LLPS-Nia-0471
A4A49_40636
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | dCTP pyrophosphatase 1 |
| Gene Name: | A4A49_40636 |
| Ensembl Gene: | A4A49_40636 |
| Ensembl Protein: | OIT19612 |
| Organism: | Nicotiana attenuata |
| Taxa ID: | 49451 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | OIT19612 | OIT19612 |
| UniProt | A0A1J6JSX5, A0A1J6JSX5_NICAT | |
| GeneBank | MJEQ01006618 | OIT19612.1 |
| RefSeq | XM_019385690.1 | XP_019241235.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTGISKEEES VTLDLLRKKM EDFAKERDWE KFHSPRNLLL ALVGEVGELS EIFQWKGEVP 60 61 KGLPDWNEKE KLHLGEELSD VLLYLVRLSD ICGIDLGKAA LRKVELNAIK YPVNLNKGSS 120 121 NKCNNEADN 129 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACAGGGA TTTCAAAGGA GGAAGAGAGT GTAACTCTTG ATCTTCTCAG GAAGAAAATG 60 61 GAAGATTTTG CTAAAGAAAG AGATTGGGAA AAGTTTCATA GCCCCAGAAA CCTTCTTTTG 120 121 GCTCTGGTGG GAGAAGTTGG AGAACTTTCA GAAATATTTC AGTGGAAAGG AGAAGTTCCA 180 181 AAAGGGTTAC CTGATTGGAA CGAAAAAGAG AAATTACATC TTGGTGAAGA ACTTTCTGAT 240 241 GTTTTGCTAT ACCTCGTTAG GCTTTCTGAT ATTTGTGGGA TTGATCTTGG CAAAGCTGCT 300 301 CTTCGTAAAG TTGAACTTAA TGCTATTAAA TACCCTGTTA ATCTCAACAA AGGTTCTTCA 360 361 AACAAATGCA ATAACGAAGC CGATAATTAA 390 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Molecular Function | Metal ion binding | |
Molecular Function | Nucleoside-triphosphate diphosphatase activity | |
Biological Process | Nucleoside triphosphate catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Viv-2266 | Vitis vinifera | 90.29 | 3e-51 | 165 |
| LLPS-Sol-1368 | Solanum lycopersicum | 89.38 | 2e-56 | 178 |
| LLPS-Amt-0410 | Amborella trichopoda | 87.16 | 1e-51 | 166 |
| LLPS-Vir-2089 | Vigna radiata | 85.71 | 3e-46 | 152 |
| LLPS-Mua-0332 | Musa acuminata | 84.35 | 5e-54 | 172 |
| LLPS-Sot-2290 | Solanum tuberosum | 84.26 | 1e-50 | 164 |
| LLPS-Mae-1833 | Manihot esculenta | 82.95 | 6e-61 | 190 |
| LLPS-Gor-0231 | Gossypium raimondii | 82.76 | 2e-53 | 172 |
| LLPS-Lep-2168 | Leersia perrieri | 81.42 | 2e-51 | 167 |
| LLPS-Orbr-1710 | Oryza brachyantha | 81.08 | 1e-49 | 162 |
| LLPS-Orp-0613 | Oryza punctata | 80.36 | 1e-49 | 163 |
| LLPS-Zem-1892 | Zea mays | 80.36 | 5e-50 | 163 |
| LLPS-Glm-2406 | Glycine max | 80.34 | 6e-53 | 170 |
| LLPS-Via-1086 | Vigna angularis | 80.34 | 3e-52 | 168 |
| LLPS-Art-2854 | Arabidopsis thaliana | 79.82 | 1e-48 | 159 |
| LLPS-Sei-1537 | Setaria italica | 79.65 | 2e-51 | 167 |
| LLPS-Brd-1271 | Brachypodium distachyon | 79.65 | 4e-50 | 163 |
