogr-1019Colletotrichum graminicola47.983e-93 286
LLPS-Cog-0098Colletotrichum gloeosporioides47.668e-92 282
LLPS-Mao-0220Magnaporthe oryzae47.665e-91 280
LLPS-Ved-0638Verticillium dahliae47.351e-91 282
LLPS-Coo-0727Colletotrichum orbiculare47.352e-89 276
LLPS-Asn-0530Aspergillus nidulans47.069e-88 272
LLPS-Trr-0831Trichoderma reesei47.046e-86 267
LLPS-Asfu-0928Aspergillus fumigatus46.893e-89 276
LLPS-Usm-1436Ustilago maydis46.842e-83 261
LLPS-Map-0629Magnaporthe poae46.732e-90 279
LLPS-Zyt-1138Zymoseptoria tritici46.715e-88 273
LLPS-Abg-0998Absidia glauca46.61e-86 268
LLPS-Miv-1174Microbotryum violaceum46.547e-89 275
LLPS-Trv-0289Trichoderma virens46.423e-85 265
LLPS-Nec-1429Neurospora crassa46.423e-88 273
LLPS-Nef-1544Neosartorya fischeri46.279e-89 275
LLPS-Asc-1206Aspergillus clavatus46.279e-90 277
LLPS-Fuo-0378Fusarium oxysporum46.112e-84 263
LLPS-Blg-0488Blumeria graminis46.114e-85 265
LLPS-Fuv-0977Fusarium verticillioides46.112e-84 263
LLPS-Asni-0566Aspergillus niger45.967e-87 270
LLPS-Phn-0679Phaeosphaeria nodorum45.832e-77 245
LLPS-Tum-0625Tuber melanosporum45.835e-75 241
LLPS-Fus-0189Fusarium solani45.822e-84 264
LLPS-Dos-1086Dothistroma septosporum45.773e-85 265
LLPS-Ast-0723Aspergillus terreus45.651e-88 274
LLPS-Asf-0850Aspergillus flavus45.512e-86 268
LLPS-Aso-0438Aspergillus oryzae45.512e-86 268
LLPS-Spr-0295Sporisorium reilianum45.312e-81 256
LLPS-Scj-1309Schizosaccharomyces japonicus45.033e-79 250
LLPS-Scp-1144Schizosaccharomyces pombe45.04e-83 260
LLPS-Pug-0201Puccinia graminis44.977e-83 259
LLPS-Beb-0942Beauveria bassiana44.382e-84 263
LLPS-Osl-0802Ostreococcus lucimarinus44.294e-30 116
LLPS-Put-0573Puccinia triticina44.031e-78 248
LLPS-Yal-0109Yarrowia lipolytica43.931e-86 270
LLPS-Mel-0182Melampsora laricipopulina43.224e-74 236
LLPS-Gag-0896Gaeumannomyces graminis42.755e-63 207
LLPS-Scc-1064Schizosaccharomyces cryophilus42.554e-76 242
LLPS-Crn-0753Cryptococcus neoformans40.853e-74 237
LLPS-Kop-0825Komagataella pastoris37.952e-65 215
LLPS-Asg-0352Ashbya gossypii37.231e-48 171
LLPS-Glm-2364Glycine max33.894e-36 136
LLPS-Prp-1482Prunus persica33.553e-43 156
LLPS-Sac-0964Saccharomyces cerevisiae33.538e-46 164
LLPS-Sem-1646Selaginella moellendorffii32.612e-41 152
LLPS-Vir-1107Vigna radiata32.513e-38 143
LLPS-Viv-2187Vitis vinifera32.285e-45 161
LLPS-Pot-1490Populus trichocarpa32.094e-41 151
LLPS-Orr-0439Oryza rufipogon32.089e-36 136
LLPS-Phv-0825Phaseolus vulgaris31.665e-39 145
LLPS-Cus-0332Cucumis sativus31.636e-38 142
LLPS-Org-0867Oryza glaberrima31.553e-41 151
LLPS-Ori-1098Oryza indica31.553e-41 151
LLPS-Met-1458Medicago truncatula31.461e-39 147
LLPS-Brd-0151Brachypodium distachyon31.234e-40 148
LLPS-Lep-1647Leersia perrieri31.232e-40 149
LLPS-Php-0148Physcomitrella patens31.235e-42 153
LLPS-Sei-1186Setaria italica31.012e-39 146
LLPS-Amt-0253Amborella trichopoda30.941e-39 146
LLPS-Orbr-1360Oryza brachyantha30.918e-41 150
LLPS-Mua-0746Musa acuminata30.916e-41 150
LLPS-Dac-1420Daucus carota30.723e-38 144
LLPS-Orp-0811Oryza punctata30.63e-35 135
LLPS-Orgl-0994Oryza glumaepatula30.62e-35 135
LLPS-Orb-0188Oryza barthii30.62e-35 135
LLPS-Hov-0465Hordeum vulgare30.512e-36 139
LLPS-Gor-1439Gossypium raimondii30.423e-37 141
LLPS-Mae-2170Manihot esculenta30.416e-40 148
LLPS-Orm-1028Oryza meridionalis30.286e-35 134
LLPS-Sob-1825Sorghum bicolor30.281e-38 144
LLPS-Orni-1177Oryza nivara30.285e-35 134
LLPS-Sot-0879Solanum tuberosum30.168e-38 142
LLPS-Sol-0544Solanum lycopersicum30.167e-38 142
LLPS-Thc-0433Theobroma cacao30.066e-38 143
LLPS-Via-1398Vigna angularis30.043e-27 113
LLPS-Tra-0577Triticum aestivum29.977e-38 142
LLPS-Hea-1903Helianthus annuus29.021e-35 136
LLPS-Nia-0658Nicotiana attenuata28.962e-33 130
LLPS-Art-2949Arabidopsis thaliana28.621e-31 125
LLPS-Arl-0295Arabidopsis lyrata28.623e-31 124
LLPS-Zem-0200Zea mays28.072e-33 130
LLPS-Tru-0244Triticum urartu26.623e-2299.0
LLPS-Bro-0697Brassica oleracea26.066e-30 120
LLPS-Brr-0816Brassica rapa26.065e-30 120
LLPS-Brn-0324Brassica napus26.066e-30 120
LLPS-Coc-1093Corchorus capsularis26.047e-1989.0
LLPS-Ors-1374Oryza sativa24.832e-1990.9