| LLPS-Coc-1865 | Corchorus capsularis | 79.51 | 1e-54 | 175 |
| LLPS-Orm-1037 | Oryza meridionalis | 79.28 | 7e-50 | 163 |
| LLPS-Thc-1473 | Theobroma cacao | 78.69 | 2e-54 | 174 |
| LLPS-Bro-1614 | Brassica oleracea | 78.18 | 9e-49 | 159 |
| LLPS-Org-2217 | Oryza glaberrima | 77.88 | 1e-49 | 162 |
| LLPS-Ori-2463 | Oryza indica | 77.88 | 5e-49 | 161 |
| LLPS-Pot-1945 | Populus trichocarpa | 77.87 | 2e-52 | 169 |
| LLPS-Brr-2922 | Brassica rapa | 77.27 | 2e-48 | 158 |
| LLPS-Brn-1141 | Brassica napus | 77.27 | 3e-48 | 157 |
| LLPS-Ors-1032 | Oryza sativa | 76.79 | 5e-48 | 158 |
| LLPS-Orr-2095 | Oryza rufipogon | 76.79 | 5e-48 | 158 |
| LLPS-Orni-2019 | Oryza nivara | 76.79 | 5e-48 | 158 |
| LLPS-Orb-2207 | Oryza barthii | 76.79 | 5e-48 | 158 |
| LLPS-Orgl-2276 | Oryza glumaepatula | 76.79 | 4e-48 | 158 |
| LLPS-Dac-2082 | Daucus carota | 76.19 | 4e-53 | 170 |
| LLPS-Cus-2222 | Cucumis sativus | 75.0 | 3e-47 | 155 |
| LLPS-Phv-1937 | Phaseolus vulgaris | 74.62 | 6e-54 | 172 |
| LLPS-Sob-2046 | Sorghum bicolor | 74.6 | 4e-51 | 166 |
| LLPS-Tra-2422 | Triticum aestivum | 73.95 | 6e-47 | 155 |
| LLPS-Tru-0046 | Triticum urartu | 73.77 | 2e-47 | 157 |
| LLPS-Arl-1879 | Arabidopsis lyrata | 73.11 | 2e-47 | 156 |
| LLPS-Sem-1928 | Selaginella moellendorffii | 72.32 | 3e-43 | 145 |
| LLPS-Met-0646 | Medicago truncatula | 72.13 | 4e-48 | 157 |
| LLPS-Hea-2160 | Helianthus annuus | 72.09 | 2e-51 | 166 |
| LLPS-Hov-2115 | Hordeum vulgare | 70.27 | 9e-40 | 137 |
| LLPS-Php-0879 | Physcomitrella patens | 69.57 | 8e-41 | 140 |
| LLPS-Prp-1511 | Prunus persica | 61.34 | 6e-36 | 126 |
| LLPS-Orn-3739 | Oreochromis niloticus | 59.81 | 5e-33 | 118 |
| LLPS-Lac-3619 | Latimeria chalumnae | 59.46 | 5e-33 | 119 |
| LLPS-Mod-3373 | Monodelphis domestica | 57.66 | 2e-26 | 102 |
| LLPS-Anc-1124 | Anolis carolinensis | 57.66 | 2e-27 | 104 |
| LLPS-Dar-3355 | Danio rerio | 56.41 | 7e-33 | 119 |
| LLPS-Sah-2534 | Sarcophilus harrisii | 55.86 | 1e-26 | 103 |
| LLPS-Mal-4409 | Mandrillus leucophaeus | 55.86 | 1e-25 | 100 |
| LLPS-Xet-0903 | Xenopus tropicalis | 55.75 | 2e-29 | 110 |
| LLPS-Chr-1582 | Chlamydomonas reinhardtii | 55.17 | 4e-27 | 105 |
| LLPS-Rhb-3840 | Rhinopithecus bieti | 54.95 | 3e-25 | 99.8 |
| LLPS-Man-0118 | Macaca nemestrina | 54.95 | 3e-25 | 99.8 |
| LLPS-Mam-2686 | Macaca mulatta | 54.95 | 3e-25 | 99.8 |
| LLPS-Cap-2568 | Cavia porcellus | 54.95 | 3e-26 | 102 |
| LLPS-Gog-4524 | Gorilla gorilla | 54.95 | 3e-25 | 99.8 |
| LLPS-Maf-1548 | Macaca fascicularis | 54.95 | 3e-25 | 99.8 |
| LLPS-Chs-4652 | Chlorocebus sabaeus | 54.95 | 3e-25 | 99.8 |
| LLPS-Paa-0538 | Papio anubis | 54.95 | 3e-25 | 99.8 |
| LLPS-Ran-3813 | Rattus norvegicus | 54.95 | 1e-26 | 103 |
| LLPS-Pof-0132 | Poecilia formosa | 54.7 | 5e-32 | 117 |
| LLPS-Icp-2981 | Ictalurus punctatus | 54.7 | 1e-31 | 115 |
| LLPS-Xim-0903 | Xiphophorus maculatus | 54.7 | 4e-32 | 117 |
| LLPS-Gaa-3835 | Gasterosteus aculeatus | 54.39 | 7e-30 | 110 |
| LLPS-Otg-4631 | Otolemur garnettii | 54.05 | 7e-25 | 98.6 |
| LLPS-Pat-0490 | Pan troglodytes | 54.05 | 2e-24 | 97.8 |
| LLPS-Pap-4468 | Pan paniscus | 54.05 | 2e-24 | 97.8 |
| LLPS-Hos-1655 | Homo sapiens | 54.05 | 2e-24 | 97.8 |
| LLPS-Nol-0077 | Nomascus leucogenys | 54.05 | 1e-24 | 97.8 |
| LLPS-Poa-4518 | Pongo abelii | 54.05 | 2e-24 | 97.8 |
| LLPS-Eqc-2549 | Equus caballus | 54.05 | 2e-23 | 95.5 |
| LLPS-Caj-1249 | Callithrix jacchus | 54.05 | 3e-25 | 99.8 |
| LLPS-Aon-1661 | Aotus nancymaae | 54.05 | 3e-25 | 99.8 |
| LLPS-Tar-2338 | Takifugu rubripes | 53.98 | 7e-30 | 111 |
| LLPS-Ora-2591 | Ornithorhynchus anatinus | 53.77 | 2e-25 | 99.8 |
| LLPS-Urm-3508 | Ursus maritimus | 53.51 | 8e-25 | 98.6 |
| LLPS-Mum-3458 | Mus musculus | 53.51 | 1e-26 | 103 |
| LLPS-Aim-4354 | Ailuropoda melanoleuca | 53.51 | 5e-25 | 99.0 |
| LLPS-Myl-1010 | Myotis lucifugus | 53.51 | 2e-25 | 100 |
| LLPS-Dio-3141 | Dipodomys ordii | 53.51 | 1e-25 | 100 |
| LLPS-Bot-2239 | Bos taurus | 53.51 | 1e-25 | 100 |
| LLPS-Ten-3777 | Tetraodon nigroviridis | 53.27 | 1e-27 | 104 |
| LLPS-Tut-1294 | Tursiops truncatus | 53.21 | 1e-24 | 97.1 |
| LLPS-Scm-0460 | Scophthalmus maximus | 52.99 | 1e-30 | 113 |
| LLPS-Orl-3904 | Oryzias latipes | 52.99 | 8e-31 | 114 |
| LLPS-Leo-1791 | Lepisosteus oculatus | 52.99 | 3e-29 | 109 |
| LLPS-Orc-3944 | Oryctolagus cuniculus | 52.63 | 4e-25 | 99.4 |
| LLPS-Ict-2974 | Ictidomys tridecemlineatus | 52.63 | 5e-26 | 101 |
| LLPS-Caf-2524 | Canis familiaris | 52.63 | 8e-25 | 98.6 |
| LLPS-Ova-4296 | Ovis aries | 52.63 | 2e-25 | 100 |
| LLPS-Mup-1583 | Mustela putorius furo | 52.03 | 3e-25 | 99.8 |
| LLPS-Fec-1257 | Felis catus | 51.75 | 3e-24 | 97.1 |
| LLPS-Sus-4327 | Sus scrofa | 51.75 | 3e-25 | 99.8 |
| LLPS-Asm-2849 | Astyanax mexicanus | 50.43 | 2e-28 | 108 |
| LLPS-Gas-0636 | Galdieria sulphuraria | 49.11 | 4e-22 | 94.0 |
| LLPS-Fus-1446 | Fusarium solani | 39.81 | 5e-14 | 68.6 |